Anne E Boyer

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. ncbi request reprint The use of Endopep-MS for the detection of botulinum toxins A, B, E, and F in serum and stool samples
    Suzanne R Kalb
    Centers for Disease Control and Prevention, National Center for Environmental Health Agency for Toxic Substances and Disease Registry, Atlanta, GA 30341, USA
    Anal Biochem 351:84-92. 2006
  2. pmc Lethal factor toxemia and anti-protective antigen antibody activity in naturally acquired cutaneous anthrax
    Anne E Boyer
    Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Infect Dis 204:1321-7. 2011
  3. ncbi request reprint From the mouse to the mass spectrometer: detection and differentiation of the endoproteinase activities of botulinum neurotoxins A-G by mass spectrometry
    Anne E Boyer
    National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Atlanta, Georgia 30341 3724, USA
    Anal Chem 77:3916-24. 2005
  4. pmc Botulinum neurotoxin detection and differentiation by mass spectrometry
    John R Barr
    Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Emerg Infect Dis 11:1578-83. 2005
  5. ncbi request reprint Comparison of MALDI-TOF-MS and HPLC-ESI-MS/MS for endopeptidase activity-based quantification of Anthrax lethal factor in serum
    Zsuzsanna Kuklenyik
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, United States
    Anal Chem 83:1760-5. 2011
  6. ncbi request reprint A rapid, sensitive method for the quantitation of specific metabolites of sulfur mustard in human urine using isotope-dilution gas chromatography-tandem mass spectrometry
    Carrie L Young
    Centers for Disease Control and Prevention, National Center for Environmental Health, 4770 Buford Highway NE, Mailstop F 47, Atlanta, Georgia 30341, USA
    J Anal Toxicol 28:339-45. 2004
  7. pmc Kinetics of lethal factor and poly-D-glutamic acid antigenemia during inhalation anthrax in rhesus macaques
    Anne E Boyer
    Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Infect Immun 77:3432-41. 2009
  8. pmc Antibody responses to a spore carbohydrate antigen as a marker of nonfatal inhalation anthrax in rhesus macaques
    Elke Saile
    Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Division of Bacterial Diseases, Atlanta, Georgia 30333, USA
    Clin Vaccine Immunol 18:743-8. 2011
  9. ncbi request reprint Detection and quantification of anthrax lethal factor in serum by mass spectrometry
    Anne E Boyer
    Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, 4770 Buford Highway, NE, Atlanta, Georgia 30341, USA
    Anal Chem 79:8463-70. 2007
  10. doi request reprint Quantitative mass spectrometry for bacterial protein toxins--a sensitive, specific, high-throughput tool for detection and diagnosis
    Anne E Boyer
    Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Atlanta, GA 30341, USA
    Molecules 16:2391-413. 2011

Detail Information

Publications12

  1. ncbi request reprint The use of Endopep-MS for the detection of botulinum toxins A, B, E, and F in serum and stool samples
    Suzanne R Kalb
    Centers for Disease Control and Prevention, National Center for Environmental Health Agency for Toxic Substances and Disease Registry, Atlanta, GA 30341, USA
    Anal Biochem 351:84-92. 2006
    ..The limits of detection in spiked stool extracts are somewhat higher due to the high-protease environment of stool extract that also requires use of protease inhibitors. The entire method can be performed in as short a time as 4 h...
  2. pmc Lethal factor toxemia and anti-protective antigen antibody activity in naturally acquired cutaneous anthrax
    Anne E Boyer
    Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Infect Dis 204:1321-7. 2011
    ..This is the first report of quantitative analysis of serum LF in cutaneous anthrax and the first to associate acute stage toxemia with subsequent antitoxin antibody responses...
  3. ncbi request reprint From the mouse to the mass spectrometer: detection and differentiation of the endoproteinase activities of botulinum neurotoxins A-G by mass spectrometry
    Anne E Boyer
    National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Atlanta, Georgia 30341 3724, USA
    Anal Chem 77:3916-24. 2005
    ..039 to 0.625 mouse LD(50)/mL for toxin types A, B, E, and F in a buffer system. The Endopep-MS assay is the first to differentiate all seven BoNT types, is sensitive, specific, and has the potential to quantify toxin activity...
  4. pmc Botulinum neurotoxin detection and differentiation by mass spectrometry
    John R Barr
    Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Emerg Infect Dis 11:1578-83. 2005
    ..62 MLD50/mL. A high-performance liquid chromatography-tandem mass spectrometry method for quantifying active toxin, where the amount of toxin can be correlated to the amount of product peptides, is also described...
  5. ncbi request reprint Comparison of MALDI-TOF-MS and HPLC-ESI-MS/MS for endopeptidase activity-based quantification of Anthrax lethal factor in serum
    Zsuzsanna Kuklenyik
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, United States
    Anal Chem 83:1760-5. 2011
    ..99 (r(2) = 0.997) and -0.25% mean relative difference (±9% standard deviation). This study shows that isotope dilution MALDI-TOF-MS is a robust and precise quantitative MS platform...
  6. ncbi request reprint A rapid, sensitive method for the quantitation of specific metabolites of sulfur mustard in human urine using isotope-dilution gas chromatography-tandem mass spectrometry
    Carrie L Young
    Centers for Disease Control and Prevention, National Center for Environmental Health, 4770 Buford Highway NE, Mailstop F 47, Atlanta, Georgia 30341, USA
    J Anal Toxicol 28:339-45. 2004
    ..Relative standard deviations were less than 8.6% at 1 ng/mL and 3.6% at 20 ng/mL. The limit of detection for SBMTE was 0.038 ng/mL in 0.5 mL of urine...
  7. pmc Kinetics of lethal factor and poly-D-glutamic acid antigenemia during inhalation anthrax in rhesus macaques
    Anne E Boyer
    Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Infect Immun 77:3432-41. 2009
    ..This study emphasizes the value of LF detection as a tool for early diagnosis of inhalation anthrax before the onset of fulminant systemic infection...
  8. pmc Antibody responses to a spore carbohydrate antigen as a marker of nonfatal inhalation anthrax in rhesus macaques
    Elke Saile
    Centers for Disease Control and Prevention, National Center for Immunization and Respiratory Diseases, Division of Bacterial Diseases, Atlanta, Georgia 30333, USA
    Clin Vaccine Immunol 18:743-8. 2011
    ..These data suggest that anti-ATS antibody responses may be used to identify aerosol exposure to B. anthracis spores. The anti-ATS antibody responses were detectable during administration of ciprofloxacin...
  9. ncbi request reprint Detection and quantification of anthrax lethal factor in serum by mass spectrometry
    Anne E Boyer
    Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, 4770 Buford Highway, NE, Atlanta, Georgia 30341, USA
    Anal Chem 79:8463-70. 2007
    ..This method represents a highly specific and rapid diagnostic tool for early anthrax and has a potential additional role as a research tool for understanding toxemia and effects of medical countermeasures for anthrax...
  10. doi request reprint Quantitative mass spectrometry for bacterial protein toxins--a sensitive, specific, high-throughput tool for detection and diagnosis
    Anne E Boyer
    Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Atlanta, GA 30341, USA
    Molecules 16:2391-413. 2011
    ..We also describe potential applications to diseases of high public health impact, including Clostridium difficile glucosylating toxins and the Bordetella pertussis adenylyl cyclase...
  11. ncbi request reprint Survey of albumin purification methods for the analysis of albumin-organic toxicant adducts by liquid chromatography-electrospray ionization-tandem mass spectrometry
    Carrie L Young
    National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, MS F47 Atlanta, GA 30341, USA
    Proteomics 5:4973-9. 2005
    ....
  12. ncbi request reprint Quantitation of the sulfur mustard metabolites 1,1'-sulfonylbis[2-(methylthio)ethane] and thiodiglycol in urine using isotope-dilution Gas chromatography-tandem mass spectrometry
    Anne E Boyer
    Centers for Disease Control and Prevention, National Center for Environmental Health, Atlanta, Georgia 30341, USA
    J Anal Toxicol 28:327-32. 2004
    ..The geometric mean concentration of TDG was 3.43 ng/mL, with concentrations ranging from < 0.5 ng/mL to 20 ng/mL...