H O Smith
Affiliation: Celera Genomics
- DNA uptake signal sequences in naturally transformable bacteriaH O Smith
The Institute for Genomic Research, Rockville, MD 20850, USA
Res Microbiol 150:603-16. 1999..Neisseria meningitidis contains 1891 copies of the USS sequence 5'-GCCGTCTGAA. The USSs are often found in the base paired stem of transcription terminators...
- The complete genome sequence of the gastric pathogen Helicobacter pyloriJ F Tomb
Institute for Genomic Research, Rockville, Maryland 20850, USA
Nature 388:539-47. 1997..pylori has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity. Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH...
- Complete genome sequence of Treponema pallidum, the syphilis spirocheteC M Fraser
Institute for Genomic Research, Rockville, MD 20850, USA
Science 281:375-88. 1998..pallidum genome sequence with that of another pathogenic spirochete, Borrelia burgdorferi, the agent of Lyme disease, identified unique and common genes and substantiates the considerable diversity observed among pathogenic spirochetes...
- Prediction of transcription terminators in bacterial genomesM D Ermolaeva
The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, MD 20850, USA
J Mol Biol 301:27-33. 2000..A set of 131 experimentally determined E. coli terminators was used to evaluate the sensitivity of the method, which ranges from 89 % to 98 %, with corresponding false positive rates of 2 % and 18 %...
- The sequence of the human genomeJ C Venter
Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
Science 291:1304-51. 2001..Less than 1% of all SNPs resulted in variation in proteins, but the task of determining which SNPs have functional consequences remains an open challenge...
- The malaria genome sequencing project: complete sequence of Plasmodium falciparum chromosome 2M J Gardner
Institute of Genomic Research, Naval Medical Research Center, Rockville, MD, USA
Parassitologia 41:69-75. 1999..Within 2-3 years, the sequence of almost all P. falciparum genes will have been determined, paving the way for genetic, biochemical, and immunological research aimed at developing new drugs and vaccines against malaria...
- Complete genome sequence of a virulent isolate of Streptococcus pneumoniaeH Tettelin
The Institute for Genomic Research (TIGR, 9712 Medical Center Drive, Rockville, MD 20850, USA
Science 293:498-506. 2001..Comparative genome hybridization with DNA arrays revealed strain differences in S. pneumoniae that could contribute to differences in virulence and antigenicity...
- Heterologous expression of Alteromonas macleodii and Thiocapsa roseopersicina [NiFe] hydrogenases in Escherichia coliP D Weyman
Department of Synthetic Biology and Bioenergy, The J Craig Venter Institute, Rockville, MD 20850, USA
Microbiology 157:1363-74. 2011..roseopersicina hydrogenase. This result demonstrates that the accessory genes from AltDE can complement their counterparts from T. roseopersicina and that the two hydrogenases share similar maturation mechanisms...