Research Topics
| R T ChenSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
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Publications
Evaluation of vaccine safety after the events of 11 September 2001: role of cohort and case-control studiesRobert T Chen
Immunization Safety Branch, National Immunization Program MS E61 Centers for Disease Control, Prevention Corporate Square Office Park, Building 12 Rm 2419 CDC, Atlanta, GA 30333, USA
Vaccine 22:2047-53. 2004..The new clinical immunization safety assessment centers may play an important role in bridging the sometimes conflicting clinical and epidemiologic perspectives in vaccine safety...
Epidemiology of autoimmune reactions induced by vaccinationR T Chen
Vaccine Safety and Development Activity, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Autoimmun 16:309-18. 2001..Examples include the possible association of immunization and multiple sclerosis (and other demyelinating diseases), type 1 diabetes mellitus, Guillain-Barre Syndrome, idiopathic thrombocytopenic purpura, and rheumatoid arthritis...
Combination vaccines: postlicensure safety evaluationR T Chen
Vaccine Safety and Development Activity, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Clin Infect Dis 33:S327-33. 2001..Only by investing in vaccine safety infrastructure at a level commensurate with investments in vaccine development can we hope to retain the public's confidence in immunization...
Myocarditis: the unexpected return of smallpox vaccine adverse eventsRobert T Chen
Immunization Safety Branch, National Immunization Program, and Smallpox Eradication Program Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Lancet 362:1345-6. 2003
Epidemiology of diarrheal disease among children enrolled in four West Coast health maintenance organizations. Vaccine Safety Datalink TeamU D Parashar
Epidemic Intelligence Service, Viral Gastroenteritis Section, CDC, Atlanta, GA 30333, USA
Pediatr Infect Dis J 17:605-11. 1998..We used information from the Vaccine Safety Datalink (VSD) about approximately 1 million children enrolled in four health maintenance organizations to assess the morbidity from diarrhea and estimate the disease burden of rotavirus...
Challenges and controversies in immunization safetyR T Chen
National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Infect Dis Clin North Am 15:21-39, viii. 2001..It also provides information on how various safety research is conducted, some of the concurrent challenges, and finally, some guidance on communicating with patients on vaccine risks...
Does influenza vaccination exacerbate asthma? Analysis of a large cohort of children with asthma. Vaccine Safety Datalink TeamP Kramarz
Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Arch Fam Med 9:617-23. 2000..One reason for low influenza vaccine coverage among children with asthma may be concern that influenza vaccination may induce an exacerbation of asthma...
Influenza vaccination in children with asthma in health maintenance organizations. Vaccine Safety Datalink TeamP Kramarz
Centers for Disease Control and Prevention, 1600 Clifton Road, MS E61, Atlanta, GA 30333, USA
Vaccine 18:2288-94. 2000..Vaccination coverage could be increased by taking advantage of all opportunities to vaccinate children with asthma whenever they make clinic visits in the fall and early winter...
Childhood vaccinations, vaccination timing, and risk of type 1 diabetes mellitusF DeStefano
National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3724, USA
Pediatrics 108:E112. 2001..To evaluate suggested associations between childhood vaccinations, particularly against hepatitis B and Haemophilus influenzae type b, and risk of developing type 1 diabetes; and to determine whether timing of vaccination influences risk...
Addressing the challenges to immunization practice with an economic algorithm for vaccine selectionB G Weniger
National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Vaccine 16:1885-97. 1998....
The Vaccine Safety Datalink: immunization research in health maintenance organizations in the USAR T Chen
National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Bull World Health Organ 78:186-94. 2000....
Ukraine, 1992: first assessment of diphtheria vaccine effectiveness during the recent resurgence of diphtheria in the Former Soviet UnionR T Chen
National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Infect Dis 181:S178-83. 2000..It is concluded that initial priority for scarce resources for controlling this outbreak should be placed on vaccination of persons susceptible to diphtheria (e.g., adults) rather than revaccination of children...
Enhancing vaccine safety surveillance: a capture-recapture analysis of intussusception after rotavirus vaccinationT Verstraeten
Epidemic Intelligence Service, Division of Applied Public Health Training, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, GA, USA
Am J Epidemiol 154:1006-12. 2001..7 and 4.4, respectively) were comparable with those reported in the two studies. Linkage of VAERS to complimentary data sources may permit more timely postmarketing assessment of vaccine safety...
The incidence of Kawasaki syndrome in West Coast health maintenance organizationsE D Belay
Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
Pediatr Infect Dis J 19:828-32. 2000..Kawasaki syndrome (KS) causes an acute vasculitis of unknown etiology. It is a leading cause of acquired heart disease of children in Japan and the United States...
A 'post-honeymoon period' measles outbreak in Muyinga sector, BurundiR T Chen
National Immunization Program MS E61 Centers for Disease Control and Prevention, Atlanta, GA 30333
Int J Epidemiol 23:185-93. 1994..Such outbreaks present new challenges to newly maturing immunization programmes in improving skills in surveillance, outbreak investigation, and public relations...
Does influenza vaccination prevent asthma exacerbations in children?P Kramarz
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Pediatr 138:306-10. 2001..The effectiveness of influenza vaccine in preventing influenza-related asthma exacerbations, however, is not known. We evaluated influenza vaccine effectiveness in protecting children against influenza-related asthma exacerbations...
Individual and community risks of measles and pertussis associated with personal exemptions to immunizationD R Feikin
Respiratory Diseases Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd, MS C23, Atlanta, GA 30333, USA
JAMA 284:3145-50. 2000..The risk of vaccine-preventable diseases among children who have philosophical and religious exemptions from immunization has been understudied...
An overview of the vaccine adverse event reporting system (VAERS) as a surveillance system. VAERS Working GroupJ A Singleton
Vaccine Safety and Development Activity, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Vaccine 17:2908-17. 1999..The acceptability, sensitivity and representativeness of VAERS are unknown. The study of vaccine safety is complicated by underreporting, erroneous reporting, frequent multiple exposures and multiple outcomes...
The National Immunization Information HotlineD A Gust
Epidemiology and Surveillance Division, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
J Health Commun 9:371-9. 2004....
National Immunization Information Hotline: Calls concerning adverse events, 1998-2000D A Gust
Epidemiology and Surveillance Division, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgi 30333, USA
J Health Commun 9:387-94. 2004....
Safety of thimerosal-containing vaccines: a two-phased study of computerized health maintenance organization databasesThomas Verstraeten
Epidemic Intelligence Service Program, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Pediatrics 112:1039-48. 2003..Conflicting results were found at different HMOs for certain outcomes. For resolving the conflicting findings, studies with uniform neurodevelopmental assessments of children with a range of cumulative thimerosal exposures are needed...
An analysis of rotavirus vaccine reports to the vaccine adverse event reporting system: more than intussusception alone?Penina Haber
National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Pediatrics 113:e353-9. 2004....
Model-based estimates of risks of disease transmission and economic costs of seven injection devices in sub-Saharan AfricaDonatus U Ekwueme
National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA, USA
Bull World Health Organ 80:859-70. 2002..To investigate and compare seven types of injection devices for their risks of iatrogenic transmission of bloodborne pathogens and their economic costs in sub-Saharan Africa...
Guillain-Barré syndrome following influenza vaccinationPenina Haber
Immunization Safety Branch, Epidemiology and Surveillance Division, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
JAMA 292:2478-81. 2004..Guillain-Barre syndrome remains the most frequent neurological condition reported after influenza vaccination to the Vaccine Adverse Events Reporting System (VAERS) since its inception in 1990...
Safety profile of smallpox vaccine: insights from the laboratory worker smallpox vaccination programJames Baggs
Centers for Disease Control and Prevention, National Immunization Program, Epidemiology and Surveillance Division, Immunization Safety Branch, 1600 Clifton Rd, Mailstop E61, Atlanta, GA 30333, USA
Clin Infect Dis 40:1133-40. 2005..This report describes the frequency of such symptoms among 936 adult smallpox vaccinees with and without a history of prior smallpox vaccination...
Active surveillance of vaccine safety: a system to detect early signs of adverse eventsRobert L Davis
Departments of Epidemiology and Pediatrics, University of Washington, Seattle, Washington, USA
Epidemiology 16:336-41. 2005..To evaluate the feasibility of developing such systems, we used 5 years of data from 4 health maintenance organizations within the Centers for Disease Control and Prevention (CDC) Vaccine Safety Datalink...
Promise of new Japanese encephalitis vaccinesMarc Fischer
National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA
Lancet 370:1806-8. 2007
Live attenuated measles and mumps viral strain-containing vaccines and hearing loss: Vaccine Adverse Event Reporting System (VAERS), United States, 1990--2003Armenak Asatryan
Science Applications International Corporation and Emory University School of Medicine, Atlanta, GA, USA
Vaccine 26:1166-72. 2008..Thus, HL following MMCV has been reported in the literature and to the VAERS. Further studies are needed to better understand if there is a causal relationship between MMCV and HL...
A process for sentinel case review to assess causal relationships between smallpox vaccination and adverse outcomes, 2003-2004Louisa E Chapman
Epidemiology and Surveillance Division, National Immunization Program, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Clin Infect Dis 46:S271-93. 2008..This review of sentinel cases augmented the ongoing safety review process and was transparent, but it shares limitations with other case-based causality-assessment methods...
HIV testing outside of the study among men who have sex with men participating in an HIV vaccine efficacy trialDeborah A Gust
National Center for HIV AIDS, Viral Hepatitis, TB and STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
J Acquir Immune Defic Syndr 52:294-8. 2009....
Hepatitis B vaccine and risk of multiple sclerosisFrank Destefano
Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3724, USA
Expert Rev Vaccines 1:461-6. 2002..The US Institute of Medicine and other review panels have concluded that the evidence favors rejection of a causal association between hepatitis B vaccine and multiple sclerosis...
Circumcision status and HIV infection among MSM: reanalysis of a Phase III HIV vaccine clinical trialDeborah A Gust
HIV Vaccine and Special Studies Team, Epidemiology Branch, Division of HIV AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
AIDS 24:1135-43. 2010..Determine whether male circumcision would be effective in reducing HIV transmission among men who have sex with men (MSM)...
Vaccinations and risk of central nervous system demyelinating diseases in adultsFrank Destefano
National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Arch Neurol 60:504-9. 2003..Several case reports of the onset or exacerbation of multiple sclerosis or other demyelinating conditions shortly after vaccination have suggested that vaccines may increase the risk of demyelinating diseases...
Prevalence of anti-gelatin IgE antibodies in people with anaphylaxis after measles-mumps rubella vaccine in the United StatesVitali Pool
Vaccine Safety and Development Activity, Epidemiology and Surveillance Division, National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Pediatrics 110:e71. 2002....
Vaccine risks: real, perceived and unknownR T Chen
Vaccine Safety and Development Branch, National Immunization Program MS E61, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA
Vaccine 17:S41-6. 1999....
Surveillance for poliovirus vaccine adverse events, 1991 to 1998: impact of a sequential vaccination schedule of inactivated poliovirus vaccine followed by oral poliovirus vaccineW A Wattigney
Centers for Disease Control and Prevention, National Immunization Program, Atlanta, Georgia 30341 3717, USA
Pediatrics 107:E83. 2001..We compared VAERS reports after the receipt of IPV to reports after OPV in infants from 1991 through 1998. Comparisons included reports listing IPV and OPV coadministered with other vaccines...
Processes for obtaining nonmedical exemptions to state immunization lawsJ S Rota
Centers for Disease Control and Prevention, Measles Virus Section, Mail Stop C 22, 1600 Clifton Rd, Atlanta, GA 30333, USA
Am J Public Health 91:645-8. 2001..This study sought to determine the specific processes required for obtaining religious and philosophical exemptions to school immunization laws...
A potential signal of Bell's palsy after parenteral inactivated influenza vaccines: reports to the Vaccine Adverse Event Reporting System (VAERS)--United States, 1991-2001Weigong Zhou
Epidemic Intelligence Service, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Pharmacoepidemiol Drug Saf 13:505-10. 2004..A population-based controlled study is needed to determine whether this association could be causal and to quantify the risk...
Childhood vaccinations and risk of asthmaFrank Destefano
Centers for Disease Control and Prevention, Atlanta, GA, USA
Pediatr Infect Dis J 21:498-504. 2002..The weak associations for Hib and hepatitis B vaccines seem to be at least partially accounted for by health care utilization or information bias...
Active telephone surveillance to evaluate adverse events among civilian smallpox vaccine recipientsArnulfo A Muralles
National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA, USA
Vaccine 24:476-84. 2006..5%), muscle pain (23.1%), chills (14.4%), joint pain 11.8%, and fever >100 degrees F (12.5%). The 12.5% reported missing work because of vaccine adverse events. Most adverse events were anticipated and of short duration...
Population-based study of rotavirus vaccination and intussusceptionP Kramarz
National Immunization Program, Centers for Disease Control and Prevention, Atlanta, GA, USA
Pediatr Infect Dis J 20:410-6. 2001..0. The attributable risk was one case of intussusception per 11 073 children vaccinated. CONCLUSIONS: RRV-TV is associated with an increased risk of intussusception. The risk is greatest 3 to 7 days after the first vaccination dose...
Autism and measles-mumps-rubella vaccination: controversy laid to rest?F DeStefano
National Center on Birth Defects and Developmental Disabilities, Atlanta, Georgia 30341 3724, USA
CNS Drugs 15:831-7. 2001..Currently, the weight of the available epidemiological and related evidence does not support a causal association between MMR vaccine, or any other vaccine or vaccine constituent, and autism...
Principles of measles controlF T Cutts
Immunization Division, Centers for Disease Control, Atlanta, GA 30333
Bull World Health Organ 69:1-7. 1991....
A retrospective cohort study of the association of varicella vaccine failure with asthma, steroid use, age at vaccination, and measles-mumps-rubella vaccinationThomas Verstraeten
Epidemic Intelligence Service Program, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Pediatrics 112:e98-103. 2003..We assessed the association of varicella breakthrough with asthma, steroids, age at varicella vaccination, and timing of measles-mumps-rubella (MMR) vaccination...
Advanced age a risk factor for illness temporally associated with yellow fever vaccinationM Martin
Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Emerg Infect Dis 7:945-51. 2001..For elderly travelers, the risk for severe illness and death due to YF infection should be balanced against the risk for systemic illness due to YF vaccine...
The role of the Vaccine Adverse Event Reporting system (VAERS) in monitoring vaccine safetyJohn K Iskander
Centers for Disease Control and Prevention, National Immunization Program, Epidemiology and Surveillance Division, Immunization Safety Branch, Atlanta, GA 30333, USA
Pediatr Ann 33:599-606. 2004..This process begins with voluntary submission of reports of possible vaccine-associated events to VAERS by the informed and conscientious health professional...
Adverse event reports following vaccination for Lyme disease: December 1998-July 2000Sarah L Lathrop
Centers for Disease Control and Prevention, Epidemic Intelligence Service, Atlanta, GA 30333, USA
Vaccine 20:1603-8. 2002....
Yellow fever vaccine: an updated assessment of advanced age as a risk factor for serious adverse eventsAlena Y Khromava
Epidemic Intelligence Service, Epidemiology Program Office, Centers for Disease Control and Prevention, Atlanta, GA, USA
Vaccine 23:3256-63. 2005..6-22.2). Yellow fever is a serious and potentially fatal disease. For elderly travelers, the risk for severe illness and death due to yellow fever infection should be balanced against the risk of a serious adverse event due to YEL...
Hepatitis B vaccine and risk of multiple sclerosisFrank Destefano
Pharmacoepidemiol Drug Saf 16:705-7, author reply 707-8. 2007
Vaccines and changes in coagulation parameters in adults on chronic warfarin therapy: a cohort studyMichael L Jackson
Group Health Center for Health Studies, Seattle, WA 98101 1448, USA
Pharmacoepidemiol Drug Saf 16:790-6. 2007..We sought to determine whether vaccinations are associated with changes in International Normalized Ratio (INR) in persons on long-term warfarin therapy...
Recombinant hepatitis B vaccine and the risk of multiple sclerosis: a prospective studyFrank Destefano
Neurology 64:1317; author reply 1317. 2005
Risk of immune thrombocytopenic purpura after measles-mumps-rubella immunization in childrenEric K France
Department of Preventive Medicine, Kaiser Pemanente Colorado, Denver, CO 80231, USA
Pediatrics 121:e687-92. 2008..The measles-mumps-rubella vaccine has been associated with immune thrombocytopenia purpura in 2 small studies...
Safety of trivalent inactivated influenza vaccine in children 6 to 23 months oldSimon J Hambidge
Clinical Research Unit, Kaiser Permanente Colorado, Denver, CO 80237 8066, USA
JAMA 296:1990-7. 2006..Beginning with the winter season of 2004-2005, influenza vaccination has been recommended for all children 6 to 23 months old in the United States. However, its safety in young children has not been adequately studied in large populations...
Validation of a screening instrument to identify persons for exclusion from smallpox vaccinationEdward A Belongia
Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA
Clin Infect Dis 40:620-3. 2005..Further assessment of screening procedures is needed if the administration of smallpox vaccine becomes more widespread in the future...
Eczematous skin disease and recall of past diagnoses: implications for smallpox vaccinationAllison L Naleway
Marshfield Clinic Research Foundation, Marshfield, Wisconsin 54449, USA
Ann Intern Med 139:1-7. 2003....
Vaccine safety surveillance using large linked databases: opportunities, hazards and proposed guidelinesThomas Verstraeten
GlaxoSmithKline Biologicals, Rixensart, Belgium
Expert Rev Vaccines 2:21-9. 2003..We also offer our opinion on the future use of large linked databases for vaccine safety surveillance purposes...
Surveillance for safety after immunization: Vaccine Adverse Event Reporting System (VAERS)--United States, 1991-2001Weigong Zhou
Epidemic Intelligence Service Program, Epidemiology Program Office, CDC, USA
MMWR Surveill Summ 52:1-24. 2003..This knowledge facilitates improvement in the safety of vaccines and the vaccination process...
Adverse event reporting rates following tetanus-diphtheria and tetanus toxoid vaccinations: data from the Vaccine Adverse Event Reporting System (VAERS), 1991-1997Jenifer C Lloyd
Office of Epidemiology, Utah Department of Health, Bureau for Children with Special Health Care Needs, P O Box 144640, Salt Lake City, UT 84114 4640, USA
Vaccine 21:3746-50. 2003..While reporting rates are lower after TT than Td, rates of reported VAEs after both vaccines are low...
Polio extraimmunization in children younger than 2 years after changes in immunization recommendationsLoren K Mell
Center for Health Studies, Group Health Cooperative, Seattle, Washington, USA
Pediatrics 111:296-301. 2003..CONCLUSIONS: Poliovirus extraimmunization rates have fallen dramatically in association with the change-over to the all inactivated polio virus schedule...
The development of standardized case definitions and guidelines for adverse events following immunizationKatrin S Kohl
Vaccine 25:5671-4. 2007
Use of the inactivated intranasal influenza vaccine and the risk of Bell's palsy in SwitzerlandMargot Mutsch
Division of Communicable Diseases, World Health Organization Collaborating Centre for Travellers Health, Institute of Social and Preventive Medicine, University of Zurich, Zurich, Switzerland
N Engl J Med 350:896-903. 2004..After the introduction of an inactivated intranasal influenza vaccine that was used only in Switzerland, 46 cases of Bell's palsy were reported...
Understanding vaccine safety information from the Vaccine Adverse Event Reporting SystemFrederick Varricchio
Division of Epidemiology, Office of Biostatistics and Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration/NIH/DHHS, Rockville MD, USA
Pediatr Infect Dis J 23:287-94. 2004..Confirmation in a controlled study is usually required. An understanding of the system's defined objectives and inherent drawbacks is vital to the effective use of VAERS data in vaccine safety investigations...
Vaccine safety issues: introductionRobert T Chen
Semin Pediatr Infect Dis 14:187. 2003
Compliance with national immunization guidelines for children younger than 2 years, 1996-1999Loren K Mell
Center for Health Studies, Group Health Cooperative, Seattle, Washington, USA
Pediatrics 115:461-7. 2005..6% of children were compliant with prevailing childhood immunization recommendations from 1996 to 1999. Efforts to improve compliance with guidelines are recommended, to optimize childhood infectious disease prevention...
Neurologic disease associated with 17D-204 yellow fever vaccination: a report of 15 casesAnn W McMahon
1401 Rockville Pike, HFM 220, Rockville, MD 20852, USA
Vaccine 25:1727-34. 2007..Laboratory and epidemiological evidence suggests that YEL caused encephalitis. Additional studies will be required to confirm whether YEL can rarely result in GBS and/or ADEM...
Lack of association between hepatitis B birth immunization and neonatal death: a population-based study from the vaccine safety datalink projectEileen M Eriksen
UCLA Center for Vaccine Research, Harbor-UCLA Medical Center, Torrance, CA 90502, USA
Pediatr Infect Dis J 23:656-62. 2004..CONCLUSIONS: A relationship between HBV and neonatal death was not identified...
Anti-ganglioside antibody induction by swine (A/NJ/1976/H1N1) and other influenza vaccines: insights into vaccine-associated Guillain-Barré syndromeIrving Nachamkin
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
J Infect Dis 198:226-33. 2008....
Standardized case definitions of adverse events following immunization (AEFI)Jan Bonhoeffer
Vaccine 22:547-50. 2004
