Ann B Begovich

Summary

Affiliation: Celera Diagnostics
Country: USA

Publications

  1. ncbi A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis
    Ann B Begovich
    Celera Diagnostics, Alameda, CA 94502, USA
    Am J Hum Genet 75:330-7. 2004
  2. ncbi Data for Genetic Analysis Workshop (GAW) 15 Problem 2, genetic causes of rheumatoid arthritis and associated traits
    Christopher I Amos
    Departments of Epidemiology and Biomathematics, University of Texas, Anderson Cancer Center, 1155 Pressler Street, Unit 1340, Houston, Texas 77030, USA
    BMC Proc 1:S3. 2007
  3. ncbi The inflammatory disease-associated variants in IL12B and IL23R are not associated with rheumatoid arthritis
    Monica Chang
    Celera, Alameda, CA, USA
    Arthritis Rheum 58:1877-81. 2008
  4. ncbi Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22
    Yonghong Li
    Celera, Alameda, California 94502, USA
    J Invest Dermatol 129:629-34. 2009
  5. ncbi Carriers of rare missense variants in IFIH1 are protected from psoriasis
    Yonghong Li
    Celera, Alameda, California 94502, USA
    J Invest Dermatol 130:2768-72. 2010
  6. ncbi The 5q31 variants associated with psoriasis and Crohn's disease are distinct
    Yonghong Li
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Hum Mol Genet 17:2978-85. 2008
  7. ncbi PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis
    Victoria E H Carlton
    Celera Diagnostics, Alameda, CA 94502, USA
    Am J Hum Genet 77:567-81. 2005
  8. ncbi The autoimmune disease-associated IL12B and IL23R polymorphisms in multiple sclerosis
    Ann B Begovich
    Celera, Alameda, CA, USA
    Hum Immunol 68:934-7. 2007
  9. ncbi A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes
    Michele Cargill
    Celera, Alameda, CA 94502, USA
    Am J Hum Genet 80:273-90. 2007
  10. ncbi Meta-analysis evidence of a differential risk of the FCRL3 -169T-->C polymorphism in white and East Asian rheumatoid arthritis patients
    Ann B Begovich
    Celera, Alameda, CA, USA
    Arthritis Rheum 56:3168-71. 2007

Collaborators

Detail Information

Publications12

  1. ncbi A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis
    Ann B Begovich
    Celera Diagnostics, Alameda, CA 94502, USA
    Am J Hum Genet 75:330-7. 2004
    ..The minor allele of this SNP recently was implicated in type 1 diabetes, suggesting that the variant phosphatase may increase overall reactivity of the immune system and may heighten an individual carrier's risk for autoimmune disease...
  2. ncbi Data for Genetic Analysis Workshop (GAW) 15 Problem 2, genetic causes of rheumatoid arthritis and associated traits
    Christopher I Amos
    Departments of Epidemiology and Biomathematics, University of Texas, Anderson Cancer Center, 1155 Pressler Street, Unit 1340, Houston, Texas 77030, USA
    BMC Proc 1:S3. 2007
    ....
  3. ncbi The inflammatory disease-associated variants in IL12B and IL23R are not associated with rheumatoid arthritis
    Monica Chang
    Celera, Alameda, CA, USA
    Arthritis Rheum 58:1877-81. 2008
  4. ncbi Further genetic evidence for three psoriasis-risk genes: ADAM33, CDKAL1, and PTPN22
    Yonghong Li
    Celera, Alameda, California 94502, USA
    J Invest Dermatol 129:629-34. 2009
    ..57 x 10(-5) (3,206 cases and 4,529 controls), and rs3789604: P=3.45 x 10(-5) (2,823 cases and 4,066 controls)). These data increase the likelihood that ADAM33, CDKAL1, and PTPN22 are true psoriasis-risk genes...
  5. ncbi Carriers of rare missense variants in IFIH1 are protected from psoriasis
    Yonghong Li
    Celera, Alameda, California 94502, USA
    J Invest Dermatol 130:2768-72. 2010
    ..Compared to noncarriers, carriers of the 923Val and/or 460Arg variants were protected from psoriasis (OR=0.46, P=5.56 × 10(-8)). To our knowledge, these results suggest that IFIH1 is a previously unreported psoriasis gene...
  6. ncbi The 5q31 variants associated with psoriasis and Crohn's disease are distinct
    Yonghong Li
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Hum Mol Genet 17:2978-85. 2008
    ..These results identify the most significant 5q31 risk variants for psoriasis and suggest that distinct 5q31 variants contribute to CD and psoriasis risk...
  7. ncbi PTPN22 genetic variation: evidence for multiple variants associated with rheumatoid arthritis
    Victoria E H Carlton
    Celera Diagnostics, Alameda, CA 94502, USA
    Am J Hum Genet 77:567-81. 2005
    ..Additional analyses identified two SNPs on a single common haplotype that are associated with RA independent of R620W, suggesting that R620W and at least one additional variant in the PTPN22 gene region influence RA susceptibility...
  8. ncbi The autoimmune disease-associated IL12B and IL23R polymorphisms in multiple sclerosis
    Ann B Begovich
    Celera, Alameda, CA, USA
    Hum Immunol 68:934-7. 2007
    ..Family-based association analysis was performed. There was no evidence of transmission distortion of any of the tested alleles in this data set...
  9. ncbi A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes
    Michele Cargill
    Celera, Alameda, CA 94502, USA
    Am J Hum Genet 80:273-90. 2007
    ..These data, and the previous observation that administration of an antibody specific for the IL-12p40 subunit to patients with psoriasis is highly efficacious, suggest that these genes play a fundamental role in psoriasis pathogenesis...
  10. ncbi Meta-analysis evidence of a differential risk of the FCRL3 -169T-->C polymorphism in white and East Asian rheumatoid arthritis patients
    Ann B Begovich
    Celera, Alameda, CA, USA
    Arthritis Rheum 56:3168-71. 2007
  11. ncbi Unraveling the genetics of complex diseases: susceptibility genes for rheumatoid arthritis and psoriasis
    Yonghong Li
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Semin Immunol 21:318-27. 2009
    ....
  12. ncbi The functional -169T-->C single-nucleotide polymorphism in FCRL3 is not associated with rheumatoid arthritis in white North Americans
    Xiaolan Hu
    Celera Diagnostics, Alameda, CA
    Arthritis Rheum 54:1022-5. 2006