David L Ashley

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. ncbi request reprint Determination of carcinogenic tobacco-specific nitrosamines in mainstream smoke from U.S.-brand and non-U.S.-brand cigarettes from 14 countries
    Weijia Wu
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Nicotine Tob Res 7:443-51. 2005
  2. ncbi request reprint Quantification of 31 volatile organic compounds in whole blood using solid-phase microextraction and gas chromatography-mass spectrometry
    Benjamin C Blount
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 832:292-301. 2006
  3. doi request reprint Automated determination of seven phenolic compounds in mainstream tobacco smoke
    Christina Vaughan
    Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laborarory Sciences, Emergency Response and Air Toxicants Branch, Atlanta, GA 31314, USA
    Nicotine Tob Res 10:1261-8. 2008
  4. doi request reprint Effect of differing levels of tobacco-specific nitrosamines in cigarette smoke on the levels of biomarkers in smokers
    David L Ashley
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Cancer Epidemiol Biomarkers Prev 19:1389-98. 2010
  5. ncbi request reprint Tobacco-specific nitrosamines in tobacco from U.S. brand and non-U.S. brand cigarettes
    David L Ashley
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Nicotine Tob Res 5:323-31. 2003
  6. ncbi request reprint Changes in blood trihalomethane concentrations resulting from differences in water quality and water use activities
    David L Ashley
    Emergency Response and Air Toxicants Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Arch Environ Occup Health 60:7-15. 2005
  7. doi request reprint Semi-volatiles in mainstream smoke delivery from select charcoal-filtered cigarette brand variants
    Bryan A Hearn
    Emergency Response and Air Toxicants Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE MS F 47, Atlanta, GA 30341, USA
    Tob Control 19:223-30. 2010
  8. doi request reprint Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in smokers in the United States: NHANES 2007-2008
    Yang Xia
    Division of Laboratory Science, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Biomarkers 16:112-9. 2011
  9. doi request reprint Levels of tobacco-specific nitrosamines and polycyclic aromatic hydrocarbons in mainstream smoke from different tobacco varieties
    Yan S Ding
    Emergency Response and Air Toxicants Branch, Division of Laboratory Science, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway Northeast, Mailstop F 47, Atlanta, GA 30341 3724, USA
    Cancer Epidemiol Biomarkers Prev 17:3366-71. 2008
  10. doi request reprint Estimating smokers' mouth-level exposure to select mainstream smoke constituents from discarded cigarette filter butts
    Gregory M Polzin
    Emergency Response and Air Toxicants Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, N E, Mailstop F 55, Atlanta, GA 30341, USA
    Nicotine Tob Res 11:868-74. 2009

Detail Information

Publications51

  1. ncbi request reprint Determination of carcinogenic tobacco-specific nitrosamines in mainstream smoke from U.S.-brand and non-U.S.-brand cigarettes from 14 countries
    Weijia Wu
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Nicotine Tob Res 7:443-51. 2005
    ....
  2. ncbi request reprint Quantification of 31 volatile organic compounds in whole blood using solid-phase microextraction and gas chromatography-mass spectrometry
    Benjamin C Blount
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 832:292-301. 2006
    ..12 microg/L, with linear calibration curves spanning three orders of magnitude. The improved throughput of this method will enable us to expand biomonitoring efforts to assess nonoccupational VOC exposure in large epidemiological studies...
  3. doi request reprint Automated determination of seven phenolic compounds in mainstream tobacco smoke
    Christina Vaughan
    Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laborarory Sciences, Emergency Response and Air Toxicants Branch, Atlanta, GA 31314, USA
    Nicotine Tob Res 10:1261-8. 2008
    ..Differences were seen in relative levels of phenolic compounds in the mainstream smoke from unfiltered cigarettes made with a single type of tobacco...
  4. doi request reprint Effect of differing levels of tobacco-specific nitrosamines in cigarette smoke on the levels of biomarkers in smokers
    David L Ashley
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Cancer Epidemiol Biomarkers Prev 19:1389-98. 2010
    ..Previous studies have shown significant global differences in the levels of TSNAs in cigarette smoke because of the variation in tobacco blending and curing practices around the world...
  5. ncbi request reprint Tobacco-specific nitrosamines in tobacco from U.S. brand and non-U.S. brand cigarettes
    David L Ashley
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
    Nicotine Tob Res 5:323-31. 2003
    ..S. brands purchased in the same country. The findings suggest that TSNA levels in tobacco can be substantially reduced in some cigarettes...
  6. ncbi request reprint Changes in blood trihalomethane concentrations resulting from differences in water quality and water use activities
    David L Ashley
    Emergency Response and Air Toxicants Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Arch Environ Occup Health 60:7-15. 2005
    ..Further studies will focus on variables in these activities that can alter exposure...
  7. doi request reprint Semi-volatiles in mainstream smoke delivery from select charcoal-filtered cigarette brand variants
    Bryan A Hearn
    Emergency Response and Air Toxicants Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE MS F 47, Atlanta, GA 30341, USA
    Tob Control 19:223-30. 2010
    ....
  8. doi request reprint Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in smokers in the United States: NHANES 2007-2008
    Yang Xia
    Division of Laboratory Science, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Biomarkers 16:112-9. 2011
    ..001). In addition to addressing current NNK exposure levels, these results will form a baseline for future estimates of tobacco users' exposure to this carcinogen...
  9. doi request reprint Levels of tobacco-specific nitrosamines and polycyclic aromatic hydrocarbons in mainstream smoke from different tobacco varieties
    Yan S Ding
    Emergency Response and Air Toxicants Branch, Division of Laboratory Science, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway Northeast, Mailstop F 47, Atlanta, GA 30341 3724, USA
    Cancer Epidemiol Biomarkers Prev 17:3366-71. 2008
    ..The influence of nitrate on mainstream smoke NNK and PAH levels were of different magnitude and direction. Our results tend to indicate an inverse relation exists between NNK and PAH deliveries when considering different tobacco blends...
  10. doi request reprint Estimating smokers' mouth-level exposure to select mainstream smoke constituents from discarded cigarette filter butts
    Gregory M Polzin
    Emergency Response and Air Toxicants Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, N E, Mailstop F 55, Atlanta, GA 30341, USA
    Nicotine Tob Res 11:868-74. 2009
    ....
  11. pmc Botulinum neurotoxin detection and differentiation by mass spectrometry
    John R Barr
    Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Emerg Infect Dis 11:1578-83. 2005
    ..62 MLD50/mL. A high-performance liquid chromatography-tandem mass spectrometry method for quantifying active toxin, where the amount of toxin can be correlated to the amount of product peptides, is also described...
  12. doi request reprint Urine concentrations of a tobacco-specific nitrosamine carcinogen in the U.S. population from secondhand smoke exposure
    John T Bernert
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Cancer Epidemiol Biomarkers Prev 19:2969-77. 2010
    ..We have measured total NNAL in the U.S. population of tobacco users and nonsmokers exposed to secondhand smoke...
  13. ncbi request reprint Determination of eugenol, anethole, and coumarin in the mainstream cigarette smoke of Indonesian clove cigarettes
    Gregory M Polzin
    Emergency Response and Air Toxicants Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, N E Atlanta, GA 30341, USA
    Food Chem Toxicol 45:1948-53. 2007
    ..8-1,030 microg/cig, and coumarin was detected in 19 brands at levels ranging from 9.2 to 215 microg/cig. These detected levels are significantly higher than the levels found in commercial cigarette brands available in the United States...
  14. doi request reprint Increases in tobacco exposure biomarkers measured in non-smokers exposed to sidestream cigarette smoke under controlled conditions
    John T Bernert
    Division of Laboratory Science, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Biomarkers 14:82-93. 2009
    ....
  15. ncbi request reprint Quantification of nerve agent VX-butyrylcholinesterase adduct biomarker from an accidental exposure
    Maria I Solano
    Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, Georgia 30341, USA
    J Anal Toxicol 32:68-72. 2008
    ..05% of BuChE can be accurately quantified. These data further indicate that the fluoride ion regeneration method is a potentially powerful tool that can be used to assess low-level exposure to VX...
  16. ncbi request reprint Analysis of urinary metabolites of sulfur mustard in two individuals after accidental exposure
    John R Barr
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, Georgia 30341, USA
    J Anal Toxicol 32:10-6. 2008
    ..The bis-mercapturate of mustard sulfone was detected in patient 1 (3.1 ng/mL) on day 2 but was not detected in samples taken on subsequent days...
  17. ncbi request reprint Determination of 14 polycyclic aromatic hydrocarbons in mainstream smoke from U.S. brand and non-U.S. brand cigarettes
    Yan S Ding
    Emergency Response and Air Toxicants Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway NE, Mailstop F 47, Atlanta, Georgia 30341, USA
    Environ Sci Technol 40:1133-8. 2006
    ..The findings suggest that tobacco blend and nitrate levels may influence PAH deliveries, but other factors may confound this relation...
  18. ncbi request reprint Determination of 10 carcinogenic polycyclic aromatic hydrocarbons in mainstream cigarette smoke
    Yan S Ding
    Emergency Response and Air Toxicants Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Mailstop F 47, Atlanta, Georgia 30341 3724, USA
    J Agric Food Chem 55:5966-73. 2007
    ..However, if highly ventilated cigarettes were smoked under more intense conditions (e.g., larger or more frequent puffs, vents blocked), their PAH levels equaled or exceeded their full-flavor counterparts under ISO conditions...
  19. doi request reprint Global surveillance of oral tobacco products: total nicotine, unionised nicotine and tobacco-specific N-nitrosamines
    Stephen B Stanfill
    Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Emergency Response and Air Toxicants Branch, 4770 Buford Highway, Atlanta, Georgia 30341, USA
    Tob Control 20:e2. 2011
    ..The aim of this study was to determine typical pH ranges and concentrations of total nicotine, unionised nicotine (the most readily absorbed form) and five TSNAs in selected oral tobacco products distributed globally...
  20. ncbi request reprint Determination of tar, nicotine, and carbon monoxide yields in the smoke of bidi cigarettes
    Clifford H Watson
    Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Atlanta, GA 30341, USA
    Nicotine Tob Res 5:747-53. 2003
    ..7+/-.4 mg/bidi), and CO (39.2+/-5.7 mg/bidi). In comparison, traditional cigarettes smoked using the bidi cigarette protocol have lower tar and CO yields, but have nicotine deliveries comparable with bidi cigarettes...
  21. doi request reprint Chemical analysis of Alaskan Iq'mik smokeless tobacco
    Bryan A Hearn
    Centers for Disease Control and Prevention, Office of Noncommunicable Diseases, Injury and Environmental Health, Atlanta, GA 30341, USA
    Nicotine Tob Res 15:1283-8. 2013
    ..Our chemical characterization of iq'mik shows that iq'mik is not a safe alternative to smoking or other ST use...
  22. doi request reprint The influence of physicochemical properties on the internal dose of trihalomethanes in humans following a controlled showering exposure
    Lalith K Silva
    Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Expo Sci Environ Epidemiol 23:39-45. 2013
    ..The physicochemical properties (volatility, partition coefficients, and Henry's law constant) are useful parameters for predicting THM movement between matrices and understanding THM exposure during showering...
  23. doi request reprint Simultaneous analysis of 28 urinary VOC metabolites using ultra high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (UPLC-ESI/MSMS)
    K Udeni Alwis
    National Center for Environmental Health, Division of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    Anal Chim Acta 750:152-60. 2012
    ..0001) correlations between serum cotinine and most of the tobacco-related biomarkers measured. These findings confirm that this method can effectively quantify urinary VOC metabolites in a population exposed to volatile organics...
  24. ncbi request reprint Quantification of fuel oxygenate ethers in human blood using solid-phase microextraction coupled with gas chromatography-high-resolution mass spectrometry
    Lalith K Silva
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Anal Toxicol 32:273-80. 2008
    ..7 to 5.4%) and accuracy (96-100%). This method provides a means to assess fuel oxygenate exposure and study the potential relationship between exposure and adverse health outcomes...
  25. ncbi request reprint Assessment of tobacco-specific nitrosamines in the tobacco and mainstream smoke of Bidi cigarettes
    Weijia Wu
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, Mailstop F 47, Atlanta, GA 30341, USA
    Carcinogenesis 25:283-7. 2004
    ..Our analytical findings concur with the previous biologic and biochemical evidence supporting epidemiologic studies linking bidi use with various cancers, especially oral cavity and lung cancers...
  26. ncbi request reprint Simultaneous determination of five tobacco-specific nitrosamines in mainstream cigarette smoke by isotope dilution liquid chromatography/electrospray ionization tandem mass spectrometry
    Weijia Wu
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, Georgia 30341, USA
    Anal Chem 75:4827-32. 2003
    ..This new method provides higher sensitivity, specificity, and throughput than earlier methods for TSNA determination...
  27. doi request reprint Quantitative analysis of six heterocyclic aromatic amines in mainstream cigarette smoke condensate using isotope dilution liquid chromatography-electrospray ionization tandem mass spectrometry
    Liqin Zhang
    Emergency Response and Air Toxicants Branch, Division of Laboratory Science, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Mailstop F 47, Atlanta, GA 30341 3724, USA
    Nicotine Tob Res 13:120-6. 2011
    ..We have developed and validated a straightforward high-throughput method to quantify HAA levels in mainstream cigarette smoke and demonstrated the applicability by analyzing select research and domestic cigarette brands...
  28. ncbi request reprint Quantitation of biomarkers of exposure to nitrogen mustards in urine from rats dosed with nitrogen mustards and from an unexposed human population
    Sharon W Lemire
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3724, USA
    J Anal Toxicol 28:320-6. 2004
    ..Neither EDEA (LOD 0.4 ng/mL) nor MDEA (LOD 0.8 ng/mL) was detected above the LOD in the human samples...
  29. ncbi request reprint Analysis of volatile organic compounds in mainstream cigarette smoke
    Gregory M Polzin
    Emergency Response and Air Toxicants Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, USA
    Environ Sci Technol 41:1297-302. 2007
    ..In this report we demonstrate the method's analytical capabilities by quantitatively analyzing 13 selected VOCs in mainstream cigarette smoke from top-selling domestic brands...
  30. doi request reprint Simultaneous determination of six mercapturic acid metabolites of volatile organic compounds in human urine
    Yan S Ding
    Emergency Response and Air Toxicants Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Mailstop F 47, Atlanta, Georgia 30341 3724, USA
    Chem Res Toxicol 22:1018-25. 2009
    ..4, 839.7, 10.2, 509.7, 2.2, and 0.9 microg/g creatinine, respectively. All VOC MAs measured were higher among smokers than among nonsmokers, with the exception of MHBMA...
  31. ncbi request reprint Solid-phase microextraction-based approach to determine free-base nicotine in trapped mainstream cigarette smoke total particulate matter
    Clifford H Watson
    Emergency Response and Air Toxicants Branch, Mailstop F 47, Centers for Disease Control and Prevention, 4770 Buford Highway N E, Atlanta, GA 30341 3724, USA
    J Agric Food Chem 52:7240-5. 2004
    ..01 to 0.08 mg/cigarette. The measured ranges of free-base nicotine were remarkably similar over the different tar and nicotine delivery categories of full-flavored, light, and ultralight cigarette brands...
  32. ncbi request reprint Measurement of trihalomethanes and methyl tert-butyl ether in whole blood using gas chromatography with high-resolution mass spectrometry
    Michael A Bonin
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Anal Toxicol 29:81-9. 2005
    ..3 to 2.4 ng/L, with linear ranges of three orders of magnitude. This method proved adequate for measuring the THMs and MTBE in most blood samples tested from a diverse U.S. reference population...
  33. doi request reprint Chemical characterization of domestic oral tobacco products: total nicotine, pH, unprotonated nicotine and tobacco-specific N-nitrosamines
    Tameka S Lawler
    Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Tobacco and Volatiles Branch, Atlanta, GA 30341, USA
    Food Chem Toxicol 57:380-6. 2013
    ..Characterizing the chemical content of these products may be helpful in further understanding the risk of marketing these products to oral tobacco users and smokers as an alternative and discrete form of tobacco...
  34. ncbi request reprint Measurement of trihalomethanes and methyl tertiary-butyl ether in tap water using solid-phase microextraction GC-MS
    Frederick L Cardinali
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA
    J Chromatogr Sci 42:200-6. 2004
    ..THMs are stable for extended periods in tap water samples after quenching of residual chlorine and buffering to pH 6.5, thus enabling larger epidemiologic field studies with simplified sample collection protocols...
  35. ncbi request reprint Quantification of flavor-related compounds in the unburned contents of bidi and clove cigarettes
    Stephen B Stanfill
    Division of Laboratory Sciences, Emergency Response and Air Toxicants Branch, National Center for Environmental Health, U S Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3719, USA
    J Agric Food Chem 54:8580-8. 2006
    ..S. cigarette tobacco. Research is underway to determine the levels of these compounds delivered in smoke. It is not known what effect inhalation of these compounds has on smokers...
  36. pmc Biological exposure assessment to tetrachloroethylene for workers in the dry cleaning industry
    Lauralynn T McKernan
    Centers for Disease Control and Prevention CDC National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R 15, Cincinnati, OH 45226, USA
    Environ Health 7:12. 2008
    ..The purpose of this study was to assess the feasibility of conducting biological tetrachloroethylene (perchloroethylene, PCE) exposure assessments of dry cleaning employees in conjunction with evaluation of possible PCE health effects...
  37. ncbi request reprint Effect of perchloroethylene, smoking, and race on oxidative DNA damage in female dry cleaners
    Mark Toraason
    The National Institute for Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
    Mutat Res 539:9-18. 2003
    ..Results indicate a reduction in oxidative DNA damage in PERC exposed dry cleaners relative to launderers, but PERC could not clearly be defined as the source of the effect...
  38. ncbi request reprint Quantitative determination of the hydrolysis products of nitrogen mustards in human urine by liquid chromatography-electrospray ionization tandem mass spectrometry
    Sharon W Lemire
    Division of Laboratory Sciences, National Center for Environmental Health Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3724, USA
    J Anal Toxicol 27:1-6. 2003
    ..The method limits of detection were 0.41 ng/mL for EDEA and 0.96 ng/mL for MDEA in 1 mL of urine with coefficients of variation < 10% for both compounds...
  39. ncbi request reprint Determination of nicotine and other minor alkaloids in international cigarettes by solid-phase microextraction and gas chromatography/mass spectrometry
    Weijia Wu
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Anal Chem 74:4878-84. 2002
    ..These results strongly suggest that such differences reflect variations associated with blend compositions, tobacco quality, and manufacturing practices...
  40. pmc Urinary levels of trichloroacetic acid, a disinfection by-product in chlorinated drinking water, in a human reference population
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 111:151-4. 2003
    ....
  41. ncbi request reprint From the mouse to the mass spectrometer: detection and differentiation of the endoproteinase activities of botulinum neurotoxins A-G by mass spectrometry
    Anne E Boyer
    National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Atlanta, Georgia 30341 3724, USA
    Anal Chem 77:3916-24. 2005
    ..039 to 0.625 mouse LD(50)/mL for toxin types A, B, E, and F in a buffer system. The Endopep-MS assay is the first to differentiate all seven BoNT types, is sensitive, specific, and has the potential to quantify toxin activity...
  42. ncbi request reprint Quantitative detection of trichloroacetic acid in human urine using isotope dilution high-performance liquid chromatography-electrospray ionization tandem mass spectrometry
    Zsuzsanna Kuklenyik
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Anal Chem 74:2058-63. 2002
    ..The method is simple and fast and is not labor intensive (sample preparation and analysis can be performed in approximately 15 min) with a limit of detection of 0.5 ng/mL in 1 mL of urine...
  43. ncbi request reprint Quantitation of 2-chlorovinylarsonous acid in human urine by automated solid-phase microextraction--gas chromatography--mass spectrometry
    Joe V Wooten
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, Mailstop F19, Atlanta, GA 30341, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 772:147-53. 2002
    ..The assay was validated on human urine samples spiked with CVAA to determine the accuracy, precision, and limit of detection (LOD). The LOD was 7.4 pg in 1 ml of urine...
  44. ncbi request reprint The recommended role of exposure biomarkers for the surveillance of environmental and occupational chemical exposures in military deployments: policy considerations
    Lisa M May
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Room A1044, Bethesda, MD 20814 4799, USA
    Mil Med 169:761-7. 2004
    ....
  45. pmc Influence of tap water quality and household water use activities on indoor air and internal dose levels of trihalomethanes
    John R Nuckols
    Environmental Health Advanced Systems Laboratory, Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523 1681, USA
    Environ Health Perspect 113:863-70. 2005
    ..Further research is also needed in designing epidemiologic studies that minimize data collection burden yet maximize accuracy in classification of dermal and inhalation THM exposure during hot water use activities...
  46. pmc Using biologic markers in blood to assess exposure to multiple environmental chemicals for inner-city children 3-6 years of age
    Ken Sexton
    University of Texas School of Public Health, Brownsville, Texas 78520 4956, USA
    Environ Health Perspect 114:453-9. 2006
    ..Results demonstrate that cumulative exposures to multiple environmental carcinogens and neurotoxins can be comparatively high for children from a poor inner-city neighborhood...
  47. pmc Changes in breath trihalomethane levels resulting from household water-use activities
    Sydney M Gordon
    Battelle Memorial Institute, 505 King Avenue, Columbus, OH 43201, USA
    Environ Health Perspect 114:514-21. 2006
    ..Future studies will address the effects that changes in these common water-use activities may have on exposure...
  48. pmc Assessing exposure in epidemiologic studies to disinfection by-products in drinking water: report from an international workshop
    Tye E Arbuckle
    Bureau of Reproductive and Child Health, Health Canada, Ottawa, Ontario, Canada
    Environ Health Perspect 110:53-60. 2002
    ..Similarly, exposure classification categories in epidemiologic studies should be chosen to make results useful for regulatory or policy decision making...
  49. ncbi request reprint Comparison of trihalomethanes in tap water and blood
    Amy M Miles
    Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill 27599 7400, USA
    Environ Sci Technol 36:1692-8. 2002
    ..This finding suggests that other factors, in addition to tap water concentrations, may be important in determining THM concentrations in the blood...
  50. ncbi request reprint The development and testing of a dermal exposure system for pharmacokinetic studies of administered and ambient water contaminants
    James D Prah
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, MD 58B, Research Triangle Park, NC 27711, USA
    J Pharmacol Toxicol Methods 47:189-95. 2002
    ..In order to investigate the pharmacokinetics of water-borne chemicals while eliminating exposures by other routes, a dermal exposure system was developed to expose the hand and forearm of human subjects...
  51. pmc Children's exposure to volatile organic compounds as determined by longitudinal measurements in blood
    Ken Sexton
    University of Texas School of Public Health, Brownsville Regional Campus, Brownsville, Texas, USA
    Environ Health Perspect 113:342-9. 2005
    ..For siblings living in the same household, we found strong statistical associations between measured blood VOC concentrations...