Research Topics
Genomes and Genes
| Yonghong LiSummaryAffiliation: Celera Genomics Country: USA Publications
| Collaborators
|
Detail Information
Publications
Genetics of late-onset Alzheimer's disease: progress and prospectYonghong Li
Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
Pharmacogenomics 8:1747-55. 2007....
Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22Yonghong Li
Celera, Alameda, California 94502, USA
J Invest Dermatol 129:629-34. 2009..57 x 10(-5) (3,206 cases and 4,529 controls), and rs3789604: P=3.45 x 10(-5) (2,823 cases and 4,066 controls)). These data increase the likelihood that ADAM33, CDKAL1, and PTPN22 are true psoriasis-risk genes...
Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's diseaseYonghong Li
Celera, Alameda, California, United States of America
PLoS ONE 3:e2707. 2008..Together, these results challenge the robustness of the reported panel of genetic markers to predict PD risk in particular and a role of the axon guidance pathway in PD genetics in general...- The 5q31 variants associated with psoriasis and Crohn's disease are distinctYonghong Li
Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
Hum Mol Genet 17:2978-85. 2008..These results identify the most significant 5q31 risk variants for psoriasis and suggest that distinct 5q31 variants contribute to CD and psoriasis risk... - Carriers of rare missense variants in IFIH1 are protected from psoriasisYonghong Li
Celera, Alameda, California 94502, USA
J Invest Dermatol 130:2768-72. 2010..Compared to noncarriers, carriers of the 923Val and/or 460Arg variants were protected from psoriasis (OR=0.46, P=5.56 × 10(-8)). To our knowledge, these results suggest that IFIH1 is a previously unreported psoriasis gene... - SORL1 variants and risk of late-onset Alzheimer's diseaseYonghong Li
Celera, 1401 Harbor Bay Parkway, Alameda, CA, USA
Neurobiol Dis 29:293-6. 2008..035); however, this result does not remain significant when accounting for multiple comparisons. Further validation in other sample sets will be required to assess the true effects of SORL1 variants in LOAD... - Multiple variants in toll-like receptor 4 gene modulate risk of liver fibrosis in Caucasians with chronic hepatitis C infectionYonghong Li
Celera Corporation, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
J Hepatol 51:750-7. 2009..Other variants in these loci have not been examined but may be associated with fibrosis risk independently of or due to linkage disequilibrium with the original polymorphisms... - Genetic variants in the KIF6 region and coronary event reduction from statin therapyYonghong Li
Hum Genet 129:17-23. 2011..These three SNPs are in high linkage disequilibrium with one another (r (2) > 0.84). Functional studies of these variants may help to understand the role of KIF6 in the pathogenesis of CHD and differential response to statin therapy... - Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's diseaseYonghong Li
Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
Hum Mol Genet 17:759-67. 2008..These data implicate NEDD9 as a novel susceptibility gene for LOAD and possibly PD... - DAPK1 variants are associated with Alzheimer's disease and allele-specific expressionYonghong Li
Celera Diagnostics, Alameda, CA 94502, USA
Hum Mol Genet 15:2560-8. 2006..015 to <0.0001). These data suggest that genetic variation in DAPK1 modulates susceptibility to LOAD... - Genetic evidence for ubiquitin-specific proteases USP24 and USP40 as candidate genes for late-onset Parkinson diseaseYonghong Li
Celera Diagnostics, Alameda, California 94502, USA
Hum Mutat 27:1017-23. 2006..Our data suggest that genetic variants in USP24 and USP40 affect the risk for late-onset PD, which is consistent with the predicted role of the ubiquitination pathway in PD etiology... - A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer diseaseAndrew Grupe
Celera Diagnostics, Alameda, CA, USA
Am J Hum Genet 78:78-88. 2006..0165). These results indicate that variants in the RPS3A homologue are associated with LOAD and implicate this gene, adjacent genes, or other functional variants (e.g., noncoding RNAs) in the pathogenesis of this disorder... - Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer diseaseYonghong Li
Celera Diagnostics, Alameda, California 94502, USA
Hum Mutat 25:270-7. 2005..43 [95% CI: 1.61-3.67]; OR(het)=2.15 [95% CI: 1.46-3.17]; P=0.00006) in the combined sample set. Our data raise the possibility that genetic variations in APBB2 may affect LOAD susceptibility... - Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene familyYonghong Li
Celera Diagnostics, Alameda, CA 94502, USA
Proc Natl Acad Sci U S A 101:15688-93. 2004..Our observations raise the possibility that GAPD genes are AD risk factors, a hypothesis that is consistent with the role of GAPD in neuronal apoptosis... - Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variantsAndrew Grupe
Celera Diagnostics, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
Hum Mol Genet 16:865-73. 2007..This is a missense mutation in the galanin-like peptide precursor gene (P = 0.00005, OR = 1.2, false positive rate = 0.87)... - Analysis of single nucleotide polymorphisms in case-control studiesYonghong Li
Celera Corporation, Alameda, CA, USA
Methods Mol Biol 719:219-34. 2011..An outline on study population selection, sample collection and genotyping platforms is presented, complemented by SNP selection, data preprocessing and analysis... - Association of ABCA1 with late-onset Alzheimer's disease is not observed in a case-control studyYonghong Li
Celera Diagnostics, Alameda, CA, USA
Neurosci Lett 366:268-71. 2004..Further, we did not observe significant and replicated association of other ABCA1 SNPs we examined with the disease, thus these ABCA1 variants do not appear to influence the risk of LOAD in this study... - KIF6 polymorphism as a predictor of risk of coronary events and of clinical event reduction by statin therapyYonghong Li
Celera, Alameda, California, USA
Am J Cardiol 106:994-8. 2010..In conclusion, assessment of 719Arg carrier status holds promise for stratification of coronary event risk and for selection of optimal therapy in primary and secondary CHD prevention... - Unraveling the genetics of complex diseases: susceptibility genes for rheumatoid arthritis and psoriasisYonghong Li
Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
Semin Immunol 21:318-27. 2009.... - Statins personalizedH Robert Superko
Celera Corporation, Alameda, CA 94502, USA
Med Clin North Am 96:123-39. 2012..A large portion of the individual response to statin therapy is attributed to single nucleotide polymorphisms that have recently been elucidated, several of which seem to have clinical utility... - A case-control association study of the 12 single-nucleotide polymorphisms implicated in Parkinson disease by a recent genome scanYonghong Li
Am J Hum Genet 78:1090-2; author reply 1092-4. 2006 - Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's diseaseScott Smemo
Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Street, St Louis, MO 63110, USA
Ann Neurol 59:21-6. 2006..We did not find any evidence that this single nucleotide polymorphism, or any of six others tested in UBQLN1, increases risk for LOAD...