Research Topics
Species | Stephen L HoffmanSummaryAffiliation: Celera Genomics Country: USA Publications
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Publications
Plasmodium, human and Anopheles genomics and malariaStephen L Hoffman
Celera Genomics, 45 West Gude Drive, Rockville, Maryland 20850, USA
Nature 415:702-9. 2002....- Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoitesStephen L Hoffman
Malaria Program, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20850, USA
J Infect Dis 185:1155-64. 2002.... 
Plasmodium: mammalian codon optimization of malaria plasmid DNA vaccines enhances antibody responses but not T cell responses nor protective immunityCarlota Dobano
Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
Exp Parasitol 122:112-23. 2009..These data demonstrate that the effect of mammalian codon optimization is antigen-dependent and may not be beneficial for vaccines designed to induce T cell dependent protective immunity in this malaria model...- Induction in humans of CD8+ and CD4+ T cell and antibody responses by sequential immunization with malaria DNA and recombinant proteinRuobing Wang
Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA
J Immunol 172:5561-9. 2004..The induction in humans of the three primary Ag-specific adaptive immune responses establishes a strategy for developing immunization regimens against diseases in desperate need of vaccines... 
Boosting of DNA vaccine-elicited gamma interferon responses in humans by exposure to malaria parasitesRuobing Wang
Sanaria, Inc, 12115 Parklawn Drive, Suite L, Rockville, MD 20852, USA
Infect Immun 73:2863-72. 2005....- Successful induction of CD8 T cell-dependent protection against malaria by sequential immunization with DNA and recombinant poxvirus of neonatal mice born to immune mothersMartha Sedegah
Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA
J Immunol 171:3148-53. 2003..yoelii parasites or immunized with the vaccine were protected and had excellent T cell responses. These data support assessment of this immunization strategy in neonates/young infants in areas in which malaria exacts its greatest toll... - Protection of rhesus macaques against lethal Plasmodium knowlesi malaria by a heterologous DNA priming and poxvirus boosting immunization regimenWilliam O Rogers
Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910, USA
Infect Immun 70:4329-35. 2002..These findings demonstrate that a multistage, multiantigen, DNA priming and poxvirus boosting vaccine regimen can protect nonhuman primates from an otherwise lethal malaria sporozoite challenge... - Anemia in parasite- and recombinant protein-immunized aotus monkeys infected with Plasmodium falciparumTrevor R Jones
Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910, USA
Am J Trop Med Hyg 66:672-9. 2002..Partial immunity-whether induced by repeated immunization with whole parasites or with vaccine-seems important to the development of anemia... - Safety, tolerability, and antibody responses in humans after sequential immunization with a PfCSP DNA vaccine followed by the recombinant protein vaccine RTS,S/AS02AJudith E Epstein
Malaria Program, Naval Medical Research Center, 503 Robert Grant Ave, Silver Spring, MD 20910, USA
Vaccine 22:1592-603. 2004.... - Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic dataDenise L Doolan
Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910-7500, USA
Proc Natl Acad Sci U S A 100:9952-7. 2003..The data suggest that immune responses to Plasmodium are dispersed on a relatively large number of parasite antigens. These studies have implications for our understanding of immunodominance and breadth of responses to complex pathogens... - Comparative genomics of the neglected human malaria parasite Plasmodium vivaxJane M Carlton
The Institute for Genomic Research J Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
Nature 455:757-63. 2008..Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species... - High-throughput generation of P. falciparum functional molecules by recombinational cloningJoão Carlos Aguiar
Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910, USA
Genome Res 14:2076-82. 2004..falciparum genome and will provide for a resource for the malaria resource community distributed through public repositories... - Immunological responses of neonates and infants to DNA vaccinesMartha Sedegah
Malaria Program, Naval Medical Research Center, Silver Spring, MD, USA
Methods Mol Med 127:239-51. 2006..These data support assessment of this immunization strategy in neonates/young infants in areas where malaria exacts the greatest toll... - Absence of antigenic competition in Aotus monkeys immunized with Plasmodium falciparum DNA vaccines delivered as a mixtureTrevor R Jones
Malaria Program, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
Vaccine 20:1675-80. 2002..The fourth immunization with the trivalent vaccine increased the mean antibody in IFAT by more than five-fold... - Nucleic acid vaccines against malariaDenise L Doolan
Malaria Program, Naval Medical Research Center, Silver Spring, MD, USA
Chem Immunol 80:308-21. 2002 - CpG oligodeoxynucleotide and Montanide ISA 51 adjuvant combination enhanced the protective efficacy of a subunit malaria vaccineSanjai Kumar
Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910, USA
Infect Immun 72:949-57. 2004..Our results indicate that this potent adjuvant formulation should be further evaluated for use in clinical trials of recombinant malarial vaccine candidates... - Safety and clinical outcome of experimental challenge of human volunteers with Plasmodium falciparum-infected mosquitoes: an updateJudith E Epstein
Malaria Program, Naval Medical Research Center, Silver Spring, MD, 20910, USA
J Infect Dis 196:145-54. 2007..In 1997, an analysis of experience with 118 volunteers indicated that mosquito inoculation of P. falciparum could be a safe, well-tolerated, reproducible, and efficient method of challenge... - Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoeliiJane M Carlton
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
Nature 419:512-9. 2002..This is the first genome sequence of a model eukaryotic parasite, and it provides insight into the use of such systems in the modelling of Plasmodium biology and disease... - Parasitology. Malaria--from infants to genomics to vaccinesCarole A Long
Malaria Vaccine Development Unit, National Institutes of Health, Rockville, MD 20852, USA
Science 297:345-7. 2002 - Persistence of protective immunity to malaria induced by DNA priming and poxvirus boosting: characterization of effector and memory CD8(+)-T-cell populationsMartha Sedegah
Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910 7500, USA
Infect Immun 70:3493-9. 2002..These results demonstrate that a heterologous priming and boosting vaccination can provide lasting protection against malaria in this model system... - The Effects of radiation on the safety and protective efficacy of an attenuated Plasmodium yoelii sporozoite malaria vaccineRana Chattopadhyay
Sanaria Inc, 9800 Medical Center Drive, Rockville, MD 20850, United States
Vaccine 27:3675-80. 2009..These results support the contention that a radiation attenuated sporozoite vaccine for malaria will be safe and effective at a range of radiation doses... - PfSPATR, a Plasmodium falciparum protein containing an altered thrombospondin type I repeat domain is expressed at several stages of the parasite life cycle and is the target of inhibitory antibodiesRana Chattopadhyay
Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910-7500, USA
J Biol Chem 278:25977-81. 2003..falciparum sporozoites specifically recognized the expression of this protein on transfected COS-7 cells. These data support the evaluation of this protein as a vaccine candidate... - Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malariaStephen L Hoffman
Sanaria Inc, Rockville, MD, USA
Hum Vaccin 6:97-106. 2010..A medium term goal is to design and build a facility for manufacturing highly potent and stable vaccine for pivotal Phase 3 studies and commercial launch... - Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14Malcolm J Gardner
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
Nature 419:531-4. 2002..We report here the nucleotide sequences of chromosomes 10, 11 and 14, and a re-analysis of the chromosome 2 sequence. These chromosomes represent about 35% of the 23-megabase P. falciparum genome... - Genome sequence of the human malaria parasite Plasmodium falciparumMalcolm J Gardner
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
Nature 419:498-511. 2002..The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria... - Safety, tolerability, and lack of antibody responses after administration of a PfCSP DNA malaria vaccine via needle or needle-free jet injection, and comparison of intramuscular and combination intramuscular/intradermal routesJudith E Epstein
Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA
Hum Gene Ther 13:1551-60. 2002.... - The genome sequence of the malaria mosquito Anopheles gambiaeRobert A Holt
Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
Science 298:129-49. 2002..An expressed sequence tag analysis of genes regulated by blood feeding provided insights into the physiological adaptations of a hematophagous insect... - A multilateral effort to develop DNA vaccines against falciparum malariaSanjai Kumar
Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA
Trends Parasitol 18:129-35. 2002.... - Seasonal malaria attack rates in infants and young children in northern GhanaJ Kevin Baird
Naval Medical Research Center, Silver Spring, Maryland, USA
Am J Trop Med Hyg 66:280-6. 2002..These findings bear upon the design of malaria drug and vaccine trials in holoendemic areas... - Cures for the Third World's problems: the application of genomics to the diseases plaguing the developing world may have huge medical and economic benefits for those countries and might even prevent armed conflictSamuel Broder
Clera Genomics, Rockville, MD, USA
EMBO Rep 3:806-12. 2002 - Comparative immunopeptidomics of humans and their pathogensSorin Istrail
Celera Genomics, Rockville, MD 20850, USA
Proc Natl Acad Sci U S A 101:13268-72. 2004.... - Controlled human malaria infections by intradermal injection of cryopreserved Plasmodium falciparum sporozoitesMeta Roestenberg
Radboud University Nijmegen Medical Center, Department of Medical Microbiology, Nijmegen, The Netherlands
Am J Trop Med Hyg 88:5-13. 2013..After further optimization, the use of such PfSPZ may facilitate and accelerate clinical development of novel malaria drugs and vaccines... - A DNA vaccine encoding the 42 kDa C-terminus of merozoite surface protein 1 of Plasmodium falciparum induces antibody, interferon-gamma and cytotoxic T cell responses in rhesus monkeys: immuno-stimulatory effects of granulocyte macrophage-colony stimulatiSanjai Kumar
Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA
Immunol Lett 81:13-24. 2002..The GM-CSF plasmid or protein appears to be less potent as an adjuvant in rhesus monkeys than each is in mice, and more work is needed to determine if GM-CSF can be a useful adjuvant in DNA vaccination of primates... - Hark back: passive immunotherapy for influenza and other serious infectionsThomas C Luke
Henry Jackson Foundation, Naval Medical Research Center, Silver Spring, MD, USA
Crit Care Med 38:e66-73. 2010..Past, current, and future uses of immunotherapy and current advisory body recommendations for this approach are presented... - Laser capture microdissection and molecular analysis of Plasmodium yoelii liver-stage parasitesJohn B Sacci
Malaria Program, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
Mol Biochem Parasitol 119:285-9. 2002 - Malaria transmission dynamics at a site in northern Ghana proposed for testing malaria vaccinesMaxwell Appawu
Noguchi Memorial Institute for Medical Research, Legon, Accra, Ghana
Trop Med Int Health 9:164-70. 2004..00 hours. Vaccine trials could be conducted in this district, with timing dependent on the seasonal patterns and intensity of transmission taking into consideration the micro-geographical differences and vaccine trial objectives... - Atovaquone/proguanil therapy for Plasmodium falciparum and Plasmodium vivax malaria in Indonesians who lack clinical immunityMark D Lacy
Parasitic Diseases Program, US Naval Medical Research Unit 2, Jakarta, Indonesia
Clin Infect Dis 35:e92-5. 2002..Atovaquone/proguanil provided safe, well-tolerated, and effective therapy for uncomplicated malaria in nonimmune Indonesians... - A randomized, double-blind, placebo-controlled, dose-ranging trial of tafenoquine for weekly prophylaxis against Plasmodium falciparumBraden R Hale
US Navy Medical Research Unit No. 3, Cairo, Egypt
Clin Infect Dis 36:541-9. 2003..Tafenoquine dosages of 50, 100, and 200 mg/week were safe, well tolerated, and effective against P. falciparum infection in this study population... - Mefloquine treatment for uncomplicated falciparum malaria in young children 6-24 months of age in northern GhanaDavid J Fryauff
US Naval Medical Research Unit No 3, Cairo, Egypt
Am J Trop Med Hyg 76:224-31. 2007..An observed recurrent parasitemia of 34,400 trophozoites/microL against a MQ blood concentration of 550 ng/mL was taken as indication of tolerance to suppressive levels of the drug at this location... - Randomized, placebo-controlled trial of atovaquone/proguanil for the prevention of Plasmodium falciparum or Plasmodium vivax malaria among migrants to Papua, IndonesiaJudith Ling
Naval Medical Research Unit 2, Jakarta, Indonesia
Clin Infect Dis 35:825-33. 2002..Atovaquone/proguanil was well tolerated, safe, and effective for the prevention of drug-resistant P. vivax and P. falciparum malaria in individuals without prior malaria exposure who migrated to Papua, Indonesia... - Primaquine for prevention of malaria in travelersJ Kevin Baird
US Naval Medical Research Center Detachment, Lima, Peru
Clin Infect Dis 37:1659-67. 2003..Primaquine's major advantage over most drugs for chemoprophylaxis is that it does not have to be taken before entering or beyond 3 days after leaving a malarious area... - Rationale and plans for developing a non-replicating, metabolically active, radiation-attenuated Plasmodium falciparum sporozoite vaccineThomas C Luke
Uniformed University of the Health Sciences, Bethesda, MD 20814, USA
J Exp Biol 206:3803-8. 2003..By producing a vaccine for travelers, Sanaria will provide the infrastructure, regulatory foundation and funds necessary to speed licensure, manufacturing and deployment of the vaccine for the infants and children who need it most... - Short report: therapeutic efficacy of chloroquine combined with primaquine against Plasmodium falciparum in northeastern Papua, IndonesiaJ Kevin Baird
US Naval Medical Research Unit No 2, American Embassy Jakarta, Indonesia
Am J Trop Med Hyg 66:659-60. 2002..2; 95% CI, 0.1-1.8; P = 0.2) or day 28 (82% versus 93%; OR, 0.31; 95% Cl, 0.04-2.1; P = 0.23). This report corroborates studies suggesting that therapeutic doses of primaquine exert no discernible effect on parasitemia by P. falciparum... - Molecular dissection of the human antibody response to the structural repeat epitope of Plasmodium falciparum sporozoite from a protected donorJonathan A Chappel
Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
Malar J 3:28. 2004..In individuals immunized by the bites of irradiated Anopheles mosquitoes carrying P. falciparum sporozoites in their salivary glands, the anti-repeat response dominates and is thought by many to play a role in protective immunity... - Characteristics of severe anemia and its association with malaria in young children of the Kassena-Nankana District of northern GhanaSeth Owusu-Agyei
Navrongo Health Research Center, Ministry of Health, Navrongo, Upper East Region, Ghana
Am J Trop Med Hyg 67:371-7. 2002..Evidence suggests that dramatic peaks and troughs of severe anemia are regular and possibly predictable events that may be used to gauge the health and survival of young children in this area... - Comparative analysis of apicomplexa and genomic diversity in eukaryotesThomas J Templeton
Department of Microbiology and Immunology, Weill Medical College and the Program in Immunology and Microbial Pathogenesis, Weill Graduate School of Medical Sciences of Cornell University, New York, New York 10021, USA
Genome Res 14:1686-95. 2004..We also describe additional molecular characteristics distinguishing Apicomplexa from other eukaryotes for which complete genome sequences are available... - Assessing the Parasight-F test in northeastern Papua, Indonesia, an area of mixed Plasmodium falciparum and Plasmodium vivax transmissionWalter R J Taylor
US Naval Medical Research Unit No 2, Jakarta, Indonesia
Am J Trop Med Hyg 66:649-52. 2002..falciparum parasitemia in patients presenting with clinical malaria. However, the high false-positive rate on day 7 limits its use for patient follow-up... - Primaquine therapy for malariaJ Kevin Baird
US Naval Medical Research Center Detachment, Lima, Peru
Clin Infect Dis 39:1336-45. 2004..5 mg/kg primaquine daily for 14 days, on the basis of superior efficacy and good tolerability and safety in nonpregnant persons without glucose-6-phosphate dehydrogenase deficiency... - Seasonal profiles of malaria infection, anaemia, and bednet use among age groups and communities in northern GhanaKwadwo A Koram
Noguchi Memorial Institute for Medical Research, Legon, Accra, Ghana
Trop Med Int Health 8:793-802. 2003..There was a significantly lower risk of parasitaemia among infants [odds ratio (OR) 6-8] and young children (OR 3-4) living in the central, more urbanized sector of the study area... - Malaria: a protective paradoxStephen L Hoffman
Nature 444:824-7. 2006