Antonia M Calafat

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. pmc Integrating biomonitoring exposure data into the risk assessment process: phthalates [diethyl phthalate and di(2-ethylhexyl) phthalate] as a case study
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 114:1783-9. 2006
  2. ncbi request reprint Mono-(3-carboxypropyl) phthalate, a metabolite of di-n-octyl phthalate
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Toxicol Environ Health A 69:215-27. 2006
  3. ncbi request reprint Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites
    Russ Hauser
    Harvard School of Public Health Massachusetts General Hospital, Boston, MA 02115, USA
    Epidemiology 17:682-91. 2006
  4. pmc Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls
    Mary S Wolff
    Mount Sinai School of Medicine, Division of Environmental Health Sciences, Department of Community and Preventive Medicine, New York, New York 10029, USA
    Environ Health Perspect 115:116-21. 2007
  5. ncbi request reprint Temporal stability of the conjugated species of bisphenol A, parabens, and other environmental phenols in human urine
    Xiaoyun Ye
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Expo Sci Environ Epidemiol 17:567-72. 2007
  6. doi request reprint The U.S. National Health and Nutrition Examination Survey and human exposure to environmental chemicals
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Int J Hyg Environ Health 215:99-101. 2012
  7. ncbi request reprint Automated solid phase extraction and quantitative analysis of human milk for 13 phthalate metabolites
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 805:49-56. 2004
  8. pmc Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 113:391-5. 2005
  9. pmc Selecting adequate exposure biomarkers of diisononyl and diisodecyl phthalates: data from the 2005-2006 National Health and Nutrition Examination Survey
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 119:50-5. 2011
  10. pmc Concentrations of the sunscreen agent benzophenone-3 in residents of the United States: National Health and Nutrition Examination Survey 2003--2004
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 116:893-7. 2008

Detail Information

Publications97

  1. pmc Integrating biomonitoring exposure data into the risk assessment process: phthalates [diethyl phthalate and di(2-ethylhexyl) phthalate] as a case study
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 114:1783-9. 2006
    ..Although the vast and growing literature on phthalates research could not be covered comprehensively in this article, we made every attempt to include the most relevant publications as of the end of 2005...
  2. ncbi request reprint Mono-(3-carboxypropyl) phthalate, a metabolite of di-n-octyl phthalate
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Toxicol Environ Health A 69:215-27. 2006
    ....
  3. ncbi request reprint Altered semen quality in relation to urinary concentrations of phthalate monoester and oxidative metabolites
    Russ Hauser
    Harvard School of Public Health Massachusetts General Hospital, Boston, MA 02115, USA
    Epidemiology 17:682-91. 2006
    ..The present study extends our work in a larger sample of men and includes measurements of di(2-ethylhexyl) phthalate (DEHP) oxidative metabolites...
  4. pmc Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls
    Mary S Wolff
    Mount Sinai School of Medicine, Division of Environmental Health Sciences, Department of Community and Preventive Medicine, New York, New York 10029, USA
    Environ Health Perspect 115:116-21. 2007
    ..S. children using exposure biomarkers in urine. However, little is known about their variation by race, age, sex, and geography, and no data exist for newly developed biomarkers...
  5. ncbi request reprint Temporal stability of the conjugated species of bisphenol A, parabens, and other environmental phenols in human urine
    Xiaoyun Ye
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Expo Sci Environ Epidemiol 17:567-72. 2007
    ....
  6. doi request reprint The U.S. National Health and Nutrition Examination Survey and human exposure to environmental chemicals
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Int J Hyg Environ Health 215:99-101. 2012
    ..NHANES human biomonitoring data can be used to establish reference ranges for selected chemicals, provide exposure data for risk assessment, and monitor exposure trends...
  7. ncbi request reprint Automated solid phase extraction and quantitative analysis of human milk for 13 phthalate metabolites
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 805:49-56. 2004
    ..We detected several phthalate metabolites in pooled human breast milk samples, suggesting that phthalates can be incorporated into breast milk and transferred to the nursing child...
  8. pmc Urinary concentrations of bisphenol A and 4-nonylphenol in a human reference population
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 113:391-5. 2005
    ..S. population) and relatively small size, this study provides the first reference range of human internal dose levels of BPA and NP in a demographically diverse human population...
  9. pmc Selecting adequate exposure biomarkers of diisononyl and diisodecyl phthalates: data from the 2005-2006 National Health and Nutrition Examination Survey
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 119:50-5. 2011
    ..Objectives: We assessed exposure to DINP and DIDP in a representative sample of persons ≥ 6 years of age in the U.S. general population from the 2005-2006 National Health and Nutrition Examination Survey (NHANES)...
  10. pmc Concentrations of the sunscreen agent benzophenone-3 in residents of the United States: National Health and Nutrition Examination Survey 2003--2004
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 116:893-7. 2008
    ..BP-3 has other uses in many consumer products (e.g., as fragrance and flavor enhancer, photoinitiator, ultraviolet curing agent, polymerization inhibitor)...
  11. pmc Urinary concentrations of triclosan in the U.S. population: 2003-2004
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 116:303-7. 2008
    ..Triclosan is a synthetic chemical with broad antimicrobial activity that has been used extensively in consumer products, including personal care products, textiles, and plastic kitchenware...
  12. pmc Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Environ Health Perspect 116:39-44. 2008
    ..Bisphenol A (BPA) and 4-tertiary-octylphenol (tOP) are industrial chemicals used in the manufacture of polycarbonate plastics and epoxy resins (BPA) and nonionic surfactants (tOP). These products are in widespread use in the United States...
  13. pmc Polyfluoroalkyl chemicals in the U.S. population: data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 115:1596-602. 2007
    ..Exposure of the general U.S. population to PFCs is widespread. Since 2002, the manufacturing practices for PFCs in the United States have changed considerably...
  14. ncbi request reprint Factors affecting the evaluation of biomonitoring data for human exposure assessment
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Int J Androl 31:139-43. 2008
    ....
  15. ncbi request reprint Serum concentrations of 11 polyfluoroalkyl compounds in the u.s. population: data from the national health and nutrition examination survey (NHANES)
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Sci Technol 41:2237-42. 2007
    ....
  16. ncbi request reprint Urinary and amniotic fluid levels of phthalate monoesters in rats after the oral administration of di(2-ethylhexyl) phthalate and di-n-butyl phthalate
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Mailstop F17, Atlanta, GA 30341, USA
    Toxicology 217:22-30. 2006
    ..Although no firm conclusions could be drawn from the urinary MBP data, the MEHP results suggest that maternal urinary MEHP levels may be useful surrogate markers for fetal exposure to DEHP...
  17. ncbi request reprint Perfluorinated chemicals in selected residents of the American continent
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Mailstop F17, Atlanta, GA 30341, USA
    Chemosphere 63:490-6. 2006
    ..Genetic variability, diet, lifestyle, or a combination of all these may contribute to the different patterns of human exposure to PFCs in the United States and Peru...
  18. ncbi request reprint Human exposure assessment to environmental chemicals using biomonitoring
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Int J Androl 29:166-71; discussion 181-5. 2006
    ..The use of biomonitoring in human risk assessment is not discussed...
  19. ncbi request reprint Perfluorochemicals in pooled serum samples from United States residents in 2001 and 2002
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Sci Technol 40:2128-34. 2006
    ..These findings indicate different patterns of human exposure to PFCs among the population groups examined and stress the importance of conducting research to identify the environmental sources and pathways of human exposure to PFCs...
  20. pmc Exposure to bisphenol A and other phenols in neonatal intensive care unit premature infants
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 117:639-44. 2009
    ..For 42 of these infants, we evaluated urinary concentrations of several phenols, including bisphenol A (BPA), in association with the use of the same medical devices...
  21. pmc What additional factors beyond state-of-the-art analytical methods are needed for optimal generation and interpretation of biomonitoring data?
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Health Perspect 117:1481-5. 2009
    ..e., measurement of environmental chemicals, their metabolites, or specific reaction products in human biological specimens) to assess internal exposure (i.e., body burden) has gained importance in exposure assessment...
  22. pmc Urinary concentrations of four parabens in the U.S. population: NHANES 2005-2006
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 118:679-85. 2010
    ..Parabens are widely used as antimicrobial preservatives in cosmetics, -pharmaceuticals, and food and beverage processing...
  23. ncbi request reprint Exposure to di-(2-ethylhexyl) phthalate among premature neonates in a neonatal intensive care unit
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Pediatrics 113:e429-34. 2004
    ..Because of their smaller size, children and especially premature and small infants may receive a larger dose of DEHP on a milligram per kilogram basis than adults when the same-size medical device is used for all ages...
  24. pmc Maternal concentrations of polyfluoroalkyl compounds during pregnancy and fetal and postnatal growth in British girls
    Mildred Maisonet
    Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Environ Health Perspect 120:1432-7. 2012
    ..Prenatal exposures to polyfluoroalkyl compounds (PFCs) may be associated with adverse changes in fetal and postnatal growth...
  25. pmc Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Atlanta, GA 30341, USA
    Environ Health Perspect 112:331-8. 2004
    ....
  26. doi request reprint Stability of the conjugated species of environmental phenols and parabens in human serum
    Xiaoyun Ye
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Environ Int 35:1160-3. 2009
    ..To our knowledge, this is the first study to report on the stability of conjugated species in serum, and as such requires replication...
  27. pmc Mono(2-ethyl-5-hydroxyhexyl) phthalate and mono-(2-ethyl-5-oxohexyl) phthalate as biomarkers for human exposure assessment to di-(2-ethylhexyl) phthalate
    Kayoko Kato
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Atlanta, GA 30341, USA
    Environ Health Perspect 112:327-30. 2004
    ....
  28. ncbi request reprint Glucuronidation patterns of common urinary and serum monoester phthalate metabolites
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy NE, Mailstop F17, Atlanta, GA 30341, USA
    Arch Toxicol 77:561-7. 2003
    ..Serum mBzP was largely below the method limit of detection. Interestingly, the serum mEP and mBP levels were less than 3% and 47%, respectively, of their urinary levels, whereas the level of mEHP was similar both in urine and serum...
  29. doi request reprint Trends in exposure to polyfluoroalkyl chemicals in the U.S. Population: 1999-2008
    Kayoko Kato
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States
    Environ Sci Technol 45:8037-45. 2011
    ..Nonetheless, these NHANES data suggest that sociodemographic factors may influence exposure and also provide unique information on temporal trends of exposure...
  30. ncbi request reprint Urinary biomarkers of di-isononyl phthalate in rats
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Toxicology 223:101-12. 2006
    ....
  31. doi request reprint Does the composition of urine change when collected from disposable diapers and other absorbent materials?
    Xiaoyun Ye
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, Mailstop F53, Atlanta, Georgia 30341, USA
    J Expo Sci Environ Epidemiol 20:644-9. 2010
    ....
  32. doi request reprint Automated on-line column-switching HPLC-MS/MS method with peak focusing for measuring parabens, triclosan, and other environmental phenols in human milk
    Xiaoyun Ye
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States
    Anal Chim Acta 622:150-6. 2008
    ..Nevertheless, to demonstrate the utility of these measures for exposure and risk assessment purposes, additional data about sampling and storage of the milk, and on the stability of the analytes in milk, are needed...
  33. doi request reprint Estimated daily intake of phthalates in occupationally exposed groups
    Cynthia J Hines
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio 45230, USA
    J Expo Sci Environ Epidemiol 21:133-41. 2011
    ..These intake estimates are subject to several uncertainties; however, an occupational contribution to phthalate daily intake is clearly indicated in some industries...
  34. pmc Variability of urinary concentrations of bisphenol A in spot samples, first morning voids, and 24-hour collections
    Xiaoyun Ye
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 119:983-8. 2011
    ..Therefore, there is considerable within-person and between-person variability of BPA concentrations in spot urine samples. However, no information exists on the within-day variability of urinary BPA concentrations...
  35. doi request reprint Concentrations of bisphenol A and seven other phenols in pooled sera from 3-11 year old children: 2001-2002 National Health and Nutrition Examination Survey
    Xiaoyun Ye
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, Mailstop F53, Atlanta, Georgia 30341, USA
    Environ Sci Technol 46:12664-71. 2012
    ....
  36. doi request reprint Occupational exposure to diisononyl phthalate (DiNP) in polyvinyl chloride processing operations
    Cynthia J Hines
    National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA
    Int Arch Occup Environ Health 85:317-25. 2012
    ..We present DiNP metabolite urinary concentrations in PVC processing workers, estimate DiNP daily intake for these workers, and compare worker estimates to other populations...
  37. doi request reprint An estimate of phthalate exposure among pregnant women living in Trujillo, Peru
    Elizabeth Ann Irvin
    Department of Environmental Health Science, The University of Georgia, College of Public Health, Athens, GA, USA
    Chemosphere 80:1301-7. 2010
    ..Five of nine unadjusted urinary metabolites and four of nine creatinine-adjusted urinary metabolites were significantly lower in this group of pregnant women living in Peru compared to pregnant women in the US general population...
  38. doi request reprint Automated on-line column-switching HPLC-MS/MS method for measuring environmental phenols and parabens in serum
    Xiaoyun Ye
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop F53, Atlanta, GA 30341, USA
    Talanta 76:865-71. 2008
    ..However, important additional factors, including validated sample collecting, handling, and storing protocols, as well as toxicokinetic data, are required if these measures are used for exposure assessment...
  39. ncbi request reprint Metabolite profiles of di-n-butyl phthalate in humans and rats
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Sci Technol 41:7576-80. 2007
    ..In addition to MBP, MCPP and MHBP may be adequate biomarkers of exposure to DBP in occupational settings orin potential high-exposure scenarios...
  40. ncbi request reprint Automated solid-phase extraction approaches for large scale biomonitoring studies
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Chromatogr Sci 47:12-8. 2009
    ....
  41. pmc Variability over 1 week in the urinary concentrations of metabolites of diethyl phthalate and di(2-ethylhexyl) phthalate among eight adults: an observational study
    James L Preau
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 118:1748-54. 2010
    ..Several reports suggest that concentrations of phthalate metabolites in a spot urine sample can provide a reliable estimation of exposure to phthalates for up to several months...
  42. ncbi request reprint Quantification of 22 phthalate metabolites in human urine
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States
    J Chromatogr B Analyt Technol Biomed Life Sci 860:106-12. 2007
    ....
  43. ncbi request reprint Quantification of the urinary concentrations of parabens in humans by on-line solid phase extraction-high performance liquid chromatography-isotope dilution tandem mass spectrometry
    Xiaoyun Ye
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 844:53-9. 2006
    ..Using this method, we detected methyl, ethyl, and propyl parabens, mostly as conjugated species, in 22 urine samples collected from anonymous adults...
  44. ncbi request reprint Detection of phthalate metabolites in human saliva
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mail Stop F 17, Atlanta, GA 30341, USA
    Arch Toxicol 79:647-52. 2005
    ....
  45. pmc Assessing human exposure to phthalates using monoesters and their oxidized metabolites as biomarkers
    Dana B Barr
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 111:1148-51. 2003
    ....
  46. pmc Oxidative metabolites of diisononyl phthalate as biomarkers for human exposure assessment
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 114:1158-61. 2006
    ..Therefore, we concluded that the prevalence of human exposure to DINP is underestimated by using MINP as the sole DINP urinary biomarker...
  47. doi request reprint In-vitro oxidation of bisphenol A: Is bisphenol A catechol a suitable biomarker for human exposure to bisphenol A?
    Xiaoyun Ye
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, Mailstop F53, Atlanta, GA 30341, USA
    Anal Bioanal Chem 399:1071-9. 2011
    ....
  48. doi request reprint Effect of temperature and duration of storage on the stability of polyfluoroalkyl chemicals in human serum
    Kayoko Kato
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Chemosphere 91:115-7. 2013
    ..Concentrations of the target analytes remained unchanged under all studied conditions, even when serum was kept at room temperature for 10 days...
  49. doi request reprint Identification of potential biomarkers of exposure to di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH), an alternative for phthalate plasticizers
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Expo Sci Environ Epidemiol 22:204-11. 2012
    ..Our results suggest that several urinary oxidative metabolites, specifically CHDA, mono oxoisononyl ester and MHNCH may be used as specific biomarkers of DINCH exposure in humans...
  50. pmc Parabens as urinary biomarkers of exposure in humans
    Xiaoyun Ye
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 114:1843-6. 2006
    ..In vivo and in vitro studies have revealed weak estrogenic activity of some parabens. Widespread use has raised concerns about the potential human health risks associated with paraben exposure...
  51. ncbi request reprint Characterizing children's exposures: beyond NHANES
    Larry L Needham
    Organic Analytical Toxicology Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Mailstop F17, 4770 Buford Highway, Atlanta, GA 30341 3724, USA
    Neurotoxicology 26:547-53. 2005
    ..We recommend additional studies to supplement the NHANES biomonitoring data...
  52. ncbi request reprint Measuring environmental phenols and chlorinated organic chemicals in breast milk using automated on-line column-switching-high performance liquid chromatography-isotope dilution tandem mass spectrometry
    Xiaoyun Ye
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop F17, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 831:110-5. 2006
    ..BPA, OPP, and BP-3 were detected in more than 60% of the samples tested. The free species of these compounds appear to be most prevalent in milk...
  53. ncbi request reprint Analysis of human urine for fifteen phthalate metabolites using automated solid-phase extraction
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, Mailstop F17, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 805:161-7. 2004
    ..The method was validated on spiked pooled urine samples and on pooled urine samples from persons with no known exposure to phthalates...
  54. ncbi request reprint Urinary oxidative metabolites of di(2-ethylhexyl) phthalate in humans
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Mailstop F17, 4770 Buford Hwy NE, Atlanta, GA 30341, USA
    Toxicology 219:22-32. 2006
    ..Although quantitative information is not available, our findings suggest that, despite potential differences among species, the oxidative metabolism of DEHP in humans and rodents results in similar urinary metabolic products...
  55. doi request reprint Improved selectivity for the analysis of maternal serum and cord serum for polyfluoroalkyl chemicals
    Kayoko Kato
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA Tel
    J Chromatogr A 1218:2133-7. 2011
    ..1 ng/mL except for PFOS (0.2 ng/mL)) than our previous method that used methanol for the HPLC separation. The present method should improve the precise and selective analysis of maternal and cord serum for PFCs...
  56. ncbi request reprint Uses of speciation techniques in biomonitoring for assessing human exposure to organic environmental chemicals
    Larry L Needham
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Anal Bioanal Chem 381:397-404. 2005
    ..Much of this information and many of these techniques are transferable to the measurement of inorganic elements in environmental and biological samples...
  57. doi request reprint Analysis of blood spots for polyfluoroalkyl chemicals
    Kayoko Kato
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Anal Chim Acta 656:51-5. 2009
    ....
  58. ncbi request reprint Automated solid-phase extraction and measurement of perfluorinated organic acids and amides in human serum and milk
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Sci Technol 38:3698-704. 2004
    ..Additional studies are needed to determine whether environmental exposure to PFCs can result in PFCs partitioning into milk. Large epidemiological studies to determine the levels of PFCs among the U.S. general population are warranted...
  59. ncbi request reprint Polyfluoroalkyl compounds in pooled sera from children participating in the National Health and Nutrition Examination Survey 2001-2002
    Kayoko Kato
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Sci Technol 43:2641-7. 2009
    ..Nevertheless,these findings suggestthat human exposure to PFCs among the population groups of children examined may differ and stress the importance of identifying the environmental sources and routes of exposure to PFCs...
  60. pmc Biomarkers of exposure to triclocarban in urine and serum
    Xiaoyun Ye
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Toxicology 286:69-74. 2011
    ..Total (free plus conjugated) TCC could serve as a potential biomarker for human exposure to TCC...
  61. doi request reprint Temporal stability of eight phthalate metabolites and their glucuronide conjugates in human urine
    Ella Samandar
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, Mailstop F 53, Atlanta, GA 30341, USA
    Environ Res 109:641-6. 2009
    ..Based on these findings, we recommend transferring urine specimens to a cooler or a refrigerator immediately after collection followed by permanent storage at subfreezing temperatures within hours of sample collection...
  62. ncbi request reprint Urinary metabolites of di-n-octyl phthalate in rats
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Mailstop F17, 4770 Buford Hwy NE, Atlanta, GA 30341, USA
    Toxicology 210:123-33. 2005
    ..We also studied the in vitro metabolism of DnOP and MnOP by rat liver microsomes. DnOP produced MnOP, MHOP, and PA in vitro whereas, MnOP produced MHOP and PA in vitro at detectable levels...
  63. doi request reprint Urinary and serum metabolites of di-n-pentyl phthalate in rats
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, United States
    Chemosphere 82:431-6. 2011
    ..Nonetheless, based on the urinary levels of MHPP, our preliminary data suggest that human exposure to DPP in the United States is rather limited...
  64. ncbi request reprint Urinary metabolites of diisodecyl phthalate in rats
    Kayoko Kato
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Toxicology 236:114-22. 2007
    ..Additional research on the toxicokinetics of these metabolites is needed to understand the extent of human exposure to DiDP from the urinary concentrations of MCiNP and other DiDP secondary metabolites...
  65. ncbi request reprint Identification of metabolites of 4-nonylphenol isomer 4-(3',6'-dimethyl-3'-heptyl) phenol by rat and human liver microsomes
    Xiaoyun Ye
    Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop MS F53, Atlanta, GA 30341, USA
    Drug Metab Dispos 35:1269-74. 2007
    ..Our findings suggest that P363-NC could be used as a biomarker to assess exposure to 4-tNP, although additional research to evaluate its suitability as a biomarker is warranted...
  66. doi request reprint Urinary phthalate metabolite concentrations among workers in selected industries: a pilot biomonitoring study
    Cynthia J Hines
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Cincinnati, OH, USA
    Ann Occup Hyg 53:1-17. 2009
    ..In summary, using urinary metabolites, we successfully identified workplaces with likely occupational phthalate exposure. Additional work is needed to distinguish occupational from non-occupational sources in low-exposure workplaces...
  67. ncbi request reprint Measurement of 18 perfluorinated organic acids and amides in human serum using on-line solid-phase extraction
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Anal Chem 77:6085-91. 2005
    ..The high throughput and low limits of detection (0.05-0.8 ng/mL) using a small sample volume (100 microL of serum) and isotope dilution quantification make this method suitable for large-scale epidemiologic studies...
  68. doi request reprint Cross validation and ruggedness testing of analytical methods used for the quantification of urinary phthalate metabolites
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States
    J Chromatogr B Analyt Technol Biomed Life Sci 873:180-6. 2008
    ....
  69. ncbi request reprint Uses and issues of biomonitoring
    Larry L Needham
    National Center for Environmental Health, Centers for Disease Control and Prevention, Mailstop F17, 4770 Buford Highway, Atlanta, GA 30341 3724, USA
    Int J Hyg Environ Health 210:229-38. 2007
    ....
  70. ncbi request reprint Quantification of urinary conjugates of bisphenol A, 2,5-dichlorophenol, and 2-hydroxy-4-methoxybenzophenone in humans by online solid phase extraction-high performance liquid chromatography-tandem mass spectrometry
    Xiaoyun Ye
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, Mailstop F17, Atlanta, GA 30341, USA
    Anal Bioanal Chem 383:638-44. 2005
    ..To our knowledge, this is the first study describing the distribution of urinary conjugates of BP-3 and 2,5-DCP in humans...
  71. ncbi request reprint Automated online and off-line solid-phase extraction methods for measuring isoflavones and lignans in urine
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Chromatogr Sci 42:495-500. 2004
    ..Both methods are adequate for analyzing a large number of samples for epidemiological studies to assess the prevalence of human exposure to isoflavones and lignans...
  72. ncbi request reprint Automated on-line column-switching HPLC-MS/MS method with peak focusing for the determination of nine environmental phenols in urine
    Xiaoyun Ye
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Anal Chem 77:5407-13. 2005
    ..The method can be used for quick and accurate analysis of large numbers of samples in epidemiologic studies for assessing the prevalence of human exposure to environmental phenols...
  73. ncbi request reprint SPE/SPME-GC/MS approach for measuring musk compounds in serum and breast milk
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 858:177-83. 2007
    ..The method, which requires only 1 mL serum or breast milk to achieve limits of detection of 0.03-0.3 ng/mL, is applicable in biomonitoring studies for human internal dose measurement of polycyclic musk compounds...
  74. ncbi request reprint Determination of total phthalates in urine by isotope-dilution liquid chromatography-tandem mass spectrometry
    Kayoko Kato
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 814:355-60. 2005
    ..The present method accurately assesses total exposure to phthalates without noticeable contamination from the ubiquitous phthalates in the environment, but it gives no information about the parent phthalate...
  75. ncbi request reprint Quantifying phthalate metabolites in human meconium and semen using automated off-line solid-phase extraction coupled with on-line SPE and isotope-dilution high-performance liquid chromatography--tandem mass spectrometry
    Kayoko Kato
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Anal Chem 78:6651-5. 2006
    ....
  76. doi request reprint Assessing developmental toxicant exposures via biomonitoring
    Larry L Needham
    Organic Analytical Toxicology Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341 3724, USA
    Basic Clin Pharmacol Toxicol 102:100-8. 2008
    ..In this paper, we examine this linkage using several chemicals as examples and providing biomonitoring information for these chemicals in the US population as a whole but also at various life stages...
  77. ncbi request reprint Determination of 16 phthalate metabolites in urine using automated sample preparation and on-line preconcentration/high-performance liquid chromatography/tandem mass spectrometry
    Kayoko Kato
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, Mailstop F17, Atlanta, Georgia 30341, USA
    Anal Chem 77:2985-91. 2005
    ....
  78. ncbi request reprint Rapid quantitation of cyanide in whole blood by automated headspace gas chromatography
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Mailstop F19, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 772:131-7. 2002
    ..This automated, high-throughput, simple, and sensitive method is suitable for the rapid diagnosis of CN in clinical and forensic specimens...
  79. pmc Urinary levels of trichloroacetic acid, a disinfection by-product in chlorinated drinking water, in a human reference population
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 111:151-4. 2003
    ....
  80. ncbi request reprint Quantitative determination of the hydrolysis products of nitrogen mustards in human urine by liquid chromatography-electrospray ionization tandem mass spectrometry
    Sharon W Lemire
    Division of Laboratory Sciences, National Center for Environmental Health Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3724, USA
    J Anal Toxicol 27:1-6. 2003
    ..The method limits of detection were 0.41 ng/mL for EDEA and 0.96 ng/mL for MDEA in 1 mL of urine with coefficients of variation < 10% for both compounds...
  81. ncbi request reprint Determination of tar, nicotine, and carbon monoxide yields in the smoke of bidi cigarettes
    Clifford H Watson
    Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Atlanta, GA 30341, USA
    Nicotine Tob Res 5:747-53. 2003
    ..7+/-.4 mg/bidi), and CO (39.2+/-5.7 mg/bidi). In comparison, traditional cigarettes smoked using the bidi cigarette protocol have lower tar and CO yields, but have nicotine deliveries comparable with bidi cigarettes...
  82. ncbi request reprint Simultaneous measurement of urinary bisphenol A and alkylphenols by automated solid-phase extractive derivatization gas chromatography/mass spectrometry
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Anal Chem 75:6820-5. 2003
    ..The method, validated on spiked pooled urine samples and on urine samples from exposed persons, has limits of detection of approximately 0.1 ng in 1 mL of urine...
  83. ncbi request reprint Quantitation of 2-chlorovinylarsonous acid in human urine by automated solid-phase microextraction--gas chromatography--mass spectrometry
    Joe V Wooten
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Mailstop F19, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 772:147-53. 2002
    ..The assay was validated on human urine samples spiked with CVAA to determine the accuracy, precision, and limit of detection (LOD). The LOD was 7.4 pg in 1 ml of urine...
  84. ncbi request reprint Quantitative detection of trichloroacetic acid in human urine using isotope dilution high-performance liquid chromatography-electrospray ionization tandem mass spectrometry
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Anal Chem 74:2058-63. 2002
    ..The method is simple and fast and is not labor intensive (sample preparation and analysis can be performed in approximately 15 min) with a limit of detection of 0.5 ng/mL in 1 mL of urine...
  85. pmc Temporal variability of urinary phthalate metabolite levels in men of reproductive age
    Russ Hauser
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 112:1734-40. 2004
    ..In particular, a single urine sample was most predictive for MEP and least predictive for MEHP. These results suggest that the most efficient exposure assessment strategy for a particular study may depend on the phthalates of interest...
  86. pmc Phthalate diesters and their metabolites in human breast milk, blood or serum, and urine as biomarkers of exposure in vulnerable populations
    Johan Hogberg
    Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Environ Health Perspect 116:334-9. 2008
    ..Phthalates may pose a risk for perinatal developmental effects. An important question relates to the choice of suitable biological matrices for assessing exposure during this period...
  87. pmc Prenatal phenol and phthalate exposures and birth outcomes
    Mary S Wolff
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Environ Health Perspect 116:1092-7. 2008
    ..Many phthalates and phenols are hormonally active and are suspected to alter the course of development...
  88. ncbi request reprint Developmental toxicity of perfluorooctanoic acid in the CD-1 mouse after cross-foster and restricted gestational exposures
    Cynthia J Wolf
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 95:462-73. 2007
    ..Exposure earlier in gestation produced stronger responses, but further study is needed to determine if this is a function of higher total dose or if there is a developmentally sensitive period...
  89. ncbi request reprint Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring
    Sally S White
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Toxicol Sci 96:133-44. 2007
    ..These findings suggest that in addition to gestational exposure, abnormal lactational development of dams may play a role in early growth retardation of developmentally exposed offspring...
  90. pmc Exposure to phthalates in neonatal intensive care unit infants: urinary concentrations of monoesters and oxidative metabolites
    Jennifer Weuve
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 114:1424-31. 2006
    ....
  91. ncbi request reprint Determinants of fetal exposure to polyfluoroalkyl compounds in Baltimore, Maryland
    Benjamin J Apelberg
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Environ Sci Technol 41:3891-7. 2007
    ..Our findings suggest that in utero exposure to PFOS and PFOA is ubiquitous in a population of babies born in Baltimore, MD...
  92. doi request reprint Baby care products: possible sources of infant phthalate exposure
    Sheela Sathyanarayana
    Department of Occupational and Environmental Health Sciences, Division of General Pediatrics, Child Health Institute, University of Washington, Building 296200, NE 74th St, Seattle, WA 98115 8160, USA
    Pediatrics 121:e260-8. 2008
    ..We investigated the relationship between phthalate metabolite concentrations in infant urine and maternal reported use of dermally applied infant care products...
  93. pmc Evidence of interaction between polychlorinated biphenyls and phthalates in relation to human sperm motility
    Russ Hauser
    Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Environ Health Perspect 113:425-30. 2005
    ....
  94. pmc Use of di(2-ethylhexyl) phthalate-containing medical products and urinary levels of mono(2-ethylhexyl) phthalate in neonatal intensive care unit infants
    Ronald Green
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Environ Health Perspect 113:1222-5. 2005
    ..Among neonates in NICUs, we studied exposure to DEHP-containing medical devices in relation to urinary levels of mono(2-ethylhexyl) phthalate (MEHP), a metabolite of DEHP...
  95. pmc Cord serum concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in relation to weight and size at birth
    Benjamin J Apelberg
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Environ Health Perspect 115:1670-6. 2007
    ..Recent studies have reported developmental toxicity among rodents dosed with perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA)...
  96. ncbi request reprint The relationship between environmental exposure to phthalates and computer-aided sperm analysis motion parameters
    Susan M Duty
    Department of Environmental Health, Occupational Health Program, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Androl 25:293-302. 2004
    ..Although we did not find statistically significant associations, trends between CASA parameters, sperm velocity, and forward progression, and increased urinary levels of MBP, MBzP, and MEHP warrant further follow-up...
  97. ncbi request reprint Impact of urine preservation methods and duration of storage on measured levels of environmental contaminants
    Jane A Hoppin
    Epidemiology Branch, NIEHS, NIH, DHHS, Research Triangle Park, NC, USA
    J Expo Sci Environ Epidemiol 16:39-48. 2006
    ..The precision of the laboratory measurements was high allowing us to observe small differences, which may not be important when categorizing individuals into broader exposure groups...