Jessica A Belser

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. pmc Ocular tropism of respiratory viruses
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Microbiol Mol Biol Rev 77:144-56. 2013
  2. pmc Pathogenesis of pandemic influenza A (H1N1) and triple-reassortant swine influenza A (H1) viruses in mice
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 84:4194-203. 2010
  3. doi request reprint Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Nature 501:556-9. 2013
  4. pmc Pathogenesis and transmission of swine origin A(H3N2)v influenza viruses in ferrets
    Melissa B Pearce
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 109:3944-9. 2012
  5. pmc Seasonal trivalent inactivated influenza vaccine protects against 1918 Spanish influenza virus infection in ferrets
    Melissa B Pearce
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 86:7118-25. 2012
  6. doi request reprint Local innate immune responses and influenza virus transmission and virulence in ferrets
    Taronna R Maines
    Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 205:474-85. 2012
  7. doi request reprint Kinetics of viral replication and induction of host responses in ferrets differs between ocular and intranasal routes of inoculation
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 438:56-60. 2013
  8. pmc Human pulmonary microvascular endothelial cells support productive replication of highly pathogenic avian influenza viruses: possible involvement in the pathogenesis of human H5N1 virus infection
    Hui Zeng
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 86:667-78. 2012
  9. doi request reprint Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 viruses
    Taronna R Maines
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G16, Atlanta, GA 30333, USA
    Virology 413:139-47. 2011
  10. pmc Pathogenesis and transmission of triple-reassortant swine H1N1 influenza viruses isolated before the 2009 H1N1 pandemic
    Jessica A Belser
    Influenza Division, Infectious Disease Pathology Branch, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 85:1563-72. 2011

Collaborators

Detail Information

Publications41

  1. pmc Ocular tropism of respiratory viruses
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Microbiol Mol Biol Rev 77:144-56. 2013
    ..Identification of shared receptor-binding preferences, host responses, and laboratory modeling protocols among these viruses provides a needed bridge between clinical and laboratory studies of virus tropism...
  2. pmc Pathogenesis of pandemic influenza A (H1N1) and triple-reassortant swine influenza A (H1) viruses in mice
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 84:4194-203. 2010
    ..Taken together, these studies demonstrate that the 2009 H1N1 viruses exhibited mild to moderate virulence in mice compared with highly pathogenic viruses...
  3. doi request reprint Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Nature 501:556-9. 2013
    ..Our results indicate that H7N9 viruses have the capacity for efficient replication in mammals and human airway cells and highlight the need for continued public health surveillance of this emerging virus. ..
  4. pmc Pathogenesis and transmission of swine origin A(H3N2)v influenza viruses in ferrets
    Melissa B Pearce
    Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 109:3944-9. 2012
    ..These findings suggest that A(H3N2)v viruses have the capacity for efficient replication and transmission in mammals and underscore the need for continued public health surveillance...
  5. pmc Seasonal trivalent inactivated influenza vaccine protects against 1918 Spanish influenza virus infection in ferrets
    Melissa B Pearce
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 86:7118-25. 2012
    ..These findings suggest that exposure to A(H1N1)pdm09 through immunization may provide protection against the reconstructed 1918 virus which, as a select agent, is considered to pose both biosafety and biosecurity threats...
  6. doi request reprint Local innate immune responses and influenza virus transmission and virulence in ferrets
    Taronna R Maines
    Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 205:474-85. 2012
    ..Our findings point to a link between localized innate immunity and influenza virus transmission and disease progression...
  7. doi request reprint Kinetics of viral replication and induction of host responses in ferrets differs between ocular and intranasal routes of inoculation
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 438:56-60. 2013
    ..These findings provide a greater understanding of the modulation of host responses following different inoculation routes and underscore the risk associated with ocular exposure to influenza viruses...
  8. pmc Human pulmonary microvascular endothelial cells support productive replication of highly pathogenic avian influenza viruses: possible involvement in the pathogenesis of human H5N1 virus infection
    Hui Zeng
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 86:667-78. 2012
    ..Our results highlight remarkable tropism and infectivity of the H5N1 viruses for human pulmonary endothelial cells, resulting in the potent induction of host inflammatory responses...
  9. doi request reprint Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 viruses
    Taronna R Maines
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, MS G16, Atlanta, GA 30333, USA
    Virology 413:139-47. 2011
    ....
  10. pmc Pathogenesis and transmission of triple-reassortant swine H1N1 influenza viruses isolated before the 2009 H1N1 pandemic
    Jessica A Belser
    Influenza Division, Infectious Disease Pathology Branch, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 85:1563-72. 2011
    ....
  11. pmc Tropism and infectivity of influenza virus, including highly pathogenic avian H5N1 virus, in ferret tracheal differentiated primary epithelial cell cultures
    Hui Zeng
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 87:2597-607. 2013
    ..This ferret tracheal differentiated primary epithelial cell culture system provides a valuable in vitro model for studying cellular tropism, infectivity, and the pathogenesis of influenza viruses...
  12. doi request reprint Multiple genes contribute to the virulent phenotype observed in ferrets of an H5N1 influenza virus isolated from Thailand in 2004
    Taronna R Maines
    Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Virology 413:226-30. 2011
    ..Our results demonstrate that H5N1 virus virulence determinants are polygenic and that there is an important correlation between polymerase adaptation, efficient replication in the host, and virulence...
  13. pmc Pathogenesis of 1918 pandemic and H5N1 influenza virus infections in a guinea pig model: antiviral potential of exogenous alpha interferon to reduce virus shedding
    Neal Van Hoeven
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 83:2851-61. 2009
    ....
  14. pmc Influenza virus respiratory infection and transmission following ocular inoculation in ferrets
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Pathog 8:e1002569. 2012
    ....
  15. pmc Influenza virus aerosol exposure and analytical system for ferrets
    Kortney M Gustin
    Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 108:8432-7. 2011
    ..These methods will provide improved risk assessment of emerging influenza viruses that pose a threat to public health...
  16. pmc Pathogenesis, transmissibility, and ocular tropism of a highly pathogenic avian influenza A (H7N3) virus associated with human conjunctivitis
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 87:5746-54. 2013
    ....
  17. doi request reprint Comparative immunogenicity and cross-clade protective efficacy of mammalian cell-grown inactivated and live attenuated H5N1 reassortant vaccines in ferrets
    Kortney M Gustin
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 204:1491-9. 2011
    ..Thus, enhanced respiratory tract antibody responses elicited by LAIV were associated with improved cross-clade protection...
  18. pmc Ocular tropism of influenza A viruses: identification of H7 subtype-specific host responses in human respiratory and ocular cells
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    J Virol 85:10117-25. 2011
    ....
  19. pmc Early control of H5N1 influenza virus replication by the type I interferon response in mice
    Kristy J Szretter
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 303331, USA
    J Virol 83:5825-34. 2009
    ..These results suggest a role for the IFN-alpha/beta response in the control of H5N1 virus replication both in vivo and in vitro, and as such it may provide some degree of protection to the host in the early stages of infection...
  20. pmc Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air
    Neal Van Hoeven
    Influenza Division, Mailstop G 16, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road Northeast, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 106:3366-71. 2009
    ..These findings demonstrate that the adaptation of the HA and PB2 proteins are critical for the development of pandemic influenza strains from avian influenza viruses...
  21. doi request reprint Simvastatin and oseltamivir combination therapy does not improve the effectiveness of oseltamivir alone following highly pathogenic avian H5N1 influenza virus infection in mice
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, United States
    Virology 439:42-6. 2013
    ..Modest reductions in lung cytokine production in H5N1 but not H1N1 virus-infected simvastatin-treated mice indicate a potential benefit for statin use in mitigating disease following severe virus infection...
  22. doi request reprint Use of animal models to understand the pandemic potential of highly pathogenic avian influenza viruses
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Adv Virus Res 73:55-97. 2009
    ..As avian influenza viruses continue to cause human disease and death, animal pathogenesis studies identify avenues of investigation for novel preventative and therapeutic agents that could be effective in the event of a future pandemic...
  23. pmc Transmission and pathogenesis of swine-origin 2009 A(H1N1) influenza viruses in ferrets and mice
    Taronna R Maines
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Science 325:484-7. 2009
    ....
  24. pmc Ocular infection of mice with influenza A (H7) viruses: a site of primary replication and spread to the respiratory tract
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Virol 83:7075-84. 2009
    ..These findings demonstrate that avian influenza viruses within H7 and H5 subtypes are capable of using the eye as a portal of entry...
  25. doi request reprint Inducible nitric oxide contributes to viral pathogenesis following highly pathogenic influenza virus infection in mice
    Lucy A Perrone
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 207:1576-84. 2013
    ..This study demonstrates that NO contributes to the pathogenic outcome of H5N1 and 1918 viral infections in the mouse model...
  26. pmc Effect of D222G mutation in the hemagglutinin protein on receptor binding, pathogenesis and transmissibility of the 2009 pandemic H1N1 influenza virus
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 6:e25091. 2011
    ..These findings suggest that although the D222G mutation does not influence virus transmission, it may be considered a molecular marker for enhanced replication in certain cell types...
  27. pmc Oseltamivir inhibits H7 influenza virus replication in mice inoculated by the ocular route
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Antimicrob Agents Chemother 56:1616-8. 2012
    ..We demonstrate that H7 viruses possess sensitivity to neuraminidase inhibitors and that administration of oseltamivir before ocular virus challenge in mice inhibits H7N7 and H7N3 virus replication in ocular and respiratory tissues...
  28. doi request reprint Pathogenesis of emerging avian influenza viruses in mammals and the host innate immune response
    Taronna R Maines
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Immunol Rev 225:68-84. 2008
    ..This review focuses on avian influenza viruses as a pandemic threat, their induction of host innate immune responses in mammalian species, and the contribution of these responses to the disease process...
  29. doi request reprint Efficacy of seasonal live attenuated influenza vaccine against virus replication and transmission of a pandemic 2009 H1N1 virus in ferrets
    Melissa B Pearce
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, United States
    Vaccine 29:2887-94. 2011
    ..The results demonstrate that prior immunization with seasonal LAIV or H1N1 virus infection provides some cross-protection against the 2009 H1N1 virus, but had no significant effect on the transmission efficiency of the 2009 H1N1 virus...
  30. pmc Infection with highly pathogenic H7 influenza viruses results in an attenuated proinflammatory cytokine and chemokine response early after infection
    Jessica A Belser
    Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30033, USA
    J Infect Dis 203:40-8. 2011
    ..These studies revealed that H7 viruses vary greatly in their ability to activate host innate responses and may contribute to the virulence of these viruses observed in humans...
  31. doi request reprint Considerations regarding appropriate sample size for conducting ferret transmission experiments
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Future Microbiol 8:961-5. 2013
    ..A closer examination of previously published studies utilizing this model as it is currently employed reveals that the 'sample size' of these studies is not always as small as it may appear. ..
  32. pmc The ferret as a model organism to study influenza A virus infection
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Dis Model Mech 4:575-9. 2011
    ..We highlight the recent and emerging uses of this species in influenza virus research that are advancing our understanding of virus-host interactions...
  33. ncbi request reprint Innovations in modeling influenza virus infections in the laboratory
    Kortney M Gustin
    Influenza Division, National Center for Immunization and Respiratory Disease, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Trends Microbiol 20:275-81. 2012
    ..Here, we briefly review the model systems used to study influenza virus infections, and focus particularly on recent advances that have increased our knowledge of these formidable respiratory pathogens...
  34. ncbi request reprint Influenza Virus Infectivity and Virulence following Ocular-Only Aerosol Inoculation of Ferrets
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Virol 88:9647-54. 2014
    ....
  35. ncbi request reprint H5N1 pathogenesis studies in mammalian models
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, United States
    Virus Res 178:168-85. 2013
    ..This research contributes not only to our understanding of influenza virus pathogenesis, but also identifies novel preventative and therapeutic targets to mitigate the disease burden caused by avian influenza viruses. ..
  36. doi request reprint Cationic liposome-DNA complexes (CLDC) adjuvant enhances the immunogenicity and cross-protective efficacy of a pre-pandemic influenza A H5N1 vaccine in mice
    Libo Dong
    Centers for Disease Control and Prevention, Atlanta, GA, USA
    Vaccine 30:254-64. 2012
    ..Thus, JVRS-100 adjuvanted H5N1 vaccine elicited enhanced humoral and T-cell responses, dose-sparing, and cross-clade protection in mice. CLDC holds promise as an adjuvant for human pre-pandemic inactivated H5N1 vaccines...
  37. doi request reprint Influenza A virus transmission: contributing factors and clinical implications
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Expert Rev Mol Med 12:e39. 2010
    ..A better understanding of the viral determinants necessary for efficient transmission will allow us to identify avian influenza viruses with pandemic potential...
  38. doi request reprint Resurrected pandemic influenza viruses
    Terrence M Tumpey
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Annu Rev Microbiol 63:79-98. 2009
    ....
  39. pmc Contemporary North American influenza H7 viruses possess human receptor specificity: Implications for virus transmissibility
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Proc Natl Acad Sci U S A 105:7558-63. 2008
    ..These results indicate that H7 influenza viruses from the North American lineage have acquired sialic acid-binding properties that more closely resemble those of human influenza viruses and have the potential to spread to naïve animals...
  40. pmc Pathogenesis of avian influenza (H7) virus infection in mice and ferrets: enhanced virulence of Eurasian H7N7 viruses isolated from humans
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, MS G 16, 1600 Clifton Rd NE, Atlanta, GA 30333, USA
    J Virol 81:11139-47. 2007
    ..Therefore, in general, the relative virulence and cell tropism of the H7 viruses in these animal models correlated with the observed virulence in humans...
  41. doi request reprint XIth International Symposium on Respiratory Viral Infections
    Jessica A Belser
    Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, USA International Activities, Wellcome Trust, London, UK
    Influenza Other Respi Viruses 5:443-e457. 2011
    ..Please cite this paper as: Belser et al. (2011) XIth International Symposium on Respiratory Viral Infections. Influenza and Other Respiratory Viruses 5(6), 443-e457...