Research Topics
Genomes and Genes | Fei ChenSummaryAffiliation: Centers for Disease Control and Prevention Country: USA Publications
| Collaborators
|
Detail Information
Publications
New insights into the role of nuclear factor-kappaB in cell growth regulationF Chen
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd, Morgantown, WV 26505, USA
Am J Pathol 159:387-97. 2001..Elucidation of the relationships between NF-kappaB activation and cell growth will be important in developing new strategies for the treatment of various human diseases, such as chronic autoimmune disorder and cancer...
Tumor promoting or tumor suppressing of NF-kappa B, a matter of cell context dependencyFei Chen
Pathology and Physiology Research Branch, The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
Int Rev Immunol 27:183-204. 2008..Thus, it is highly possible that tumor promoting or tumor suppressing of NF-kappa B signaling is determined by the type of cells, stimuli, simultaneous or asynchronous intracellular signals, and other cellular contexts...- JNK1, a potential therapeutic target for hepatocellular carcinomaFei Chen
Laboratory of Cancer Signaling and Epigenetics, Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
Biochim Biophys Acta 1796:242-51. 2009..In this review the various associations between JNK1 and HCC are discussed with the hope that targeting this pivotal kinase may lead to novel therapeutic approaches for this fatal disease... 
Signaling from toxic metals to NF-kappaB and beyond: not just a matter of reactive oxygen speciesFei Chen
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
Environ Health Perspect 110:807-11. 2002..In the present review, we have attempted to evaluate and update the possible mechanisms of metal signals on the activation and function of NF-kappaB...
Upstream signal transduction of NF-kappaB activationFei Chen
The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
Curr Drug Targets Inflamm Allergy 1:137-49. 2002..Such inhibitors would be predicted to have potent anti-inflammatory and/or anti-carcinogenic effects...- Inhibitor of nuclear factor kappaB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenicFei Chen
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
Cancer Res 63:7689-93. 2003..Inhibition of CYP1B1 reduced both oxidative stress and arsenic-stimulated JNK activation. Thus, increased CYP1B1 expression is central to and seems to be responsible for sensitizing Ikkbeta(-/-) cells to stress-induced JNK activation... - Loss of Ikkbeta promotes migration and proliferation of mouse embryo fibroblast cellsFei Chen
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
J Biol Chem 281:37142-9. 2006..These data thus suggest that IKKbeta provides inhibitory signals for cell mobility and growth. Deficiency in the Ikkbeta gene promotes cell mobilization, at least partially, through a ROS-dependent mechanism... - Finding NEMO by K63-linked polyubiquitin chainF Chen
The Health Effect Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Cell Death Differ 13:1835-8. 2006 - Intracellular signal transduction of cells in response to carcinogenic metalsFei Chen
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
Crit Rev Oncol Hematol 42:105-21. 2002..This review summarizes current knowledge and our recent studies concerning intracellular signal transduction pathways initiated by carcinogenic metals and the cross-talk that occurs among these pathways in cells in response to metals... - Arsenite-induced Cdc25C degradation is through the KEN-box and ubiquitin-proteasome pathwayFei Chen
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
Proc Natl Acad Sci U S A 99:1990-5. 2002.... - Endogenous inhibitors of nuclear factor-kappaB, an opportunity for cancer controlFei Chen
The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Cancer Res 64:8135-8. 2004..The question to be asked is how NF-kappaB is sustained activated in a number of cancers in which so many antagonists are surrounded... - Protective roles of NF-kappa B for chromium(VI)-induced cytotoxicity is revealed by expression of Ikappa B kinase-beta mutantFei Chen
Health Effects Laboratory Division, NIOSH, Morgantown, West Virginia 26505, USA
J Biol Chem 277:3342-9. 2002..Such inhibition may involve up-regulation of the expression of anti-death proteins including cIAP1 that prevents spontaneous caspase activation and subsequent cleavage of Bcl-xL protein... - Beyond apoptosis of JNK1 in liver cancerFei Chen
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
Cell Cycle 8:1145-7. 2009..Accordingly, we believe that targeting JNK1 is not only mechanistically sound but also clinically feasible for the treatment of HCC... - Characterization of an alternatively spliced GADD45alpha, GADD45alpha1 isoform, in arsenic-treated epithelial cellsYadong Zhang
The Laboratory of Cancer Signaling and Epigenetics, The Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Mol Carcinog 48:454-64. 2009..Thus, these data suggest that the generation of the GADD45alpha1 isoform may not only offset but also antagonize the effects of arsenic and GADD45alpha on cell growth and cell cycle regulation... - Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3Yongju Lu
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Cell Cycle 8:2101-9. 2009..The pronounced expression of mdig in lung cancer tissues but not normal lung tissues, thus, suggests that mdig possesses oncogenic property through antagonizing tri-methyl lysine 9 on histone H3 and promoting ribosomal RNA synthesis... - miR-190-mediated downregulation of PHLPP contributes to arsenic-induced Akt activation and carcinogenesisKevin Beezhold
The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Toxicol Sci 123:411-20. 2011..Accordingly, the data presented suggest that induction of miR-190 is one of the key mechanisms in As(3+)-induced carcinogenesis... - The Fas death signaling pathway connecting reactive oxygen species generation and FLICE inhibitory protein down-regulationLiying Wang
Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
J Immunol 180:3072-80. 2008.... - Vanadate induces G2/M phase arrest in p53-deficient mouse embryo fibroblastsZhuo Zhang
Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
J Environ Pathol Toxicol Oncol 21:223-31. 2002..These results demonstrate that vanadate induced G2/M phase arrest in p53-deficient mouse embryo fibroblasts, and promoted S phase entry in p53 wild-type mouse embryo fibroblasts... - Phosphatidylinositol 3-kinase/Akt positively regulates Fas (CD95)-mediated apoptosis in epidermal Cl41 cellsBin Lu
Department of Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
J Immunol 176:6785-93. 2006..Together, our results indicate that the PI3K/Akt, in addition to its normal prosurvival role, also plays an apoptotic role in Fas-mediated cell death through a mechanism that involves transcriptional activation of Fas receptor... - NF-kappaB prevents cells from undergoing Cr(VI)-induced apoptosisSuwei Wang
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Mol Cell Biochem 255:129-37. 2004..Cell morphological and TUNEL analyses indicated that the KM cells showed apoptotic features. These results suggest that NF-kappaB activation is required to prevent the cells from undergoing Cr(VI)-induced apoptosis... - As(III) transcriptionally activates the gadd45a gene via the formation of H2O2Jacquelyn J Bower
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Free Radic Biol Med 41:285-94. 2006..In addition, this transcriptional induction was abrogated in the presence of H2O2 scavengers, suggesting a role for H2O2 in the transcriptional control of the gadd45a gene through a Fenton-like free radical mechanism... - Incorporation of an internal ribosome entry site-dependent mechanism in arsenic-induced GADD45 alpha expressionQingshan Chang
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, West Verginia University, Morgantown, WV 26505, USA
Cancer Res 67:6146-54. 2007..Thus, these results suggest that in growth-arrested cells, As(3+) is still capable of inducing GADD45 alpha expression through an IRES-dependent translational regulation... - Response of alveolar macrophages from inducible nitric oxide synthase knockout or wild-type mice to an in vitro lipopolysaccharide or silica exposurePatti C Zeidler
Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 26505, USA
J Toxicol Environ Health A 66:995-1013. 2003..In addition, LPS induced TNF-รก and MIP-2 production tend to be higher in AMs from iNOS KO mice. Such compensatory changes in the AM response may affect the response of iNOS KO mice to inflammatory exposures... - MAPKs mediate S phase arrest induced by vanadate through a p53-dependent pathway in mouse epidermal C141 cellsZhuo Zhang
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
Chem Res Toxicol 15:950-6. 2002..The study demonstrated that vanadate-induced S phase arrest is mediated by both ERK and p38 in a p53-dependent pathway... - NF-kappaB, a pivotal transcription factor in silica-induced diseasesFei Chen
The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Mol Cell Biochem 234:169-76. 2002..This review summarizes the molecular mechanisms involved in silica-induced NF-kappaB activation and discusses the importance of NF-kappaB as a critical transcription factor in mediating silica-induced lung diseases... - Microprocessor of microRNAs: regulation and potential for therapeutic interventionKevin J Beezhold
Laboratory of Cancer Signaling and Epigenetics, Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
Mol Cancer 9:134. 2010..In this review, we briefly discuss most recent discoveries on the regulation of miRNAs at the level of microprocessor-mediated biogenesis of miRNAs... - Nuclear factor-kappaB, an unappreciated tumor suppressorFei Chen
The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Cancer Res 67:11093-8. 2007.... - Inducible degradation of checkpoint kinase 2 links to cisplatin-induced resistance in ovarian cancer cellsPeilin Zhang
Department of Pathology, West Virginia University, Morgantown, WV 26506, USA
Biochem Biophys Res Commun 328:567-72. 2005..Therefore, these results are the first to indicate a novel mechanism of regulating Chk2 in cisplatin-induced resistance of cancer cells... - Pulmonary exposure of rats to ultrafine titanium dioxide enhances cardiac protein phosphorylation and substance P synthesis in nodose gangliaHong Kan
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
Nanotoxicology 6:736-45. 2012..In conclusion, the inhalation of UFTiO(2) enhanced the phosphorylation levels of cardiac proteins. Such responses are likely independent of systemic inflammation, but may involve a lung-neuron-regulated pathway... - Diseases caused by silica: mechanisms of injury and disease developmentMin Ding
Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Int Immunopharmacol 2:173-82. 2002..Silica-induced AP-1 activation, protooncogene expression, and the role of ROS in these processes are also briefly discussed... - Is NF-kappaB a culprit in type 2 diabetes?Fei Chen
The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Biochem Biophys Res Commun 332:1-3. 2005..However, it was unknown whether IKKbeta itself, or its downstream target, NF-kappaB, plays major roles in insulin resistance. New data suggest that NF-kappaB and NF-kappaB-regulated cytokines are crucial for the diabetogenesis... - Cloning and characterization of a novel splice variant of human U2AF1L3 geneFei Chen
State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, People's Republic of China
DNA Seq 17:282-6. 2006..Reverse transcription-PCR (RT-PCR) shows that this isoform has different expression pattern with U2AF1L3 and is highly expressed in heart, brain and lung... - Carvedilol ameliorates endothelial dysfunction in streptozotocin-induced diabetic ratsGuo Sheng Fu
Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 East Qingchun Road, Hangzhou, 310016, China
Eur J Pharmacol 567:223-30. 2007..In conclusion, chronic carvedilol administration significantly ameliorated the endothelial dysfunction in diabetic rat aortas, in which increased NO level, up-regulated NOS3 mRNA and phosphorylation at Ser1177 may be involved... - Regulation of Fas (CD95)-induced apoptosis by nuclear factor-kappaB and tumor necrosis factor-alpha in macrophagesBin Lu
Department of Basic Pharmaceutical Sciences, Health Sciences Center, West Virginia University, Morgantown 26506, USA
Am J Physiol Cell Physiol 283:C831-8. 2002.... - Up-regulation of Egr1 by 1,25-dihydroxyvitamin D3 contributes to increased expression of p35 activator of cyclin-dependent kinase 5 and consequent onset of the terminal phase of HL60 cell differentiationFei Chen
Department of Pathology and Laboratory Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
Cancer Res 64:5425-33. 2004.... - The Human mineral dust-induced gene, mdig, is a cell growth regulating gene associated with lung cancerYadong Zhang
Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China
Oncogene 24:4873-82. 2005..These results suggest that the mdig gene may be involved in the regulation of cell growth and possibly the development of cancer... - Thermal sensitization through ROS modulation: a strategy to improve the efficacy of hyperthermic intraperitoneal chemotherapyChia Chi Wang
Division of Surgical Oncology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
Surgery 142:384-92. 2007..The purpose of this study was to investigate whether modulation of cellular reactive oxygen species (ROS) provides a synergistic effect with hyperthermia to induce tumor cell death in a colon cancer cell line... - Reactive oxygen species (ROS), troublemakers between nuclear factor-kappaB (NF-kappaB) and c-Jun NH(2)-terminal kinase (JNK)Yadong Zhang
Institute for Nutritional Sciences, Chinese Academy of Sciences, Shanghai, P. R. China
Cancer Res 64:1902-5. 2004..Conversely, sustained activation of NF-kappaB inhibits cytokine-induced JNK activation. The mechanisms of how NF-kappaB and JNK become rivals for each other are under extensive debate... - Distinct nuclear and cytoplasmic functions of androgen receptor cofactor p44 and association with androgen-independent prostate cancerYi Peng
Departments of Pathology and Microbiology, New York University School of Medicine, New York, NY 10010, USA
Proc Natl Acad Sci U S A 105:5236-41. 2008..Our results indicate that nuclear p44 and cytoplasmic p44 have distinct and opposing functions in the regulation of prostate cancer cell proliferation... - Baclofen, a GABAB receptor agonist, inhibits human hepatocellular carcinoma cell growth in vitro and in vivoTao Wang
National Engineering Center for Biochip at Shanghai, China
Life Sci 82:536-41. 2008..Our data support the inhibitory effect of GABABR activation on HCC development, which would raise the possibility to develop Bac as a therapeutic drug for the treatment of HCC... - Phosphorylation of PPARgamma via active ERK1/2 leads to its physical association with p65 and inhibition of NF-kappabetaFei Chen
Division of Surgical Oncology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, Newark, New Jersey 07103, USA
J Cell Biochem 90:732-44. 2003..Ciglitazone induced phosphorylation of PPARgamma through the MAP kinase pathway provides a potential regulatory mechanism for PPARgamma's physical interaction with p65, leading to inhibition of NF-kappabeta and subsequent apoptosis... - Down-modulation of heat shock protein 70 and up-modulation of Caspase-3 during schisandrin B-induced apoptosis in human hepatoma SMMC-7721 cellsYi-Feng Wu
College of Life Sciences, Zhejiang University, Hangzhou 310027, Zhejiang Province, China
World J Gastroenterol 10:2944-8. 2004.... - Myocardial protection by remote preconditioning: the role of nuclear factor kappa-B p105 and inducible nitric oxide synthaseGuohu Li
Crafoord Laboratory for Experimental Surgery L6.00, Karolinska Hospital, S-17176 Stockholm, Sweden
Eur J Cardiothorac Surg 26:968-73. 2004..CONCLUSIONS: Delayed cardioprotection induced by hind limb preconditioning involves signaling through NFkappaB and iNOS... - Proteasome inhibition potentiates the cytotoxic effects of hyperthermia in HT-29 colon cancer cells through inhibition of heat shock protein 27Fei Chen
Division of Surgical Oncology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
Oncology 73:98-103. 2007..The purpose of this study was to investigate whether proteasome inhibition acts as a thermal sensitizing agent to induce tumor cell death in a colon cancer cell line... - Inhibition of NF-kappaB stabilizes gadd45alpha mRNAXue Zheng
Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, PR China
Biochem Biophys Res Commun 329:95-9. 2005..Thus, these data are the first to suggest that inhibition of Ikkbeta-NF-kappaB signaling up-regulates the expression of gadd45alpha mNRA through a post-transcriptional, rather than a transcriptional, mechanism... - Ciglitazone-induced cellular anti-proliferation increases p27kip1 protein levels through both increased transcriptional activity and inhibition of proteasome degradationFei Chen
Department of Surgery, Division of Surgical Oncology, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, MSB G524, Newark, NJ 07103, USA
Cell Signal 17:809-16. 2005..These data suggest that ciglitazone-induced G1/S arrest is through Cdk2 inhibition and an increase of p27kip1 protein levels which in turn is due a balance of ciglitazone's affect on new protein synthesis and degradation... - Stimulation of prostate cancer cellular proliferation and invasion by the androgen receptor co-activator ARA70Yi Peng
Department of Pathology, New York University School of Medicine, New York Harbor Healthcare System, 423 E 23rd St, Room 6140N, New York, NY 10010, USA
Am J Pathol 172:225-35. 2008..Our findings implicate ARA70 beta as a regulator of tumor cell growth and metastasis by affecting gene expression... - Ciglitazone induces early cellular proliferation and NF-kappaB transcriptional activity in colon cancer cells through p65 phosphorylationFei Chen
Department of Surgery, Division of Surgical Oncology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, MSB G588, Newark, NJ 07103, USA
Int J Biochem Cell Biol 37:645-54. 2005..These data suggest that the early proliferative phase of PPARgamma ligand exposure is associated with activation of NF-kappaB by p65 phosphorylation and cofactor recruitment and not through increased DNA binding... - Ciglitazone-induced p27 gene transcriptional activity is mediated through Sp1 and is negatively regulated by the MAPK signaling pathwayFei Chen
Division of Surgical Oncology, UMDNJ-New Jersey Medical School, 185 South Orange Avenue, MSB G524, Newark, New Jersey 07103, United States
Cell Signal 17:1572-7. 2005.... - TNF inhibition rapidly down-regulates multiple proinflammatory pathways in psoriasis plaquesAlice B Gottlieb
Clinical Research Center, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
J Immunol 175:2721-9. 2005..This results in reversal of the epidermal hyperplasia and cutaneous inflammation characteristic of psoriatic plaques... - Deficiency in Ikkbeta gene enhances arsenic-induced gadd45alpha expressionYadong Zhang
Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai, P.R. China
Mol Cell Biochem 279:163-8. 2005..Thus, these results uncover the molecular mechanism by which NF-kappaB signalling contributes to the regulation of gadd family gene expression induced by arsenic... - Nucleolin links to arsenic-induced stabilization of GADD45alpha mRNAYadong Zhang
Institute for Nutritional Sciences, Chinese Academy of Sciences, Shanghai 200031, China
Nucleic Acids Res 34:485-95. 2006..Stabilization of GADD45alpha mRNA, thus, represents a novel mechanism contributing to the production of GADD45alpha and cell cycle arrest in response to As3+... - Activation of nuclear factor-kappaB and not activator protein-1 in cellular response to nickel compoundsYi Huang
Monroe-Woodbury High School, Central Valley, New York, USA
Environ Health Perspect 110:835-9. 2002..We also investigated the role of NF-kappaB in the induction of Cap43 by nickel compounds using dominant negative mutant Ikappabeta kinase b-KM BEAS-2B transfectants... - Effects of spontaneous or induced brain ischemia on vessel reactivity: the role of inducible nitric oxide synthaseShinichi Tokuno
Crafoord Laboratory of Experimental Surgery L6 00, Karolinska Hospital, 17176, Stockholm, Sweden
Life Sci 71:679-92. 2002..These findings suggest that induced brain ischemia as a model of delayed, remote preconditioning protects vessel reactivity, and this protection is mediated by iNOS... - The inhibitory effect of BSP-A1/-A2 on protein kinase C and tyrosine protein kinaseBingzhi Yu
Department of Biochemistry, China Medical University, 92, North Second Road, Shenyang, Liaoning Province, 110001, People s Republic of China
Cell Biochem Funct 21:183-8. 2003..When the PKC and TPK activities are expressed as the logarithm of percentage activity taking the activity in the absence of the BSP-A1/-A2 as 100%, there is a linear relationship between the their activities and the dose of BSP-A1/-A2... - Hyperthermia in combination with oxidative stress induces autophagic cell death in HT-29 colon cancer cellsFei Chen
Department of Surgery, Division of Surgical Oncology, UMDNJ New Jersey Medical School, 185 South Orange Avenue, MSB G524, Newark, NJ 07103, USA
Cell Biol Int 32:715-23. 2008..Thermal sensitization through modulation of cellular ROS may represent a novel approach to increase the efficacy of hyperthermia as an anticancer modality... - Wnt/beta-catenin signaling suppresses Rapsyn expression and inhibits acetylcholine receptor clustering at the neuromuscular junctionJia Wang
Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai, China
J Biol Chem 283:21668-75. 2008..Together, these results suggest that Wnt/beta-catenin signaling plays a negative role for postsynaptic differentiation at the neuromuscular junction, probably by regulating the expression of synaptic proteins, such as Rapsyn... - Bacillus nealsonii sp. nov., isolated from a spacecraft-assembly facility, whose spores are gamma-radiation resistantKasthuri Venkateswaran
Biotechnology and Planetary Protection Group, Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109, USA
Int J Syst Evol Microbiol 53:165-72. 2003..nov. (type strain is FO-92T =ATCC BAAM-519T =DSM 15077T)... - The effect of bone marrow stromal cells on neuronal differentiation of mesencephalic neural stem cells in Sprague-Dawley ratsShu jie Lou
Department of Neurobiology, The Second Military Medical University, 800 Xiangyin Road, 200433, Shanghai, China
Brain Res 968:114-21. 2003..Therefore, BMSCs may provide a powerful tool for therapeutic neurological applications... - Dihydrotanshinone I inhibits angiogenesis both in vitro and in vivoWeipeng Bian
School of Life Science, East China Normal University, Shanghai 200062, China
Acta Biochim Biophys Sin (Shanghai) 40:1-6. 2008.... - Nuclear localization signal of ING4 plays a key role in its binding to p53Xin Zhang
State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, China
Biochem Biophys Res Commun 331:1032-8. 2005..All data indicated that the NLS domain of ING4 is essential for the binding of ING4 to p53 and the function of ING4 associated with p53... - CDK5 is a novel regulatory protein in PPARgamma ligand-induced antiproliferationEugene Kim
Division of Surgical Oncology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
Int J Oncol 28:191-4. 2006..This is the first report of cdk5/p35 expression and kinase activity in colon cancer cells, which is associated with ciglitazone-induced antiproliferation in HT-29 cells... - Honokiol: a potent chemotherapy candidate for human colorectal carcinomaFei Chen
Cancer Institute, Second Affiliated Hospital of Zhejiang University, Hangzhou 310009, Zhejiang Province, China
World J Gastroenterol 10:3459-63. 2004..CONCLUSION: With its few toxicity to normal cells and potent anticancer activity in vitro and in vivo, honokiol might be a potential chemotherapy candidate in treating human colorectal carcinoma... - Condensation of amino acids to form peptides in aqueous solution induced by the oxidation of sulfur(iv): an oxidative model for prebiotic peptide formationFei Chen
Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P R China
Orig Life Evol Biosph 37:47-54. 2007..This might be a general reaction contributing to prebiotic peptide formation... - Inhibition of ampicillin-resistant bacteria by novel mono-DNAzymes and di-DNAzyme targeted to beta-lactamase mRNAFei Chen
Key Lab for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, Changchun City, Jilin Province, 130023, P. R. China
Oligonucleotides 14:80-9. 2004..The results indicated a potential possibility for DNAzymes to act as a new type of antibacterial or a tool of gene functional analysis for prokaryocytes... - Dishevelled promotes axon differentiation by regulating atypical protein kinase CXian Zhang
Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
Nat Cell Biol 9:743-54. 2007..The Wnt5a effect on axon differentiation was attenuated by downregulating Dvl or inhibiting aPKC. Thus, Dvl-aPKC interaction can promote axon differentiation mediated by the PAR3-PAR6-aPKC complex... - A cross-linker-sensitive myeloid leukemia cell line from a 2-year-old boy with severe Fanconi anemia and biallelic FANCD1/BRCA2 mutationsStefan Meyer
Cancer Immunogenetics Laboratory, University of Manchester, St Mary s Hospital, Hathersage Road, Manchester M13 0JH, United Kingdom
Genes Chromosomes Cancer 42:404-15. 2005.... - Cadmium translocation and accumulation in developing barley grainsFei Chen
Department of Agronomy, College of Agriculture and Biotechnology, Zhejiang University, Huajiachi Campus, Hangzhou, PR China
Planta 227:223-32. 2007..Our results suggested that increasing RH to 90% and Zn addition in the medium at grain filling stage would be beneficial to decrease Cd accumulation in grains... - [Comparison of safety and sensitivity in diagnosis of liver lesion between ultrasound-guided 16 gauges and 18 gauges core needle biopsy]Fei Chen
Department of Diagnostic Ultrasound, Peking University First Hospital, Beijing 100034, China
Zhonghua Yi Xue Za Zhi 87:823-5. 2007..To compare safety and sensitivity in diagnosis of liver lesion between ultrasound-guided 16 gauges (G) and 18 G core needle biopsy... - Apoptosis and angiogenesis are induced in the unstable coronary atherosclerotic plaqueFei Chen
Crafoord Laboratory of Experimental Surgery, Karolinska Institute, South Hospital, Stockholm, Sweden
Coron Artery Dis 16:191-7. 2005..The plaques had an increased neovascularization, probably induced by VEGF-A. These factors may contribute to explaining plaque destabilization and intraplaque haemorrhage...