Run Yu

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. doi request reprint Cardiac complications as initial manifestation of pheochromocytoma: frequency, outcome, and predictors
    Run Yu
    Division of Endocrinology and Carcinoid and Neuroendocrine Tumor Center, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Endocr Pract 18:483-92. 2012
  2. doi request reprint Mixed acinar-endocrine carcinoma of the pancreas: new clinical and pathological features in a contemporary series
    Run Yu
    Division of Endocrinology, Department of Pathology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Pancreas 42:429-35. 2013
  3. pmc Pancreatic neuroendocrine tumors: biology, diagnosis,and treatment
    Cynthia Ro
    Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Chin J Cancer 32:312-24. 2013
  4. ncbi request reprint Perioperative management of pheochromocytoma: the heart of the issue
    J Shen
    Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Minerva Endocrinol 38:77-93. 2013
  5. doi request reprint Glucagon receptor is required for long-term survival: a natural history study of the Mahvash disease in a murine model
    Run Yu
    Division of Endocrinology and Carcinoid and Neuroendocrine Tumor Center, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Endocrinol Nutr 59:523-30. 2012
  6. doi request reprint Rescue of a pathogenic mutant human glucagon receptor by pharmacological chaperones
    Run Yu
    Division of Endocrinology and Carcinoid and Neuroendocrine Tumor Center, Cedars Sinai Medical Center, B 131, 8700 Beverly Boulevard, Los Angeles, California 90048, USA
    J Mol Endocrinol 49:69-78. 2012
  7. ncbi request reprint Novel syndrome of four-limb proximal fragility fractures associated with HIV infection, cholestatic liver failure, and histiocytic infiltration of bone marrow
    Run Yu
    Division of Endocrinology, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    Hormones (Athens) 11:203-6. 2012
  8. doi request reprint Small pheochromocytomas: significance, diagnosis, and outcome
    Run Yu
    Division of Endocrinology and Hypertension Center of Excellence, Cedars Sinai Medical Center, B 131, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    J Clin Hypertens (Greenwich) 14:307-15. 2012
  9. doi request reprint False positive test results for pheochromocytoma from 2000 to 2008
    R Yu
    Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Exp Clin Endocrinol Diabetes 118:577-85. 2010
  10. ncbi request reprint Cardiac abnormalities associated with pheochromocytoma and other adrenal tumors
    Run Yu
    Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Endocr Pract 15:10-6. 2009

Research Grants

Collaborators

Detail Information

Publications44

  1. doi request reprint Cardiac complications as initial manifestation of pheochromocytoma: frequency, outcome, and predictors
    Run Yu
    Division of Endocrinology and Carcinoid and Neuroendocrine Tumor Center, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Endocr Pract 18:483-92. 2012
    ..To examine the frequency, outcome, and clinical predictors of cardiac complications as the initial manifestation of pheochromocytoma...
  2. doi request reprint Mixed acinar-endocrine carcinoma of the pancreas: new clinical and pathological features in a contemporary series
    Run Yu
    Division of Endocrinology, Department of Pathology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Pancreas 42:429-35. 2013
    ..The objective of this study was to characterize the novel clinical and pathological features of mixed acinar-endocrine carcinoma of the pancreas...
  3. pmc Pancreatic neuroendocrine tumors: biology, diagnosis,and treatment
    Cynthia Ro
    Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Chin J Cancer 32:312-24. 2013
    ..The clinical presentation, diagnosis, and treatment of specific types of PNETs and familial PNET syndromes, including the novel Mahvash disease, are summarized...
  4. ncbi request reprint Perioperative management of pheochromocytoma: the heart of the issue
    J Shen
    Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Minerva Endocrinol 38:77-93. 2013
    ..Perioperative management in unique clinical situations is also discussed...
  5. doi request reprint Glucagon receptor is required for long-term survival: a natural history study of the Mahvash disease in a murine model
    Run Yu
    Division of Endocrinology and Carcinoid and Neuroendocrine Tumor Center, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Endocrinol Nutr 59:523-30. 2012
    ..We aim to elucidate the natural history of the rare Mahvash disease by long-term observation of the Gcgr(-/-) mice...
  6. doi request reprint Rescue of a pathogenic mutant human glucagon receptor by pharmacological chaperones
    Run Yu
    Division of Endocrinology and Carcinoid and Neuroendocrine Tumor Center, Cedars Sinai Medical Center, B 131, 8700 Beverly Boulevard, Los Angeles, California 90048, USA
    J Mol Endocrinol 49:69-78. 2012
    ..The novel glucagon analogs, however, failed to interact with P86S more effectively...
  7. ncbi request reprint Novel syndrome of four-limb proximal fragility fractures associated with HIV infection, cholestatic liver failure, and histiocytic infiltration of bone marrow
    Run Yu
    Division of Endocrinology, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    Hormones (Athens) 11:203-6. 2012
    ..The case further calls for the need for monitoring of bone health in patients with HIV infection or liver disease...
  8. doi request reprint Small pheochromocytomas: significance, diagnosis, and outcome
    Run Yu
    Division of Endocrinology and Hypertension Center of Excellence, Cedars Sinai Medical Center, B 131, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    J Clin Hypertens (Greenwich) 14:307-15. 2012
    ..Small pheochromocytomas should be removed to prevent hypertensive crisis and future complications of pheochromocytoma...
  9. doi request reprint False positive test results for pheochromocytoma from 2000 to 2008
    R Yu
    Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Exp Clin Endocrinol Diabetes 118:577-85. 2010
    ..Pretest risk, physiological variations of catecholamine levels, laboratory errors, and drug interference should be considered in interpreting abnormal test results...
  10. ncbi request reprint Cardiac abnormalities associated with pheochromocytoma and other adrenal tumors
    Run Yu
    Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Endocr Pract 15:10-6. 2009
    ..To study the specific cardiac abnormalities associated with pheochromocytoma and to suggest a strategy for evaluating cardiac function in patients with pheochromocytoma...
  11. ncbi request reprint Murine pituitary tumor-transforming gene functions as a securin protein in insulin-secreting cells
    Run Yu
    UCLA School of Medicine, Cedars Sinai Research Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Room D3066, Los Angeles, California 90048, USA
    J Endocrinol 191:45-53. 2006
    ....
  12. doi request reprint A natural inactivating mutant of human glucagon receptor exhibits multiple abnormalities in processing and signaling
    Run Yu
    Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, California, USA
    Endocrinol Nutr 58:258-66. 2011
    ..To elucidate the pathogenetic mechanisms of a mutant P86S glucagon receptor (GCGR) in causing a novel human disease (Mahvash disease)...
  13. doi request reprint Ordering pattern and performance of biochemical tests for diagnosing pheochromocytoma between 2000 and 2008
    Run Yu
    Division of Endocrinology and Carcinoid and Neuroendocrine Tumor Center, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Endocr Pract 15:313-21. 2009
    ..To examine what tests are ordered by physicians for pheochromocytoma diagnosis and how those tests perform in modern clinical practice...
  14. doi request reprint Diagnosis and treatment of pheochromocytoma in an academic hospital from 1997 to 2007
    Run Yu
    Division of Endocrinology and Carcinoid and Neuroendocrine Tumor Center, Cedars Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90084, USA
    Am J Med 122:85-95. 2009
    ..We aimed to systemically study the diagnostic accuracy and treatment outcomes of pheochromocytoma and to reveal the causes and consequences of misdiagnosis (including both overdiagnosis and underdiagnosis)...
  15. ncbi request reprint Pheochromocytoma in patients suspected of harboring adrenal metastasis: management and clinical predictors
    Run Yu
    Division of Endocrinology and Carcinoid and Neuroendocrine Tumor Center, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Endocr Pract 14:967-72. 2008
    ..To study clinical management of patients with suspected adrenal metastasis and to assess whether there are clinical predictors of pheochromocytoma in this patient population...
  16. doi request reprint Nesidioblastosis and hyperplasia of alpha cells, microglucagonoma, and nonfunctioning islet cell tumor of the pancreas: review of the literature
    Run Yu
    Division of Endocrinology, Cedars Sinai Medical Cente, Los Angeles, CA 90048, USA
    Pancreas 36:428-31. 2008
    ..Nesidioblastosis and hyperplasia of alpha cells should be considered in the differential diagnosis of hyperglucagonemia. Somatostatin analog may be used to suppress glucagon secretion in alpha-cell hyperplasia...
  17. pmc Pancreatic neuroendocrine tumors in glucagon receptor-deficient mice
    Run Yu
    Division of Endocrinology, Cedars Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
    PLoS ONE 6:e23397. 2011
    ..Our results further suggest that completely inhibiting glucagon signaling may not be a safe approach to treat diabetes...
  18. doi request reprint Diagnosis and management of pheochromocytoma in an academic hospital 3 years after formation of a pheochromocytoma interest group
    Run Yu
    Cedars Sinai Medical Center, Los Angeles, CA, USA
    Endocr Pract 17:356-62. 2011
    ..To examine whether establishment of a pheochromocytoma interest group improves diagnosis and management of pheochromocytoma in an academic hospital...
  19. pmc Homozygous P86S mutation of the human glucagon receptor is associated with hyperglucagonemia, alpha cell hyperplasia, and islet cell tumor
    Cuiqi Zhou
    Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Pancreas 38:941-6. 2009
    ..The goal of the study was to investigate the genetic and molecular basis of a novel syndrome of marked hyperglucagonemia and pancreatic alpha cell hyperplasia without glucagonoma syndrome...
  20. ncbi request reprint Clinical utility of FDG-PET for diagnosis of adrenal mass: a large single-center experience
    Allison Pitts
    Division of Endocrinology, 2Department of Imaging, Cedars Sinai Medical Center, Los Angeles, California, USA
    Hormones (Athens) 12:417-27. 2013
    ..To examine the clinical utility of 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) for diagnosing whether an adrenal mass is malignant, in contemporary clinical practice...
  21. pmc Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth
    Vera Chesnokova
    Department of Medicine, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90048, USA
    Cancer Res 67:10564-72. 2007
    ....
  22. ncbi request reprint Transfection of pancreatic-derived beta-cells with a minigene encoding for human glucagon-like peptide-1 regulates glucose-dependent insulin synthesis and secretion
    Hongxiang Hui
    Division of Diabetes, Endocrinology, and Metabolism, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Endocrinology 143:3529-39. 2002
    ..The present study lays the research foundation to investigate the potential use of GLP-1 for the gene or cell therapy of diabetes...
  23. pmc Diminished pancreatic beta-cell mass in securin-null mice is caused by beta-cell apoptosis and senescence
    Vera Chesnokova
    Division of Endocrinology, Diabetes, and Metabolism, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90048, USA
    Endocrinology 150:2603-10. 2009
    ..Our results also suggest that ductal progenitor beta-cells are exhausted by excessive neogenesis induced by apoptosis in PTTG(-/-) mice...
  24. doi request reprint Humoral hypercalcemia of malignancy caused by parathyroid hormone-related peptide-secreting neuroendocrine tumors. Report of six cases
    Anna Milanesi
    Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Pancreatology 13:324-6. 2013
    ..To our knowledge, this is the largest series to date of hypercalcemia mediated by PTHrP-secreting NET...
  25. ncbi request reprint A novel molecular marker of pituitary tumor transforming gene involves in a rat liver regeneration
    Kozo Akino
    Department of Medicine, Cedars Sinai Research Institute UCLA School of Medicine, Los Angeles, California, USA
    J Surg Res 129:142-6. 2005
    ..Because the liver is a regenerative organ, the relevant biological function of PTTG in the liver would be more feasible to understand PTTG. Also, PTTG may be involved in the liver regeneration...
  26. pmc Pituitary tumor transforming gene-null male mice exhibit impaired pancreatic beta cell proliferation and diabetes
    Zhiyong Wang
    Department of Medicine, Cedars Sinai Research Institute, University of California School of Medicine, Los Angeles, CA 90048, USA
    Proc Natl Acad Sci U S A 100:3428-32. 2003
    ..PTTG-/- beta cells had pleiotropic nuclei, suggesting defects in cell division. The results indicated that securin is indispensable for normal pancreatic beta cell proliferation...
  27. pmc Anti-aging therapy with human growth hormone associated with metastatic colon cancer in a patient with Crohn's colitis
    Gil Y Melmed
    Department of Medicine, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California, Los Angeles, California 90048, USA
    Clin Gastroenterol Hepatol 6:360-3. 2008
    ..The nonapproved use of human growth hormone (HGH) for anti-aging has been increasing. Theoretical concerns for neoplastic potentiation by HGH have been raised, but not proven clinically...
  28. doi request reprint FDG PET/CT as a prognostic test after 90Y radioembolization in patients with metastatic hepatic disease
    Martina Zalom
    Department of Hematology Oncology, Olive View UCLA Medical Center, Sylmar, Los Angeles, CA 90048, USA
    Clin Nucl Med 37:862-5. 2012
    ..Absence of new lesions outside the liver on postprocedure FDG PET/CT imaging helps identify patients achieving long-term survival...
  29. ncbi request reprint Pituitary tumor transforming gene: an update
    Run Yu
    Cedars Sinai Research Institute, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Front Horm Res 32:175-85. 2004
    ....
  30. ncbi request reprint Pancreatic neuroendocrine tumors: presentation, management, and outcomes
    Nicholas N Nissen
    Department of Surgery, Center for Liver Diseases and Transplantation, Cedars Sinai Medical Center, 8635 W 3rd Street, Suite 590W, Los Angeles, CA 90048, USA
    Am Surg 75:1025-9. 2009
    ..Pancreatic resection results in greater than 80 per cent 3-year survival in nonmetastatic pNET. In patients presenting with metastatic pNET, excellent survival rates are also achievable using a multidisciplinary multimodal approach...
  31. doi request reprint Concurrent primary hyperparathyroidism and humoral hypercalcemia of malignancy in a patient with multiple endocrine neoplasia type 1
    Anna Milanesi
    Division of Endocrinology, Samuel Oschin Comprehensive Cancer Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Pancreas 40:634-7. 2011
    ..Thus, in multiple endocrine neoplasia type 1, correct identification of the cause of hypercalcemia as PTHrP production from a PNET or PTH production from a parathyroid tumor has important therapeutic implications...
  32. ncbi request reprint Aryl hydrocarbon receptor interacting protein variants in sporadic pituitary adenomas
    Run Yu
    Cedars Sinai Medical Center, 8700 Beverly Boulevard, Room 2015, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 91:5126-9. 2006
    ....
  33. doi request reprint Ki-67 proliferative index predicts progression-free survival of patients with well-differentiated ileal neuroendocrine tumors
    Deepti Dhall
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Hum Pathol 43:489-95. 2012
    ..In conclusion, the Ki-67 index predicts PFS of patients with ileal wNETs...
  34. doi request reprint Pathogenesis of pituitary tumors
    Run Yu
    Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Prog Brain Res 182:207-27. 2010
    ....
  35. ncbi request reprint Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells
    Run Yu
    Cedars Sinai Research Institute, Universityof California Los Angeles School of Medicine, 90048, USA
    Endocrinology 144:4991-8. 2003
    ..These results demonstrate that PTTG induces aneuploidy in single, live, human cancer cells...
  36. doi request reprint Clinical use and utility of metaiodobenzylguanidine scintigraphy in pheochromocytoma diagnosis
    Irina Lev
    Department of Imaging, Cedars Sinai Medical Center, Los Angeles, California, USA
    Endocr Pract 16:398-407. 2010
    ..To examine the indications for metaiodobenzylguanidine (MIBG) scintigraphy and to assess its performance in localizing pheochromocytoma in the post-computed tomography and magnetic resonance imaging era...
  37. doi request reprint Metabolic and receptor imaging in patients with neuroendocrine tumors: comparison of fludeoxyglucose-positron emission tomography and computed tomography with indium in 111 pentetreotide
    Martina L Zalom
    Department of Internal Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
    Endocr Pract 15:521-7. 2009
    ..To determine whether positron emission tomography/computed tomography (PET/CT) and indium In 111 pentetreotide, individually or collectively, predict the outcome of patients with neuroendocrine tumors (NETs)...
  38. doi request reprint Animal models and cell lines of pancreatic neuroendocrine tumors
    Varsha Babu
    Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Pancreas 42:912-23. 2013
    ..In the future, animal models and cell lines of PNETs should also be used to study early tumor detection and molecular predictors of tumor behavior and to test the responses to, and mechanisms for, novel targeted drug therapies. ..
  39. ncbi request reprint Functional association of somatostatin receptor subtypes 2 and 5 in inhibiting human growth hormone secretion
    Song Guang Ren
    Cedars Sinai Research Institute, University of California, Los Angeles, School of Medicine, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 88:4239-45. 2003
    ....
  40. ncbi request reprint Cyclin-dependent kinase inhibitor gene polymorphisms in pituitary gigantism
    Run Yu
    Cedars Sinai Research Institute, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Endocrine 29:119-20. 2006
  41. ncbi request reprint Dietary galactose inhibits GDF-9 mediated follicular development in the rat ovary
    Gentao Liu
    Burns and Allen Research Institute, Cedars Sinai Medical Center, University of California Los Angeles School of Medicine, 90048, USA
    Reprod Toxicol 21:26-33. 2006
    ..The present study suggests that a high galactose diet inhibits follicular development, possibly through down-regulation of GDF-9 in the rat ovary, implying that GDF-9 may be involved in galactose-related ovarian toxicity...
  42. doi request reprint Morphologic features of carcinoid heart disease as assessed by three-dimensional transesophageal echocardiography
    Smruti S Nalawadi
    Division of Cardiology, Cedars Sinai Medical Center, Los Angeles, California, USA
    Echocardiography 27:1098-105. 2010
    ..We undertook this study to examine the incremental value of 3DTEE in the diagnosis of CHD...
  43. pmc Pathologic pancreatic endocrine cell hyperplasia
    Debra Ouyang
    World J Gastroenterol 17:137-43. 2011
    ..Further studies of pathologic pancreatic endocrine cell hyperplasia will likely yield insights into the pathogenesis and treatment of diabetes and pancreatic neuroendocrine tumors...
  44. ncbi request reprint The cell adhesion molecules N-cadherin and neural cell adhesion molecule regulate human growth hormone: a novel mechanism for regulating pituitary hormone secretion
    Tami Rubinek
    Institute of Endocrinology, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
    J Clin Endocrinol Metab 88:3724-30. 2003
    ..05). This study indicates that pituitary cell-cell contact mediated by homophilic interactions between adhesion molecules regulates human GH secretion...

Research Grants2

  1. SECURIN REGULATION OF PANCREATIC beta CELL MASS
    Run Yu; Fiscal Year: 2007
    ..John Adams and Basil Rapoport). Building on my extensive basic and clinical training, I expect to become an independent endocrine researcher upon completion of this K08 grant . ..