Bernard Beall

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. pmc Non-pneumococcal mitis-group streptococci confound detection of pneumococcal capsular serotype-specific loci in upper respiratory tract
    Maria Da Gloria Carvalho
    National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, USA
    Peerj 1:e97. 2013
  2. pmc High rate of pneumococcal bacteremia in a prospective cohort of older children and adults in an area of high HIV prevalence in rural western Kenya
    Daniel R Feikin
    International Emerging Infections Program, Centers for Disease Control and Prevention, Mbagathi Road, off Mbagathi Way, Nairobi, Kenya
    BMC Infect Dis 10:186. 2010
  3. pmc Shifting genetic structure of invasive serotype 19A pneumococci in the United States
    Bernard W Beall
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 203:1360-8. 2011
  4. pmc Pre- and postvaccination clonal compositions of invasive pneumococcal serotypes for isolates collected in the United States in 1999, 2001, and 2002
    Bernard Beall
    Repsiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Mailstop C02, Atlanta, Georgia 30333, USA
    J Clin Microbiol 44:999-1017. 2006
  5. ncbi request reprint Emergence of a novel penicillin-nonsusceptible, invasive serotype 35B clone of Streptococcus pneumoniae within the United States
    Bernard Beall
    Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 186:118-22. 2002
  6. doi request reprint Population snapshot of emergent Streptococcus pneumoniae serotype 19A in the United States, 2005
    Matthew R Moore
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    J Infect Dis 197:1016-27. 2008
  7. pmc Clonal distribution of invasive pneumococcal isolates from children and selected adults in the United States prior to 7-valent conjugate vaccine introduction
    Robert E Gertz
    Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 41:4194-216. 2003
  8. ncbi request reprint Postvaccine genetic structure of Streptococcus pneumoniae serotype 19A from children in the United States
    Rekha Pai
    Division of Bacterial and Mycotic Diseases, Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 192:1988-95. 2005
  9. pmc Invasive group A streptococcal infection in older adults in long-term care facilities and the community, United States, 1998-2003
    Michael C Thigpen
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 13:1852-9. 2007
  10. doi request reprint Prevention of antibiotic-nonsusceptible Streptococcus pneumoniae with conjugate vaccines
    Lee M Hampton
    Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, USA
    J Infect Dis 205:401-11. 2012

Detail Information

Publications78

  1. pmc Non-pneumococcal mitis-group streptococci confound detection of pneumococcal capsular serotype-specific loci in upper respiratory tract
    Maria Da Gloria Carvalho
    National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, USA
    Peerj 1:e97. 2013
    ..Our findings indicate that non-pneumococcal species can confound serotype-specific PCR and other sequence-based assays due to evolutionarily conserved genes most likely involved in biosynthesis of surface polysaccharide structures. ..
  2. pmc High rate of pneumococcal bacteremia in a prospective cohort of older children and adults in an area of high HIV prevalence in rural western Kenya
    Daniel R Feikin
    International Emerging Infections Program, Centers for Disease Control and Prevention, Mbagathi Road, off Mbagathi Way, Nairobi, Kenya
    BMC Infect Dis 10:186. 2010
    ..We evaluated pneumococcal bacteremia among 21,000 persons > or =5 years old in a prospective cohort as part of population-based infectious disease surveillance in rural western Kenya from October 2006-September 2008...
  3. pmc Shifting genetic structure of invasive serotype 19A pneumococci in the United States
    Bernard W Beall
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 203:1360-8. 2011
    ..7% to 43.7%). To better understand changes, we characterized sero19A isolates recovered during 2004-2008...
  4. pmc Pre- and postvaccination clonal compositions of invasive pneumococcal serotypes for isolates collected in the United States in 1999, 2001, and 2002
    Bernard Beall
    Repsiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Rd, NE, Mailstop C02, Atlanta, Georgia 30333, USA
    J Clin Microbiol 44:999-1017. 2006
    ..Continued genotypic surveillance is warranted, since certain clones not targeted by PCV7 are expanding, and their emergence as significant pathogens could occur with maintained vaccine pressure...
  5. ncbi request reprint Emergence of a novel penicillin-nonsusceptible, invasive serotype 35B clone of Streptococcus pneumoniae within the United States
    Bernard Beall
    Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 186:118-22. 2002
    ..The mosaic pbp2b and divergent ddl sequences were suggestive of interspecies recombination at the ddl-pbp2b chromosomal region...
  6. doi request reprint Population snapshot of emergent Streptococcus pneumoniae serotype 19A in the United States, 2005
    Matthew R Moore
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    J Infect Dis 197:1016-27. 2008
    ..To understand this increase, we characterized serotype 19A isolates recovered during 2005...
  7. pmc Clonal distribution of invasive pneumococcal isolates from children and selected adults in the United States prior to 7-valent conjugate vaccine introduction
    Robert E Gertz
    Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 41:4194-216. 2003
    ..In this work, we established the basic genetic structure within individual serotypes prior to PC7V use. The resultant database will be useful for detecting potential selective effects of this vaccine in postvaccine surveillance...
  8. ncbi request reprint Postvaccine genetic structure of Streptococcus pneumoniae serotype 19A from children in the United States
    Rekha Pai
    Division of Bacterial and Mycotic Diseases, Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 192:1988-95. 2005
    ..We estimated the rate of increase of invasive pneumococcal disease (IPD) caused by serotype 19A in children <5 years old and determined the genetic composition of these isolates...
  9. pmc Invasive group A streptococcal infection in older adults in long-term care facilities and the community, United States, 1998-2003
    Michael C Thigpen
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 13:1852-9. 2007
    ..95%, p<0.01). In multivariate logistic regression modeling, LTCF residence remained an independent predictor of death. Additional prevention strategies against GAS infection in this high-risk population are urgently needed...
  10. doi request reprint Prevention of antibiotic-nonsusceptible Streptococcus pneumoniae with conjugate vaccines
    Lee M Hampton
    Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, USA
    J Infect Dis 205:401-11. 2012
    ....
  11. pmc In vitro evaluation of the antimicrobial activity of ceftaroline against cephalosporin-resistant isolates of Streptococcus pneumoniae
    Lesley McGee
    Emory University, Atlanta, Georgia 30322, USA
    Antimicrob Agents Chemother 53:552-6. 2009
    ..pneumoniae strains resistant to existing parenteral cephalosporins and support its continued development for the treatment of infections caused by resistant S. pneumoniae strains...
  12. pmc Levofloxacin-resistant invasive Streptococcus pneumoniae in the United States: evidence for clonal spread and the impact of conjugate pneumococcal vaccine
    Mathias W R Pletz
    Department of International Health, Rollins School of Public Health, Emory University, 1518 Clifton Rd, Atlanta, GA 30322, USA
    Antimicrob Agents Chemother 48:3491-7. 2004
    ..Our results suggest that invasive pneumococcal isolates resistant to levofloxacin in the United States show considerable evidence of multiple resistance and of clonal spread...
  13. ncbi request reprint Incidence of pneumococcal disease due to non-pneumococcal conjugate vaccine (PCV7) serotypes in the United States during the era of widespread PCV7 vaccination, 1998-2004
    Lauri A Hicks
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Infect Dis 196:1346-54. 2007
    ..The benefits may be offset by increases in disease due to serotypes not included in the vaccine (hereafter, "nonvaccine serotypes"). We evaluated the effect of PCV7 on incidence of disease due to nonvaccine serotypes...
  14. pmc Genetically diverse group A streptococci from children in far-western Nepal share high genetic relatedness with isolates from other countries
    Varja Sakota
    Division of Bacterial and Myotic Diseases, Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Clin Microbiol 44:2160-6. 2006
    ..Similarly, since most (40/51) strain types were highly related to strains found elsewhere, it is likely that a major fraction of the existing GAS clonal complexes have been discovered...
  15. ncbi request reprint Novel antibiotic-resistant pneumococcal strains recovered from the upper respiratory tracts of HIV-infected adults and their children in Kisumu, Kenya
    Marie Jo Medina
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Microb Drug Resist 11:9-17. 2005
    ..mlst.net...
  16. pmc Clonal association between Streptococcus pneumoniae serotype 23A, circulating within the United States, and an internationally dispersed clone of serotype 23F
    Rekha Pai
    CDC Respiratory Diseases Branch, Mailstop C02, 1600 Clifton Rd, NE, Atlanta, GA 30333, USA
    J Clin Microbiol 43:5440-4. 2005
    ..The emergence of such new serotype and genotype associations highlights the dynamic nature of the pneumococcal population, necessitating continuous monitoring in the post-vaccine era...
  17. doi request reprint Outbreak of late-onset group B Streptococcus in a neonatal intensive care unit
    Jennifer K MacFarquhar
    Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Am J Infect Control 38:283-8. 2010
    ..In September 2007, the Tennessee Department of Health was notified of a cluster of late-onset group B streptococcal (GBS) infections in a neonatal intensive care unit (NICU). Outbreaks of late-onset GBS are rare...
  18. pmc Emergence of Streptococcus pneumoniae with very-high-level resistance to penicillin
    Stephanie J Schrag
    Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Antimicrob Agents Chemother 48:3016-23. 2004
    ..The emergence, clonality, and association of very-high-level penicillin resistance with multiple drug resistance requires further monitoring and highlights the need for novel agents active against the pneumococcus...
  19. pmc Sequential triplex real-time PCR assay for detecting 21 pneumococcal capsular serotypes that account for a high global disease burden
    Fabiana C Pimenta
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Clin Microbiol 51:647-52. 2013
    ..Advantages over other serotyping assays are described. The assay will be expanded to 40 serotypes/serogroups. We will provide periodic updates at our protocol website...
  20. pmc Interspecies recombination in type II topoisomerase genes is not a major cause of fluoroquinolone resistance in invasive Streptococcus pneumoniae isolates in the United States
    Mathias W R Pletz
    Department of International Health, Rollins School of Public Health, Emory University, 1518 Clifton Rd, Atlanta, GA 30322, USA
    Antimicrob Agents Chemother 49:779-80. 2005
    ..We analyzed the nucleotide sequences of the quinolone resistance-determining regions of 49 invasive levofloxacin-resistant pneumococcal isolates and did not find any evidence for interspecies recombination...
  21. pmc Prevalence of first-step mutants among levofloxacin-susceptible invasive isolates of Streptococcus pneumoniae in the United States
    Mathias W R Pletz
    Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA
    Antimicrob Agents Chemother 50:1561-3. 2006
    ..Among those with a levofloxacin MIC of 2 mg/liter, 16.2% of isolates recovered from nursing home residents and 6.4% from non-nursing home residents had first-step mutations...
  22. doi request reprint Population-based study of invasive disease due to beta-hemolytic streptococci of groups other than A and B
    Laura N Broyles
    Division of Infectious Diseases, Emory University School of Medicine, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30308, USA
    Clin Infect Dis 48:706-12. 2009
    ..We report the incidence of NABS infection and describe the epidemiologic and clinical characteristics...
  23. pmc Using PCR-based detection and genotyping to trace Streptococcus salivarius meningitis outbreak strain to oral flora of radiology physician assistant
    Velusamy Srinivasan
    Respiratory Diseases Branch, Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 7:e32169. 2012
    ..We also demonstrate that the newly characterized strains from this study are distinct from previously characterized S. salivarius strains associated with carriage and meningitis...
  24. ncbi request reprint Array of M protein gene subtypes in 1064 recent invasive group A streptococcus isolates recovered from the active bacterial core surveillance
    Zhongya Li
    Division of Bacterial and Mycotic Diseases, Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Infect Dis 188:1587-92. 2003
    ..htm) currently contains 225 distinct emm types encompassing 450 subtypes. Although this subtyping scheme increases specificity, limited variation within individual types favors introduction of M protein type-specific vaccines...
  25. ncbi request reprint Tightly clustered outbreak of group A streptococcal disease at a long-term care facility
    Kathryn E Arnold
    Georgia Department of Human Resources, Division of Public Health, Epidemiology Branch, Atlanta, GA 30303, USA
    Infect Control Hosp Epidemiol 27:1377-84. 2006
    ..To describe investigation of a tightly clustered outbreak of invasive group A streptococcal (GAS) disease associated with a high mortality rate in a long-term care facility (LTCF)...
  26. ncbi request reprint The epidemiology of invasive group A streptococcal infection and potential vaccine implications: United States, 2000-2004
    Rosalyn E O'Loughlin
    Respiratory Diseases Branch, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Clin Infect Dis 45:853-62. 2007
    ..We report the current epidemiologic characteristics of invasive GAS infections and estimate the potential impact of a multivalent GAS vaccine...
  27. doi request reprint Epidemiology of invasive pneumococcal disease among high-risk adults since the introduction of pneumococcal conjugate vaccine for children
    Riyadh D Muhammad
    Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Clin Infect Dis 56:e59-67. 2013
    ..The relative magnitude of these indirect effects among persons with and without PPV23 indications is unknown...
  28. pmc Streptococcus pneumoniae serotype 15A in psychiatric unit, Rhode Island, USA, 2010-2011
    Katherine Fleming-Dutra
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA kfl
    Emerg Infect Dis 18:1889-93. 2012
    ..The outbreak subsided after implementation of antimicrobial drug prophylaxis and enhanced infection control measures...
  29. pmc An assessment of the screening method to evaluate vaccine effectiveness: the case of 7-valent pneumococcal conjugate vaccine in the United States
    Adam L Cohen
    Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 7:e41785. 2012
    ..The screening method yields estimates of VE that are highly dependent on the time period during which it is used and the choice of outcome. The method should be used cautiously to evaluate VE of PCVs...
  30. ncbi request reprint Nursing home outbreak of invasive group a streptococcal infections caused by 2 distinct strains
    Michael C Thigpen
    Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Atlanta, GA 30333, USA
    Infect Control Hosp Epidemiol 28:68-74. 2007
    ..To identify factors contributing to a cluster of deaths from invasive group A streptococcus (GAS) infection in a nursing home facility and to prevent additional cases...
  31. ncbi request reprint Identification of superantigen genes speM, ssa, and smeZ in invasive strains of beta-hemolytic group C and G streptococci recovered from humans
    Emeka I Igwe
    Centers for Disease Control and Prevention, Respiratory Diseases Branch, 1600 Clifton Rd, Mailstop CO2, 30333, Atlanta, GA, USA
    FEMS Microbiol Lett 229:259-64. 2003
    ..dysgalactiae subsp. equisimilis and S. canis with identical or near-identical sequences to their counterparts in S. pyogenes suggests frequent interspecies gene exchange between the three beta-hemolytic streptococcal species...
  32. pmc Use of pyrosequencing to differentiate Streptococcus pneumoniae serotypes 6A and 6B
    Rekha Pai
    Bacterial and Mycotic Diseases, Respiratory Diseases Branch, Atlanta, GA 30333, USA
    J Clin Microbiol 43:4820-2. 2005
    ..We observed complete concordance between capsular serotyping results and wciP pyrosequencing among 210 isolates examined, indicating that pyrosequencing is a rapid and accurate technique for deducing serotypes 6A and 6B...
  33. pmc Sequential multiplex PCR approach for determining capsular serotypes of Streptococcus pneumoniae isolates
    Rekha Pai
    Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Clin Microbiol 44:124-31. 2006
    ....
  34. pmc Evaluation of three commercial broth media for pigment detection and identification of a group B Streptococcus (Streptococcus agalactiae)
    Maria Da Gloria Carvalho
    Streptococcus Laboratory, Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    J Clin Microbiol 47:4161-3. 2009
    ....
  35. doi request reprint Effect of the 2009 influenza A(H1N1) pandemic on invasive pneumococcal pneumonia
    Katherine E Fleming-Dutra
    Epidemic Intelligence Service, Centers for Disease Control and Prevention CDC, Atlanta, GA 30333, USA
    J Infect Dis 207:1135-43. 2013
    ..Because pneumococcal pneumonia was prevalent during previous influenza pandemics, we evaluated invasive pneumococcal pneumonia (IPP) rates during the 2009 influenza A(H1N1) pandemic...
  36. ncbi request reprint Effectiveness of seven-valent pneumococcal conjugate vaccine against invasive pneumococcal disease: a matched case-control study
    Cynthia G Whitney
    Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Lancet 368:1495-502. 2006
    ..Our aim was to assess the effectiveness of the vaccine against various pneumococcal serotypes, and to measure the effectiveness of the recommended dose schedule and of catch-up and incomplete schedules...
  37. ncbi request reprint Epidemiology of invasive group a streptococcus disease in the United States, 1995-1999
    Katherine L O'Brien
    Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Clin Infect Dis 35:268-76. 2002
    ..We estimate that 9600-9700 cases of invasive GAS disease occur in the United States each year, resulting in 1100-1300 deaths...
  38. ncbi request reprint Cluster of deaths from group A streptococcus in a long-term care facility--Georgia, 2001
    Carolyn M Greene
    Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Infect Control 33:108-13. 2005
    ..Invasive group A streptococcus (GAS) affects approximately 10,500 persons annually; 1 in 5 patients >/=65 years die. In August 2001, CDC investigated a cluster of GAS deaths in a Georgia long-term care facility (LTCF)...
  39. doi request reprint Incidence of pneumococcal bacteremia requiring hospitalization in rural Thailand
    Henry C Baggett
    International Emerging Infections Program, Thailand Ministry of Public Health US Centers for Disease Control and Prevention Collaboration, Sa Kaeo, Thailand
    Clin Infect Dis 48:S65-74. 2009
    ..We estimated the incidence of pneumococcal bacteremia cases requiring hospitalization in rural Thailand...
  40. ncbi request reprint An outbreak of conjunctivitis due to atypical Streptococcus pneumoniae
    Michael Martin
    Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 348:1112-21. 2003
    ..An investigation was begun to determine the extent of the outbreak, confirm the cause, identify modes of transmission, and implement control measures...
  41. ncbi request reprint Invasive group-A streptococcal infection in an allograft recipient. A case report
    Ellen H Lee
    Epidemic Intelligence Service, Career Development Division, Office of Workforce and Career Development, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    J Bone Joint Surg Am 89:2044-7. 2007
  42. ncbi request reprint Extension of the Lancefield classification for group A streptococci by addition of 22 new M protein gene sequence types from clinical isolates: emm103 to emm124
    Richard F Facklam
    Centers for Disease Control and Prevention, World Health Organization WHO Collaborating Center for Streptococci, Atlanta, GA 30333, USA
    Clin Infect Dis 34:28-38. 2002
    ....
  43. ncbi request reprint Population-based surveillance for postpartum invasive group a streptococcus infections, 1995-2000
    Ilin Chuang
    Respiratory Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, 30333, USA
    Clin Infect Dis 35:665-70. 2002
    ..Although postpartum GAS infections are rare, the clustering of infections due to identical strains suggests that some invasive cases may have a common source and, therefore, may be preventable...
  44. ncbi request reprint Toxic shock due to Streptococcus pyogenes in a rhesus monkey (Macaca mulatta)
    Anapatricia Garcia
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
    J Am Assoc Lab Anim Sci 45:79-82. 2006
    ..S. pyogenes was isolated from intracardiac blood, liver, placenta, and fetal tissues. This isolate also had a unique M protein gene...
  45. doi request reprint Pneumococcal Carriage and Invasive Disease in Children Before Introduction of the 13-valent Conjugate Vaccine: Comparison With the Era Before 7-valent Conjugate Vaccine
    Dolly Sharma
    From the Emory University School of Medicine Children s Healthcare of Atlanta Georgia Emerging Infections Program Veteran Affairs Medical Center Respiratory Diseases Branch, Centers for Disease Control and Prevention CDC, Atlanta, GA
    Pediatr Infect Dis J 32:196. 2013
    ..Characteristics of pneumococcal carriage and IPD among children in Atlanta, GA, were compared during 2 time periods: before PCV7 introduction and before 13-valent PCV (PCV13) introduction...
  46. pmc Genotypes of invasive pneumococcal isolates recently recovered from Italian patients
    Giordano Dicuonzo
    Dipartimento di Medicina di Laboratorio e Microbiologia, Università Campus Bio Medico, Via Emilio Longoni 47, 00155 Rome, Italy
    J Clin Microbiol 40:3660-5. 2002
    ..One PSSP isolate was a novel type 24F isolate related to the multiresistant clone France(9V)-3. This work reports new PNSP strains and new serotype-clone associations...
  47. ncbi request reprint Streptolysin S and necrotising infections produced by group G streptococcus
    Deepali Humar
    Department of Medicine, Division of Infectious Diseases, University of California, San Diego 92093, USA
    Lancet 359:124-9. 2002
    ..Due to strong clinical similarities with invasive infections produced by group A streptococcus, we investigated a potential link of shared beta-haemolytic phenotype to disease pathogenesis...
  48. pmc Changes in serotypes and antimicrobial susceptibility of invasive Streptococcus pneumoniae strains in Cleveland: a quarter century of experience
    Michael R Jacobs
    Department of Pathology, University Hospitals Case Medical Center, Case Western Reserve University, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    J Clin Microbiol 46:982-90. 2008
    ..This study documents the emergence of resistance over a quarter century among invasive pneumococci in the Cleveland area, as well as the reduction in disease caused by PCV7 serotypes following the introduction of PCV7 in 2000...
  49. pmc Molecular genetic analysis of a group A Streptococcus operon encoding serum opacity factor and a novel fibronectin-binding protein, SfbX
    Arthur Jeng
    Department of Pediatrics, Division of Pediatric Infectious Diseases, University of California, San Diego 92093, USA
    J Bacteriol 185:1208-17. 2003
    ..The sfbX gene was found to be present only in sof-positive strains, and together these genes could influence the spectrum of tissues colonized by sof-positive GAS...
  50. pmc M protein gene type distribution among group A streptococcal clinical isolates recovered in Mexico City, Mexico, from 1991 to 2000, and Durango, Mexico, from 1998 to 1999: overlap with type distribution within the United States
    Luz Elena Espinosa
    Infectious Diseases, Hospital Infantil de Mexico Federico Gomez, Col Doctores, México D F C P 06720, Mexico
    J Clin Microbiol 41:373-8. 2003
    ....
  51. pmc Invasive group a streptococcal disease in nursing homes, Minnesota, 1995-2006
    Jean Rainbow
    Minnesota Department of Health, St Paul, Minnesota 55164 0975, USA
    Emerg Infect Dis 14:772-7. 2008
    ..Measures to ensure identification of case-patients as residents of specific nursing homes need to be included in standard guidelines for the prevention and control of invasive GAS disease in this setting...
  52. pmc Immunogenicity of a 26-valent group A streptococcal vaccine
    Mary C Hu
    ID Biomedical Corporation, Bothell, Washington, USA
    Infect Immun 70:2171-7. 2002
    ..Our results indicate that type-specific, protective M protein epitopes can be incorporated into complex, multivalent vaccines designed to elicit broadly protective opsonic antibodies in the absence of tissue-cross-reactive antibodies...
  53. ncbi request reprint Multicentre surveillance of the prevalence and molecular epidemiology of macrolide resistance among pharyngeal isolates of group A streptococci in the USA
    Michael D Green
    Department of Pediatrics, Division of Infectious Diseases, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine Pittsburgh, PA, USA
    J Antimicrob Chemother 57:1240-3. 2006
    ..In an effort to define the current prevalence of macrolide-resistant GAS in the US, a multicentre surveillance project was initiated...
  54. ncbi request reprint The heterogeneity of endemic community pediatric group a streptococcal pharyngeal isolates and their relationship to invasive isolates
    Heather A Haukness
    Division of General Medicine, Children s Memorial Hospital, Northwestern University Medical School, Chicago, Illinois 60614, USA
    J Infect Dis 185:915-20. 2002
    ..Pharyngeal isolates were more likely to be speA and speC positive than were the invasive isolates...
  55. pmc Vaccine escape recombinants emerge after pneumococcal vaccination in the United States
    Angela B Brueggemann
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 3:e168. 2007
    ..Vaccine escape by genetic recombination at the capsular locus has the potential to reduce PCV7 effectiveness in the longer term...
  56. pmc Reemergence of macrolide resistance in pharyngeal isolates of group a streptococci in southwestern Pennsylvania
    Michael Green
    Department of Pediatrics, Division of Allergy, Immunology and Infectious Diseases, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Antimicrob Agents Chemother 48:473-6. 2004
    ..Longitudinal surveillance of isolates from multiple centers is needed to define the prevalence of antimicrobial agent-resistant GAS in the United States...
  57. ncbi request reprint Group A streptococci from a remote community have novel multilocus genotypes but share emm types and housekeeping alleles with isolates from worldwide sources
    Karen F McGregor
    Department of Infectious Disease Epidemiology, Imperial College, London, United Kingdom
    J Infect Dis 189:717-23. 2004
    ....
  58. ncbi request reprint Temporal changes in streptococcal M protein types and the near-disappearance of acute rheumatic fever in the United States
    Stanford T Shulman
    Division of Infectious Diseases, Children s Memorial Hospital, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA
    Clin Infect Dis 42:441-7. 2006
    ..It has been proposed that certain M types of group A streptococci (GAS) include strains that are particularly rheumatogenic and that others are nonrheumatogenic...
  59. ncbi request reprint Characterization of group A streptococci (Streptococcus pyogenes): correlation of M-protein and emm-gene type with T-protein agglutination pattern and serum opacity factor
    Dwight R Johnson
    Department of Pediatrics, World Health Organization Collaborating Center for Reference and Research on Streptococci, University of Minnesota, Minneapolis, MN 55455, USA
    J Med Microbiol 55:157-64. 2006
    ..Data from more than 40,000 strains (representing uncomplicated GAS infections, systemic invasive infections and strains associated with non-suppurative sequelae, collected from the US and diverse locations worldwide) were analysed...
  60. pmc Six-month multicenter study on invasive infections due to Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis in Argentina
    Horacio A Lopardo
    Servicio de Microbiología Hospital de Pediatría Prof Dr Juan P Garrahan, Combate de los Pozos 1881 1245 Buenos Aires, Argentina
    J Clin Microbiol 43:802-7. 2005
    ....
  61. ncbi request reprint Serum opacity factor promotes group A streptococcal epithelial cell invasion and virulence
    Anjuli M Timmer
    Department of Pediatrics, Division of Pharmacology and Drug Discovery, University of California, San Diego, La Jolla, CA, USA
    Mol Microbiol 62:15-25. 2006
    ..Finally, the first in vivo studies to employ a single gene allelic replacement mutant of SOF demonstrate that this protein contributes to GAS virulence in a murine model of necrotizing skin infection...
  62. ncbi request reprint Age influences the emm type distribution of pediatric group A streptococcal pharyngeal isolates
    Preeti Jaggi
    Children s Memorial Hospital, Chicago, IL 60614, USA
    Pediatr Infect Dis J 24:1089-92. 2005
    ..emm types 12, 1, 28, 3, 4, 2 and 6 (in that order) are the types most commonly associated with uncomplicated group A streptococcal (GAS) pharyngitis in the United States, together accounting for approximately 78% of isolates...
  63. ncbi request reprint A community outbreak of conjunctivitis caused by nontypeable Streptococcus pneumoniae in Minnesota
    Jessica M Buck
    Acute Disease Investigation and Control Section, Minnesota Department of Health, St Paul, MN 55164 0975, USA
    Pediatr Infect Dis J 25:906-11. 2006
    ..The Minnesota Department of Health (MDH) was notified of an outbreak of conjunctivitis in city A with cultures positive for Streptococcus pneumoniae...
  64. ncbi request reprint Group A streptococcal pharyngitis serotype surveillance in North America, 2000-2002
    Stanford T Shulman
    Division of Infectious Diseases, Children s Memorial Hospital, Chicago, IL, USA
    Clin Infect Dis 39:325-32. 2004
    ....
  65. ncbi request reprint Sequential multiplex PCR for determining capsular serotypes of pneumococci recovered from Brazilian children
    Cícero A Dias
    Fundacao Faculdade Federal de Ciencias Medicas de Porto Alegre, and Hospital Mãe de Deus, Porto Alegre, Rio Grande do Sul, Brazil
    J Med Microbiol 56:1185-8. 2007
    ..The revised protocol successfully serotyped 139/147 pneumococci (94.6%) from Brazilian children, demonstrating a labour-efficient, accurate method requiring only conventional PCR capability...
  66. pmc International quality assurance study for characterization of Streptococcus pyogenes
    Shona Neal
    Respiratory and Systemic Infection Laboratory, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5HT, United Kingdom
    J Clin Microbiol 45:1175-9. 2007
    ..With the rapid expansion and use of molecular genotypic methods to characterize GAS, continuation of EQA is essential in order to achieve international standardization and comparison of type distributions...
  67. ncbi request reprint Macrolide resistance and emm type distribution of invasive pediatric group A streptococcal isolates: three-year prospective surveillance from a children's hospital
    Preeti Jaggi
    Columbus Children s Hospital, Columbus, OH, USA
    Pediatr Infect Dis J 26:253-5. 2007
    ..We sought to define the GAS emm types and macrolide resistance rates among pediatric invasive GAS isolates collected prospectively during a recent 40-month period at our children's hospital...
  68. ncbi request reprint Sequential multiplex PCR for identifying pneumococcal capsular serotypes from South-Saharan African clinical isolates
    Luis Morais
    Centro de Investigação em Saúde da Manhiça CISM, Ministerio de Saude, CP1929 Maputo, Mozambique
    J Med Microbiol 56:1181-4. 2007
    ..8%) of 153 isolates; 126 (82.4%) were identified within two reactions. This approach in developing countries would require minimal training and could provide useful serotype information without requiring transport of specimens...
  69. ncbi request reprint Vaccination with the pneumococcal 7-valent conjugate: a successful experiment but the species is adapting
    Bernard Beall
    Expert Rev Vaccines 6:297-300. 2007
  70. pmc Multilocus sequence typing of Streptococcus pyogenes representing most known emm types and distinctions among subpopulation genetic structures
    Karen F McGregor
    Department of Infectious Disease Epidemiology, Imperial College London, United Kingdom
    J Bacteriol 186:4285-94. 2004
    ..The findings suggest that the population genetic structure differs for the tissue-defined subpopulations of S. pyogenes. The observed differences may partly reflect differential host immune selection pressures...
  71. pmc Multivalent group A streptococcal vaccine elicits bactericidal antibodies against variant M subtypes
    James B Dale
    Department of Veterans Affairs, The University of Health Science Center, Memphis, TN 38104, USA
    Clin Diagn Lab Immunol 12:833-6. 2005
    ....
  72. pmc Extreme sequence divergence but conserved ligand-binding specificity in Streptococcus pyogenes M protein
    Jenny Persson
    Division of Medical Microbiology, Department of Laboratory Medicine, Lund University, Lund, Sweden
    PLoS Pathog 2:e47. 2006
    ..Together, these findings show that HVRs of M proteins have an extraordinary capacity for sequence divergence and antigenic variability while retaining a specific ligand-binding function...
  73. pmc Group G streptococcal bacteremia in Jerusalem
    Ronit Cohen-Poradosu
    Hadassah Hebrew University Medical Center, Jerusalem, Israel
    Emerg Infect Dis 10:1455-60. 2004
    ..0 in every episode. Recurrent bacteremia has not been described for invasive group A Streptococcus. We describe an entity of recurrent GGS bacteremia, which is associated with lymphatic disorders and possibly with emm stG840.0...
  74. ncbi request reprint Late-onset group B streptococcal infection in identical twins: insight to disease pathogenesis
    Kelly S Doran
    Division of Pediatric Infectious Diseases, University of California, San Diego, La Jolla, CA 92093, USA
    J Perinatol 22:326-30. 2002
    ..The case histories and experimental data are reviewed to underscore key features of GBS disease pathogenesis...
  75. ncbi request reprint A novel, multiple drug-resistant, serotype 24F strain of Streptococcus pneumoniae that caused meningitis in patients in Naples, Italy
    Annalisa Pantosti
    Laboratorio di Batteriologia e Micologia Medica, Istituto Superiore di Sanita, 00161 Rome, Italy
    Clin Infect Dis 35:205-8. 2002
    ..The novel strain has probably arisen through transformation of a serotype 14 strain with type 24F capsular biosynthetic operon sequences...
  76. pmc Erythromycin-resistant pharyngeal isolates of Streptococcus pyogenes recovered in Italy
    Giordano Dicuonzo
    Department of Laboratory Medicine Hospital Infection Control Program, Università Campus Bio Medico, Rome, Italy
    Antimicrob Agents Chemother 46:3987-90. 2002
    ..These data suggest a strong association between macrolide resistance and the presence of sof among GAS isolates recovered from Italian pediatric pharyngitis patients...
  77. pmc Erythromycin-resistant group A streptococcal isolates recovered in Sofia, Bulgaria, from 1995 to 2001
    Antoaneta Detcheva
    National Center of Infectious and Parasitic Diseases, 26 Yanko Sakazov Boulevard, Sofia 1504, Bulgaria
    J Clin Microbiol 40:3831-4. 2002
    ..6% had the M phenotype. Eleven different emm sequence types were found among 25 erythromycin-resistant isolates tested. Nineteen of 26 erythromycin-resistant isolates were additionally resistant to tetracycline and/or chloramphenicol...
  78. doi request reprint emm type diversity of beta-haemolytic streptococci recovered in Chennai, India
    Thangam Menon
    J Med Microbiol 57:540-2. 2008