Dov Shiffman

Summary

Affiliation: Celera Genomics
Country: USA

Publications

  1. pmc Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy
    Dov Shiffman
    Celera Inc, Alameda, California, United States of America
    PLoS ONE 7:e38240. 2012
  2. pmc Analysis of 17,576 potentially functional SNPs in three case-control studies of myocardial infarction
    Dov Shiffman
    Celera, Alameda, California, United States of America
    PLoS ONE 3:e2895. 2008
  3. doi Effect of pravastatin therapy on coronary events in carriers of the KIF6 719Arg allele from the cholesterol and recurrent events trial
    Dov Shiffman
    Celera, Alameda, CA, USA
    Am J Cardiol 105:1300-5. 2010
  4. doi A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study
    Dov Shiffman
    Celera, Alameda, California 94502, USA
    J Am Coll Cardiol 51:444-8. 2008
  5. doi Single variants can explain the association between coronary heart disease and haplotypes in the apolipoprotein(a) locus
    Dov Shiffman
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Atherosclerosis 212:193-6. 2010
  6. pmc Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study
    Dov Shiffman
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Arterioscler Thromb Vasc Biol 28:173-9. 2008
  7. pmc The contribution of a 9p21.3 variant, a KIF6 variant, and C-reactive protein to predicting risk of myocardial infarction in a prospective study
    Dov Shiffman
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502 USA
    BMC Cardiovasc Disord 11:10. 2011
  8. doi Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials
    Olga A Iakoubova
    Celera, Inc, Alameda, California 94502, USA
    J Am Coll Cardiol 51:435-43. 2008
  9. ncbi Five common gene variants identify elevated genetic risk for coronary heart disease
    Lance A Bare
    Celera, Alameda, California 94502, USA
    Genet Med 9:682-9. 2007
  10. pmc Gene variants associated with ischemic stroke: the cardiovascular health study
    May M Luke
    Celera, Alameda, California 94502, USA
    Stroke 40:363-8. 2009

Detail Information

Publications19

  1. pmc Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy
    Dov Shiffman
    Celera Inc, Alameda, California, United States of America
    PLoS ONE 7:e38240. 2012
    ..52 to 0.75) for each extra copy of the minor allele (P = 4.8 × 10(-7)). This SNP is located in DnaJ homolog subfamily C member 5B (DNAJC5B) and merits investigation in additional randomized studies of pravastatin and other statins...
  2. pmc Analysis of 17,576 potentially functional SNPs in three case-control studies of myocardial infarction
    Dov Shiffman
    Celera, Alameda, California, United States of America
    PLoS ONE 3:e2895. 2008
    ..23. Thus, we have identified 5 SNPs that merit further examination for their potential association with MI. One of these SNPs (in LPA), has been previously shown to be associated with risk of cardiovascular disease in other studies...
  3. doi Effect of pravastatin therapy on coronary events in carriers of the KIF6 719Arg allele from the cholesterol and recurrent events trial
    Dov Shiffman
    Celera, Alameda, CA, USA
    Am J Cardiol 105:1300-5. 2010
    ..14). In conclusion, in an analysis that included CARE patients of all ethnic groups, pravastatin therapy significantly and substantially reduced primary end point events in carriers of the KIF6 719Arg allele but not in noncarriers...
  4. doi A kinesin family member 6 variant is associated with coronary heart disease in the Women's Health Study
    Dov Shiffman
    Celera, Alameda, California 94502, USA
    J Am Coll Cardiol 51:444-8. 2008
    ..We asked if carriers of the 719Arg allele of kinesin family member 6 (KIF6) have increased risk of coronary heart disease (CHD) in a cohort of initially healthy Caucasian American women...
  5. doi Single variants can explain the association between coronary heart disease and haplotypes in the apolipoprotein(a) locus
    Dov Shiffman
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Atherosclerosis 212:193-6. 2010
    ..The 4399Met variant (rs3798220) of LPA has a risk estimate for CHD similar to that of the CCTC haplotype. We asked whether co-incidence with the 4399Met variant explained the association of the haplotype with CHD...
  6. pmc Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study
    Dov Shiffman
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Arterioscler Thromb Vasc Biol 28:173-9. 2008
    ....
  7. pmc The contribution of a 9p21.3 variant, a KIF6 variant, and C-reactive protein to predicting risk of myocardial infarction in a prospective study
    Dov Shiffman
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502 USA
    BMC Cardiovasc Disord 11:10. 2011
    ....
  8. doi Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials
    Olga A Iakoubova
    Celera, Inc, Alameda, California 94502, USA
    J Am Coll Cardiol 51:435-43. 2008
    ....
  9. ncbi Five common gene variants identify elevated genetic risk for coronary heart disease
    Lance A Bare
    Celera, Alameda, California 94502, USA
    Genet Med 9:682-9. 2007
    ....
  10. pmc Gene variants associated with ischemic stroke: the cardiovascular health study
    May M Luke
    Celera, Alameda, California 94502, USA
    Stroke 40:363-8. 2009
    ..The purpose of this study was to determine whether 74 single nucleotide polymorphisms (SNPs), which had been associated with coronary heart disease, are associated with incident ischemic stroke...
  11. ncbi A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery disease
    May M Luke
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Arterioscler Thromb Vasc Biol 27:2030-6. 2007
    ..The purpose of this study was to identify genetic variants associated with severe coronary artery disease (CAD)...
  12. ncbi Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction
    Dov Shiffman
    Celera Inc, 1401 Harbor Bay Pkwy, Alameda, California 94502, USA
    Arterioscler Thromb Vasc Biol 26:1613-8. 2006
    ..Identify gene variants associated with early-onset myocardial infarction (MI)...
  13. doi KIF6 polymorphism as a predictor of risk of coronary events and of clinical event reduction by statin therapy
    Yonghong Li
    Celera, Alameda, California, USA
    Am J Cardiol 106:994-8. 2010
    ..In conclusion, assessment of 719Arg carrier status holds promise for stratification of coronary event risk and for selection of optimal therapy in primary and secondary CHD prevention...
  14. pmc Identification of four gene variants associated with myocardial infarction
    Dov Shiffman
    Celera Diagnostics, Alameda, CA, USA
    Am J Hum Genet 77:596-605. 2005
    ..58] and OR13G1 [OR 1.40]); all ORs are for carriers of two versus zero risk alleles. These findings could lead to a better understanding of MI pathophysiology and improved patient risk assessment...
  15. ncbi Lipoprotein (a), LPA Ile4399Met, and fibrin clot properties
    Charles M Rowland
    Celera A Division of Quest Diagnostics, 1311 Harbor Bay Parkway, Alameda, CA 94502, USA Electronic address
    Thromb Res 133:863-7. 2014
    ..We investigated whether Ile4399Met was associated with fibrin clot properties...
  16. ncbi Polymorphisms associated with coronary heart disease: better by the score
    Dov Shiffman
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Curr Opin Mol Ther 8:493-9. 2006
    ..Common strategies to address these issues are described, including methods to aggregate risk estimates from several polymorphisms into a genetic risk score...
  17. doi Cost-effectiveness model of use of genetic testing as an aid in assessing the likely benefit of aspirin therapy for primary prevention of cardiovascular disease
    Dov Shiffman
    Celera Corp, Alameda, California, USA
    Clin Ther 34:1387-94. 2012
    ..Genetic information could be used to modify this CVD risk assessment; for example, 2 variants of the LPA gene, which encodes apolipoprotein(a), are associated with increased risk of CVD...
  18. doi Analysis of single nucleotide polymorphisms in case-control studies
    Yonghong Li
    Celera Corporation, Alameda, CA, USA
    Methods Mol Biol 719:219-34. 2011
    ..An outline on study population selection, sample collection and genotyping platforms is presented, complemented by SNP selection, data preprocessing and analysis...
  19. pmc Gene expression signature in peripheral blood detects thoracic aortic aneurysm
    Yulei Wang
    Applied Biosystems, Foster City, California, United States of America
    PLoS ONE 2:e1050. 2007
    ..Our goal was to identify a distinct gene expression signature in peripheral blood that may identify individuals at risk for TAA...