Yonghong Li

Summary

Affiliation: Celera Genomics
Country: USA

Publications

  1. ncbi request reprint Genetics of late-onset Alzheimer's disease: progress and prospect
    Yonghong Li
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Pharmacogenomics 8:1747-55. 2007
  2. doi request reprint Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22
    Yonghong Li
    Celera, Alameda, California 94502, USA
    J Invest Dermatol 129:629-34. 2009
  3. pmc Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease
    Yonghong Li
    Celera, Alameda, California, United States of America
    PLoS ONE 3:e2707. 2008
  4. pmc The 5q31 variants associated with psoriasis and Crohn's disease are distinct
    Yonghong Li
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Hum Mol Genet 17:2978-85. 2008
  5. pmc Carriers of rare missense variants in IFIH1 are protected from psoriasis
    Yonghong Li
    Celera, Alameda, California 94502, USA
    J Invest Dermatol 130:2768-72. 2010
  6. pmc SORL1 variants and risk of late-onset Alzheimer's disease
    Yonghong Li
    Celera, 1401 Harbor Bay Parkway, Alameda, CA, USA
    Neurobiol Dis 29:293-6. 2008
  7. pmc Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infection
    Yonghong Li
    Celera Corporation, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    J Hepatol 51:750-7. 2009
  8. pmc Genetic variants in the KIF6 region and coronary event reduction from statin therapy
    Yonghong Li
    Hum Genet 129:17-23. 2011
  9. ncbi request reprint Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease
    Yonghong Li
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Hum Mol Genet 17:759-67. 2008
  10. ncbi request reprint DAPK1 variants are associated with Alzheimer's disease and allele-specific expression
    Yonghong Li
    Celera Diagnostics, Alameda, CA 94502, USA
    Hum Mol Genet 15:2560-8. 2006

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Genetics of late-onset Alzheimer's disease: progress and prospect
    Yonghong Li
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Pharmacogenomics 8:1747-55. 2007
    ....
  2. doi request reprint Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22
    Yonghong Li
    Celera, Alameda, California 94502, USA
    J Invest Dermatol 129:629-34. 2009
    ..57 x 10(-5) (3,206 cases and 4,529 controls), and rs3789604: P=3.45 x 10(-5) (2,823 cases and 4,066 controls)). These data increase the likelihood that ADAM33, CDKAL1, and PTPN22 are true psoriasis-risk genes...
  3. pmc Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease
    Yonghong Li
    Celera, Alameda, California, United States of America
    PLoS ONE 3:e2707. 2008
    ..Together, these results challenge the robustness of the reported panel of genetic markers to predict PD risk in particular and a role of the axon guidance pathway in PD genetics in general...
  4. pmc The 5q31 variants associated with psoriasis and Crohn's disease are distinct
    Yonghong Li
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Hum Mol Genet 17:2978-85. 2008
    ..These results identify the most significant 5q31 risk variants for psoriasis and suggest that distinct 5q31 variants contribute to CD and psoriasis risk...
  5. pmc Carriers of rare missense variants in IFIH1 are protected from psoriasis
    Yonghong Li
    Celera, Alameda, California 94502, USA
    J Invest Dermatol 130:2768-72. 2010
    ..Compared to noncarriers, carriers of the 923Val and/or 460Arg variants were protected from psoriasis (OR=0.46, P=5.56 × 10(-8)). To our knowledge, these results suggest that IFIH1 is a previously unreported psoriasis gene...
  6. pmc SORL1 variants and risk of late-onset Alzheimer's disease
    Yonghong Li
    Celera, 1401 Harbor Bay Parkway, Alameda, CA, USA
    Neurobiol Dis 29:293-6. 2008
    ..035); however, this result does not remain significant when accounting for multiple comparisons. Further validation in other sample sets will be required to assess the true effects of SORL1 variants in LOAD...
  7. pmc Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infection
    Yonghong Li
    Celera Corporation, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    J Hepatol 51:750-7. 2009
    ..Other variants in these loci have not been examined but may be associated with fibrosis risk independently of or due to linkage disequilibrium with the original polymorphisms...
  8. pmc Genetic variants in the KIF6 region and coronary event reduction from statin therapy
    Yonghong Li
    Hum Genet 129:17-23. 2011
    ..These three SNPs are in high linkage disequilibrium with one another (r (2) > 0.84). Functional studies of these variants may help to understand the role of KIF6 in the pathogenesis of CHD and differential response to statin therapy...
  9. ncbi request reprint Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease
    Yonghong Li
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Hum Mol Genet 17:759-67. 2008
    ..These data implicate NEDD9 as a novel susceptibility gene for LOAD and possibly PD...
  10. ncbi request reprint DAPK1 variants are associated with Alzheimer's disease and allele-specific expression
    Yonghong Li
    Celera Diagnostics, Alameda, CA 94502, USA
    Hum Mol Genet 15:2560-8. 2006
    ..015 to <0.0001). These data suggest that genetic variation in DAPK1 modulates susceptibility to LOAD...
  11. pmc A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease
    Andrew Grupe
    Celera Diagnostics, Alameda, CA, USA
    Am J Hum Genet 78:78-88. 2006
    ..0165). These results indicate that variants in the RPS3A homologue are associated with LOAD and implicate this gene, adjacent genes, or other functional variants (e.g., noncoding RNAs) in the pathogenesis of this disorder...
  12. pmc Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family
    Yonghong Li
    Celera Diagnostics, Alameda, CA 94502, USA
    Proc Natl Acad Sci U S A 101:15688-93. 2004
    ..Our observations raise the possibility that GAPD genes are AD risk factors, a hypothesis that is consistent with the role of GAPD in neuronal apoptosis...
  13. ncbi request reprint Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson disease
    Yonghong Li
    Celera Diagnostics, Alameda, California 94502, USA
    Hum Mutat 27:1017-23. 2006
    ..Our data suggest that genetic variants in USP24 and USP40 affect the risk for late-onset PD, which is consistent with the predicted role of the ubiquitination pathway in PD etiology...
  14. ncbi request reprint Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease
    Yonghong Li
    Celera Diagnostics, Alameda, California 94502, USA
    Hum Mutat 25:270-7. 2005
    ..43 [95% CI: 1.61-3.67]; OR(het)=2.15 [95% CI: 1.46-3.17]; P=0.00006) in the combined sample set. Our data raise the possibility that genetic variations in APBB2 may affect LOAD susceptibility...
  15. ncbi request reprint Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants
    Andrew Grupe
    Celera Diagnostics, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Hum Mol Genet 16:865-73. 2007
    ..This is a missense mutation in the galanin-like peptide precursor gene (P = 0.00005, OR = 1.2, false positive rate = 0.87)...
  16. doi request reprint Analysis of single nucleotide polymorphisms in case-control studies
    Yonghong Li
    Celera Corporation, Alameda, CA, USA
    Methods Mol Biol 719:219-34. 2011
    ..An outline on study population selection, sample collection and genotyping platforms is presented, complemented by SNP selection, data preprocessing and analysis...
  17. ncbi request reprint Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control study
    Yonghong Li
    Celera Diagnostics, Alameda, CA, USA
    Neurosci Lett 366:268-71. 2004
    ..Further, we did not observe significant and replicated association of other ABCA1 SNPs we examined with the disease, thus these ABCA1 variants do not appear to influence the risk of LOAD in this study...
  18. doi request reprint KIF6 polymorphism as a predictor of risk of coronary events and of clinical event reduction by statin therapy
    Yonghong Li
    Celera, Alameda, California, USA
    Am J Cardiol 106:994-8. 2010
    ..In conclusion, assessment of 719Arg carrier status holds promise for stratification of coronary event risk and for selection of optimal therapy in primary and secondary CHD prevention...
  19. doi request reprint Unraveling the genetics of complex diseases: susceptibility genes for rheumatoid arthritis and psoriasis
    Yonghong Li
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Semin Immunol 21:318-27. 2009
    ....
  20. doi request reprint Statins personalized
    H Robert Superko
    Celera Corporation, Alameda, CA 94502, USA
    Med Clin North Am 96:123-39. 2012
    ..A large portion of the individual response to statin therapy is attributed to single nucleotide polymorphisms that have recently been elucidated, several of which seem to have clinical utility...
  21. pmc A case-control association study of the 12 single-nucleotide polymorphisms implicated in Parkinson disease by a recent genome scan
    Yonghong Li
    Am J Hum Genet 78:1090-2; author reply 1092-4. 2006
  22. ncbi request reprint Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease
    Scott Smemo
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Street, St Louis, MO 63110, USA
    Ann Neurol 59:21-6. 2006
    ..We did not find any evidence that this single nucleotide polymorphism, or any of six others tested in UBQLN1, increases risk for LOAD...