Douglas A Jeffery

Summary

Affiliation: Celera Genomics
Country: USA

Publications

  1. ncbi request reprint Chemical proteomics and its application to drug discovery
    Douglas A Jeffery
    Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA
    Drug Discov Today 9:S19-26. 2004
  2. ncbi request reprint Chemical proteomics and its application to drug discovery
    Douglas A Jeffery
    Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA
    Curr Opin Biotechnol 14:87-95. 2003
  3. ncbi request reprint Development of activity-based probes for trypsin-family serine proteases
    Zhengying Pan
    Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA
    Bioorg Med Chem Lett 16:2882-5. 2006
  4. ncbi request reprint Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase
    Zhengying Pan
    Department of Medicinal Chemistry, Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA
    ChemMedChem 2:58-61. 2007
  5. ncbi request reprint Enzyme activity--it's all about image
    Amos Baruch
    Department of Chemical Proteomics, Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA
    Trends Cell Biol 14:29-35. 2004
  6. ncbi request reprint 3,4-disubstituted azetidinones as selective inhibitors of the cysteine protease cathepsin K. Exploring P3 elements for potency and selectivity
    Eduardo L Setti
    Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA
    Bioorg Med Chem Lett 15:1529-34. 2005
  7. doi request reprint Applications for chemical probes of proteolytic activity
    Matthew Bogyo
    Stanford University, Stanford, California, USA
    Curr Protoc Protein Sci . 2004

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Chemical proteomics and its application to drug discovery
    Douglas A Jeffery
    Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA
    Drug Discov Today 9:S19-26. 2004
    ..Furthermore, such methods enable rapid biochemical analysis and small-molecule screening of targets thereby accelerating the often difficult process of target validation and drug discovery...
  2. ncbi request reprint Chemical proteomics and its application to drug discovery
    Douglas A Jeffery
    Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA
    Curr Opin Biotechnol 14:87-95. 2003
    ..Furthermore, such methods enable rapid biochemical analysis and small-molecule screening of targets thereby accelerating the often difficult process of target validation and drug discovery...
  3. ncbi request reprint Development of activity-based probes for trypsin-family serine proteases
    Zhengying Pan
    Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA
    Bioorg Med Chem Lett 16:2882-5. 2006
    ..We present here the application of multiple probes in enzyme activity profiling of intact mast cells, a type of inflammatory cell implicated in allergy and autoimmune diseases...
  4. ncbi request reprint Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase
    Zhengying Pan
    Department of Medicinal Chemistry, Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA
    ChemMedChem 2:58-61. 2007
  5. ncbi request reprint Enzyme activity--it's all about image
    Amos Baruch
    Department of Chemical Proteomics, Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA
    Trends Cell Biol 14:29-35. 2004
    ..Such technologies have the potential to be integrated into drug-development programs to facilitate both the functional validation of pharmaceutical targets and the treatment of human disease...
  6. ncbi request reprint 3,4-disubstituted azetidinones as selective inhibitors of the cysteine protease cathepsin K. Exploring P3 elements for potency and selectivity
    Eduardo L Setti
    Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA
    Bioorg Med Chem Lett 15:1529-34. 2005
    ..Data from kinetic and mass spectrometry experiments are consistent with the interpretation that compounds of this series transiently acylate the sulfhydrile of cathepsin K...
  7. doi request reprint Applications for chemical probes of proteolytic activity
    Matthew Bogyo
    Stanford University, Stanford, California, USA
    Curr Protoc Protein Sci . 2004
    ....