Stephen L Hoffman

Summary

Affiliation: Celera Genomics
Country: USA

Publications

  1. ncbi Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites
    Stephen L Hoffman
    Malaria Program, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20850, USA
    J Infect Dis 185:1155-64. 2002
  2. ncbi Plasmodium, human and Anopheles genomics and malaria
    Stephen L Hoffman
    Celera Genomics, 45 West Gude Drive, Rockville, Maryland 20850, USA
    Nature 415:702-9. 2002
  3. doi Plasmodium: mammalian codon optimization of malaria plasmid DNA vaccines enhances antibody responses but not T cell responses nor protective immunity
    Carlota Dobano
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Exp Parasitol 122:112-23. 2009
  4. pmc Boosting of DNA vaccine-elicited gamma interferon responses in humans by exposure to malaria parasites
    Ruobing Wang
    Sanaria, Inc, 12115 Parklawn Drive, Suite L, Rockville, MD 20852, USA
    Infect Immun 73:2863-72. 2005
  5. ncbi Induction in humans of CD8+ and CD4+ T cell and antibody responses by sequential immunization with malaria DNA and recombinant protein
    Ruobing Wang
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA
    J Immunol 172:5561-9. 2004
  6. ncbi Successful induction of CD8 T cell-dependent protection against malaria by sequential immunization with DNA and recombinant poxvirus of neonatal mice born to immune mothers
    Martha Sedegah
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA
    J Immunol 171:3148-53. 2003
  7. pmc Protection of rhesus macaques against lethal Plasmodium knowlesi malaria by a heterologous DNA priming and poxvirus boosting immunization regimen
    William O Rogers
    Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910, USA
    Infect Immun 70:4329-35. 2002
  8. ncbi Anemia in parasite- and recombinant protein-immunized aotus monkeys infected with Plasmodium falciparum
    Trevor R Jones
    Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910, USA
    Am J Trop Med Hyg 66:672-9. 2002
  9. pmc Comparative genomics of the neglected human malaria parasite Plasmodium vivax
    Jane M Carlton
    The Institute for Genomic Research J Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
    Nature 455:757-63. 2008
  10. ncbi Safety and clinical outcome of experimental challenge of human volunteers with Plasmodium falciparum-infected mosquitoes: an update
    Judith E Epstein
    Malaria Program, Naval Medical Research Center, Silver Spring, MD, 20910, USA
    J Infect Dis 196:145-54. 2007

Detail Information

Publications50

  1. ncbi Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites
    Stephen L Hoffman
    Malaria Program, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20850, USA
    J Infect Dis 185:1155-64. 2002
    ....
  2. ncbi Plasmodium, human and Anopheles genomics and malaria
    Stephen L Hoffman
    Celera Genomics, 45 West Gude Drive, Rockville, Maryland 20850, USA
    Nature 415:702-9. 2002
    ....
  3. doi Plasmodium: mammalian codon optimization of malaria plasmid DNA vaccines enhances antibody responses but not T cell responses nor protective immunity
    Carlota Dobano
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Exp Parasitol 122:112-23. 2009
    ..These data demonstrate that the effect of mammalian codon optimization is antigen-dependent and may not be beneficial for vaccines designed to induce T cell dependent protective immunity in this malaria model...
  4. pmc Boosting of DNA vaccine-elicited gamma interferon responses in humans by exposure to malaria parasites
    Ruobing Wang
    Sanaria, Inc, 12115 Parklawn Drive, Suite L, Rockville, MD 20852, USA
    Infect Immun 73:2863-72. 2005
    ....
  5. ncbi Induction in humans of CD8+ and CD4+ T cell and antibody responses by sequential immunization with malaria DNA and recombinant protein
    Ruobing Wang
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA
    J Immunol 172:5561-9. 2004
    ..The induction in humans of the three primary Ag-specific adaptive immune responses establishes a strategy for developing immunization regimens against diseases in desperate need of vaccines...
  6. ncbi Successful induction of CD8 T cell-dependent protection against malaria by sequential immunization with DNA and recombinant poxvirus of neonatal mice born to immune mothers
    Martha Sedegah
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA
    J Immunol 171:3148-53. 2003
    ..yoelii parasites or immunized with the vaccine were protected and had excellent T cell responses. These data support assessment of this immunization strategy in neonates/young infants in areas in which malaria exacts its greatest toll...
  7. pmc Protection of rhesus macaques against lethal Plasmodium knowlesi malaria by a heterologous DNA priming and poxvirus boosting immunization regimen
    William O Rogers
    Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910, USA
    Infect Immun 70:4329-35. 2002
    ..These findings demonstrate that a multistage, multiantigen, DNA priming and poxvirus boosting vaccine regimen can protect nonhuman primates from an otherwise lethal malaria sporozoite challenge...
  8. ncbi Anemia in parasite- and recombinant protein-immunized aotus monkeys infected with Plasmodium falciparum
    Trevor R Jones
    Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910, USA
    Am J Trop Med Hyg 66:672-9. 2002
    ..Partial immunity-whether induced by repeated immunization with whole parasites or with vaccine-seems important to the development of anemia...
  9. pmc Comparative genomics of the neglected human malaria parasite Plasmodium vivax
    Jane M Carlton
    The Institute for Genomic Research J Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
    Nature 455:757-63. 2008
    ..Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species...
  10. ncbi Safety and clinical outcome of experimental challenge of human volunteers with Plasmodium falciparum-infected mosquitoes: an update
    Judith E Epstein
    Malaria Program, Naval Medical Research Center, Silver Spring, MD, 20910, USA
    J Infect Dis 196:145-54. 2007
    ..In 1997, an analysis of experience with 118 volunteers indicated that mosquito inoculation of P. falciparum could be a safe, well-tolerated, reproducible, and efficient method of challenge...
  11. ncbi Nucleic acid vaccines against malaria
    Denise L Doolan
    Malaria Program, Naval Medical Research Center, Silver Spring, MD, USA
    Chem Immunol 80:308-21. 2002
  12. ncbi Immunological responses of neonates and infants to DNA vaccines
    Martha Sedegah
    Malaria Program, Naval Medical Research Center, Silver Spring, MD, USA
    Methods Mol Med 127:239-51. 2006
    ..These data support assessment of this immunization strategy in neonates/young infants in areas where malaria exacts the greatest toll...
  13. pmc High-throughput generation of P. falciparum functional molecules by recombinational cloning
    João Carlos Aguiar
    Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910, USA
    Genome Res 14:2076-82. 2004
    ..falciparum genome and will provide for a resource for the malaria resource community distributed through public repositories...
  14. ncbi Absence of antigenic competition in Aotus monkeys immunized with Plasmodium falciparum DNA vaccines delivered as a mixture
    Trevor R Jones
    Malaria Program, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Vaccine 20:1675-80. 2002
    ..The fourth immunization with the trivalent vaccine increased the mean antibody in IFAT by more than five-fold...
  15. ncbi Safety, tolerability, and antibody responses in humans after sequential immunization with a PfCSP DNA vaccine followed by the recombinant protein vaccine RTS,S/AS02A
    Judith E Epstein
    Malaria Program, Naval Medical Research Center, 503 Robert Grant Ave, Silver Spring, MD 20910, USA
    Vaccine 22:1592-603. 2004
    ....
  16. pmc Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data
    Denise L Doolan
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Proc Natl Acad Sci U S A 100:9952-7. 2003
    ..The data suggest that immune responses to Plasmodium are dispersed on a relatively large number of parasite antigens. These studies have implications for our understanding of immunodominance and breadth of responses to complex pathogens...
  17. pmc CpG oligodeoxynucleotide and Montanide ISA 51 adjuvant combination enhanced the protective efficacy of a subunit malaria vaccine
    Sanjai Kumar
    Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910, USA
    Infect Immun 72:949-57. 2004
    ..Our results indicate that this potent adjuvant formulation should be further evaluated for use in clinical trials of recombinant malarial vaccine candidates...
  18. ncbi Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii
    Jane M Carlton
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 419:512-9. 2002
    ..This is the first genome sequence of a model eukaryotic parasite, and it provides insight into the use of such systems in the modelling of Plasmodium biology and disease...
  19. ncbi Parasitology. Malaria--from infants to genomics to vaccines
    Carole A Long
    Malaria Vaccine Development Unit, National Institutes of Health, Rockville, MD 20852, USA
    Science 297:345-7. 2002
  20. pmc Persistence of protective immunity to malaria induced by DNA priming and poxvirus boosting: characterization of effector and memory CD8(+)-T-cell populations
    Martha Sedegah
    Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910 7500, USA
    Infect Immun 70:3493-9. 2002
    ..These results demonstrate that a heterologous priming and boosting vaccination can provide lasting protection against malaria in this model system...
  21. doi The Effects of radiation on the safety and protective efficacy of an attenuated Plasmodium yoelii sporozoite malaria vaccine
    Rana Chattopadhyay
    Sanaria Inc, 9800 Medical Center Drive, Rockville, MD 20850, United States
    Vaccine 27:3675-80. 2009
    ..These results support the contention that a radiation attenuated sporozoite vaccine for malaria will be safe and effective at a range of radiation doses...
  22. ncbi PfSPATR, a Plasmodium falciparum protein containing an altered thrombospondin type I repeat domain is expressed at several stages of the parasite life cycle and is the target of inhibitory antibodies
    Rana Chattopadhyay
    Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910 7500, USA
    J Biol Chem 278:25977-81. 2003
    ..falciparum sporozoites specifically recognized the expression of this protein on transfected COS-7 cells. These data support the evaluation of this protein as a vaccine candidate...
  23. ncbi Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14
    Malcolm J Gardner
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 419:531-4. 2002
    ..We report here the nucleotide sequences of chromosomes 10, 11 and 14, and a re-analysis of the chromosome 2 sequence. These chromosomes represent about 35% of the 23-megabase P. falciparum genome...
  24. ncbi Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria
    Stephen L Hoffman
    Sanaria Inc, Rockville, MD, USA
    Hum Vaccin 6:97-106. 2010
    ..A medium term goal is to design and build a facility for manufacturing highly potent and stable vaccine for pivotal Phase 3 studies and commercial launch...
  25. pmc Genome sequence of the human malaria parasite Plasmodium falciparum
    Malcolm J Gardner
    The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA
    Nature 419:498-511. 2002
    ..The genome sequence provides the foundation for future studies of this organism, and is being exploited in the search for new drugs and vaccines to fight malaria...
  26. ncbi Safety, tolerability, and lack of antibody responses after administration of a PfCSP DNA malaria vaccine via needle or needle-free jet injection, and comparison of intramuscular and combination intramuscular/intradermal routes
    Judith E Epstein
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA
    Hum Gene Ther 13:1551-60. 2002
    ....
  27. ncbi A multilateral effort to develop DNA vaccines against falciparum malaria
    Sanjai Kumar
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA
    Trends Parasitol 18:129-35. 2002
    ....
  28. ncbi Seasonal malaria attack rates in infants and young children in northern Ghana
    J Kevin Baird
    Naval Medical Research Center, Silver Spring, Maryland, USA
    Am J Trop Med Hyg 66:280-6. 2002
    ..These findings bear upon the design of malaria drug and vaccine trials in holoendemic areas...
  29. ncbi The genome sequence of the malaria mosquito Anopheles gambiae
    Robert A Holt
    Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
    Science 298:129-49. 2002
    ..An expressed sequence tag analysis of genes regulated by blood feeding provided insights into the physiological adaptations of a hematophagous insect...
  30. pmc Cures for the Third World's problems: the application of genomics to the diseases plaguing the developing world may have huge medical and economic benefits for those countries and might even prevent armed conflict
    Samuel Broder
    Clera Genomics, Rockville, MD, USA
    EMBO Rep 3:806-12. 2002
  31. pmc Comparative immunopeptidomics of humans and their pathogens
    Sorin Istrail
    Celera Genomics, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 101:13268-72. 2004
    ....
  32. pmc Controlled human malaria infections by intradermal injection of cryopreserved Plasmodium falciparum sporozoites
    Meta Roestenberg
    Radboud University Nijmegen Medical Center, Department of Medical Microbiology, Nijmegen, The Netherlands
    Am J Trop Med Hyg 88:5-13. 2013
    ..After further optimization, the use of such PfSPZ may facilitate and accelerate clinical development of novel malaria drugs and vaccines...
  33. ncbi A DNA vaccine encoding the 42 kDa C-terminus of merozoite surface protein 1 of Plasmodium falciparum induces antibody, interferon-gamma and cytotoxic T cell responses in rhesus monkeys: immuno-stimulatory effects of granulocyte macrophage-colony stimulati
    Sanjai Kumar
    Malaria Program, Naval Medical Research Center, Silver Spring, MD 20910, USA
    Immunol Lett 81:13-24. 2002
    ..The GM-CSF plasmid or protein appears to be less potent as an adjuvant in rhesus monkeys than each is in mice, and more work is needed to determine if GM-CSF can be a useful adjuvant in DNA vaccination of primates...
  34. doi Hark back: passive immunotherapy for influenza and other serious infections
    Thomas C Luke
    Henry Jackson Foundation, Naval Medical Research Center, Silver Spring, MD, USA
    Crit Care Med 38:e66-73. 2010
    ..Past, current, and future uses of immunotherapy and current advisory body recommendations for this approach are presented...
  35. ncbi Laser capture microdissection and molecular analysis of Plasmodium yoelii liver-stage parasites
    John B Sacci
    Malaria Program, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Mol Biochem Parasitol 119:285-9. 2002
  36. ncbi Randomized, placebo-controlled trial of atovaquone/proguanil for the prevention of Plasmodium falciparum or Plasmodium vivax malaria among migrants to Papua, Indonesia
    Judith Ling
    Naval Medical Research Unit 2, Jakarta, Indonesia
    Clin Infect Dis 35:825-33. 2002
    ..Atovaquone/proguanil was well tolerated, safe, and effective for the prevention of drug-resistant P. vivax and P. falciparum malaria in individuals without prior malaria exposure who migrated to Papua, Indonesia...
  37. ncbi Atovaquone/proguanil therapy for Plasmodium falciparum and Plasmodium vivax malaria in Indonesians who lack clinical immunity
    Mark D Lacy
    Parasitic Diseases Program, US Naval Medical Research Unit 2, Jakarta, Indonesia
    Clin Infect Dis 35:e92-5. 2002
    ..Atovaquone/proguanil provided safe, well-tolerated, and effective therapy for uncomplicated malaria in nonimmune Indonesians...
  38. ncbi Mefloquine treatment for uncomplicated falciparum malaria in young children 6-24 months of age in northern Ghana
    David J Fryauff
    US Naval Medical Research Unit No 3, Cairo, Egypt
    Am J Trop Med Hyg 76:224-31. 2007
    ..An observed recurrent parasitemia of 34,400 trophozoites/microL against a MQ blood concentration of 550 ng/mL was taken as indication of tolerance to suppressive levels of the drug at this location...
  39. ncbi A randomized, double-blind, placebo-controlled, dose-ranging trial of tafenoquine for weekly prophylaxis against Plasmodium falciparum
    Braden R Hale
    US Navy Medical Research Unit No 3, Cairo, Egypt
    Clin Infect Dis 36:541-9. 2003
    ..Tafenoquine dosages of 50, 100, and 200 mg/week were safe, well tolerated, and effective against P. falciparum infection in this study population...
  40. ncbi Malaria transmission dynamics at a site in northern Ghana proposed for testing malaria vaccines
    Maxwell Appawu
    Noguchi Memorial Institute for Medical Research, Legon, Accra, Ghana
    Trop Med Int Health 9:164-70. 2004
    ..00 hours. Vaccine trials could be conducted in this district, with timing dependent on the seasonal patterns and intensity of transmission taking into consideration the micro-geographical differences and vaccine trial objectives...
  41. ncbi Primaquine for prevention of malaria in travelers
    J Kevin Baird
    US Naval Medical Research Center Detachment, Lima, Peru
    Clin Infect Dis 37:1659-67. 2003
    ..Primaquine's major advantage over most drugs for chemoprophylaxis is that it does not have to be taken before entering or beyond 3 days after leaving a malarious area...
  42. ncbi Rationale and plans for developing a non-replicating, metabolically active, radiation-attenuated Plasmodium falciparum sporozoite vaccine
    Thomas C Luke
    Uniformed University of the Health Sciences, Bethesda, MD 20814, USA
    J Exp Biol 206:3803-8. 2003
    ..By producing a vaccine for travelers, Sanaria will provide the infrastructure, regulatory foundation and funds necessary to speed licensure, manufacturing and deployment of the vaccine for the infants and children who need it most...
  43. ncbi Assessing the Parasight-F test in northeastern Papua, Indonesia, an area of mixed Plasmodium falciparum and Plasmodium vivax transmission
    Walter R J Taylor
    US Naval Medical Research Unit No 2, Jakarta, Indonesia
    Am J Trop Med Hyg 66:649-52. 2002
    ..falciparum parasitemia in patients presenting with clinical malaria. However, the high false-positive rate on day 7 limits its use for patient follow-up...
  44. pmc Molecular dissection of the human antibody response to the structural repeat epitope of Plasmodium falciparum sporozoite from a protected donor
    Jonathan A Chappel
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Malar J 3:28. 2004
    ..In individuals immunized by the bites of irradiated Anopheles mosquitoes carrying P. falciparum sporozoites in their salivary glands, the anti-repeat response dominates and is thought by many to play a role in protective immunity...
  45. ncbi Characteristics of severe anemia and its association with malaria in young children of the Kassena-Nankana District of northern Ghana
    Seth Owusu-Agyei
    Navrongo Health Research Center, Ministry of Health, Navrongo, Upper East Region, Ghana
    Am J Trop Med Hyg 67:371-7. 2002
    ..Evidence suggests that dramatic peaks and troughs of severe anemia are regular and possibly predictable events that may be used to gauge the health and survival of young children in this area...
  46. pmc Comparative analysis of apicomplexa and genomic diversity in eukaryotes
    Thomas J Templeton
    Department of Microbiology and Immunology, Weill Medical College and the Program in Immunology and Microbial Pathogenesis, Weill Graduate School of Medical Sciences of Cornell University, New York, New York 10021, USA
    Genome Res 14:1686-95. 2004
    ..We also describe additional molecular characteristics distinguishing Apicomplexa from other eukaryotes for which complete genome sequences are available...
  47. ncbi Short report: therapeutic efficacy of chloroquine combined with primaquine against Plasmodium falciparum in northeastern Papua, Indonesia
    J Kevin Baird
    US Naval Medical Research Unit No 2, American Embassy Jakarta, Indonesia
    Am J Trop Med Hyg 66:659-60. 2002
    ..2; 95% CI, 0.1-1.8; P = 0.2) or day 28 (82% versus 93%; OR, 0.31; 95% Cl, 0.04-2.1; P = 0.23). This report corroborates studies suggesting that therapeutic doses of primaquine exert no discernible effect on parasitemia by P. falciparum...
  48. ncbi Malaria: a protective paradox
    Stephen L Hoffman
    Nature 444:824-7. 2006
  49. ncbi Primaquine therapy for malaria
    J Kevin Baird
    US Naval Medical Research Center Detachment, Lima, Peru
    Clin Infect Dis 39:1336-45. 2004
    ..5 mg/kg primaquine daily for 14 days, on the basis of superior efficacy and good tolerability and safety in nonpregnant persons without glucose-6-phosphate dehydrogenase deficiency...
  50. ncbi Seasonal profiles of malaria infection, anaemia, and bednet use among age groups and communities in northern Ghana
    Kwadwo A Koram
    Noguchi Memorial Institute for Medical Research, Legon, Accra, Ghana
    Trop Med Int Health 8:793-802. 2003
    ..There was a significantly lower risk of parasitaemia among infants [odds ratio (OR) 6-8] and young children (OR 3-4) living in the central, more urbanized sector of the study area...