V Castranova

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. pmc Multi-walled carbon nanotubes induce human microvascular endothelial cellular effects in an alveolar-capillary co-culture with small airway epithelial cells
    Brandi N Snyder-Talkington
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505 2888, USA
    Part Fibre Toxicol 10:35. 2013
  2. pmc Titanium dioxide nanoparticles: a review of current toxicological data
    Hongbo Shi
    Public Health Department of Medical School, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Ningbo University, Ningbo, Zhejiang Province, 315211, PR China
    Part Fibre Toxicol 10:15. 2013
  3. pmc Lung toxicity and biodistribution of Cd/Se-ZnS quantum dots with different surface functional groups after pulmonary exposure in rats
    Jenny R Roberts
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Part Fibre Toxicol 10:5. 2013
  4. doi request reprint Occupational nanosafety considerations for carbon nanotubes and carbon nanofibers
    Vincent Castranova
    National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Acc Chem Res 46:642-9. 2013
  5. pmc Toxicology of Nanomaterials: Permanent interactive learning
    Paul Borm
    Zuyd University, Centre of Expertise in Life Sciences, PO Box 550, 6400 AN, Heerlen, The Netherlands
    Part Fibre Toxicol 6:28. 2009
  6. pmc Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunction
    Timothy R Nurkiewicz
    Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, WV, USA
    Part Fibre Toxicol 5:1. 2008
  7. pmc The limits of testing particle-mediated oxidative stress in vitro in predicting diverse pathologies; relevance for testing of nanoparticles
    Ken Donaldson
    MRC University of Edinburgh Centre for Inflammation Research, ELEGI Colt Laboratory, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Part Fibre Toxicol 6:13. 2009
  8. pmc Dispersion of single-walled carbon nanotubes by a natural lung surfactant for pulmonary in vitro and in vivo toxicity studies
    Liying Wang
    National Institute for Occupational Safety and Health, HELD PPRB, Morgantown, WV 26505, USA
    Part Fibre Toxicol 7:31. 2010
  9. pmc Microprocessor of microRNAs: regulation and potential for therapeutic intervention
    Kevin J Beezhold
    Laboratory of Cancer Signaling and Epigenetics, Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Mol Cancer 9:134. 2010
  10. pmc Metallic nickel nano- and fine particles induce JB6 cell apoptosis through a caspase-8/AIF mediated cytochrome c-independent pathway
    Jinshun Zhao
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, 26505, USA
    J Nanobiotechnology 7:2. 2009

Collaborators

Detail Information

Publications88

  1. pmc Multi-walled carbon nanotubes induce human microvascular endothelial cellular effects in an alveolar-capillary co-culture with small airway epithelial cells
    Brandi N Snyder-Talkington
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505 2888, USA
    Part Fibre Toxicol 10:35. 2013
    ..This study aimed to determine if an alveolar-capillary co-culture model could determine changes in the vascular endothelium after epithelial exposure to MWCNT...
  2. pmc Titanium dioxide nanoparticles: a review of current toxicological data
    Hongbo Shi
    Public Health Department of Medical School, Zhejiang Provincial Key Laboratory of Pathological and Physiological Technology, Ningbo University, Ningbo, Zhejiang Province, 315211, PR China
    Part Fibre Toxicol 10:15. 2013
    ..However, long-term inhalation studies in rats have reported lung tumors. This review summarizes the current knowledge on the toxicology of TiO2 NPs and points out areas where further information is needed...
  3. pmc Lung toxicity and biodistribution of Cd/Se-ZnS quantum dots with different surface functional groups after pulmonary exposure in rats
    Jenny R Roberts
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Part Fibre Toxicol 10:5. 2013
    ..The goal of the present study was to assess pulmonary toxicity, clearance, and biodistribution of QD with different functional groups in rats after pulmonary exposure...
  4. doi request reprint Occupational nanosafety considerations for carbon nanotubes and carbon nanofibers
    Vincent Castranova
    National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Acc Chem Res 46:642-9. 2013
    ..NIOSH has published a document containing recommendations for the safe handling of nanomaterials...
  5. pmc Toxicology of Nanomaterials: Permanent interactive learning
    Paul Borm
    Zuyd University, Centre of Expertise in Life Sciences, PO Box 550, 6400 AN, Heerlen, The Netherlands
    Part Fibre Toxicol 6:28. 2009
    ..Finally, we take the opportunity discuss some recent reports from the nanotech literature, and more specifically a Chinese study that claims severe consequences of nanoparticle exposure...
  6. pmc Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunction
    Timothy R Nurkiewicz
    Center for Interdisciplinary Research in Cardiovascular Sciences, West Virginia University School of Medicine, Morgantown, WV, USA
    Part Fibre Toxicol 5:1. 2008
    ..abstract:..
  7. pmc The limits of testing particle-mediated oxidative stress in vitro in predicting diverse pathologies; relevance for testing of nanoparticles
    Ken Donaldson
    MRC University of Edinburgh Centre for Inflammation Research, ELEGI Colt Laboratory, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    Part Fibre Toxicol 6:13. 2009
    ..We discuss the likely explanation and implications of this apparent paradox, and its relevance for testing in nanotoxicology...
  8. pmc Dispersion of single-walled carbon nanotubes by a natural lung surfactant for pulmonary in vitro and in vivo toxicity studies
    Liying Wang
    National Institute for Occupational Safety and Health, HELD PPRB, Morgantown, WV 26505, USA
    Part Fibre Toxicol 7:31. 2010
    ..The aims of this study were to develop a simple and rapid method of nanoparticle dispersion using a natural lung surfactant and to evaluate the effect of dispersion status of SWCNT on cytotoxicity and fibrogenicity in vitro and in vivo...
  9. pmc Microprocessor of microRNAs: regulation and potential for therapeutic intervention
    Kevin J Beezhold
    Laboratory of Cancer Signaling and Epigenetics, Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Mol Cancer 9:134. 2010
    ..In this review, we briefly discuss most recent discoveries on the regulation of miRNAs at the level of microprocessor-mediated biogenesis of miRNAs...
  10. pmc Metallic nickel nano- and fine particles induce JB6 cell apoptosis through a caspase-8/AIF mediated cytochrome c-independent pathway
    Jinshun Zhao
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, 26505, USA
    J Nanobiotechnology 7:2. 2009
    ..abstract:..
  11. ncbi request reprint Role of nitric oxide in the progression of pneumoconiosis
    V Castranova
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Biochemistry (Mosc) 69:32-7. 2004
    ..Therefore, NO may play an important role in the initiation and progression of pneumoconiosis...
  12. ncbi request reprint Response of alveolar macrophages from inducible nitric oxide synthase knockout or wild-type mice to an in vitro lipopolysaccharide or silica exposure
    Patti C Zeidler
    Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 66:995-1013. 2003
    ..In addition, LPS induced TNF-รก and MIP-2 production tend to be higher in AMs from iNOS KO mice. Such compensatory changes in the AM response may affect the response of iNOS KO mice to inflammatory exposures...
  13. pmc Pulmonary response to intratracheal instillation of ultrafine versus fine titanium dioxide: role of particle surface area
    Tina M Sager
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    Part Fibre Toxicol 5:17. 2008
    ..abstract:..
  14. ncbi request reprint Pulmonary alterations associated with inhalation of occupational and environmental irritants
    V Castranova
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Int Immunopharmacol 2:163-72. 2002
    ....
  15. pmc Surface area of particle administered versus mass in determining the pulmonary toxicity of ultrafine and fine carbon black: comparison to ultrafine titanium dioxide
    Tina M Sager
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    Part Fibre Toxicol 6:15. 2009
    ..abstract:..
  16. pmc Augmentation of pulmonary reactions to quartz inhalation by trace amounts of iron-containing particles
    V Castranova
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Environ Health Perspect 105:1319-24. 1997
    ..These results suggest that inhalation of freshly fractured quartz contaminated with trace levels of Fe may be more pathogenic than inhalation of quartz alone...
  17. pmc Enhancement of nitric oxide production by pulmonary cells following silica exposure
    V Castranova
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Environ Health Perspect 106:1165-9. 1998
    ..NO-dependent CL from AM. These data suggest that .NO may play a role in silicosis and that human pulmonary phagocytes exhibit enhanced .NO production in response to an inflammatory insult...
  18. doi request reprint Overview of current toxicological knowledge of engineered nanoparticles
    Vincent Castranova
    National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Occup Environ Med 53:S14-7. 2011
    ..Therefore, evaluation of the biological effects of nanoparticles is critical...
  19. pmc Effect of exposure to diesel exhaust particles on the susceptibility of the lung to infection
    V Castranova
    National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Environ Health Perspect 109:609-12. 2001
    ..This inhibitory effect appears to be due to adsorbed organic chemicals rather than the carbonaceous core of the diesel particles...
  20. pmc Silicosis and coal workers' pneumoconiosis
    V Castranova
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    Environ Health Perspect 108:675-84. 2000
    ..Results of in vitro and animal studies provide a basis for proposing these mechanisms for the initiation and progression of pneumoconiosis. Data obtained from exposed workers lend support to these mechanisms...
  21. doi request reprint Size-dependent effects of tungsten carbide-cobalt particles on oxygen radical production and activation of cell signaling pathways in murine epidermal cells
    M Ding
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Toxicol Appl Pharmacol 241:260-8. 2009
    ....
  22. ncbi request reprint Oxidative stress and inflammatory response in dermal toxicity of single-walled carbon nanotubes
    A R Murray
    Health Effects Laboratory Division, Pathology and Physiology Research Branch, NIOSH, M L 2015, 1095 Willowdale Road, Morgantown, WV 26505, United States
    Toxicology 257:161-71. 2009
    ..Altogether, these data indicated that topical exposure to unpurified SWCNT, induced free radical generation, oxidative stress, and inflammation, thus causing dermal toxicity...
  23. pmc Diesel exhaust particles suppress macrophage function and slow the pulmonary clearance of Listeria monocytogenes in rats
    H M Yang
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Environ Health Perspect 109:515-21. 2001
    ..This DEP-induced suppression is caused partially by chemicals adsorbed onto the carbon core of DEP, because impaired macrophage function and decreased Listeria clearance were not observed following exposure to CB...
  24. ncbi request reprint Interleukin-10-mediated inhibition of free radical generation in macrophages
    S Dokka
    Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506, USA
    Am J Physiol Lung Cell Mol Physiol 280:L1196-202. 2001
    ..OH radicals in response to LPS stimulation. These results demonstrate, for the first time, direct evidence for the role of IL-10 in ROS-dependent NF-kappaB activation...
  25. ncbi request reprint Role of reactive oxygen species and p53 in chromium(VI)-induced apoptosis
    J Ye
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Biol Chem 274:34974-80. 1999
    ....
  26. ncbi request reprint Cr(IV) causes activation of nuclear transcription factor-kappa B, DNA strand breaks and dG hydroxylation via free radical reactions
    X Shi
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Inorg Biochem 75:37-44. 1999
    ..The results also suggest that the Cr(IV)-glutathione complex may be used as a model compound to study the role of Cr(IV) in Cr(VI) carcinogenicity...
  27. ncbi request reprint Phenol-induced in vivo oxidative stress in skin: evidence for enhanced free radical generation, thiol oxidation, and antioxidant depletion
    A R Murray
    Department of Physiology and Pharmacology, West Virginia University, Morgantown 26506, USA
    Chem Res Toxicol 20:1769-77. 2007
    ..Since dermal exposure to PhOH produced ESR-detectable PBN spin-trapped signals of lipid-derived radicals, we conclude that this PhOH-induced radical formation is involved in oxidative stress and dermal toxicity in vivo...
  28. ncbi request reprint Acute inflammation and recovery in rats after intratracheal instillation of a 1-->3-beta-glucan (zymosan A)
    S H Young
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 64:311-25. 2001
    ..A good correlation (r2= .8) between recovery of PMN in BAL, CL, or nitric oxide production and the days postexposure was observed...
  29. ncbi request reprint Reactive oxygen species and molecular mechanism of silica-induced lung injury
    X Shi
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Environ Pathol Toxicol Oncol 20:85-93. 2001
    ....
  30. ncbi request reprint Comparative pulmonary toxicity of 6 abrasive blasting agents
    A F Hubbs
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA
    Toxicol Sci 61:135-43. 2001
    ..In contrast, specular hematite did not significantly elevate LDH or PMN levels and did not stimulate macrophage activity 4 weeks postexposure...
  31. ncbi request reprint Changes in bronchoalveolar lavage indices associated with radiographic classification in coal miners
    V Vallyathan
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, and Section of Pulmonary and Critical Care Medicine, West Virginia University, Morgantown, West Virginia, USA
    Am J Respir Crit Care Med 162:958-65. 2000
    ..These results are in good agreement with our hypothesis that development of CWP and its progression may be correlated with an oxidative stress and up-regulation of cytokines and mediators of growth...
  32. ncbi request reprint Induction of activator protein-1 through reactive oxygen species by crystalline silica in JB6 cells
    M Ding
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Biol Chem 276:9108-14. 2001
    ..These studies indicate that freshly ground silica is more biologically active than aged silica and that ROS, in particular H(2)O(2), play a significant role in silica-induced AP-1 activation...
  33. ncbi request reprint Alteration of deposition pattern and pulmonary response as a result of improved dispersion of aspirated single-walled carbon nanotubes in a mouse model
    R R Mercer
    Pathology and Physiology Research Branch, Health Effects Laboratory, NIOSH, Morgantown, WV 26505, USA
    Am J Physiol Lung Cell Mol Physiol 294:L87-97. 2008
    ..The results demonstrate that dispersed SWCNT are rapidly incorporated into the alveolar interstitium and that they produce an increase in collagen deposition...
  34. pmc Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis
    A A Shvedova
    Health Effects Laboratory Div, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Am J Physiol Lung Cell Mol Physiol 295:L552-65. 2008
    ..SWCNT inhalation was more effective than aspiration in causing inflammatory response, oxidative stress, collagen deposition, and fibrosis as well as mutations of K-ras gene locus in the lung of C57BL/6 mice...
  35. ncbi request reprint Biological and statistical approaches to predicting human lung cancer risk from silica
    E D Kuempel
    National Institute for Occupational Safety and Health, Education and Information Division, Risk Evaluation Branch, Cincinnati, OH 45226 1998, USA
    J Environ Pathol Toxicol Oncol 20:15-32. 2001
    ..This study illustrates that assumptions about the relevant biological mechanism, animal model, and statistical approach can all influence the magnitude of lung cancer risk estimates in humans exposed to crystalline silica...
  36. ncbi request reprint Effects of asphalt fume condensate exposure on acute pulmonary responses
    J Y Ma
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505 2888, USA
    Arch Toxicol 74:452-9. 2000
    ..The present study was carried out to characterize the effects of in vitro exposure to paving asphalt fume condensate (AFC) on alveolar macrophage (AM) functions and to monitor acute pulmonary responses to in vivo AFC exposure in rats...
  37. ncbi request reprint Silica-induced pulmonary inflammation in rats: activation of NF-kappa B and its suppression by dexamethasone
    M Sacks
    Program in Genetics and Developmental Biology, West Virginia University, Morgantown 26506, USA
    Biochem Biophys Res Commun 253:181-4. 1998
    ..These results show that activation of NF-kappa B is associated with silica-induced pulmonary inflammation, and the inhibition of its activation correlates temporally with suppression of inflammation...
  38. ncbi request reprint Pro/antioxidant status and AP-1 transcription factor in murine skin following topical exposure to cumene hydroperoxide
    A R Murray
    Department of Physiology and Pharmacology, West Virginia University, Morgantown, WV 26505, USA
    Carcinogenesis 28:1582-8. 2007
    ..These results suggest that Cum-OOH-induced carcinogenesis is accompanied by increased AP-1 activation and changes in antioxidant status...
  39. ncbi request reprint Effects of exposure to diesel exhaust particles (DEP) on pulmonary metabolic activation of mutagenic agents
    H W Zhao
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505 2888, USA
    Mutat Res 564:103-13. 2004
    ..The bioactivation of mutagens are metabolic enzyme- and substrate-specific, and both CYP1A1 and CYP2B1 play important roles in pulmonary mutagen activation...
  40. pmc Reactive oxygen species: their relation to pneumoconiosis and carcinogenesis
    V Vallyathan
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Environ Health Perspect 106:1151-5. 1998
    ..This article briefly summarizes some of the recent findings from our laboratories with emphasis on the molecular events by which ROS are involved in promoting pneumoconiosis and carcinogenesis...
  41. ncbi request reprint Pro/antioxidant status in murine skin following topical exposure to cumene hydroperoxide throughout the ontogeny of skin cancer
    A A Shvedova
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    Biochemistry (Mosc) 69:23-31. 2004
    ..These results suggest that COX-2-dependent oxidative metabolism is at least partially involved in Cum-OOH-induced inflammatory responses and thus tumor promotion...
  42. ncbi request reprint Reactive oxygen species and silica-induced carcinogenesis
    X Shi
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Toxicol Environ Health B Crit Rev 1:181-97. 1998
    ..Understanding the role of ROS in silica-mediated reactions may help develop therapeutic agents to block silica-induced free radical reactions and thus prevent or attenuate silica-induced carcinogenesis...
  43. ncbi request reprint Effects of paving asphalt fume exposure on genotoxic and mutagenic activities in the rat lung
    H W Zhao
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Mutat Res 557:137-49. 2004
    ....
  44. doi request reprint Pulmonary and cardiovascular responses of rats to inhalation of a commercial antimicrobial spray containing titanium dioxide nanoparticles
    W McKinney
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Inhal Toxicol 24:447-57. 2012
    ..It would be prudent to avoid exposure to children or those with pre-existing respiratory disease...
  45. ncbi request reprint Interaction between primary alveolar macrophages and primary alveolar type II cells under basal conditions and after lipopolysaccharide or quartz exposure
    R S Kanj
    National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 69:1097-116. 2006
    ....
  46. ncbi request reprint Time-dependent apoptosis of alveolar macrophages from rats exposed to bleomycin: involvement of tnf receptor 2
    H W Zhao
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    J Toxicol Environ Health A 67:1391-406. 2004
    ..These results indicate that the sustained expression of TNF-R2 in AM by BLM exposure may sensitize these cells to TNF-a-mediated toxicity...
  47. pmc Nanoparticle inhalation impairs endothelium-dependent vasodilation in subepicardial arterioles
    A J Leblanc
    Center for Cardiovascular and Respiratory Sciences, West Virginia University School of Medicine, Morgantown 26506 9105, West Virginia, USA
    J Toxicol Environ Health A 72:1576-84. 2009
    ..Such disturbances in coronary microvascular function are consistent with the cardiac events associated with particle pollution exposure...
  48. ncbi request reprint Subchronic silica exposure enhances respiratory defense mechanisms and the pulmonary clearance of Listeria monocytogenes in rats
    J M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Inhal Toxicol 12:1017-36. 2000
    ..These elevations in pulmonary immune response are likely responsible for the increase in pulmonary clearance of L. monocytogenes observed with preexposure to silica...
  49. doi request reprint Cell permeability, migration, and reactive oxygen species induced by multiwalled carbon nanotubes in human microvascular endothelial cells
    M Pacurari
    Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506 9300, USA
    J Toxicol Environ Health A 75:129-47. 2012
    ..The results generated from this study also elucidate the potential adverse effects of MWCNT exposure on humans at the cellular level...
  50. pmc Nanoparticle inhalation impairs coronary microvascular reactivity via a local reactive oxygen species-dependent mechanism
    A J Leblanc
    Center for Cardiovascular and Respiratory Sciences, West Virginia University School of Medicine, Morgantown, 26506 9105, USA
    Cardiovasc Toxicol 10:27-36. 2010
    ..Furthermore, altered prostanoid formation may also contribute to this dysfunction. Such disturbances in coronary microvascular function may contribute to the cardiac events associated with exposure to particles in this size range...
  51. ncbi request reprint Increased accumulation of neutrophils and decreased fibrosis in the lung of NADPH oxidase-deficient C57BL/6 mice exposed to carbon nanotubes
    A A Shvedova
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, West Virginia University, Morgantown, WV, USA
    Toxicol Appl Pharmacol 231:235-40. 2008
    ..These results demonstrate a role for NADPH oxidase-derived reactive oxygen species in determining course of pulmonary response to SWCNT...
  52. ncbi request reprint Diesel exhaust particle-induced alterations of pulmonary phase I and phase II enzymes of rats
    A Rengasamy
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    J Toxicol Environ Health A 66:153-67. 2003
    ..This study suggests that DEP may induce CYP1A1 and QR enzymes via a chemical effect, while the carbonaceous core may be involved in the attenuation of CYP2B1, GST, and catalase proteins and enzyme activities...
  53. ncbi request reprint Reactivity of free radicals on hydroxylated quartz surface and its implications for pathogenicity experimental and quantum mechanical study
    R Konecny
    National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888, USA
    J Environ Pathol Toxicol Oncol 20:119-32. 2001
    ..The theoretical predictions are supported experimentally using chemiluminescence to monitor reactivation of the aged silica surface by superoxide anion radicals...
  54. ncbi request reprint Opposite effect of NF-kappa B and c-Jun N-terminal kinase on p53-independent GADD45 induction by arsenite
    F Chen
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Biol Chem 276:11414-9. 2001
    ..These results indicate a molecular mechanism by which NF-kappaB and JNK may differentially contribute to cell cycle regulation in response to arsenite...
  55. ncbi request reprint Time course of pulmonary response of rats to inhalation of crystalline silica: histological results and biochemical indices of damage, lipidosis, and fibrosis
    D W Porter
    National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV 26505, USA
    J Environ Pathol Toxicol Oncol 20:1-14. 2001
    ....
  56. ncbi request reprint Molecular mechanism of tumor necrosis factor-alpha production in 1-->3-beta-glucan (zymosan)-activated macrophages
    S H Young
    Engineering Control and Technology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, National Institutes of Health, Morgantown, West Virginia 26505, USA
    J Biol Chem 276:20781-7. 2001
    ..Together, these results strongly suggest that NF-kappaB is involved in signal transduction of 1-->3-beta-glucans-induced TNF-alpha expression...
  57. ncbi request reprint Reduction of chromium(VI) and its relationship to carcinogenesis
    X Shi
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health B Crit Rev 2:87-104. 1999
    ....
  58. ncbi request reprint Mechanisms of pulmonary toxicity and medical applications of carbon nanotubes: Two faces of Janus?
    A A Shvedova
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, United States
    Pharmacol Ther 121:192-204. 2009
    ....
  59. pmc Multi-walled carbon nanotube-induced gene expression in the mouse lung: association with lung pathology
    M Pacurari
    Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, WV 26506 9300, USA
    Toxicol Appl Pharmacol 255:18-31. 2011
    ..Taken together, this study identifies that MWCNT exposure affects a subset of lung cancer biomarkers in mouse lungs...
  60. ncbi request reprint Elevated oxidative stress in skin of B6C3F1 mice affects dermal exposure to metal working fluid
    A A Shvedova
    Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
    Toxicol Ind Health 16:267-76. 2000
    ..Such changes were not observed with MWF treatment alone. These data indicate that oxidative stress can enhance dermal inflammation caused by occupational exposure to MWF...
  61. ncbi request reprint Lung dosimetry and risk assessment of nanoparticles: evaluating and extending current models in rats and humans
    E D Kuempel
    National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA
    Inhal Toxicol 18:717-24. 2006
    ..Such analyses would provide improved prediction of nanoparticle dose for risk assessment...
  62. pmc Cell permeability, migration, and reactive oxygen species induced by multiwalled carbon nanotubes in human microvascular endothelial cells
    M Pacurari
    Mary Babb Randolph Cancer Center, West Virginia University, Morgantown, West Virginia 26506 9300, USA
    J Toxicol Environ Health A 75:112-28. 2012
    ..The results generated from this study also elucidate the potential adverse effects of MWCNT exposure on humans at the cellular level...
  63. ncbi request reprint Cell apoptosis induced by carcinogenic metals
    F Chen
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Mol Cell Biochem 222:183-8. 2001
    ..A possible contribution of reactive oxygen species to metal-induced cell death is also discussed...
  64. ncbi request reprint Activation of mitogen-activated protein kinase p38 and extracellular signal-regulated kinase is involved in glass fiber-induced tumor necrosis factor-alpha production in macrophages
    J Ye
    National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Biol Chem 276:5360-7. 2001
    ..These results suggest that in addition to the NF-kappaB pathway for TNF-alpha production, glass fibers are able to activate c-Jun through MAP kinase pathways that lead to induction of TNF-alpha expression...
  65. doi request reprint Genotoxicity of carbon nanofibers: are they potentially more or less dangerous than carbon nanotubes or asbestos?
    E R Kisin
    Pathology and Physiology Research Branch, Health Effects Lab Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Toxicol Appl Pharmacol 252:1-10. 2011
    ..Further investigations are warranted to elucidate the possible mechanisms involved in CNF-induced genotoxicity...
  66. ncbi request reprint Characterization of asphalt fume composition under simulated road paving conditions by GC/MS and microflow LC/quadrupole time-of-flight MS
    J Wang
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, US Department of Health and Human Services, Morgantown, West Virginia 26505, USA
    Anal Chem 73:3691-700. 2001
    ..This method is suitable for support toxicity studies using simulated occupational exposure to asphalt fumes...
  67. ncbi request reprint Impairment of NF-kappaB activation and modulation of gene expression by calpastatin
    F Chen
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Am J Physiol Cell Physiol 279:C709-16. 2000
    ....
  68. pmc New insights into the role of nuclear factor-kappaB in cell growth regulation
    F Chen
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd, Morgantown, WV 26505, USA
    Am J Pathol 159:387-97. 2001
    ..Elucidation of the relationships between NF-kappaB activation and cell growth will be important in developing new strategies for the treatment of various human diseases, such as chronic autoimmune disorder and cancer...
  69. pmc Pulmonary reactions to organic dust exposures: development of an animal model
    V Castranova
    Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505 2888, USA
    Environ Health Perspect 104:41-53. 1996
    ..Information concerning the applicability of various animal models to humans and progress toward elucidation of causative agents and mechanisms of action is presented...
  70. ncbi request reprint Measurement of the release of inflammatory mediators from rat alveolar macrophages and alveolar type II cells following lipopolysaccharide or silica exposure: a comparative study
    R S Kanj
    National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 68:185-207. 2005
    ..However, compared to LPS, silica exhibited equal or greater potency as an inducer of cellular oxidant generation, especially from primary TII cells...
  71. ncbi request reprint Necrosis of nasal and airway epithelium in rats inhaling vapors of artificial butter flavoring
    A F Hubbs
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health1, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA
    Toxicol Appl Pharmacol 185:128-35. 2002
    ..Control rats were unaffected. Therefore, concentrations of butter flavoring vapors that can occur during the manufacture of foods are associated with epithelial injury in the nasal passages and pulmonary airways of rats...
  72. ncbi request reprint Cr (VI) induces cell growth arrest through hydrogen peroxide-mediated reactions
    Z Zhang
    Department of Basic Pharmaceutical Sciences, West Virginia University, Morgantown, USA
    Mol Cell Biochem 222:77-83. 2001
    ....
  73. ncbi request reprint Regulation of a cell type-specific silencer in the human interleukin-3 gene promoter by the transcription factor YY1 and an AP2 sequence-recognizing factor
    J Ye
    Pathology and Physiology Research Branch, Health Effect Laboratory Division, NIOSH, National Institutes of Health, Morgantown, West Virginia 26505, USA
    J Biol Chem 274:26661-7. 1999
    ..These data indicate that a cell type-specific silencer activity might be determined by a unique profile of ubiquitous transcription factors...
  74. ncbi request reprint Alteration of pulmonary cytochrome p-450 system: effects of asphalt fume condensate exposure
    J Y C Ma
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505 2888, USA
    J Toxicol Environ Health A 65:1247-60. 2002
    ..Alteration of cytochrome P-450 metabolism of PACs may contribute to the AFC-induced genotoxic effects demonstrated as MN formation...
  75. ncbi request reprint Finding NEMO by K63-linked polyubiquitin chain
    F Chen
    The Health Effect Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Cell Death Differ 13:1835-8. 2006
  76. ncbi request reprint Pulmonary inflammation and crystalline silica in respirable coal mine dust: dose-response
    E D Kuempel
    National Institute for Occupational Safety and Health NIOSH, Education and Information Division, Risk Evaluation Branch, Cincinnati, OH 45226 1998, USA
    J Biosci 28:61-9. 2003
    ..4). This study demonstrates dose-response relationships between respirable crystalline silica in coal mine dust and pulmonary inflammation, antioxidant production, and radiographic small opacities...
  77. ncbi request reprint Antioxidant balance and free radical generation in vitamin e-deficient mice after dermal exposure to cumene hydroperoxide
    A A Shvedova
    National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Chem Res Toxicol 15:1451-9. 2002
    ..PBN adducts detected by ESR in vitamin E-deficient mice provide direct evidence for in vivo free radical generation in the skin after exposure to cumene hydroperoxide...
  78. pmc Nitric oxide inhibits HIV tat-induced NF-kappaB activation
    F Chen
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, West Virginia University, Morgantown, USA
    Am J Pathol 155:275-84. 1999
    ..Rather, several Sp-1 sites adjoining the putative NF-kappaB binding site in the promoter region of NOS-3 gene are required for the induction of NOS-3 gene expression by Tat...
  79. ncbi request reprint New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases
    F Chen
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA lfd32cdc gov
    Clin Chem 45:7-17. 1999
    ..Therefore, development of modulatory strategies targeting this transcription factor may provide a novel therapeutic tool for the treatment or prevention of various diseases...
  80. ncbi request reprint Carcinogenic metals and NF-kappaB activation
    F Chen
    Health Effects Laboratory Division, National Institute for Occupational State and Health, Morgantown, WV 26505, USA
    Mol Cell Biochem 222:159-71. 2001
    ....
  81. ncbi request reprint Involvement of Erks activation in cadmium-induced AP-1 transactivation in vitro and in vivo
    C Huang
    Nelson Institute of Environmental Medicine, New York University School of Medicine, NY 10016, USA
    Mol Cell Biochem 222:141-7. 2001
    ..Considering the role of AP-1 activation in tumor promotion, the results presented in this study provide a possible molecular mechanism for cadmium-induced carcinogenesis...
  82. ncbi request reprint Mechanistically identified suitable biomarkers of exposure, effect, and susceptibility for silicosis and coal-worker's pneumoconiosis: a comprehensive review
    M Gulumian
    Department of Toxicology and Biochemistry Research, National Institute for Occupational Health, Johannesburg, South Africa
    J Toxicol Environ Health B Crit Rev 9:357-95. 2006
    ..Further studies are planned to test the validity and feasibility of these biomarkers to detect either high exposure to crystalline silica and early silicosis or susceptibility to silicosis in gold miners in South Africa...
  83. ncbi request reprint Potential pulmonary effects of man-made organic fiber (MMOF) dusts
    D B Warheit
    DuPont Haskell Lab
    Crit Rev Toxicol 31:697-736. 2001
    ..Thus, it is appropriate and timely to review the current data regarding MMOF workplace exposure and pulmonary health effects, including the database on epidemiological, exposure assessment, and toxicology studies...
  84. ncbi request reprint Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: role of iron
    V E Kagan
    Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15219, United States
    Toxicol Lett 165:88-100. 2006
    ..Thus, the presence of iron in SWCNT may be important in determining redox-dependent responses of macrophages...
  85. ncbi request reprint Effect of Cr(VI) exposure on sperm quality: human and animal studies
    H Li
    Department of Occupational Health, College of Public Health, Henan Medical University, Zhengzhou, Henan 450052, People's Republic of China
    Ann Occup Hyg 45:505-11. 2001
    ..The diameters of seminiferous tubules in exposed rats were smaller. These results suggest that occupational exposure to chromium(VI) leads to alteration of semen status and may affect the reproductive success of exposed workers...
  86. ncbi request reprint Pharmacological study of oyster mushroom (Pleurotus ostreatus) extract on isolated guinea pig trachea smooth muscle
    E N Schachter
    Mount Sinai School of Medicine, One Gustave L Levy Place, New York, New York, 10029 6574, USA
    Lung 183:63-71. 2005
    ..This effect is not dependent on pre-sensitization of the guinea pigs...
  87. ncbi request reprint Arsenic-induced NFkappaB transactivation through Erks- and JNKs-dependent pathways in mouse epidermal JB6 cells
    C Huang
    Nelson Institute of Environmental Medicine, New York University School of Medicine, NY 10016, USA
    Mol Cell Biochem 222:29-34. 2001
    ..That Erks activation is required for arsenic-induced NFkappaB transactivation was further supported by the findings that arsenic-induced NFkappaB transactivation was impaired in JB6 30.7b cells, which were deficient in Erks...
  88. ncbi request reprint Vanadium-induced nuclear factor of activated T cells activation through hydrogen peroxide
    C Huang
    Nelson Institute of Environmental Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 276:22397-403. 2001
    ....