Dana B Barr

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. ncbi request reprint Identification and quantification of diethylene glycol in pharmaceuticals implicated in poisoning epidemics: an historical laboratory perspective
    Dana B Barr
    National Center of Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Anal Toxicol 31:295-303. 2007
  2. pmc Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the U.S. population
    Dana B Barr
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 112:186-200. 2004
  3. pmc Biomonitoring of exposure in farmworker studies
    Dana B Barr
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Health Perspect 114:936-42. 2006
  4. ncbi request reprint Concentrations of selective metabolites of organophosphorus pesticides in the United States population
    Dana B Barr
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Environ Res 99:314-26. 2005
  5. pmc A survey of laboratory and statistical issues related to farmworker exposure studies
    Dana B Barr
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Health Perspect 114:961-8. 2006
  6. pmc Assessing exposure to atrazine and its metabolites using biomonitoring
    Dana B Barr
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 115:1474-8. 2007
  7. ncbi request reprint Serum polychlorinated biphenyl and organochlorine insecticide concentrations in a Faroese birth cohort
    Dana B Barr
    Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop F17, Atlanta, GA 30341, USA
    Chemosphere 62:1167-82. 2006
  8. ncbi request reprint Method for determination of acephate, methamidophos, omethoate, dimethoate, ethylenethiourea and propylenethiourea in human urine using high-performance liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry
    M Angela Montesano
    Centers for Disease Control and Prevention, 4770 Buford Hwy NE, Mailstop F 17, Atlanta, Georgia 30341, USA
    J Expo Sci Environ Epidemiol 17:321-30. 2007
  9. pmc Measurement of p-nitrophenol in the urine of residents whose homes were contaminated with methyl parathion
    Dana B Barr
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Health Perspect 110:1085-91. 2002
  10. pmc Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements
    Dana B Barr
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 113:192-200. 2005

Detail Information

Publications86

  1. ncbi request reprint Identification and quantification of diethylene glycol in pharmaceuticals implicated in poisoning epidemics: an historical laboratory perspective
    Dana B Barr
    National Center of Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Anal Toxicol 31:295-303. 2007
    ..This methodology includes the development of biomarkers of DEG exposure, which would be extremely useful in instances where pharmaceuticals are not clearly implicated...
  2. pmc Concentrations of dialkyl phosphate metabolites of organophosphorus pesticides in the U.S. population
    Dana B Barr
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 112:186-200. 2004
    ..These data will be important in evaluating the impact of organophosphorus pesticide exposure in the U.S. population and the effectiveness of regulatory actions...
  3. pmc Biomonitoring of exposure in farmworker studies
    Dana B Barr
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Health Perspect 114:936-42. 2006
    ..In addition, we provide recommendations to improve the utility of biomonitoring in farmworker studies...
  4. ncbi request reprint Concentrations of selective metabolites of organophosphorus pesticides in the United States population
    Dana B Barr
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Environ Res 99:314-26. 2005
    ..Similarly, adolescents had significantly higher TCPY concentrations than adults. Although the concentrations between sexes and among composite racial/ethnic groups varied, no significant differences were observed...
  5. pmc A survey of laboratory and statistical issues related to farmworker exposure studies
    Dana B Barr
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Health Perspect 114:961-8. 2006
    ..Key words: analytical methodology, biomarkers, laboratory, limit of detection, omics, quality control, sample size, statistics...
  6. pmc Assessing exposure to atrazine and its metabolites using biomonitoring
    Dana B Barr
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 115:1474-8. 2007
    ..When we assessed exposure to ATZ by measuring its urinary mercapturic acid metabolite, general population data indicated that < 5% of the population was exposed to ATZ-related chemicals (limit of detection < 0.8 ng/mL)...
  7. ncbi request reprint Serum polychlorinated biphenyl and organochlorine insecticide concentrations in a Faroese birth cohort
    Dana B Barr
    Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop F17, Atlanta, GA 30341, USA
    Chemosphere 62:1167-82. 2006
    ....
  8. ncbi request reprint Method for determination of acephate, methamidophos, omethoate, dimethoate, ethylenethiourea and propylenethiourea in human urine using high-performance liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry
    M Angela Montesano
    Centers for Disease Control and Prevention, 4770 Buford Hwy NE, Mailstop F 17, Atlanta, Georgia 30341, USA
    J Expo Sci Environ Epidemiol 17:321-30. 2007
    ..For all compounds the extraction efficiency ranged between 52% and 63%, relative recoveries were about 100%, and the limits of detection were in the range of 0.001-0.282 ng/ml...
  9. pmc Measurement of p-nitrophenol in the urine of residents whose homes were contaminated with methyl parathion
    Dana B Barr
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Health Perspect 110:1085-91. 2002
    ....
  10. pmc Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements
    Dana B Barr
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 113:192-200. 2005
    ..This approach allows the urinary analyte concentration to be appropriately adjusted for urinary creatinine and the statistical significance of other variables in the model to be independent of effects of creatinine concentration...
  11. pmc Biologic monitoring of exposure to environmental chemicals throughout the life stages: requirements and issues for consideration for the National Children's Study
    Dana B Barr
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Health Perspect 113:1083-91. 2005
    ....
  12. doi request reprint A mass spectrometry-based method to measure dialkylphosphate degradation products of organophosphorous insecticides in dust and orange juice
    Gayanga Weerasekera
    National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop F 17, Atlanta, Georgia, USA
    J Environ Monit 11:1345-51. 2009
    ..Evaluation of the conversion of intact pesticides in the samples to DAPs will help us to better understand the contribution of preformed DAPs to urinary DAP concentrations...
  13. ncbi request reprint Concentrations of xenobiotic chemicals in the maternal-fetal unit
    Dana B Barr
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, United States
    Reprod Toxicol 23:260-6. 2007
    ..In some instances where known health outcomes have occurred from these exposures, we note these and any caveats associated with the exposures...
  14. ncbi request reprint A multi-analyte method for the quantification of contemporary pesticides in human serum and plasma using high-resolution mass spectrometry
    Dana B Barr
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy NE, Mailstop F17, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 778:99-111. 2002
    ..We found detectable concentrations of carbaryl/naphthalene, propoxur, bendiocarb, chlorpyrifos, diazinon, dicloran, captan and folpet or their metabolites in more than 20% of the plasma samples tested...
  15. ncbi request reprint Analytical methods for biological monitoring of exposure to pesticides: a review
    Dana B Barr
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop F17, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 778:5-29. 2002
    ..We also present a critical assessment of the existing methodology and explore areas in which more research is needed...
  16. pmc Potential uses of biomonitoring data: a case study using the organophosphorus pesticides chlorpyrifos and malathion
    Dana B Barr
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Health Perspect 114:1763-9. 2006
    ..For assessing early effects and susceptibility, cholinesterase and microsomal esterase activities, respectively, have been measured...
  17. ncbi request reprint Cross validation of multiple methods for measuring pyrethroid and pyrethrum insecticide metabolites in human urine
    Dana B Barr
    National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop F17, Atlanta, GA 30341, USA
    Anal Bioanal Chem 389:811-8. 2007
    ....
  18. pmc Exposure assessment in the National Children's Study: introduction
    Larry L Needham
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Health Perspect 113:1076-82. 2005
    ..Criteria for the analytical method of choice are discussed with particular emphasis on the need for long-term quality control and quality assurance measures...
  19. pmc Outbreak of acute renal failure in Panama in 2006: a case-control study
    E Danielle Rentz
    Centers for Disease Control and Prevention, Atlanta, GA, USA
    Bull World Health Organ 86:749-56. 2008
    ..Twelve (57%) of 21 patients had died of the illness. This paper describes the investigation into the cause of the illness and the source of the outbreak...
  20. pmc Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Atlanta, GA 30341, USA
    Environ Health Perspect 112:331-8. 2004
    ....
  21. pmc Mono(2-ethyl-5-hydroxyhexyl) phthalate and mono-(2-ethyl-5-oxohexyl) phthalate as biomarkers for human exposure assessment to di-(2-ethylhexyl) phthalate
    Kayoko Kato
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Atlanta, GA 30341, USA
    Environ Health Perspect 112:327-30. 2004
    ....
  22. ncbi request reprint Glucuronidation patterns of common urinary and serum monoester phthalate metabolites
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy NE, Mailstop F17, Atlanta, GA 30341, USA
    Arch Toxicol 77:561-7. 2003
    ..Serum mBzP was largely below the method limit of detection. Interestingly, the serum mEP and mBP levels were less than 3% and 47%, respectively, of their urinary levels, whereas the level of mEHP was similar both in urine and serum...
  23. ncbi request reprint Quantification of atrazine, phenylurea, and sulfonylurea herbicide metabolites in urine by high-performance liquid chromatography-tandem mass spectrometry
    Johnny V Nguyen
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, M S F 17, Atlanta, Georgia 30341, USA
    J Anal Toxicol 31:181-6. 2007
    ..Extraction recoveries ranged from 88% to 104% (n = 5). Limits of detection for the entire method ranged from 0.125 to 1 ng/mL, and the average relative standard deviation of repeat measurements was about 13% (n = 30)...
  24. ncbi request reprint A rapid, cost-effective method for analyzing organophosphorus pesticide metabolites in human urine for counter-terrorism response
    Gayanga Weerasekera
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Anal Toxicol 32:106-15. 2008
    ..Because this method is lower in cost, it may be a more viable option for equipping multiple laboratories with chemical-terrorism response capabilities...
  25. ncbi request reprint Concentrations of environmental chemicals associated with neurodevelopmental effects in U.S. population
    Larry L Needham
    Organic Analytical Toxicology Branch, Mailstop F17, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341 3724, USA
    Neurotoxicology 26:531-45. 2005
    ..S. population. These data will continue to be collected in 2-year cycles and thus allow changes in human levels to be followed...
  26. ncbi request reprint Measurement of dialkyl phosphate metabolites of organophosphorus pesticides in human urine using lyophilization with gas chromatography-tandem mass spectrometry and isotope dilution quantification
    Roberto Bravo
    Centers for Disease Control and Prevention, 4770 Buford Hwy NE, Mailstop F 17, Atlanta, GA 30341, USA
    J Expo Anal Environ Epidemiol 14:249-59. 2004
    ..Use of this method with approximately 1100 urine samples collected from pregnant women and children indicate that the low limits of detection allow this method to be used in general population studies...
  27. ncbi request reprint Isotope dilution high-performance liquid chromatography-tandem mass spectrometry method for quantifying urinary metabolites of synthetic pyrethroid insecticides
    Samuel E Baker
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4771 Buford Highway, N E, Atlanta, Georgia 30341, USA
    Arch Environ Contam Toxicol 46:281-8. 2004
    ..Metabolites of synthetic pyrethroids were detected in 74% of the samples analyzed. cis-DCCA, trans-DCCA, DBCA, 4F3PBA, and 3PBA were detected in 36, 50, 3, 9, and 64% of the samples analyzed, respectively...
  28. ncbi request reprint New high-resolution mass spectrometric approach for the measurement of polychlorinated biphenyls and organochlorine pesticides in human serum
    John R Barr
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 794:137-48. 2003
    ..We used this method to analyze approximately 350 serum samples over a period of several months. We found that our new method was as reliable in automated, overnight runs as our current method...
  29. pmc A longitudinal approach to assessing urban and suburban children's exposure to pyrethroid pesticides
    Chensheng Lu
    Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    Environ Health Perspect 114:1419-23. 2006
    ..Because of the wide use of pyrethroids in the United States, the findings of this study are important for both children's pesticide exposure assessment and environmental public health...
  30. pmc Effects of environmental agents on the attainment of puberty: considerations when assessing exposure to environmental chemicals in the National Children's Study
    Richard Y Wang
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 113:1100-7. 2005
    ..The NCS is uniquely poised to evaluate the effects of environmental chemicals on the age at puberty, and the above approach will allow the NCS to accomplish this task...
  31. pmc Dietary intake and its contribution to longitudinal organophosphorus pesticide exposure in urban/suburban children
    Chensheng Lu
    Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Environ Health Perspect 116:537-42. 2008
    ..Because such exposure may cause adverse health effects, particularly in children, the sources and patterns of exposure need to be studied further...
  32. pmc Public health decisions: the laboratory's role in the Lorain County, Ohio, investigation
    Robert H Hill
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Environ Health Perspect 110:1057-9. 2002
    ..Furthermore, it illustrates how a multidisciplinary team from various governmental agencies worked together to protect the public's health...
  33. ncbi request reprint Identification of human urinary metabolites of acetochlor in exposed herbicide applicators by high-performance liquid chromatography-tandem mass spectrometry
    Dana B Barr
    Centers for Disease Control and Prevention, National Center for Environmental Health, Atlanta, Georgia 30341, USA
    J Expo Sci Environ Epidemiol 17:559-66. 2007
    ..At lower exposures (classified as ACM<10 microg/l), ACM and acetochlor concentrations were similar. Additionally, we tentatively identified another acetochlor metabolite that appeared to be important at low levels of exposure...
  34. ncbi request reprint Urinary and amniotic fluid levels of phthalate monoesters in rats after the oral administration of di(2-ethylhexyl) phthalate and di-n-butyl phthalate
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Mailstop F17, Atlanta, GA 30341, USA
    Toxicology 217:22-30. 2006
    ..Although no firm conclusions could be drawn from the urinary MBP data, the MEHP results suggest that maternal urinary MEHP levels may be useful surrogate markers for fetal exposure to DEHP...
  35. ncbi request reprint Quantitative detection of nine phthalate metabolites in human serum using reversed-phase high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry
    Kayoko Kato
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Anal Toxicol 27:284-9. 2003
    ..In addition, it allows the direct measurement of the active phthalate monoester metabolites reportedly responsible for the reproductive and developmental toxicity of certain phthalates...
  36. ncbi request reprint A liquid chromatography/electrospray ionization-tandem mass spectrometry method for quantification of specific organophosphorus pesticide biomarkers in human urine
    Anders O Olsson
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy N E MS F17, Atlanta, Georgia 30341, USA
    Anal Bioanal Chem 376:808-15. 2003
    ..We detected concentrations of most of these pesticides and/or their metabolites in urine samples from non-occupationally exposed persons using our method. Our frequencies of detection for the analytes measured ranged from 1% to 98%...
  37. doi request reprint Quantification of atrazine and its metabolites in urine by on-line solid-phase extraction-high-performance liquid chromatography-tandem mass spectrometry
    Parinya Panuwet
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, N E, MS F 17, Atlanta, GA, 30360, USA
    Anal Bioanal Chem 391:1931-9. 2008
    ..More importantly, this method will allow us to better assess human exposure to atrazine-related chemicals...
  38. doi request reprint The attribution of urban and suburban children's exposure to synthetic pyrethroid insecticides: a longitudinal assessment
    Chensheng Lu
    Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    J Expo Sci Environ Epidemiol 19:69-78. 2009
    ..Future research should be devoted to enhancing our understanding of the complexity of pyrethroid insecticide exposure patterns...
  39. ncbi request reprint Quantification of phenolic metabolites of environmental chemicals in human urine using gas chromatography-tandem mass spectrometry and isotope dilution quantification
    Roberto Bravo
    National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Mailstop F 17, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 820:229-36. 2005
    ..Using our method, we measured concentrations of the target chemicals in urine samples from the general population...
  40. ncbi request reprint Quantification of six herbicide metabolites in human urine
    Jessica Norrgran
    National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, Mailstop F17, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 830:185-95. 2006
    ..We validated our selective method against a less selective method used previously in our laboratory by analyzing human specimens using both methods. The methods produced results that were in agreement, with no significant bias observed...
  41. ncbi request reprint Quantitation of dialkyl phosphate metabolites of organophosphate pesticides in human urine using GC-MS-MS with isotopic internal standards
    Roberto Bravo
    Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Anal Toxicol 26:245-52. 2002
    ..The use of stable isotope analogues as internal standards for each of these metabolites allows for the highest degree of accuracy and precision. Additionally, the low LODs allow the use of this method in general population studies...
  42. pmc Assessing human exposure to phthalates using monoesters and their oxidized metabolites as biomarkers
    Dana B Barr
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 111:1148-51. 2003
    ....
  43. ncbi request reprint Uses and issues of biomonitoring
    Larry L Needham
    National Center for Environmental Health, Centers for Disease Control and Prevention, Mailstop F17, 4770 Buford Highway, Atlanta, GA 30341 3724, USA
    Int J Hyg Environ Health 210:229-38. 2007
    ....
  44. ncbi request reprint Determination of dialkyl phosphate metabolites of organophosphorus pesticides in human urine by automated solid-phase extraction, derivatization, and gas chromatography-mass spectrometry
    G K Hemakanthi De Alwis
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop F 17, Atlanta, Georgia 30341, USA
    J Anal Toxicol 32:721-7. 2008
    ..We compared performance of DBP as an internal standard with that of isotope-labeled compounds and found that DBP gives reliable results for the analytical procedure. We also optimized reaction parameters of pentafluorobenzylation...
  45. ncbi request reprint Uses of speciation techniques in biomonitoring for assessing human exposure to organic environmental chemicals
    Larry L Needham
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Anal Bioanal Chem 381:397-404. 2005
    ..Much of this information and many of these techniques are transferable to the measurement of inorganic elements in environmental and biological samples...
  46. ncbi request reprint A liquid chromatography--tandem mass spectrometry multiresidue method for quantification of specific metabolites of organophosphorus pesticides, synthetic pyrethroids, selected herbicides, and deet in human urine
    Anders O Olsson
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, N E, MS F 17, Atlanta, Georgia 30360, USA
    Anal Chem 76:2453-61. 2004
    ..However, the analysis time with the TIS application is much shorter, and if only pyrethroid metabolite data are of interest, the throughput can be increased to 100-150 samples/day...
  47. ncbi request reprint Characterizing children's exposures: beyond NHANES
    Larry L Needham
    Organic Analytical Toxicology Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Mailstop F17, 4770 Buford Highway, Atlanta, GA 30341 3724, USA
    Neurotoxicology 26:547-53. 2005
    ..We recommend additional studies to supplement the NHANES biomonitoring data...
  48. doi request reprint Automated solid phase extraction, on-support derivatization and isotope dilution-GC/MS method for the detection of urinary dialkyl phosphates in humans
    G K Hemakanthi De Alwis
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, NE, Atlanta, GA 30341, USA
    Talanta 77:1063-7. 2009
    ..1 to 0.3 ng/mL. The recoveries were high and comparable with those of our previous method. Relative standard deviation, indicative of the repeatability and precision of the method, was 1-17% for the metabolites...
  49. pmc Investigating childhood leukemia in Churchill County, Nevada
    Carol S Rubin
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 115:151-7. 2007
    ..Considering the county population and statewide cancer rate, fewer than two cases would be expected...
  50. ncbi request reprint Comprehensive solid-phase extraction method for persistent organic pollutants. Validation and application to the analysis of persistent chlorinated pesticides
    Courtney D Sandau
    National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop F17, Atlanta, Georgia, 30341 3724, USA
    Anal Chem 75:71-7. 2003
    ..The method represents a preliminary step in establishing an automated, comprehensive multiresidue analysis method for POPs in human serum...
  51. doi request reprint Organophosphorus and pyrethroid insecticide urinary metabolite concentrations in young children living in a southeastern United States city
    Luke P Naeher
    Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Sci Total Environ 408:1145-53. 2010
    ....
  52. doi request reprint Comparison of immunoassay and HPLC-MS/MS used to measure urinary metabolites of atrazine, metolachlor, and chlorpyrifos from farmers and non-farmers in Iowa
    Brian D Curwin
    Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations, and Field Studies, Cincinnati, Ohio 45226, USA
    J Expo Sci Environ Epidemiol 20:205-12. 2010
    ..0015-0.0039 microg l(-1), 0.12-0.16 microg l(-1), and 2.9-3.0 microg l(-1), respectively. Immunoassays tend to be cheaper and faster than HPLC-MS/MS, however, they may result in an upward bias of urinary pesticide metabolite levels...
  53. ncbi request reprint Quantitation of the sulfur mustard metabolites 1,1'-sulfonylbis[2-(methylthio)ethane] and thiodiglycol in urine using isotope-dilution Gas chromatography-tandem mass spectrometry
    Anne E Boyer
    Centers for Disease Control and Prevention, National Center for Environmental Health, Atlanta, Georgia 30341, USA
    J Anal Toxicol 28:327-32. 2004
    ..The geometric mean concentration of TDG was 3.43 ng/mL, with concentrations ranging from < 0.5 ng/mL to 20 ng/mL...
  54. doi request reprint Current and historically used pesticides in residential soil from 11 homes in Atlanta, Georgia, USA
    Anne M Riederer
    Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Arch Environ Contam Toxicol 58:908-17. 2010
    ..Although our small sample size limits comparison to other studies, our results provide evidence that residential soil is a potential source of human exposure to both current and historically used pesticides...
  55. pmc Diet and nondiet predictors of urinary 3-phenoxybenzoic acid in NHANES 1999-2002
    Anne M Riederer
    Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Environ Health Perspect 116:1015-22. 2008
    ..S. National Health and Nutrition Examination Survey (NHANES) 1999-2002. NHANES also includes 24-hr diet data and information on household pesticide use, activities, occupation, demographics, and other exposure factors...
  56. pmc Diethylene glycol in health products sold over-the-counter and imported from Asian countries
    Joshua G Schier
    Centers for Disease Control and Prevention, Atlanta, GA, USA
    J Med Toxicol 7:33-8. 2011
    ..Based on current standards, these levels probably do not represent an acute public health threat. Additional research focusing on why DEG is found in these products and on the minimum amount of DEG needed to result in toxicity is needed...
  57. pmc Organic diets significantly lower children's dietary exposure to organophosphorus pesticides
    Chensheng Lu
    Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    Environ Health Perspect 114:260-3. 2006
    ..To our knowledge, this is the first study to employ a longitudinal design with a dietary intervention to assess children's exposure to pesticides. It provides new and persuasive evidence of the effectiveness of this intervention...
  58. ncbi request reprint Measurement of human urinary organophosphate pesticide metabolites by automated solid-phase extraction derivation and gas chromatography-tandem mass spectromy
    G K Hemakanthi De Alwis
    Division of Laboratory Sciences, National Center for Enviromental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 843:34-41. 2006
    ..The method limits of detection were excellent for all analytes ranging from 50 pg/ml to 170 pg/ml. Relative standard deviations ranged from 2% to 12%...
  59. ncbi request reprint Quantitation of organophosphorus nerve agent metabolites in human urine using isotope dilution gas chromatography-tandem mass spectrometry
    W Jack Driskell
    Centers for Disease Control and Prevention, National Center for Environmental Health, Atlanta, Georgia 30341, USA
    J Anal Toxicol 26:6-10. 2002
    ..The limits of detection were less than 4 microg/L for all the analytes except for the GA metabolite, which had a limit of detection of less than 20 microg/L...
  60. ncbi request reprint High-performance liquid chromatography-tandem mass spectrometry method for quantifying sulfonylurea herbicides in human urine: reconsidering the validation process
    Samuel E Baker
    Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Anal Bioanal Chem 383:963-76. 2005
    ..Estimated days for 10% and 50% degradation in urine and acetonitrile ranged from 0.7 days to >318 days. The influence of matrix effects on precision and accuracy was also explored...
  61. pmc Perinatal exposure to perchlorate. thiocyanate, and nitrate in New Jersey mothers and newborns
    Benjamin C Blount
    Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Sci Technol 43:7543-9. 2009
    ..In this panel of healthy infants, we found no association between cord blood levels of these anions and newborn weight length, and head circumference...
  62. ncbi request reprint Automated solid phase extraction and quantitative measurement of 2,3-dibromo-1-propanol in urine using gas chromatography-mass spectrometry
    G K Hemakanthi De Alwis
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Mailstop F 17, Atlanta, GA 30341, USA
    Arch Environ Contam Toxicol 53:134-9. 2007
    ..This method involves enzymatic cleavage of the DBP-glucuronide or sulfate conjugate, automated solid phase extraction, and analysis by gas chromatography-mass spectrometry using 1,4-dibromo-2-butanol as the internal standard...
  63. doi request reprint Assessing developmental toxicant exposures via biomonitoring
    Larry L Needham
    Organic Analytical Toxicology Branch, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341 3724, USA
    Basic Clin Pharmacol Toxicol 102:100-8. 2008
    ..In this paper, we examine this linkage using several chemicals as examples and providing biomonitoring information for these chemicals in the US population as a whole but also at various life stages...
  64. ncbi request reprint Improved quantitative detection of 11 urinary phthalate metabolites in humans using liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry
    Manori J Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy NE, Mailstop F17, Atlanta, GA 30341 3724, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 789:393-404. 2003
    ....
  65. ncbi request reprint Urinary and hand wipe pesticide levels among farmers and nonfarmers in Iowa
    Brian D Curwin
    Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA
    J Expo Anal Environ Epidemiol 15:500-8. 2005
    ..The majority of the hand wipe samples were nondetectable. However, detection of atrazine in the hand wipes was significantly associated with urinary levels of atrazine above the median (P-value <0.01)...
  66. ncbi request reprint Urinary phytoestrogen concentrations in the U.S. population (1999-2000)
    Liza Valentin-Blasini
    National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Expo Anal Environ Epidemiol 15:509-23. 2005
    ....
  67. pmc Use of biomarkers to indicate exposure of children to organophosphate pesticides: implications for a longitudinal study of children's environmental health
    Denise Wessels
    School of Public and Environmental Affairs, Indiana University, Bloomington, Indiana, USA
    Environ Health Perspect 111:1939-46. 2003
    ..Biomarkers of OP exposure can be a valuable tool in epidemiology of children's environmental health, as long as they are applied and interpreted appropriately...
  68. pmc Measurement of pesticides and other toxicants in amniotic fluid as a potential biomarker of prenatal exposure: a validation study
    Asa Bradman
    Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, California 94720 7380, USA
    Environ Health Perspect 111:1779-82. 2003
    ..Results of this pilot study suggest that amniotic fluid offers a unique opportunity to investigate fetal exposures and health risks...
  69. pmc Cumulative organophosphate pesticide exposure and risk assessment among pregnant women living in an agricultural community: a case study from the CHAMACOS cohort
    Rosemary Castorina
    Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, California 94720, USA
    Environ Health Perspect 111:1640-8. 2003
    ..In future analyses, we will use pesticide-specific urinary metabolites, when available, to evaluate cumulative OP pesticide exposures...
  70. pmc Semen quality in relation to biomarkers of pesticide exposure
    Shanna H Swan
    Department of Family and Community Medicine, MA 306 Medical Sciences Building, University of Missouri Columbia School of Medicine, Columbia, MO 65212, USA
    Environ Health Perspect 111:1478-84. 2003
    ..These associations between current-use pesticides and reduced semen quality suggest that agricultural chemicals may have contributed to the reduction in semen quality in fertile men from mid-Missouri we reported previously...
  71. pmc Contemporary-use pesticides in personal air samples during pregnancy and blood samples at delivery among urban minority mothers and newborns
    Robin M Whyatt
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 111:749-56. 2003
    ..Findings indicate that pesticide exposures are frequent but decreasing and that the pesticides are readily transferred to the developing fetus during pregnancy...
  72. pmc Chicago area methyl parathion response
    Kenneth G McCann
    Illinois Department of Public Health, Division of Environmental Health, Environmental Toxicology Section, Springfield, Illinois, USA
    Environ Health Perspect 110:1075-8. 2002
    ..Urine samples were collected and analyzed for p-nitrophenol in 1,913 individuals. Implementation of the protocol resulted in 550 residents being relocated during the remediation of 100 households...
  73. ncbi request reprint Nondietary ingestion of pesticides by children in an agricultural community on the US/Mexico border: preliminary results
    Stuart L Shalat
    Environmental and Occupational Health Sciences Institute, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    J Expo Anal Environ Epidemiol 13:42-50. 2003
    ....
  74. pmc Effects of exposure to polychlorinated biphenyls and organochlorine pesticides on thyroid function during pregnancy
    Jonathan Chevrier
    Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, Berkeley, CA 94704 7380, USA
    Am J Epidemiol 168:298-310. 2008
    ..These findings are of particular significance, since thyroid hormones of maternal origin may play an essential role in fetal neurodevelopment...
  75. ncbi request reprint Estimating pesticide dose from urinary pesticide concentration data by creatinine correction in the Third National Health and Nutrition Examination Survey (NHANES-III)
    David T Mage
    Institute for Survey Research, Temple University, Philadelphia, PA 19122 6099, USA
    J Expo Anal Environ Epidemiol 14:457-65. 2004
    ....
  76. pmc An intervention to reduce residential insecticide exposure during pregnancy among an inner-city cohort
    Megan K Williams
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 114:1684-9. 2006
    ....
  77. ncbi request reprint Factors predicting organochlorine pesticide levels in pregnant Latina women living in a United States agricultural area
    A S A Bradman
    Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, CA 94720 7380, USA
    J Expo Sci Environ Epidemiol 17:388-99. 2007
    ..Although the weight of evidence from this study indicates that most exposure occurred before moving to the United States, the results for HCB indicate the possibility of ongoing exposure in this country...
  78. ncbi request reprint Prenatal organophosphate metabolite and organochlorine levels and performance on the Brazelton Neonatal Behavioral Assessment Scale in a multiethnic pregnancy cohort
    Stephanie M Engel
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Am J Epidemiol 165:1397-404. 2007
    ..The authors uncovered additional evidence that prenatal levels of organophosphate pesticide metabolites are associated with anomalies in primitive reflexes, which are a critical marker of neurologic integrity...
  79. ncbi request reprint Environmental pyrethroid and organophosphorus insecticide exposures and sperm concentration
    Melissa J Perry
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA
    Reprod Toxicol 23:113-8. 2007
    ....
  80. pmc Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children
    Brenda Eskenazi
    Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, California 94720 7380, USA
    Environ Health Perspect 115:792-8. 2007
    ..Organophosphate (OP) pesticides are widely used in agriculture and homes. Animal studies suggest that even moderate doses are neurodevelopmental toxicants, but there are few studies in humans...
  81. ncbi request reprint Organophosphorus pesticide urinary metabolite levels of children in farmworker households in eastern North Carolina
    Thomas A Arcury
    Department of Family and Community Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1084, USA
    Am J Ind Med 49:751-60. 2006
    ..The relative importance of para-occupational, residential, and environment risk factors are delineated...
  82. ncbi request reprint Pesticides and their metabolites in the homes and urine of farmworker children living in the Salinas Valley, CA
    Asa Bradman
    Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, CA 94720 7380, USA
    J Expo Sci Environ Epidemiol 17:331-49. 2007
    ..The child activity timeline, a novel, low-literacy instrument based on pictures, was successfully used by our participants. Future uses of these data include the development of pesticide exposure models and risk assessment...
  83. pmc Association of in utero organochlorine pesticide exposure and fetal growth and length of gestation in an agricultural population
    Laura Fenster
    Division of Environmental and Occupational Disease Control, California Department of Health Services, Richmond, CA 94804, USA
    Environ Health Perspect 114:597-602. 2006
    ..Our finding of decreased length of gestation related to HCB does not seem to have had clinical implications for this population, given its relatively low rate of preterm delivery (6.5%)...
  84. doi request reprint Pesticide toxicity and the developing brain
    Brenda Eskenazi
    Center for Children s Environmental Health Research, School of Public Health, University of California, Berkeley, CA 94704, USA
    Basic Clin Pharmacol Toxicol 102:228-36. 2008
    ..We also observed adverse associations of prenatal but not postnatal organophosphate pesticide exposure with mental development and pervasive developmental disorder at 24 months...
  85. ncbi request reprint Prenatal pesticide and PCB exposures and birth outcomes
    Mary S Wolff
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Pediatr Res 61:243-50. 2007
    ..In summary, we found suggestive relationships between prenatal environmental biomarkers and birth outcomes in this population. Maternal susceptibility factors including PON1 and maternal weight contributed to the observed effects...
  86. pmc Pesticide urinary metabolite levels of children in eastern North Carolina farmworker households
    Thomas A Arcury
    Department of Family and Community Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1084, USA
    Environ Health Perspect 115:1254-60. 2007
    ....