Aaron C Brault

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. pmc A naturally occurring mutation within the probe-binding region compromises a molecular-based West Nile virus surveillance assay for mosquito pools (Diptera: Culicidae)
    Aaron C Brault
    Division of Vector Borne Diseases, Centers for Disease Control and Prevention, 3150 Rampart Rd, Fort Collins, CO 80521, USA
    J Med Entomol 49:939-41. 2012
  2. doi request reprint Replication of the primary dog kidney-53 dengue 2 virus vaccine candidate in Aedes aegypti is modulated by a mutation in the 5' untranslated region and amino acid substitutions in nonstructural proteins 1 and 3
    Aaron C Brault
    Department of Pathology, Microbiology, and Immunology, Center for Vector borne Diseases, School of Veterinary Medicine, University of California, Davis, USA
    Vector Borne Zoonotic Dis 11:683-9. 2011
  3. pmc Reduced avian virulence and viremia of West Nile virus isolates from Mexico and Texas
    Aaron C Brault
    Division of Vector Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80521, USA
    Am J Trop Med Hyg 85:758-67. 2011
  4. pmc Envelope and pre-membrane protein structural amino acid mutations mediate diminished avian growth and virulence of a Mexican West Nile virus isolate
    Stanley A Langevin
    Center for Vectorborne Diseases and Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Gen Virol 92:2810-20. 2011
  5. ncbi request reprint Avian virulence and thermostable replication of the North American strain of West Nile virus
    Richard M Kinney
    Division of Vector Borne Infectious Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA
    J Gen Virol 87:3611-22. 2006
  6. pmc A single positively selected West Nile viral mutation confers increased virogenesis in American crows
    Aaron C Brault
    Center for Vector Borne Diseases and Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Nat Genet 39:1162-6. 2007
  7. pmc North American West Nile virus genotype isolates demonstrate differential replicative capacities in response to temperature
    Christy C Andrade
    Center for Vector Borne Diseases and Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA, USA
    J Gen Virol 92:2523-33. 2011
  8. ncbi request reprint West Nile virus detection in nonvascular feathers from avian carcasses
    Nicole M Nemeth
    Division of Vector Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA
    J Vet Diagn Invest 21:616-22. 2009
  9. ncbi request reprint Limited interdecadal variation in mosquito (Diptera: Culicidae) and avian host competence for Western equine encephalomyelitis virus (Togaviridae: Alphavirus)
    William K Reisen
    Arbovirus Research Unit, Center for Vectorborne Diseases, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Am J Trop Med Hyg 78:681-6. 2008
  10. pmc Structural gene (prME) chimeras of St Louis encephalitis virus and West Nile virus exhibit altered in vitro cytopathic and growth phenotypes
    Payal D Maharaj
    Division of Vector Borne Diseases, Centers for Disease Control and Prevention CDC, Fort Collins, CO 80521, USA
    J Gen Virol 93:39-49. 2012

Collaborators

Detail Information

Publications32

  1. pmc A naturally occurring mutation within the probe-binding region compromises a molecular-based West Nile virus surveillance assay for mosquito pools (Diptera: Culicidae)
    Aaron C Brault
    Division of Vector Borne Diseases, Centers for Disease Control and Prevention, 3150 Rampart Rd, Fort Collins, CO 80521, USA
    J Med Entomol 49:939-41. 2012
    ..The mutation caused a 0.4% false negative error rate during 2011. These data emphasized the importance of confirmational testing and redundancy in surveillance systems relying on highly specific nucleic acid detection platforms...
  2. doi request reprint Replication of the primary dog kidney-53 dengue 2 virus vaccine candidate in Aedes aegypti is modulated by a mutation in the 5' untranslated region and amino acid substitutions in nonstructural proteins 1 and 3
    Aaron C Brault
    Department of Pathology, Microbiology, and Immunology, Center for Vector borne Diseases, School of Veterinary Medicine, University of California, Davis, USA
    Vector Borne Zoonotic Dis 11:683-9. 2011
    ....
  3. pmc Reduced avian virulence and viremia of West Nile virus isolates from Mexico and Texas
    Aaron C Brault
    Division of Vector Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80521, USA
    Am J Trop Med Hyg 85:758-67. 2011
    ..The implications of reduced avian replication of variants from Mexico for restricted WNV transmission in Latin America is discussed...
  4. pmc Envelope and pre-membrane protein structural amino acid mutations mediate diminished avian growth and virulence of a Mexican West Nile virus isolate
    Stanley A Langevin
    Center for Vectorborne Diseases and Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Gen Virol 92:2810-20. 2011
    ....
  5. ncbi request reprint Avian virulence and thermostable replication of the North American strain of West Nile virus
    Richard M Kinney
    Division of Vector Borne Infectious Diseases, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, US Department of Health and Human Services, PO Box 2087, Fort Collins, CO 80522, USA
    J Gen Virol 87:3611-22. 2006
    ..These results indicated that the ability of WNV NY99 to replicate at the high temperatures measured in infected AMCRs could be an important factor leading to the increased avian virulence and emergence of this strain of WNV...
  6. pmc A single positively selected West Nile viral mutation confers increased virogenesis in American crows
    Aaron C Brault
    Center for Vector Borne Diseases and Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Nat Genet 39:1162-6. 2007
    ..These phenotypic and evolutionary results provide compelling evidence for the positive selection of a mutation encoding increased viremia potential and virulence in the AMCR sentinel bird species...
  7. pmc North American West Nile virus genotype isolates demonstrate differential replicative capacities in response to temperature
    Christy C Andrade
    Center for Vector Borne Diseases and Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA, USA
    J Gen Virol 92:2523-33. 2011
    ..These data indicate that the NS1 and NS4A mutations identified in some WN02 isolates could reduce thermal stability and impede replication of virus at temperatures observed in febrile avian hosts...
  8. ncbi request reprint West Nile virus detection in nonvascular feathers from avian carcasses
    Nicole M Nemeth
    Division of Vector Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA
    J Vet Diagn Invest 21:616-22. 2009
    ....
  9. ncbi request reprint Limited interdecadal variation in mosquito (Diptera: Culicidae) and avian host competence for Western equine encephalomyelitis virus (Togaviridae: Alphavirus)
    William K Reisen
    Arbovirus Research Unit, Center for Vectorborne Diseases, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Am J Trop Med Hyg 78:681-6. 2008
    ..tarsalis. Although temporal and spatial genetic changes have been documented, these seem to present limited phenotypic change in host competence and cannot explain the absence of equine and human cases...
  10. pmc Structural gene (prME) chimeras of St Louis encephalitis virus and West Nile virus exhibit altered in vitro cytopathic and growth phenotypes
    Payal D Maharaj
    Division of Vector Borne Diseases, Centers for Disease Control and Prevention CDC, Fort Collins, CO 80521, USA
    J Gen Virol 93:39-49. 2012
    ..These data provide genetic insight into divergent enzootic maintenance strategies that could also be useful for the assessment of emergence mechanisms of closely related flaviviruses...
  11. ncbi request reprint Variation in virulence of West Nile virus strains for house sparrows (Passer domesticus)
    Stanley A Langevin
    Center for Vector borne Diseases, Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis 95616, USA
    Am J Trop Med Hyg 72:99-102. 2005
    ..This study suggests that natural mortality in house sparrows due to Old World strains of WNV may be occurring where the KEN strain occurs...
  12. pmc Stone Lakes virus (family Togaviridae, genus Alphavirus), a variant of Fort Morgan virus isolated from swallow bugs (Hemiptera: Cimicidae) west of the Continental Divide
    Aaron C Brault
    Center for Vector borne Diseases, Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Old Davis Road, Davis, CA 95616, USA
    J Med Entomol 46:1203-9. 2009
    ....
  13. pmc Rapid West Nile virus antigen detection
    Nicholas A Panella
    Arbovirus Diseases Branch, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Emerg Infect Dis 11:1633-5. 2005
    ..The VecTest detected WNV more frequently than the plaque assay and was comparable to a TaqMan reverse transcription-polymerase chain reaction...
  14. pmc Detection of persistent west nile virus RNA in experimentally and naturally infected avian hosts
    Sarah S Wheeler
    Center for Vectorborne Diseases, Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, California, USA
    Am J Trop Med Hyg 87:559-64. 2012
    ....
  15. pmc Virulence variation among isolates of western equine encephalitis virus in an outbred mouse model
    Christopher H Logue
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA
    J Gen Virol 90:1848-58. 2009
    ....
  16. ncbi request reprint Comparative thermostability of West Nile, St. Louis encephalitis, and western equine encephalomyelitis viruses during heat inactivation for serologic diagnostics
    Ying Fang
    Center for Vectorborne Diseases and Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Am J Trop Med Hyg 80:862-3. 2009
    ..Occasional presence of live virus within sera could lead to false negatives using standard plaque reduction neutralization test protocols...
  17. ncbi request reprint Avian hosts for West Nile virus in St. Tammany Parish, Louisiana, 2002
    Nicholas Komar
    Division of Vector Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Am J Trop Med Hyg 73:1031-7. 2005
    ..The blue jay population was reduced by an estimated 47%. A variety of passerine bird species combined to play an important role as amplifying hosts in the WNV transmission cycle...
  18. ncbi request reprint Overwintering of West Nile virus in Southern California
    William K Reisen
    Department of Pathology, Microbiology and Immunology, Center for Vectorborne Diseases, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    J Med Entomol 43:344-55. 2006
    ..Continued transmission andvertical transmission by Culex p. quinquefasciatus Say seem likely candidates for further study...
  19. doi request reprint West Nile virus: review of the literature
    Lyle R Petersen
    Division of Vector Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, US Public Health Service, Department of Health and Human Services, Fort Collins, Colorado 80521, USA
    JAMA 310:308-15. 2013
    ..Since its introduction in North America in 1999, West Nile virus has produced the 3 largest arboviral neuroinvasive disease outbreaks ever recorded in the United States...
  20. pmc Changing patterns of West Nile virus transmission: altered vector competence and host susceptibility
    Aaron C Brault
    Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Vet Res 40:43. 2009
    ....
  21. ncbi request reprint Venezuelan equine encephalitis virus in the guinea pig model: evidence for epizootic virulence determinants outside the E2 envelope glycoprotein gene
    Ivorlyne P Greene
    Center for Biodefense and Emerging Infectious Diseases, Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555 0609, USA
    Am J Trop Med Hyg 72:330-8. 2005
    ..However, early replication in lymphoid tissues appeared to be primarily envelope dependent...
  22. pmc Comparative pathogenesis of epidemic and enzootic Chikungunya viruses in a pregnant Rhesus macaque model
    Ching I Chen
    Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, California 95616, USA
    Am J Trop Med Hyg 83:1249-58. 2010
    ..Our study establishes a non-human primate model for evaluating vaccines and antiviral therapies and indicates that Rhesus macaques could serve as a competent enzootic reservoir...
  23. ncbi request reprint Phylogenetic analysis of North American West Nile virus isolates, 2001-2004: evidence for the emergence of a dominant genotype
    C Todd Davis
    Department of Pathology, Center for Biodefense and Emerging Infectious Diseases, and Sealy Center for Vaccine Development, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77550 0609, USA
    Virology 342:252-65. 2005
    ..The implications of these findings are discussed as they relate to transmission and spread of the virus in the Western Hemisphere...
  24. ncbi request reprint Acute encephalitis, polyarthritis, and myocarditis associated with West Nile virus infection in a dog
    Allison B Cannon
    Department of Medicine and Epidemiology, University of California, Davis 95616, USA
    J Vet Intern Med 20:1219-23. 2006
  25. ncbi request reprint West Nile virus infection in a green-winged macaw (Ara chloropterus)
    Jonathan Stockman
    William R Pritchard Veterinary Medical Teaching Hospital VMTH, School of Veterinary Medicine, University of California, Davis, Davis 95616, USA
    Avian Dis 54:164-9. 2010
    ..WNV was successfully isolated from brain, pancreas, spleen, and liver. To our knowledge, this is the first report characterizing WNV disease in a green-winged macaw and one of few reports of this disease in a psittacine bird...
  26. ncbi request reprint Genetic relationships among Mayaro and Una viruses suggest distinct patterns of transmission
    Ann M Powers
    Centers for Disease Control and Prevention, Division of Vector Borne Infectious Diseases, Fort Collins, Colorado 80522, USA
    Am J Trop Med Hyg 75:461-9. 2006
    ..These analyses provide possible explanations for the natural ecology and transmission of MAYV and UNAV...
  27. pmc Differential virulence of West Nile strains for American crows
    Aaron C Brault
    Centers for Disease Control and Prevention, Fort Collins, Colorado, USA
    Emerg Infect Dis 10:2161-8. 2004
    ..These results suggest that genetic alterations in NY99 WNV are responsible for the crow-virulent phenotype and that increased replication of this strain in crows could spread WNV in North America...
  28. pmc Seroprevalence of Powassan virus in New England deer, 1979-2010
    Robert A Nofchissey
    University of New Mexico School of Medicine, Albuquerque, NM, USA
    Am J Trop Med Hyg 88:1159-62. 2013
    ..Evidence of exposure was detected in all three states. Overall our results demonstrate that seroprevalence is variable in time and space, suggesting that risk of exposure to Powassan virus is similarly variable...
  29. doi request reprint The contribution of rodent models to the pathological assessment of flaviviral infections of the central nervous system
    David C Clark
    Center for Vectorborne Diseases and Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis 95616, USA
    Arch Virol 157:1423-40. 2012
    ..In this review, we discuss the current understanding of flavivirus neuroinvasive disease and outline the host, viral and experimental factors that influence the outcome and reliability of virus infection of small-animal models...
  30. pmc Recombinant Rift Valley fever vaccines induce protective levels of antibody in baboons and resistance to lethal challenge in mice
    James F Papin
    International Laboratory of Molecular Biology for Tropical Disease Agents, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 108:14926-31. 2011
    ..Furthermore, both vaccines induced protective levels of antibody titers in vaccinated mice and baboons. Mice were protected from lethal RVFV challenge. Thus, we have developed two safe and efficacious recombinant vaccines for RVF...
  31. ncbi request reprint West Nile virus in North America: perspectives on epidemiology and intervention
    William Reisen
    Center for Vector Borne Diseases and Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Pest Manag Sci 63:641-6. 2007
    ..Intervention has included mass vaccination of equines, and proactive and reactive mosquito control. Proactive mosquito control in areas with established infrastructure has been successful in reducing case incidence...
  32. pmc Genetic and phenotypic characterization of manufacturing seeds for a tetravalent dengue vaccine (DENVax)
    Claire Y H Huang
    Arboviral Diseases Branch, Division of Vector Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado, USA
    PLoS Negl Trop Dis 7:e2243. 2013
    ..These viruses, containing the pre-membrane (prM) and envelope (E) genes of dengue serotypes 1-4 in the replicative background of the attenuated dengue-2 PDK-53 vaccine virus candidate, were manufactured under cGMP...