Fei Chen

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. pmc Nucleolin links to arsenic-induced stabilization of GADD45alpha mRNA
    Yadong Zhang
    Institute for Nutritional Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Nucleic Acids Res 34:485-95. 2006
  2. pmc New insights into the role of nuclear factor-kappaB in cell growth regulation
    F Chen
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd, Morgantown, WV 26505, USA
    Am J Pathol 159:387-97. 2001
  3. ncbi request reprint Upstream signal transduction of NF-kappaB activation
    Fei Chen
    The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Curr Drug Targets Inflamm Allergy 1:137-49. 2002
  4. ncbi request reprint Inhibitor of nuclear factor kappaB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenic
    Fei Chen
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Cancer Res 63:7689-93. 2003
  5. ncbi request reprint Loss of Ikkbeta promotes migration and proliferation of mouse embryo fibroblast cells
    Fei Chen
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Biol Chem 281:37142-9. 2006
  6. ncbi request reprint Tumor promoting or tumor suppressing of NF-kappa B, a matter of cell context dependency
    Fei Chen
    Pathology and Physiology Research Branch, The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    Int Rev Immunol 27:183-204. 2008
  7. pmc Signaling from toxic metals to NF-kappaB and beyond: not just a matter of reactive oxygen species
    Fei Chen
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Environ Health Perspect 110:807-11. 2002
  8. ncbi request reprint Finding NEMO by K63-linked polyubiquitin chain
    F Chen
    The Health Effect Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Cell Death Differ 13:1835-8. 2006
  9. ncbi request reprint Beyond apoptosis of JNK1 in liver cancer
    Fei Chen
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Cell Cycle 8:1145-7. 2009
  10. doi request reprint JNK1, a potential therapeutic target for hepatocellular carcinoma
    Fei Chen
    Laboratory of Cancer Signaling and Epigenetics, Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Biochim Biophys Acta 1796:242-51. 2009

Collaborators

Detail Information

Publications76

  1. pmc Nucleolin links to arsenic-induced stabilization of GADD45alpha mRNA
    Yadong Zhang
    Institute for Nutritional Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Nucleic Acids Res 34:485-95. 2006
    ..Stabilization of GADD45alpha mRNA, thus, represents a novel mechanism contributing to the production of GADD45alpha and cell cycle arrest in response to As3+...
  2. pmc New insights into the role of nuclear factor-kappaB in cell growth regulation
    F Chen
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd, Morgantown, WV 26505, USA
    Am J Pathol 159:387-97. 2001
    ..Elucidation of the relationships between NF-kappaB activation and cell growth will be important in developing new strategies for the treatment of various human diseases, such as chronic autoimmune disorder and cancer...
  3. ncbi request reprint Upstream signal transduction of NF-kappaB activation
    Fei Chen
    The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Curr Drug Targets Inflamm Allergy 1:137-49. 2002
    ..Such inhibitors would be predicted to have potent anti-inflammatory and/or anti-carcinogenic effects...
  4. ncbi request reprint Inhibitor of nuclear factor kappaB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenic
    Fei Chen
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Cancer Res 63:7689-93. 2003
    ..Inhibition of CYP1B1 reduced both oxidative stress and arsenic-stimulated JNK activation. Thus, increased CYP1B1 expression is central to and seems to be responsible for sensitizing Ikkbeta(-/-) cells to stress-induced JNK activation...
  5. ncbi request reprint Loss of Ikkbeta promotes migration and proliferation of mouse embryo fibroblast cells
    Fei Chen
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Biol Chem 281:37142-9. 2006
    ..These data thus suggest that IKKbeta provides inhibitory signals for cell mobility and growth. Deficiency in the Ikkbeta gene promotes cell mobilization, at least partially, through a ROS-dependent mechanism...
  6. ncbi request reprint Tumor promoting or tumor suppressing of NF-kappa B, a matter of cell context dependency
    Fei Chen
    Pathology and Physiology Research Branch, The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    Int Rev Immunol 27:183-204. 2008
    ..Thus, it is highly possible that tumor promoting or tumor suppressing of NF-kappa B signaling is determined by the type of cells, stimuli, simultaneous or asynchronous intracellular signals, and other cellular contexts...
  7. pmc Signaling from toxic metals to NF-kappaB and beyond: not just a matter of reactive oxygen species
    Fei Chen
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Environ Health Perspect 110:807-11. 2002
    ..In the present review, we have attempted to evaluate and update the possible mechanisms of metal signals on the activation and function of NF-kappaB...
  8. ncbi request reprint Finding NEMO by K63-linked polyubiquitin chain
    F Chen
    The Health Effect Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Cell Death Differ 13:1835-8. 2006
  9. ncbi request reprint Beyond apoptosis of JNK1 in liver cancer
    Fei Chen
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Cell Cycle 8:1145-7. 2009
    ..Accordingly, we believe that targeting JNK1 is not only mechanistically sound but also clinically feasible for the treatment of HCC...
  10. doi request reprint JNK1, a potential therapeutic target for hepatocellular carcinoma
    Fei Chen
    Laboratory of Cancer Signaling and Epigenetics, Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Biochim Biophys Acta 1796:242-51. 2009
    ..In this review the various associations between JNK1 and HCC are discussed with the hope that targeting this pivotal kinase may lead to novel therapeutic approaches for this fatal disease...
  11. ncbi request reprint Intracellular signal transduction of cells in response to carcinogenic metals
    Fei Chen
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Crit Rev Oncol Hematol 42:105-21. 2002
    ..This review summarizes current knowledge and our recent studies concerning intracellular signal transduction pathways initiated by carcinogenic metals and the cross-talk that occurs among these pathways in cells in response to metals...
  12. pmc Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathway
    Fei Chen
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Proc Natl Acad Sci U S A 99:1990-5. 2002
    ....
  13. ncbi request reprint Endogenous inhibitors of nuclear factor-kappaB, an opportunity for cancer control
    Fei Chen
    The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Cancer Res 64:8135-8. 2004
    ..The question to be asked is how NF-kappaB is sustained activated in a number of cancers in which so many antagonists are surrounded...
  14. ncbi request reprint Protective roles of NF-kappa B for chromium(VI)-induced cytotoxicity is revealed by expression of Ikappa B kinase-beta mutant
    Fei Chen
    Health Effects Laboratory Division, NIOSH, Morgantown, West Virginia 26505, USA
    J Biol Chem 277:3342-9. 2002
    ..Such inhibition may involve up-regulation of the expression of anti-death proteins including cIAP1 that prevents spontaneous caspase activation and subsequent cleavage of Bcl-xL protein...
  15. ncbi request reprint Inhibition of NF-kappaB stabilizes gadd45alpha mRNA
    Xue Zheng
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, PR China
    Biochem Biophys Res Commun 329:95-9. 2005
    ..Thus, these data are the first to suggest that inhibition of Ikkbeta-NF-kappaB signaling up-regulates the expression of gadd45alpha mNRA through a post-transcriptional, rather than a transcriptional, mechanism...
  16. pmc Characterization of an alternatively spliced GADD45alpha, GADD45alpha1 isoform, in arsenic-treated epithelial cells
    Yadong Zhang
    The Laboratory of Cancer Signaling and Epigenetics, The Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Mol Carcinog 48:454-64. 2009
    ..Thus, these data suggest that the generation of the GADD45alpha1 isoform may not only offset but also antagonize the effects of arsenic and GADD45alpha on cell growth and cell cycle regulation...
  17. ncbi request reprint The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancer
    Yadong Zhang
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China
    Oncogene 24:4873-82. 2005
    ..These results suggest that the mdig gene may be involved in the regulation of cell growth and possibly the development of cancer...
  18. ncbi request reprint Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3
    Yongju Lu
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Cell Cycle 8:2101-9. 2009
    ..The pronounced expression of mdig in lung cancer tissues but not normal lung tissues, thus, suggests that mdig possesses oncogenic property through antagonizing tri-methyl lysine 9 on histone H3 and promoting ribosomal RNA synthesis...
  19. pmc miR-190-mediated downregulation of PHLPP contributes to arsenic-induced Akt activation and carcinogenesis
    Kevin Beezhold
    The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Toxicol Sci 123:411-20. 2011
    ..Accordingly, the data presented suggest that induction of miR-190 is one of the key mechanisms in As(3+)-induced carcinogenesis...
  20. ncbi request reprint Incorporation of an internal ribosome entry site-dependent mechanism in arsenic-induced GADD45 alpha expression
    Qingshan Chang
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, West Verginia University, Morgantown, WV 26505, USA
    Cancer Res 67:6146-54. 2007
    ..Thus, these results suggest that in growth-arrested cells, As(3+) is still capable of inducing GADD45 alpha expression through an IRES-dependent translational regulation...
  21. pmc The Fas death signaling pathway connecting reactive oxygen species generation and FLICE inhibitory protein down-regulation
    Liying Wang
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Immunol 180:3072-80. 2008
    ....
  22. doi request reprint Wnt/beta-catenin signaling suppresses Rapsyn expression and inhibits acetylcholine receptor clustering at the neuromuscular junction
    Jia Wang
    Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, China
    J Biol Chem 283:21668-75. 2008
    ..Together, these results suggest that Wnt/beta-catenin signaling plays a negative role for postsynaptic differentiation at the neuromuscular junction, probably by regulating the expression of synaptic proteins, such as Rapsyn...
  23. ncbi request reprint As(III) transcriptionally activates the gadd45a gene via the formation of H2O2
    Jacquelyn J Bower
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Free Radic Biol Med 41:285-94. 2006
    ..In addition, this transcriptional induction was abrogated in the presence of H2O2 scavengers, suggesting a role for H2O2 in the transcriptional control of the gadd45a gene through a Fenton-like free radical mechanism...
  24. ncbi request reprint Phosphatidylinositol 3-kinase/Akt positively regulates Fas (CD95)-mediated apoptosis in epidermal Cl41 cells
    Bin Lu
    Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
    J Immunol 176:6785-93. 2006
    ..Together, our results indicate that the PI3K/Akt, in addition to its normal prosurvival role, also plays an apoptotic role in Fas-mediated cell death through a mechanism that involves transcriptional activation of Fas receptor...
  25. ncbi request reprint Vanadate induces G2/M phase arrest in p53-deficient mouse embryo fibroblasts
    Zhuo Zhang
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Environ Pathol Toxicol Oncol 21:223-31. 2002
    ..These results demonstrate that vanadate induced G2/M phase arrest in p53-deficient mouse embryo fibroblasts, and promoted S phase entry in p53 wild-type mouse embryo fibroblasts...
  26. ncbi request reprint NF-kappaB prevents cells from undergoing Cr(VI)-induced apoptosis
    Suwei Wang
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Mol Cell Biochem 255:129-37. 2004
    ..Cell morphological and TUNEL analyses indicated that the KM cells showed apoptotic features. These results suggest that NF-kappaB activation is required to prevent the cells from undergoing Cr(VI)-induced apoptosis...
  27. ncbi request reprint Reactive oxygen species (ROS), troublemakers between nuclear factor-kappaB (NF-kappaB) and c-Jun NH(2)-terminal kinase (JNK)
    Yadong Zhang
    Institute for Nutritional Sciences, Chinese Academy of Sciences, Shanghai, P R China
    Cancer Res 64:1902-5. 2004
    ..Conversely, sustained activation of NF-kappaB inhibits cytokine-induced JNK activation. The mechanisms of how NF-kappaB and JNK become rivals for each other are under extensive debate...
  28. doi request reprint Pulmonary exposure of rats to ultrafine titanium dioxide enhances cardiac protein phosphorylation and substance P synthesis in nodose ganglia
    Hong Kan
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Nanotoxicology 6:736-45. 2012
    ..In conclusion, the inhalation of UFTiO(2) enhanced the phosphorylation levels of cardiac proteins. Such responses are likely independent of systemic inflammation, but may involve a lung-neuron-regulated pathway...
  29. ncbi request reprint Response of alveolar macrophages from inducible nitric oxide synthase knockout or wild-type mice to an in vitro lipopolysaccharide or silica exposure
    Patti C Zeidler
    Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 66:995-1013. 2003
    ..In addition, LPS induced TNF-á and MIP-2 production tend to be higher in AMs from iNOS KO mice. Such compensatory changes in the AM response may affect the response of iNOS KO mice to inflammatory exposures...
  30. ncbi request reprint Caspase-3 cleavage of dishevelled induces elimination of postsynaptic structures
    Jin Yuan Wang
    Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China Graduate School, University of Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
    Dev Cell 28:670-84. 2014
    ..Thus, caspase-3 plays an important role in the elimination of postsynaptic structures during the development of NMJs...
  31. doi request reprint Copper catalyzed cross-coupling of iodobenzoates with bromozinc-difluorophosphonate
    Zhang Feng
    Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
    Org Lett 14:1938-41. 2012
    ..This protocol provides a useful and facile access to aryldifluorophosphonates of interest in life science...
  32. ncbi request reprint NF-kappaB, a pivotal transcription factor in silica-induced diseases
    Fei Chen
    The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Mol Cell Biochem 234:169-76. 2002
    ..This review summarizes the molecular mechanisms involved in silica-induced NF-kappaB activation and discusses the importance of NF-kappaB as a critical transcription factor in mediating silica-induced lung diseases...
  33. ncbi request reprint MAPKs mediate S phase arrest induced by vanadate through a p53-dependent pathway in mouse epidermal C141 cells
    Zhuo Zhang
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Chem Res Toxicol 15:950-6. 2002
    ..The study demonstrated that vanadate-induced S phase arrest is mediated by both ERK and p38 in a p53-dependent pathway...
  34. pmc Microprocessor of microRNAs: regulation and potential for therapeutic intervention
    Kevin J Beezhold
    Laboratory of Cancer Signaling and Epigenetics, Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Mol Cancer 9:134. 2010
    ..In this review, we briefly discuss most recent discoveries on the regulation of miRNAs at the level of microprocessor-mediated biogenesis of miRNAs...
  35. ncbi request reprint Inducible degradation of checkpoint kinase 2 links to cisplatin-induced resistance in ovarian cancer cells
    Peilin Zhang
    Department of Pathology, West Virginia University, Morgantown, WV 26506, USA
    Biochem Biophys Res Commun 328:567-72. 2005
    ..Therefore, these results are the first to indicate a novel mechanism of regulating Chk2 in cisplatin-induced resistance of cancer cells...
  36. ncbi request reprint Nuclear factor-kappaB, an unappreciated tumor suppressor
    Fei Chen
    The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Cancer Res 67:11093-8. 2007
    ....
  37. ncbi request reprint Dishevelled promotes axon differentiation by regulating atypical protein kinase C
    Xian Zhang
    Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Nat Cell Biol 9:743-54. 2007
    ..The Wnt5a effect on axon differentiation was attenuated by downregulating Dvl or inhibiting aPKC. Thus, Dvl-aPKC interaction can promote axon differentiation mediated by the PAR3-PAR6-aPKC complex...
  38. ncbi request reprint Diseases caused by silica: mechanisms of injury and disease development
    Min Ding
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Int Immunopharmacol 2:173-82. 2002
    ..Silica-induced AP-1 activation, protooncogene expression, and the role of ROS in these processes are also briefly discussed...
  39. doi request reprint Pd-catalyzed dehydrogenative cross-coupling of polyfluoroarenes with heteroatom-substituted enones
    Fei Chen
    Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
    Org Lett 14:1176-9. 2012
    ..This approach provides rapid access to a wide range of α-fluoroarylated enones of interest in life science...
  40. ncbi request reprint Rapsyn interaction with calpain stabilizes AChR clusters at the neuromuscular junction
    Fei Chen
    Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Neuron 55:247-60. 2007
    ..These results demonstrate that calpain participates in ACh-induced dispersion of AChR clusters, and rapsyn stabilizes AChR clusters by suppressing calpain activity...
  41. doi request reprint The history and advances of reversible terminators used in new generations of sequencing technology
    Fei Chen
    CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
    Genomics Proteomics Bioinformatics 11:34-40. 2013
    ..At the end of this review, we discussed current limitations of this approach and provided potential solutions to extend its application...
  42. ncbi request reprint Pd-catalyzed direct arylation of polyfluoroarenes on water under mild conditions using PPh3 ligand
    Fei Chen
    Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China
    J Org Chem 77:2992-8. 2012
    ..The usefulness of this reaction has also been demonstrated by rapid preparation of highly functionalized polyfluoroarenes via iterative Pd-catalyzed C-H bond functionalization...
  43. ncbi request reprint Is NF-kappaB a culprit in type 2 diabetes?
    Fei Chen
    The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Biochem Biophys Res Commun 332:1-3. 2005
    ..However, it was unknown whether IKKbeta itself, or its downstream target, NF-kappaB, plays major roles in insulin resistance. New data suggest that NF-kappaB and NF-kappaB-regulated cytokines are crucial for the diabetogenesis...
  44. ncbi request reprint Regulation of Fas (CD95)-induced apoptosis by nuclear factor-kappaB and tumor necrosis factor-alpha in macrophages
    Bin Lu
    Department of Basic Pharmaceutical Sciences, Health Sciences Center, West Virginia University, Morgantown 26506, USA
    Am J Physiol Cell Physiol 283:C831-8. 2002
    ....
  45. pmc Distinct nuclear and cytoplasmic functions of androgen receptor cofactor p44 and association with androgen-independent prostate cancer
    Yi Peng
    Departments of Pathology and Microbiology, New York University School of Medicine, New York, NY 10010, USA
    Proc Natl Acad Sci U S A 105:5236-41. 2008
    ..Our results indicate that nuclear p44 and cytoplasmic p44 have distinct and opposing functions in the regulation of prostate cancer cell proliferation...
  46. doi request reprint Proteasome inhibition potentiates the cytotoxic effects of hyperthermia in HT-29 colon cancer cells through inhibition of heat shock protein 27
    Fei Chen
    Division of Surgical Oncology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Oncology 73:98-103. 2007
    ..The purpose of this study was to investigate whether proteasome inhibition acts as a thermal sensitizing agent to induce tumor cell death in a colon cancer cell line...
  47. pmc Stimulation of prostate cancer cellular proliferation and invasion by the androgen receptor co-activator ARA70
    Yi Peng
    Department of Pathology, New York University School of Medicine, New York Harbor Healthcare System, 423 E 23rd St, Room 6140N, New York, NY 10010, USA
    Am J Pathol 172:225-35. 2008
    ..Our findings implicate ARA70 beta as a regulator of tumor cell growth and metastasis by affecting gene expression...
  48. doi request reprint Baclofen, a GABAB receptor agonist, inhibits human hepatocellular carcinoma cell growth in vitro and in vivo
    Tao Wang
    National Engineering Center for Biochip at Shanghai, China
    Life Sci 82:536-41. 2008
    ..Our data support the inhibitory effect of GABABR activation on HCC development, which would raise the possibility to develop Bac as a therapeutic drug for the treatment of HCC...
  49. ncbi request reprint Thermal sensitization through ROS modulation: a strategy to improve the efficacy of hyperthermic intraperitoneal chemotherapy
    Chia Chi Wang
    Division of Surgical Oncology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Surgery 142:384-92. 2007
    ..The purpose of this study was to investigate whether modulation of cellular reactive oxygen species (ROS) provides a synergistic effect with hyperthermia to induce tumor cell death in a colon cancer cell line...
  50. pmc Activation of nuclear factor-kappaB and not activator protein-1 in cellular response to nickel compounds
    Yi Huang
    Monroe Woodbury High School, Central Valley, New York, USA
    Environ Health Perspect 110:835-9. 2002
    ..We also investigated the role of NF-kappaB in the induction of Cap43 by nickel compounds using dominant negative mutant Ikappabeta kinase b-KM BEAS-2B transfectants...
  51. ncbi request reprint Phosphorylation of PPARgamma via active ERK1/2 leads to its physical association with p65 and inhibition of NF-kappabeta
    Fei Chen
    Division of Surgical Oncology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, New Jersey 07103, USA
    J Cell Biochem 90:732-44. 2003
    ..Ciglitazone induced phosphorylation of PPARgamma through the MAP kinase pathway provides a potential regulatory mechanism for PPARgamma's physical interaction with p65, leading to inhibition of NF-kappabeta and subsequent apoptosis...
  52. ncbi request reprint Ciglitazone-induced cellular anti-proliferation increases p27kip1 protein levels through both increased transcriptional activity and inhibition of proteasome degradation
    Fei Chen
    Department of Surgery, Division of Surgical Oncology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, MSB G524, Newark, NJ 07103, USA
    Cell Signal 17:809-16. 2005
    ..These data suggest that ciglitazone-induced G1/S arrest is through Cdk2 inhibition and an increase of p27kip1 protein levels which in turn is due a balance of ciglitazone's affect on new protein synthesis and degradation...
  53. ncbi request reprint Down-modulation of heat shock protein 70 and up-modulation of Caspase-3 during schisandrin B-induced apoptosis in human hepatoma SMMC-7721 cells
    Yi Feng Wu
    College of Life Sciences, Zhejiang University, Hangzhou 310027, Zhejiang Province, China
    World J Gastroenterol 10:2944-8. 2004
    ..To investigate the effect of schisandrin B (Sch B) on proliferation and apoptosis of human hepatoma SMMC-7721 cells in vitro and regulation of Hsp70 and Caspases-3, 7, 9 expression by Sch B...
  54. ncbi request reprint Ciglitazone induces early cellular proliferation and NF-kappaB transcriptional activity in colon cancer cells through p65 phosphorylation
    Fei Chen
    Department of Surgery, Division of Surgical Oncology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, MSB G588, Newark, NJ 07103, USA
    Int J Biochem Cell Biol 37:645-54. 2005
    ..These data suggest that the early proliferative phase of PPARgamma ligand exposure is associated with activation of NF-kappaB by p65 phosphorylation and cofactor recruitment and not through increased DNA binding...
  55. ncbi request reprint Up-regulation of Egr1 by 1,25-dihydroxyvitamin D3 contributes to increased expression of p35 activator of cyclin-dependent kinase 5 and consequent onset of the terminal phase of HL60 cell differentiation
    Fei Chen
    Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    Cancer Res 64:5425-33. 2004
    ....
  56. ncbi request reprint TNF inhibition rapidly down-regulates multiple proinflammatory pathways in psoriasis plaques
    Alice B Gottlieb
    Clinical Research Center, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
    J Immunol 175:2721-9. 2005
    ..This results in reversal of the epidermal hyperplasia and cutaneous inflammation characteristic of psoriatic plaques...
  57. ncbi request reprint Ciglitazone-induced p27 gene transcriptional activity is mediated through Sp1 and is negatively regulated by the MAPK signaling pathway
    Fei Chen
    Division of Surgical Oncology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, MSB G524, Newark, New Jersey 07103, United States
    Cell Signal 17:1572-7. 2005
    ....
  58. ncbi request reprint Cloning and characterization of a novel splice variant of human U2AF1L3 gene
    Fei Chen
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, People s Republic of China
    DNA Seq 17:282-6. 2006
    ..Reverse transcription-PCR (RT-PCR) shows that this isoform has different expression pattern with U2AF1L3 and is highly expressed in heart, brain and lung...
  59. ncbi request reprint Deficiency in Ikkbeta gene enhances arsenic-induced gadd45alpha expression
    Yadong Zhang
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai, P R China
    Mol Cell Biochem 279:163-8. 2005
    ..Thus, these results uncover the molecular mechanism by which NF-kappaB signalling contributes to the regulation of gadd family gene expression induced by arsenic...
  60. ncbi request reprint Carvedilol ameliorates endothelial dysfunction in streptozotocin-induced diabetic rats
    Guo Sheng Fu
    Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 East Qingchun Road, Hangzhou, 310016, China
    Eur J Pharmacol 567:223-30. 2007
    ..In conclusion, chronic carvedilol administration significantly ameliorated the endothelial dysfunction in diabetic rat aortas, in which increased NO level, up-regulated NOS3 mRNA and phosphorylation at Ser1177 may be involved...
  61. ncbi request reprint Myocardial protection by remote preconditioning: the role of nuclear factor kappa-B p105 and inducible nitric oxide synthase
    Guohu Li
    Crafoord Laboratory for Experimental Surgery L6 00, Karolinska Hospital, S 17176 Stockholm, Sweden
    Eur J Cardiothorac Surg 26:968-73. 2004
    ..The present study investigates a possible role for NFkappaB and inducible nitric oxide synthase (iNOS) in adaption to ischemia by remote, delayed protection...
  62. ncbi request reprint Nuclear localization signal of ING4 plays a key role in its binding to p53
    Xin Zhang
    State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, China
    Biochem Biophys Res Commun 331:1032-8. 2005
    ..All data indicated that the NLS domain of ING4 is essential for the binding of ING4 to p53 and the function of ING4 associated with p53...
  63. ncbi request reprint A cross-linker-sensitive myeloid leukemia cell line from a 2-year-old boy with severe Fanconi anemia and biallelic FANCD1/BRCA2 mutations
    Stefan Meyer
    Cancer Immunogenetics Laboratory, University of Manchester, St Mary s Hospital, Hathersage Road, Manchester M13 0JH, United Kingdom
    Genes Chromosomes Cancer 42:404-15. 2005
    ....
  64. ncbi request reprint Effects of spontaneous or induced brain ischemia on vessel reactivity: the role of inducible nitric oxide synthase
    Shinichi Tokuno
    Crafoord Laboratory of Experimental Surgery L6 00, Karolinska Hospital, 17176, Stockholm, Sweden
    Life Sci 71:679-92. 2002
    ..These findings suggest that induced brain ischemia as a model of delayed, remote preconditioning protects vessel reactivity, and this protection is mediated by iNOS...
  65. ncbi request reprint CDK5 is a novel regulatory protein in PPARgamma ligand-induced antiproliferation
    Eugene Kim
    Division of Surgical Oncology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Int J Oncol 28:191-4. 2006
    ..This is the first report of cdk5/p35 expression and kinase activity in colon cancer cells, which is associated with ciglitazone-induced antiproliferation in HT-29 cells...
  66. ncbi request reprint Apoptosis and angiogenesis are induced in the unstable coronary atherosclerotic plaque
    Fei Chen
    Crafoord Laboratory of Experimental Surgery, Karolinska Institute, South Hospital, Stockholm, Sweden
    Coron Artery Dis 16:191-7. 2005
    ..In this study, we investigated if apoptosis and angiogenesis were induced in the unstable human coronary atherosclerotic plaque compared to stable atherosclerotic plaque...
  67. ncbi request reprint Honokiol: a potent chemotherapy candidate for human colorectal carcinoma
    Fei Chen
    Cancer Institute, Second Affiliated Hospital of Zhejiang University, Hangzhou 310009, Zhejiang Province, China
    World J Gastroenterol 10:3459-63. 2004
    ..To investigate the anticancer activity of honokiol on RKO, a human colorectal carcinoma cell line in vitro and in vivo, and to evaluate its possible use in clinic...
  68. ncbi request reprint Condensation of amino acids to form peptides in aqueous solution induced by the oxidation of sulfur(iv): an oxidative model for prebiotic peptide formation
    Fei Chen
    Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P R China
    Orig Life Evol Biosph 37:47-54. 2007
    ..This might be a general reaction contributing to prebiotic peptide formation...
  69. ncbi request reprint The effect of bone marrow stromal cells on neuronal differentiation of mesencephalic neural stem cells in Sprague-Dawley rats
    Shu jie Lou
    Department of Neurobiology, The Second Military Medical University, 800 Xiangyin Road, 200433, Shanghai, China
    Brain Res 968:114-21. 2003
    ..Therefore, BMSCs may provide a powerful tool for therapeutic neurological applications...
  70. ncbi request reprint Hyperthermia in combination with oxidative stress induces autophagic cell death in HT-29 colon cancer cells
    Fei Chen
    Department of Surgery, Division of Surgical Oncology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, MSB G524, Newark, NJ 07103, USA
    Cell Biol Int 32:715-23. 2008
    ..Thermal sensitization through modulation of cellular ROS may represent a novel approach to increase the efficacy of hyperthermia as an anticancer modality...
  71. ncbi request reprint Inhibition of ampicillin-resistant bacteria by novel mono-DNAzymes and di-DNAzyme targeted to beta-lactamase mRNA
    Fei Chen
    Key Lab for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, Changchun City, Jilin Province, 130023, P R China
    Oligonucleotides 14:80-9. 2004
    ..The results indicated a potential possibility for DNAzymes to act as a new type of antibacterial or a tool of gene functional analysis for prokaryocytes...
  72. ncbi request reprint Bacillus nealsonii sp. nov., isolated from a spacecraft-assembly facility, whose spores are gamma-radiation resistant
    Kasthuri Venkateswaran
    Biotechnology and Planetary Protection Group, Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109, USA
    Int J Syst Evol Microbiol 53:165-72. 2003
    ..nov. (type strain is FO-92T =ATCC BAAM-519T =DSM 15077T)...
  73. ncbi request reprint The inhibitory effect of BSP-A1/-A2 on protein kinase C and tyrosine protein kinase
    Bingzhi Yu
    Department of Biochemistry, China Medical University, 92, North Second Road, Shenyang, Liaoning Province, 110001, People s Republic of China
    Cell Biochem Funct 21:183-8. 2003
    ..When the PKC and TPK activities are expressed as the logarithm of percentage activity taking the activity in the absence of the BSP-A1/-A2 as 100%, there is a linear relationship between the their activities and the dose of BSP-A1/-A2...
  74. ncbi request reprint Dihydrotanshinone I inhibits angiogenesis both in vitro and in vivo
    Weipeng Bian
    School of Life Science, East China Normal University, Shanghai 200062, China
    Acta Biochim Biophys Sin (Shanghai) 40:1-6. 2008
    ....
  75. ncbi request reprint Cadmium translocation and accumulation in developing barley grains
    Fei Chen
    Department of Agronomy, College of Agriculture and Biotechnology, Zhejiang University, Huajiachi Campus, Hangzhou, PR China
    Planta 227:223-32. 2007
    ..Our results suggested that increasing RH to 90% and Zn addition in the medium at grain filling stage would be beneficial to decrease Cd accumulation in grains...
  76. ncbi request reprint [Comparison of safety and sensitivity in diagnosis of liver lesion between ultrasound-guided 16 gauges and 18 gauges core needle biopsy]
    Fei Chen
    Department of Diagnostic Ultrasound, Peking University First Hospital, Beijing 100034, China
    Zhonghua Yi Xue Za Zhi 87:823-5. 2007
    ..To compare safety and sensitivity in diagnosis of liver lesion between ultrasound-guided 16 gauges (G) and 18 G core needle biopsy...