James M Antonini

Summary

Affiliation: Centers for Disease Control and Prevention
Country: USA

Publications

  1. doi request reprint Alterations in welding process voltage affect the generation of ultrafine particles, fume composition, and pulmonary toxicity
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Nanotoxicology 5:700-10. 2011
  2. doi request reprint Systemic immune cell response in rats after pulmonary exposure to manganese-containing particles collected from welding aerosols
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Immunotoxicol 9:184-92. 2012
  3. ncbi request reprint Effect of asphalt fume inhalation exposure at simulated road paving conditions prior to bacterial infection on lung defense responses in rats
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Inhal Toxicol 15:1347-68. 2003
  4. ncbi request reprint Pulmonary responses to welding fumes: role of metal constituents
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 67:233-49. 2004
  5. ncbi request reprint Effect of short-term stainless steel welding fume inhalation exposure on lung inflammation, injury, and defense responses in rats
    James M Antonini
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, Morgantown, WV 26505, USA
    Toxicol Appl Pharmacol 223:234-45. 2007
  6. doi request reprint Persistence of deposited metals in the lungs after stainless steel and mild steel welding fume inhalation in rats
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Arch Toxicol 85:487-98. 2011
  7. ncbi request reprint Metal composition and solubility determine lung toxicity induced by residual oil fly ash collected from different sites within a power plant
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Mol Cell Biochem 255:257-65. 2004
  8. doi request reprint Pulmonary toxicity and extrapulmonary tissue distribution of metals after repeated exposure to different welding fumes
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virgina 26505, USA
    Inhal Toxicol 22:805-16. 2010
  9. ncbi request reprint Suppression in lung defense responses after bacterial infection in rats pretreated with different welding fumes
    James M Antonini
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Toxicol Appl Pharmacol 200:206-18. 2004
  10. ncbi request reprint Development of an animal model to study the potential neurotoxic effects associated with welding fume inhalation
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Neurotoxicology 27:745-51. 2006

Detail Information

Publications68

  1. doi request reprint Alterations in welding process voltage affect the generation of ultrafine particles, fume composition, and pulmonary toxicity
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Nanotoxicology 5:700-10. 2011
    ..In summary, a modest raise in welding voltage affected fume size and elemental composition and altered the temporal lung toxicity profile...
  2. doi request reprint Systemic immune cell response in rats after pulmonary exposure to manganese-containing particles collected from welding aerosols
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Immunotoxicol 9:184-92. 2012
    ....
  3. ncbi request reprint Effect of asphalt fume inhalation exposure at simulated road paving conditions prior to bacterial infection on lung defense responses in rats
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Inhal Toxicol 15:1347-68. 2003
    ..It was concluded that acute inhalation of asphalt fumes at a high concentration had a minimal effect on lung immune responses to infection in rats...
  4. ncbi request reprint Pulmonary responses to welding fumes: role of metal constituents
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 67:233-49. 2004
    ..This article reviews the role that metals play in the pulmonary effects associated with welding fume exposure in workers and laboratory animals...
  5. ncbi request reprint Effect of short-term stainless steel welding fume inhalation exposure on lung inflammation, injury, and defense responses in rats
    James M Antonini
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 2015, Morgantown, WV 26505, USA
    Toxicol Appl Pharmacol 223:234-45. 2007
    ..Additional chronic inhalation studies are needed to further examine the lung effects associated with SS welding fume exposure...
  6. doi request reprint Persistence of deposited metals in the lungs after stainless steel and mild steel welding fume inhalation in rats
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Arch Toxicol 85:487-98. 2011
    ..The potentially more toxic metals (e.g., Mn, Cr) present in the stainless steel fume were cleared from the lungs more quickly than Fe, likely increasing their translocation from the respiratory system to other organs...
  7. ncbi request reprint Metal composition and solubility determine lung toxicity induced by residual oil fly ash collected from different sites within a power plant
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Mol Cell Biochem 255:257-65. 2004
    ..These results are most likely due to differences in metal composition and solubility of the ROFA samples...
  8. doi request reprint Pulmonary toxicity and extrapulmonary tissue distribution of metals after repeated exposure to different welding fumes
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virgina 26505, USA
    Inhal Toxicol 22:805-16. 2010
    ..Importantly, increased deposition of Mn, but not other metals, was observed in discrete brain regions, including dopamine-rich areas (e.g., striatum and midbrain)...
  9. ncbi request reprint Suppression in lung defense responses after bacterial infection in rats pretreated with different welding fumes
    James M Antonini
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Toxicol Appl Pharmacol 200:206-18. 2004
    ....
  10. ncbi request reprint Development of an animal model to study the potential neurotoxic effects associated with welding fume inhalation
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Neurotoxicology 27:745-51. 2006
    ..With the development of this novel system, an animal model has been established using controlled welding exposures to investigate the possible mechanisms by which welding fume may affect the central nervous system...
  11. ncbi request reprint Fate of manganese associated with the inhalation of welding fumes: potential neurological effects
    James M Antonini
    Health Effects Laboratory Division, National Institute of Occupational Safety and Health, 1095 Willowdale Road M S 2015, Morgantown WV 26505, USA
    Neurotoxicology 27:304-10. 2006
    ....
  12. ncbi request reprint Effect of stainless steel manual metal arc welding fume on free radical production, DNA damage, and apoptosis induction
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Mol Cell Biochem 279:17-23. 2005
    ..A more comprehensive in vivo animal study is ongoing in the laboratory that is continuing these experiments to try to elucidate the potential mechanisms that may be involved with welding fume-induced lung disease...
  13. doi request reprint Mild steel welding fume causes manganese accumulation and subtle neuroinflammatory changes but not overt neuronal damage in discrete brain regions of rats after short-term inhalation exposure
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Neurotoxicology 30:915-25. 2009
    ..The neurofunctional significance of these findings currently is being investigated in longer, more chronic welding fume exposure studies...
  14. ncbi request reprint Design, construction, and characterization of a novel robotic welding fume generator and inhalation exposure system for laboratory animals
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Occup Environ Hyg 3:194-203; quiz D45. 2006
    ....
  15. ncbi request reprint Short-term inhalation exposure to mild steel welding fume had no effect on lung inflammation and injury but did alter defense responses to bacteria in rats
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Inhal Toxicol 21:182-92. 2009
    ..More chronic inhalation studies are needed to further examine the immune effects and to elucidate the possible mechanisms of the suppressed lung defense response to infection associated with the inhalation of MS welding fume...
  16. ncbi request reprint Welding fume exposure and associated inflammatory and hyperplastic changes in the lungs of tumor susceptible a/j mice
    Claudia Solano-Lopez
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, 26505, USA
    Toxicol Pathol 34:364-72. 2006
    ..Our findings that WF causes persistent bronchiolar and peribronchiolar epithelial changes, suggest a need for studies of bronchiolar changes after WF exposure...
  17. ncbi request reprint Application of laser scanning confocal microscopy in the analysis of particle-induced pulmonary fibrosis
    J M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Toxicol Sci 51:126-34. 1999
    ..LSCM, and its associated advanced image analysis and three-dimensional capabilities, is an alternative method to both quickly quantitate and examine fibrotic lung disease without physical disruption of the tissue specimen...
  18. ncbi request reprint Changes in F-actin organization induced by hard metal particle exposure in rat pulmonary epithelial cells using laser scanning confocal microscopy
    J M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    In Vitr Mol Toxicol 13:5-16. 2000
    ..We conclude the pulmonary response evoked in the lung by inhalation of high levels of WC-Co particles is unlikely due to alterations in the F-actin microfilaments of lung-epithelial cells...
  19. ncbi request reprint Subchronic silica exposure enhances respiratory defense mechanisms and the pulmonary clearance of Listeria monocytogenes in rats
    J M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Inhal Toxicol 12:1017-36. 2000
    ..These elevations in pulmonary immune response are likely responsible for the increase in pulmonary clearance of L. monocytogenes observed with preexposure to silica...
  20. ncbi request reprint Strain-related differences of nonspecific respiratory defense mechanisms in rats using a pulmonary infectivity model
    J M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Inhal Toxicol 13:85-102. 2001
    ..F344 rats may then represent a sensitive model for the examination of respiratory defense mechanisms after bacterial challenge...
  21. ncbi request reprint Effect of age on respiratory defense mechanisms: pulmonary bacterial clearance in Fischer 344 rats after intratracheal instillation of Listeria monocytogenes
    J M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Chest 120:240-9. 2001
    ..To examine the lung defense mechanisms of both young and aged rats before and after pulmonary challenge with a bacterial pathogen...
  22. ncbi request reprint Residual oil fly ash increases the susceptibility to infection and severely damages the lungs after pulmonary challenge with a bacterial pathogen
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, MS 2015, Morgantown, West Virginia 26505, USA
    Toxicol Sci 70:110-9. 2002
    ..These results suggest that pulmonary exposure to ROFA may alter AM function and lead to increased susceptibility to lung infection in exposed populations...
  23. ncbi request reprint Pulmonary effects of welding fumes: review of worker and experimental animal studies
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Am J Ind Med 43:350-60. 2003
    ..Approximately one million workers worldwide perform welding as part of their work duties. Electric arc welding processes produce metal fumes and gases which may be harmful to exposed workers...
  24. ncbi request reprint Health effects of welding
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road M S 2015, Morgantown, WV 26505, USA
    Crit Rev Toxicol 33:61-103. 2003
    ..Therefore, an understanding of possible adverse health effects of exposure to welding fumes is essential to risk assessment and the development of prevention strategies and will impact a large population of workers...
  25. ncbi request reprint Exposure of brown Norway rats to diesel exhaust particles prior to ovalbumin (OVA) sensitization elicits IgE adjuvant activity but attenuates OVA-induced airway inflammation
    Caroline C Dong
    School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506 9530, USA
    Toxicol Sci 88:150-60. 2005
    ....
  26. doi request reprint Short-term inhalation of stainless steel welding fume causes sustained lung toxicity but no tumorigenesis in lung tumor susceptible A/J mice
    Patti C Zeidler-Erdely
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, WV 26505, USA
    Inhal Toxicol 23:112-20. 2011
    ..Under our exposure conditions, GMA-SS exposure resulted in no significant tumor development in A/J mice...
  27. ncbi request reprint Effect of diesel exhaust particles on allergic reactions and airway responsiveness in ovalbumin-sensitized brown Norway rats
    Caroline C Dong
    School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506 9530, USA
    Toxicol Sci 88:202-12. 2005
    ..This DEP effect may be, at least partially, attributed to the elevated generation of ROS in AM and ATII cells, a depletion of GSH in AM and lymphocytes, and an increase in AM and ATII cell production of NO...
  28. doi request reprint Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes
    Krishnan Sriram
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Arch Toxicol 84:521-40. 2010
    ..Whether such perturbations will lead to PD-like neuropathological manifestations remains to be elucidated...
  29. ncbi request reprint Intratracheal amiodarone administration to F344 rats directly damages lung airway and parenchymal cells
    Michael D Taylor
    Department of Pharmacology and Toxicology, West Virginia University, Morgantown, WV 26506, USA
    Toxicol Appl Pharmacol 188:92-103. 2003
    ..t. AD treatment are similar to the mechanisms that underlie human AIPT. Therefore these data suggest that investigators should use caution in extrapolating results from animal studies that utilize i.t. administration of AD to human AIPT...
  30. ncbi request reprint Sustained effect of inhaled diesel exhaust particles on T-lymphocyte-mediated immune responses against Listeria monocytogenes
    Xuejun J Yin
    School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506 9530, USA
    Toxicol Sci 88:73-81. 2005
    ..The results support the epidemiological observations that exposure to DEP may be responsible for the pulmonary health effects on humans...
  31. ncbi request reprint Effects of welding fumes of differing composition and solubility on free radical production and acute lung injury and inflammation in rats
    Michael D Taylor
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Toxicol Sci 75:181-91. 2003
    ..Additionally, both the soluble and insoluble fractions of the MMA-SS fume were required to produce most effects, indicating that the responses are not dependent exclusively on the soluble metals...
  32. ncbi request reprint Pulmonary exposure to 1 --> 3-beta-glucan alters adaptive immune responses in rats
    Shih Houng Young
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Inhal Toxicol 18:865-74. 2006
    ..In summary, rats exposed to zymosan had an increase in acute inflammation, and the altered lymphocyte profiles were consistent with the findings of epidemiology studies...
  33. doi request reprint The soluble nickel component of residual oil fly ash alters pulmonary host defense in rats
    Jenny R Roberts
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, and West Virginia University, Morgantown, West Virginia 26505, USA
    J Immunotoxicol 6:49-61. 2009
    ..Soluble Ni is likely the primary metal involved in the increased susceptibility to infection observed in rats exposed to the soluble metals of ROFA...
  34. ncbi request reprint Suppression of cell-mediated immune responses to listeria infection by repeated exposure to diesel exhaust particles in brown Norway rats
    Xuejun J Yin
    School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506, USA
    Toxicol Sci 77:263-71. 2004
    ....
  35. ncbi request reprint Suppression of phagocytic and bactericidal functions of rat alveolar macrophages by the organic component of diesel exhaust particles
    Xuejun J Yin
    School of Medicine, West Virginia University, Morgantown, West Virginia 26506 9203, USA
    J Toxicol Environ Health A 70:820-8. 2007
    ..monocytogenes and an increased susceptibility of the lung to bacterial infection...
  36. ncbi request reprint Soluble metals associated with residual oil fly ash increase morbidity and lung injury after bacterial infection in rats
    Jenny R Roberts
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, and Department of Physiology and Pharmacology, West Virginia University, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 67:251-63. 2004
    ..These results suggest that soluble metals present in ROFA may play a key role in increased susceptibility to pulmonary infection in exposed populations...
  37. ncbi request reprint Soluble metals in residual oil fly ash alter innate and adaptive pulmonary immune responses to bacterial infection in rats
    Jenny R Roberts
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Toxicol Appl Pharmacol 221:306-19. 2007
    ..The results suggest that soluble metals in ROFA increase lung injury and inflammation, and alter both innate and adaptive pulmonary immune responses...
  38. doi request reprint Manganese accumulation in nail clippings as a biomarker of welding fume exposure and neurotoxicity
    Krishnan Sriram
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA
    Toxicology 291:73-82. 2012
    ..The non-invasive means by which nail clippings can be collected, stored, and transported with relative ease, make it an attractive surrogate for biomonitoring WF exposures in occupational settings...
  39. ncbi request reprint Role of metal-induced reactive oxygen species generation in lung responses caused by residual oil fly ash
    Anthony B Lewis
    Department of Safety and Environmental Management, College of Engineering and Mineral Resources, Morgantown, WV 26506, USA
    J Biosci 28:13-8. 2003
    ..particulate forms. ROS generated by ROFA-sol. as measured by ESR appear not to play a major role in the lung injury caused after ROFA exposure...
  40. pmc Type I interferon and pattern recognition receptor signaling following particulate matter inhalation
    Aaron Erdely
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Part Fibre Toxicol 9:25. 2012
    ..Whole blood cells, aorta and lung were harvested for global gene expression analysis with subsequent Ingenuity Pathway Analysis and confirmatory qRT-PCR. Serum was collected for protein profiling...
  41. pmc Lung toxicity and biodistribution of Cd/Se-ZnS quantum dots with different surface functional groups after pulmonary exposure in rats
    Jenny R Roberts
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Part Fibre Toxicol 10:5. 2013
    ..The goal of the present study was to assess pulmonary toxicity, clearance, and biodistribution of QD with different functional groups in rats after pulmonary exposure...
  42. pmc Response of the mouse lung transcriptome to welding fume: effects of stainless and mild steel fumes on lung gene expression in A/J and C57BL/6J mice
    Patti C Zeidler-Erdely
    Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown 26505, USA
    Respir Res 11:70. 2010
    ....
  43. pmc Alteration of pulmonary immunity to Listeria monocytogenes by diesel exhaust particles (DEPs). II. Effects of DEPs on T-cell-mediated immune responses in rats
    Xue Jun Yin
    School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506, USA
    Environ Health Perspect 111:524-30. 2003
    ..This T-cell immune response was sufficient to allow the Brown Norway rats to clear the bacteria at 7 days postinfection and overcome the down-regulation of the innate immunity by the acute DEP exposure...
  44. pmc Comparison of stainless and mild steel welding fumes in generation of reactive oxygen species
    Stephen S Leonard
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV, USA
    Part Fibre Toxicol 7:32. 2010
    ..An inhalation exposure chamber located at NIOSH was used to collect the welding fume particles...
  45. ncbi request reprint Induction of secondary apoptosis, inflammation, and lung fibrosis after intratracheal instillation of apoptotic cells in rats
    Liying Wang
    National Institute for Occupational Safety and Health, 1095 Willowdale Rd, Morgantown, WV 26505, USA
    Am J Physiol Lung Cell Mol Physiol 290:L695-L702. 2006
    ..Together, our results demonstrate a direct effect of apoptotic cell accumulation on inflammatory and fibrotic pulmonary responses and the continuous induction of lung cell apoptosis by apoptotic cell instillation...
  46. pmc Alteration of pulmonary immunity to Listeria monocytogenes by diesel exhaust particles (DEPs). I. Effects of DEPs on early pulmonary responses
    Xue Jun Yin
    School of Pharmacy, West Virginia University, Morgantown, West Virginia 26506 9530, USA
    Environ Health Perspect 110:1105-11. 2002
    ..DEPs may also suppress cell-mediated immunity by inhibiting AM secretion of IL-12, a key cytokine for the initiation of T helper type 1 cell development in Listeria infection...
  47. ncbi request reprint Roles of reactive oxygen species and heme oxygenase-1 in modulation of alveolar macrophage-mediated pulmonary immune responses to Listeria monocytogenes by diesel exhaust particles
    Xuejun J Yin
    School of Pharmacy, West Virginia University, 1 Medical Center Drive, Morgantown, WV 26506, USA
    Toxicol Sci 82:143-53. 2004
    ..The results also suggest that HO-1 may play an important role in regulating production of IL-10 by DEP-exposed and L. monocytogenes-infected AM...
  48. doi request reprint Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding fumes
    Krishnan Sriram
    Toxicology and Molecular Biology Branch, Mailstop L 3014, CDC NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505, USA
    FASEB J 24:4989-5002. 2010
    ..Whether these molecular alterations culminate in neurobehavioral and neuropathological deficits reminiscent of PD remains to be ascertained...
  49. doi request reprint Inhalation exposure of gas-metal arc stainless steel welding fume increased atherosclerotic lesions in apolipoprotein E knockout mice
    Aaron Erdely
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505 2888, United States
    Toxicol Lett 204:12-6. 2011
    ..These results complement epidemiological and functional human studies that suggest welding may result in adverse cardiovascular effects...
  50. ncbi request reprint Quantitative image analysis of drug-induced lung fibrosis using laser scanning confocal microscopy
    Michael D Taylor
    Department of Pharmacology and Toxicology, Robert C Byrd Health Sciences Center of West Virginia University, Morgantown, WV 26506, USA
    Toxicol Sci 67:295-302. 2002
    ..LSCM could be particularly useful when tissue quantity is limited, such as when tissue has been archived from previous studies, or when analyzing human lung biopsy samples for disease diagnosis, where biochemical analysis is difficult...
  51. doi request reprint Lung tumor production and tissue metal distribution after exposure to manual metal ARC-stainless steel welding fume in A/J and C57BL/6J mice
    Patti C Zeidler-Erdely
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Health Effects Laboratory Division, 1095 Willowdale Road M S L2015, Morgantown, WV 26505, USA
    J Toxicol Environ Health A 74:728-36. 2011
    ..In addition, long-term extrapulmonary tissue alterations in metals in the susceptible A/J mouse suggest that the adverse effects of this fume might be cumulative...
  52. ncbi request reprint Role of lung surfactant in phagocytic clearance of apoptotic cells by macrophages in rats
    Liying Wang
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Lab Invest 86:458-66. 2006
    ....
  53. ncbi request reprint Performance evaluation of cytometric bead assays for the measurement of lung cytokines in two rodent models
    Shih Houng Young
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Immunol Methods 331:59-68. 2008
    ..In the case of the mouse CBA, a companion measurement is recommended if samples with low concentrations of an analyte are reported and extrapolated below sensitivity or zero...
  54. doi request reprint Toxicological evaluation of lung responses after intratracheal exposure to non-dispersed titanium dioxide nanorods
    Jenny R Roberts
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 74:790-810. 2011
    ..To summarize, non-dispersed TiO₂ nanorods were found to induce radical formation and cellular oxidant production, and to generate transient and reversible pneumotoxic effects, and to not markedly alter pulmonary immune function...
  55. ncbi request reprint Matrix metalloproteinase induction in fibrosis and fibrotic nodule formation due to silica inhalation
    James F Scabilloni
    National Institute for Occupational Safety and Health, Pathology and Physiology Research Branch, 1095 Willowdale Rd, Morgantown, WV 26505, USA
    Am J Physiol Lung Cell Mol Physiol 288:L709-17. 2005
    ..In summary, MMP activity was upregulated at 40 days of silica exposure and progressively increased during ensuing fibrotic responses. Early expression of stromelysin was found in fibrosing alveolar walls and fibrotic nodules...
  56. pmc Sequential exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity
    Anna A Shvedova
    Pathology Physiology Research Branch, HELD, National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA
    Am J Respir Cell Mol Biol 38:579-90. 2008
    ..In conclusion, enhanced acute inflammation and pulmonary injury with delayed bacterial clearance after SWCNT exposure may lead to increased susceptibility to lung infection in exposed populations...
  57. doi request reprint Relationship between pulmonary and systemic markers of exposure to multiple types of welding particulate matter
    Aaron Erdely
    Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, Morgantown, WV 26505 2888, United States
    Toxicology 287:153-9. 2011
    ..In conclusion, varying types of welding fumes elicit quantitatively different systemic inflammatory and/or stress responses...
  58. doi request reprint Immunotoxicology of arc welding fume: worker and experimental animal studies
    Patti C Zeidler-Erdely
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Immunotoxicol 9:411-25. 2012
    ..The objective of this report was to review both human and animal studies that have examined the effect of welding fume pulmonary exposure on local and systemic immune responses...
  59. ncbi request reprint Efficacy of a technique for exposing the mouse lung to particles aspirated from the pharynx
    G V S Rao
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 66:1441-52. 2003
    ..2% of the administered beryllium. These findings demonstrate that following aspiration of pharyngeal deposited particles, exposures to the deep lung are repeatable, technically simple, and highly correlated to the administered dose...
  60. ncbi request reprint Preexposure to repeated low doses of zymosan increases the susceptibility to pulmonary infection in rats
    Shih Houng Young
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Exp Lung Res 35:570-90. 2009
    ..The innate immune response was down-regulated and a Th2 immune response was preferentially induced rather than a Th1 response, the latter being more effective toward the resolution of a L. monocytogenes infection...
  61. ncbi request reprint A comparison of the pulmonary inflammatory potential of different components of yeast cell wall
    Shih Houng Young
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    J Toxicol Environ Health A 70:1116-24. 2007
    ..There is also evidence that zymosan is more potent than purified 1-->3-beta-glucan alone. Evidence indicates that 1-->3-beta-glucan is the major inflammatory component in yeast and fungal cell walls...
  62. pmc Pulmonary inflammation and tumor induction in lung tumor susceptible A/J and resistant C57BL/6J mice exposed to welding fume
    Patti C Zeidler-Erdely
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, USA
    Part Fibre Toxicol 5:12. 2008
    ..abstract:..
  63. ncbi request reprint Potential role of apoptotic macrophages in pulmonary inflammation and fibrosis
    Liying Wang
    National Institute for Occupational Safety and Health, Physiology and Pathology Research Branch, Morgantown, West Virginia 26505, USA
    J Cell Physiol 194:215-24. 2003
    ..Published 2002 Wiley-Liss, Inc...
  64. doi request reprint Single pre-exposure to a high dose of zymosan enhances lung defense mechanisms and accelerates the pulmonary clearance of a bacterial pathogen in rats
    Shih Houng Young
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Exp Lung Res 34:559-78. 2008
    ....
  65. ncbi request reprint PbCrO4 mediates cellular responses via reactive oxygen species
    Stephen S Leonard
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Mol Cell Biochem 255:171-9. 2004
    ..These particles could induce chronic production of ROS and activation of NF-kappaB and AP-1. Such induction of transcription pathways may be involved in the inflammatory and carcinogenic responses induced by Cr(VI)-containing particles...
  66. pmc Skin as a route of exposure and sensitization in chronic beryllium disease
    Sally S Tinkle
    Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Environ Health Perspect 111:1202-8. 2003
    ....
  67. doi request reprint A case report of elevated blood cadmium
    Christopher J Martin
    Institute of Occupational and Environmental Health, School of Medicine, West Virginia University, Morgantown, WV 26506 9190, USA
    Occup Med (Lond) 59:130-2. 2009
    ..5-fold greater than the original brand. These results suggest that the consumption of different brands of cigarettes can lead to marked variations in whole-blood cadmium levels...
  68. ncbi request reprint State-of-the-science review: Does manganese exposure during welding pose a neurological risk?
    Annette B Santamaria
    ENVIRON International Corporation, Houston, Texas 77042, USA
    J Toxicol Environ Health B Crit Rev 10:417-65. 2007
    ..Our review ends with a discussion of the data gaps and areas for future research...