Research Topics
Genomes and Genes
| Dov ShiffmanSummaryAffiliation: Celera Diagnostics Country: USA Publications
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Detail Information
Publications
Identification of four gene variants associated with myocardial infarctionDov Shiffman
Celera Diagnostics, Alameda, CA, USA
Am J Hum Genet 77:596-605. 2005..58] and OR13G1 [OR 1.40]); all ORs are for carriers of two versus zero risk alleles. These findings could lead to a better understanding of MI pathophysiology and improved patient risk assessment...
Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarctionDov Shiffman
Celera Inc, 1401 Harbor Bay Pkwy, Alameda, California 94502, USA
Arterioscler Thromb Vasc Biol 26:1613-8. 2006..Identify gene variants associated with early-onset myocardial infarction (MI)...- Polymorphisms associated with coronary heart disease: better by the scoreDov Shiffman
Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
Curr Opin Mol Ther 8:493-9. 2006..Common strategies to address these issues are described, including methods to aggregate risk estimates from several polymorphisms into a genetic risk score... 
Effect of pravastatin therapy on coronary events in carriers of the KIF6 719Arg allele from the cholesterol and recurrent events trialDov Shiffman
Celera, Alameda, CA, USA
Am J Cardiol 105:1300-5. 2010..14). In conclusion, in an analysis that included CARE patients of all ethnic groups, pravastatin therapy significantly and substantially reduced primary end point events in carriers of the KIF6 719Arg allele but not in noncarriers...- Analysis of 17,576 potentially functional SNPs in three case-control studies of myocardial infarctionDov Shiffman
Celera, Alameda, California, United States of America
PLoS ONE 3:e2895. 2008..23. Thus, we have identified 5 SNPs that merit further examination for their potential association with MI. One of these SNPs (in LPA), has been previously shown to be associated with risk of cardiovascular disease in other studies... - Five common gene variants identify elevated genetic risk for coronary heart diseaseLance A Bare
Celera, Alameda, California 94502, USA
Genet Med 9:682-9. 2007.... - Single variants can explain the association between coronary heart disease and haplotypes in the apolipoprotein(a) locusDov Shiffman
Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
Atherosclerosis 212:193-6. 2010..The 4399Met variant (rs3798220) of LPA has a risk estimate for CHD similar to that of the CCTC haplotype. We asked whether co-incidence with the 4399Met variant explained the association of the haplotype with CHD... - Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trialsOlga A Iakoubova
Celera, Inc, Alameda, California 94502, USA
J Am Coll Cardiol 51:435-43. 2008.... - Gene variants associated with ischemic stroke: the cardiovascular health studyMay M Luke
Celera, Alameda, California 94502, USA
Stroke 40:363-8. 2009..The purpose of this study was to determine whether 74 single nucleotide polymorphisms (SNPs), which had been associated with coronary heart disease, are associated with incident ischemic stroke... - The contribution of a 9p21.3 variant, a KIF6 variant, and C-reactive protein to predicting risk of myocardial infarction in a prospective studyDov Shiffman
Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502 USA
BMC Cardiovasc Disord 11:10. 2011.... - A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health StudyDov Shiffman
Celera, Alameda, California 94502, USA
J Am Coll Cardiol 51:444-8. 2008..We asked if carriers of the 719Arg allele of kinesin family member 6 (KIF6) have increased risk of coronary heart disease (CHD) in a cohort of initially healthy Caucasian American women... - Association of gene variants with incident myocardial infarction in the Cardiovascular Health StudyDov Shiffman
Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
Arterioscler Thromb Vasc Biol 28:173-9. 2008.... - Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapyDov Shiffman
Celera Inc, Alameda, California, United States of America
PLoS ONE 7:e38240. 2012..52 to 0.75) for each extra copy of the minor allele (P = 4.8 × 10(-7)). This SNP is located in DnaJ homolog subfamily C member 5B (DNAJC5B) and merits investigation in additional randomized studies of pravastatin and other statins... - KIF6 polymorphism as a predictor of risk of coronary events and of clinical event reduction by statin therapyYonghong Li
Celera, Alameda, California, USA
Am J Cardiol 106:994-8. 2010..In conclusion, assessment of 719Arg carrier status holds promise for stratification of coronary event risk and for selection of optimal therapy in primary and secondary CHD prevention... - A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery diseaseMay M Luke
Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
Arterioscler Thromb Vasc Biol 27:2030-6. 2007..The purpose of this study was to identify genetic variants associated with severe coronary artery disease (CAD)... - Cost-effectiveness model of use of genetic testing as an aid in assessing the likely benefit of aspirin therapy for primary prevention of cardiovascular diseaseDov Shiffman
Celera Corp, Alameda, California, USA
Clin Ther 34:1387-94. 2012..Genetic information could be used to modify this CVD risk assessment; for example, 2 variants of the LPA gene, which encodes apolipoprotein(a), are associated with increased risk of CVD... - Analysis of single nucleotide polymorphisms in case-control studiesYonghong Li
Celera Corporation, Alameda, CA, USA
Methods Mol Biol 719:219-34. 2011..An outline on study population selection, sample collection and genotyping platforms is presented, complemented by SNP selection, data preprocessing and analysis... - Gene expression signature in peripheral blood detects thoracic aortic aneurysmYulei Wang
Applied Biosystems, Foster City, California, United States of America
PLoS ONE 2:e1050. 2007..Our goal was to identify a distinct gene expression signature in peripheral blood that may identify individuals at risk for TAA...