John S Yu

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. ncbi request reprint Sensitization of malignant glioma to chemotherapy through dendritic cell vaccination
    Gentao Liu
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, and Division of Hematology Oncology, Cedars Sinai Medical Center David Geffen Schol of Medicine at UCLA, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    Expert Rev Vaccines 5:233-47. 2006
  2. ncbi request reprint Isolation of cancer stem cells from adult glioblastoma multiforme
    Xiangpeng Yuan
    Maxine Dunitz Neurosurgical Institute, Suite 800 East, 8631 West 3rd Street, Los Angeles, CA 90048, USA
    Oncogene 23:9392-400. 2004
  3. doi request reprint Vaccination elicits correlated immune and clinical responses in glioblastoma multiforme patients
    Christopher J Wheeler
    Maxine Dunitz Neurosurgical Institute, Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, California, USA
    Cancer Res 68:5955-64. 2008
  4. ncbi request reprint Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma
    John S Yu
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, 8631 West Third Street, Suite 800E, Los Angeles, CA 90048, USA
    Cancer Res 64:4973-9. 2004
  5. ncbi request reprint Immunomodulatory neural stem cells for brain tumour therapy
    Jeffrey J Yu
    Cedars Sinai Medical Center, Department of Neurosurgery, Los Angeles, CA, USA
    Expert Opin Biol Ther 6:1255-62. 2006
  6. ncbi request reprint AIM-2: a novel tumor antigen is expressed and presented by human glioma cells
    Gentao Liu
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Immunother 27:220-6. 2004
  7. pmc Chemokine CXC receptor 4--mediated glioma tumor tracking by bone marrow--derived neural progenitor/stem cells
    Qijin Xu
    Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, California, USA
    Mol Cancer Ther 8:2746-53. 2009
  8. doi request reprint Antigen-specific T-cell response from dendritic cell vaccination using cancer stem-like cell-associated antigens
    Qijin Xu
    Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, California, USA
    Stem Cells 27:1734-40. 2009
  9. ncbi request reprint Spheres isolated from 9L gliosarcoma rat cell line possess chemoresistant and aggressive cancer stem-like cells
    Ali Jourabchi Ghods
    Maxine Dunitz Neurosugical Institute, Los Angeles, California, USA
    Stem Cells 25:1645-53. 2007
  10. pmc Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma
    Gentao Liu
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, CA, 90048, USA
    Mol Cancer 5:67. 2006

Collaborators

Detail Information

Publications61

  1. ncbi request reprint Sensitization of malignant glioma to chemotherapy through dendritic cell vaccination
    Gentao Liu
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, and Division of Hematology Oncology, Cedars Sinai Medical Center David Geffen Schol of Medicine at UCLA, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    Expert Rev Vaccines 5:233-47. 2006
    ..In addition, the current research status and the future direction of a DC-based vaccine to treat glioma in animal models and clinical trials will also be discussed...
  2. ncbi request reprint Isolation of cancer stem cells from adult glioblastoma multiforme
    Xiangpeng Yuan
    Maxine Dunitz Neurosurgical Institute, Suite 800 East, 8631 West 3rd Street, Los Angeles, CA 90048, USA
    Oncogene 23:9392-400. 2004
    ..The identification of tumor stem cells within adult GBM may represent a major step forward in understanding the origin and maintenance of GBM and lead to the identification and testing of new therapeutic targets...
  3. doi request reprint Vaccination elicits correlated immune and clinical responses in glioblastoma multiforme patients
    Christopher J Wheeler
    Maxine Dunitz Neurosurgical Institute, Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, California, USA
    Cancer Res 68:5955-64. 2008
    ..As such, our findings offer unique opportunities to identify cellular and molecular components of clinically meaningful antitumor immunity in humans...
  4. ncbi request reprint Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma
    John S Yu
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, 8631 West Third Street, Suite 800E, Los Angeles, CA 90048, USA
    Cancer Res 64:4973-9. 2004
    ..We demonstrate for the first time the ability of an active immunotherapy strategy to generate antigen-specific cytotoxicity in brain tumor patients...
  5. ncbi request reprint Immunomodulatory neural stem cells for brain tumour therapy
    Jeffrey J Yu
    Cedars Sinai Medical Center, Department of Neurosurgery, Los Angeles, CA, USA
    Expert Opin Biol Ther 6:1255-62. 2006
    ..Here, the preclinical advances and the results supporting the effectiveness of stem cell therapies are reviewed. In addition, the obstacles to clinical development and methods to circumvent these caveats are discussed...
  6. ncbi request reprint AIM-2: a novel tumor antigen is expressed and presented by human glioma cells
    Gentao Liu
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Immunother 27:220-6. 2004
    ..These data indicate that AIM-2 could be used as a tumor antigen target for monitoring vaccine trials or to develop antigen specific active immunotherapy for glioma patients...
  7. pmc Chemokine CXC receptor 4--mediated glioma tumor tracking by bone marrow--derived neural progenitor/stem cells
    Qijin Xu
    Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, California, USA
    Mol Cancer Ther 8:2746-53. 2009
    ..Elucidating the molecular mechanism of brain tumor tracking by adult source stem cells may provide basis for the development of future targeted therapy for malignant brain tumors...
  8. doi request reprint Antigen-specific T-cell response from dendritic cell vaccination using cancer stem-like cell-associated antigens
    Qijin Xu
    Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, California, USA
    Stem Cells 27:1734-40. 2009
    ..Understanding how immunization with CSCs generates superior antitumor immunity may accelerate development of CSC-specific immunotherapies and cancer vaccines...
  9. ncbi request reprint Spheres isolated from 9L gliosarcoma rat cell line possess chemoresistant and aggressive cancer stem-like cells
    Ali Jourabchi Ghods
    Maxine Dunitz Neurosugical Institute, Los Angeles, California, USA
    Stem Cells 25:1645-53. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  10. pmc Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma
    Gentao Liu
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, CA, 90048, USA
    Mol Cancer 5:67. 2006
    ..The gene expression and the drug resistance property of CD133 positive cancer stem cells, however, are still unknown...
  11. pmc Glioma tropic neural stem cells consist of astrocytic precursors and their migratory capacity is mediated by CXCR4
    Moneeb Ehtesham
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Neoplasia 6:287-93. 2004
    ..Blocking of CXCR4 significantly inhibits NSC migration toward the tumor. These findings define specific characteristics associated with the cell populations within transplanted NSCs that demonstrate glioma-tracking behavior...
  12. ncbi request reprint Thymic CD8+ T cell production strongly influences tumor antigen recognition and age-dependent glioma mortality
    Christopher J Wheeler
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Immunol 171:4927-33. 2003
    ....
  13. ncbi request reprint Cytotoxic T cell targeting of TRP-2 sensitizes human malignant glioma to chemotherapy
    Gentao Liu
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Oncogene 24:5226-34. 2005
    ..For the first time, we provide evidence that immunological targeting of tumor-associated antigen TRP-2 significantly increases sensitivity to chemotherapy...
  14. pmc High levels of phosphorylated MAP kinase are associated with poor survival among patients with glioblastoma during the temozolomide era
    Chirag G Patil
    Center for Neurosurgical Outcomes Research, Department of Neurosurgery, Cedars Sinai Medical Center, 8631 W Third St, Suite 800E, Los Angeles, CA 90048, USA
    Neuro Oncol 15:104-11. 2013
    ..It confirms the significant and independent prognostic relevance of p-MAPK in predicting survival of patients with GBM treated in the temozolomide era and highlights the need for therapies targeting the p-MAPK oncogenic pathway...
  15. ncbi request reprint Interleukin-23-expressing bone marrow-derived neural stem-like cells exhibit antitumor activity against intracranial glioma
    Xiangpeng Yuan
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Cancer Res 66:2630-8. 2006
    ..CD8(+) T cells are critical for such antitumor activity; in addition, CD4(+) T cells and NK cells are also involved...
  16. ncbi request reprint Induction of glioblastoma apoptosis using neural stem cell-mediated delivery of tumor necrosis factor-related apoptosis-inducing ligand
    Moneeb Ehtesham
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Cancer Res 62:7170-4. 2002
    ..These results add credence to the potential of NSCs as therapeutically effective delivery vehicles for the treatment of intracranial glioma...
  17. ncbi request reprint HER-2, gp100, and MAGE-1 are expressed in human glioblastoma and recognized by cytotoxic T cells
    Gentao Liu
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, 8631 West Third Street, Suite 800E, Los Angeles, CA 90048, USA
    Cancer Res 64:4980-6. 2004
    ..These data indicate that HER-2, gp100, and MAGE-1 could be used as tumor antigen targets for surrogate assays for antigen-specific CTLs or to develop antigen-specific active immunotherapy strategies for glioma patients...
  18. doi request reprint Prognosis of patients with multifocal glioblastoma: a case-control study
    Chirag G Patil
    Center for Neurosurgical Outcomes Research, Maxine Dunitz Neurosurgical Institute, Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, CA, USA
    J Neurosurg 117:705-11. 2012
    ..The prognosis of patients with glioblastoma who present with multifocal disease is not well documented. The objective of this study was to determine whether multifocal disease on initial presentation is associated with worse survival...
  19. ncbi request reprint Treatment of intracranial glioma with in situ interferon-gamma and tumor necrosis factor-alpha gene transfer
    Moneeb Ehtesham
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Cancer Gene Ther 9:925-34. 2002
    ..These findings demonstrate the effectiveness of local IFNgamma and TNFalpha gene transfer as a treatment strategy for glioma and illustrate possible physiological pathways responsible for the therapeutic benefit observed...
  20. ncbi request reprint Induction of a CD4+ T regulatory type 1 response by cyclooxygenase-2-overexpressing glioma
    Yasuharu Akasaki
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Immunol 173:4352-9. 2004
    ..These results indicate that COX-2-overexpressing tumors induce a Tr1 response, which is mediated by tumor-exposed, IL-10-enhanced DCs...
  21. ncbi request reprint The use of interleukin 12-secreting neural stem cells for the treatment of intracranial glioma
    Moneeb Ehtesham
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Cancer Res 62:5657-63. 2002
    ..These results indicate that the use of tumor tracking NSCs represents a potent new therapeutic modality for glioma...
  22. ncbi request reprint Small interference RNA modulation of IL-10 in human monocyte-derived dendritic cells enhances the Th1 response
    Gentao Liu
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, 90048, USA
    Eur J Immunol 34:1680-7. 2004
    ....
  23. ncbi request reprint Intratumoral dendritic cell vaccination elicits potent tumoricidal immunity against malignant glioma in rats
    Moneeb Ehtesham
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA
    J Immunother 26:107-16. 2003
    ..DC therapy resulted in prolonged survival and immunity to subsequent intracranial tumor re-challenge. These results demonstrate the viability of intratumoral DC vaccination as an effective therapeutic strategy for intracranial glioma...
  24. ncbi request reprint A peroxisome proliferator-activated receptor-gamma agonist, troglitazone, facilitates caspase-8 and -9 activities by increasing the enzymatic activity of protein-tyrosine phosphatase-1B on human glioma cells
    Yasuharu Akasaki
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Biol Chem 281:6165-74. 2006
    ....
  25. ncbi request reprint Manipulation of proliferation and differentiation of human bone marrow-derived neural stem cells in vitro and in vivo
    Zhaohui Zeng
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Neurosci Res 85:310-20. 2007
    ..Our findings suggest that HBM-NSC can be efficiently expanded and differentiated in vitro and in vivo by overexpressing Gli-1, Shh or Nurr1...
  26. ncbi request reprint Molecular and functional analysis of tyrosinase-related protein (TRP)-2 as a cytotoxic T lymphocyte target in patients with malignant glioma
    Gentao Liu
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    J Immunother 26:301-12. 2003
    ..The authors' studies demonstrate that TRP-2 could be a useful antigen target for monitoring or developing immunotherapeutic strategies for glioma patients...
  27. doi request reprint Hedgehog signaling regulates brain tumor-initiating cell proliferation and portends shorter survival for patients with PTEN-coexpressing glioblastomas
    Qijin Xu
    Maxine Dunitz Neurosurgical Institute, Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, California 90049, USA
    Stem Cells 26:3018-26. 2008
    ..Thus, distinct proliferation signaling dependence may underpin glioblastoma propagation by BTSCs. Modeling these BTSC proliferation mechanisms may provide a rationale for individualized glioblastoma treatment...
  28. ncbi request reprint Cellular immunity in the treatment of brain tumors
    Christopher J Wheeler
    Cedars Sinai Medical Center, Maxine Dunitz Neurosurgical Institute, Los Angeles, California, USA
    Clin Neurosurg 51:132-9. 2004
  29. pmc Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma
    Surasak Phuphanich
    Neuro Oncology Program, Department of Neurosurgery and Neurology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Cancer Immunol Immunother 62:125-35. 2013
    ....
  30. doi request reprint Glioma stem cell research for the development of immunotherapy
    Qijin Xu
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Adv Exp Med Biol 746:216-25. 2012
    ..Future progress in glioma stem cell research may fundamentally improve the prospect of malignant glioma treatments...
  31. doi request reprint Stimuli-responsive antioxidant nanoprodrugs of NSAIDs
    Bong Seop Lee
    Department of Neurosurgery, Cedars Sinai Medical Center, 8631 W Third Street, Los Angeles, CA 90048, USA
    Int J Pharm 372:112-24. 2009
    ..Furthermore, the rate of hydrolysis was higher when the nanoprodrugs were oxidized and destabilized upon HOCl scavenging suggesting an enhanced activation of the nanoprodrugs in the oxidative environment...
  32. pmc Glioma stem cell research for the development of immunotherapy
    Jianfei Ji
    Department of Neurosurgery, Cedars Sinai Medical Center, Maxine Dunitz Neurosurgical Institute, 8631 West Third Street, Suite 800 E, Los Angeles, CA 90048, USA
    Neurosurg Clin N Am 21:159-66. 2010
    ..The authors have reviewed recent studies related with GBM CSCs (particularly CD133(+) CSCs) and the novel therapeutic strategies targeting these cells...
  33. ncbi request reprint Brain tumor stem cells: new targets for clinical treatments?
    Patrizia Tunici
    Maxine Dunitz Neurosurgical Institute, Los Angeles, California 90048, USA
    Neurosurg Focus 20:E27. 2006
    ..The identification and characterization of this new category of cells call for new therapies capable of selectively targeting and killing these multifaceted cells...
  34. ncbi request reprint Induction of potent antitumor immunity by intratumoral injection of interleukin 23-transduced dendritic cells
    Jinwei Hu
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Cancer Res 66:8887-96. 2006
    ..These findings suggest a new approach to induce potent tumor-specific immunity to intracranial tumors. This approach may have therapeutic potential for treating human glioma...
  35. ncbi request reprint Mahaley Clinical Research Award: chemosensitization of glioma through dendritic cell vaccination
    John S Yu
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Clin Neurosurg 53:345-51. 2006
    ..The current research status and the future direction of DC vaccines to treat glioma in animal models and clinical trials will also be discussed...
  36. doi request reprint Differentiation of nestin-positive cells derived from bone marrow into pancreatic endocrine and ductal cells in vitro
    Anna Milanesi
    Division of Endocrinology Department of Neurosurgery, Maxime Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, East, Los Angeles, California 90048, USA
    J Endocrinol 209:193-201. 2011
    ..Our results delineate a new model system to study islet neogenesis and possible pharmaceutical targets. Nestin-positive bone marrow stem cells may be therapeutically relevant for β-cell replacement in type 1 diabetes...
  37. ncbi request reprint Clinical responsiveness of glioblastoma multiforme to chemotherapy after vaccination
    Christopher J Wheeler
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Clin Cancer Res 10:5316-26. 2004
    ..To broaden the search for vaccine-induced benefits, we examined synergy of vaccines with conventional chemotherapy...
  38. ncbi request reprint T cell immunity in patients with malignant glioma: recent progress in dendritic cell-based immunotherapeutic approaches
    Yasuharu Akasaki
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Front Biosci 10:2908-21. 2005
    ....
  39. doi request reprint Racial and gender disparities and the role of primary tumor type on inpatient outcomes following craniotomy for brain metastases
    Miriam Nuno
    Center for Neurosurgical Outcomes Research, Maxine Dunitz Neurosurgical Institute, Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Ann Surg Oncol 19:2657-63. 2012
    ..Our study evaluated the role of race, gender, and tumor primary site in predicting in-hospital mortality, discharge disposition, and complications among patients with brain metastases...
  40. doi request reprint Immunotherapy targeting glioma stem cells--insights and perspectives
    Zhenhua Li
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, 8361 West Third Street, Suite 800 E, Los Angeles, CA 90048, USA
    Expert Opin Biol Ther 12:165-78. 2012
    ..Currently, there are very few studies that apply immunotherapy to target GSC...
  41. ncbi request reprint Generation of neural progenitor cells from whole adult bone marrow
    Peter Kabos
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Exp Neurol 178:288-93. 2002
    ..We demonstrate that bone marrow may offer a renewable autologous extracranial source of neural progenitor cells...
  42. ncbi request reprint Neural stem cells as delivery vehicles
    Peter Kabos
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Ste 800E, 8631 W 3rd St, Los Angeles, CA 90048, USA
    Expert Opin Biol Ther 3:759-70. 2003
    ..Here, the recent preclinical advances in the use of NSCs for the delivery of therapeutic products are reviewed, in particular the employment of their migratory potential and the homing ability to pathology in the nervous system...
  43. ncbi request reprint Intratumoral T cell subset ratios and Fas ligand expression on brain tumor endothelium
    John S Yu
    The Marine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Neurooncol 64:55-61. 2003
    ..Fas ligand, a pro-apoptotic cell surface protein, may play a key role in reduction of T cells in tumor tissue...
  44. doi request reprint Oxidative stimuli-responsive nanoprodrug of camptothecin kills glioblastoma cells
    Bong Seop Lee
    Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Bioorg Med Chem Lett 20:5262-8. 2010
    ..The camptothecin nanoprodrug was found to possess significant inhibitory effect on the proliferation of U87-MG glioma cells with an IC(50) of 20 nM...
  45. ncbi request reprint Dendritic cell immunotherapy for malignant gliomas
    Anne Luptrawan
    Department of Neurosurgery, Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, CA, 90048, USA
    Rev Recent Clin Trials 3:10-21. 2008
    ..This review will discuss the results of dendritic-cell based immunotherapy clinical trials for the treatment of malignant gliomas and explore the future strategies of DC vaccines for glioma immunotherapy...
  46. pmc Loss of PTEN is not associated with poor survival in newly diagnosed glioblastoma patients of the temozolomide era
    Christine Carico
    Department of Neurosurgery, Center for Neurosurgical Outcomes Research, Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California, United States of America
    PLoS ONE 7:e33684. 2012
    ..We investigated whether loss of PTEN predicted shorter survival in the temozolomide era. The role of PTEN in the PI3K/Akt pathway is also reviewed...
  47. ncbi request reprint In situ adenoviral interleukin 12 gene transfer confers potent and long-lasting cytotoxic immunity in glioma
    Yunhui Liu
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center Los Angeles, California 90048, USA
    Cancer Gene Ther 9:9-15. 2002
    ..Based on IL-12's known ability to enhance Th1-type cytotoxic antitumor immune responses, we postulate our findings to be a result of localized induction of tumor immunity...
  48. ncbi request reprint Dendritic cell-based immunotherapy for malignant gliomas
    Yasuharu Akasaki
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Suite 800 East, 8631 West 3 Street, Los Angeles, CA 90048, USA
    Expert Rev Neurother 5:497-508. 2005
    ....
  49. doi request reprint Reactive oxygen species responsive nanoprodrug to treat intracranial glioblastoma
    Bong Seop Lee
    Department of Neurosurgery, Cedars Sinai Medical Center, 8631 West Third Street, Suite 800 East, Los Angeles, California 90048, United States
    ACS Nano 7:3061-77. 2013
    ..The nontoxic, tumor-specific targeting properties of the nanoprodrug system make it a safe, low cost, and versatile nanocarrier for pharmaceuticals, imaging agents, and diagnostic agents...
  50. pmc β-Cell regeneration mediated by human bone marrow mesenchymal stem cells
    Anna Milanesi
    Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, California, United States of America
    PLoS ONE 7:e42177. 2012
    ..Our study demonstrated the possible benefit of hBMSCs for the treatment of insulin-dependent diabetes and gives new insight into the mechanism of β-cell recovery after injury mediated by hBMSC therapy...
  51. ncbi request reprint Development of an intracranial ependymoma at the site of a pre-existing cavernous malformation
    Moneeb Ehtesham
    Maxine Dunitz Neurosurgical Institute, Suite 800E, 8631 West 3rd Street, Los Angeles, CA 90048, USA
    Surg Neurol 60:80-2; discussion 83. 2003
    ..We present a novel case in which a patient with a pre-existing cavernous malformation developed an adjacent ependymoma...
  52. ncbi request reprint Recent progress in immunotherapy for malignant glioma: treatment strategies and results from clinical trials
    Moneeb Ehtesham
    Maxine Dunitz Neurosurgical, Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Cancer Control 11:192-207. 2004
    ..Despite advances in surgical and adjuvant radiation therapy and chemotherapy strategies, malignant gliomas continue to be associated with poor prognoses...
  53. ncbi request reprint Neural progenitors populate the cerebrospinal fluid of preterm patients with hydrocephalus
    Richard C Krueger
    Ahmanson Pediactric Center, Division of Neonatology, Cedars Sinai Medical Center, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90048, USA
    J Pediatr 148:337-340. 2006
    ..To evaluate cerebrospinal fluid (CSF) of preterm patients with hydrocephalus for neural progenitors...
  54. pmc Reactive oxygen species-activated nanoprodrug of Ibuprofen for targeting traumatic brain injury in mice
    Morgan A Clond
    Department of Surgery, Division of Trauma and Critical Care, Cedars Sinai Medical Center, Los Angeles, California, United States of America
    PLoS ONE 8:e61819. 2013
    ..The use of a nanoprodrug approach to deliver therapeutics in TBI represents a promising potential therapeutic modality...
  55. doi request reprint Pituitary adenoma stem cells
    Patrizia Tunici
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Centre, Los Angeles, CA, USA
    Methods Mol Biol 568:195-201. 2009
    ....
  56. doi request reprint Preparation and characterization of antioxidant nanospheres from multiple alpha-lipoic acid-containing compounds
    Bong Seop Lee
    Department of Neurosurgery, Cedars Sinai Medical Center, 8631 W Third Street, Suite 800 East, Los Angeles, CA 90048, USA
    Bioorg Med Chem Lett 19:1678-81. 2009
    ....
  57. ncbi request reprint A herpes simplex virus type 1 mutant with gamma 34.5 and LAT deletions effectively oncolyses human U87 glioblastomas in nude mice
    Ken Samoto
    Maxine Dunitz Neurosurgical Institute, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Neurosurgery 50:599-605; discussion 605-6. 2002
    ..The objective of this study was to demonstrate the therapeutic efficiency of this virus in the treatment of human gliomas in nude mice...
  58. pmc Nanoprodrugs of NSAIDs: Preparation and Characterization of Flufenamic Acid Nanoprodrugs
    Bong Seop Lee
    Department of Neurosurgery, Cedars Sinai Medical Center, 8631 West Third Street, Suite 800 East, Los Angeles, CA 90048, USA
    J Drug Deliv 2011:980720. 2011
    ..The nanoprodrug inhibited the growth of U87-MG glioma cells with IC(50) of 20 μM, whereas FA showed IC(50) of 100 μM, suggesting that more efficient drug delivery was achieved with nanoprodrugs...
  59. ncbi request reprint Neural precursors express multiple chondroitin sulfate proteoglycans, including the lectican family
    Peter Kabos
    Department of Pediatrics, Division of Molecular and Human Genetics, Children s Research Institute, The Ohio State University, Columbus, OH, USA
    Biochem Biophys Res Commun 318:955-63. 2004
    ..This is the first report to show that proliferating neural precursors synthesize lecticans, including aggrecan, which are downregulated with differentiation. These observations suggest novel links between CSPGs and CNS precursor biology...
  60. ncbi request reprint Cancer vaccines: a novel strategy to sensitize malignant glioma to chemotherapy
    Gentao Liu
    Expert Rev Neurother 7:1235-7. 2007
  61. ncbi request reprint Quality of life for patients with glioblastoma
    John S Yu
    Lancet Oncol 6:913-4. 2005

Research Grants7

  1. ACTIVE IMMUNOTHERAPY FOR GLIOBLASTOMA
    John Yu; Fiscal Year: 2004
    ..A phase II trial will be initiated in year 3 of the training grant based on the phase I studies. ..
  2. Human Bone Marrow Derived Neural Stem Cell Therapy
    John Yu; Fiscal Year: 2006
    ..3) Human BM-NSC is safe and effective in an experimental rodent glioma model. ..
  3. Bone marrow derived neural stem cell therapy for glioma
    John Yu; Fiscal Year: 2007
    ..4) Promoting BM-NSC proliferation and astrocytic fate will (i) lead to increased migration to glioma and (ii) increase tumor control and prolong survival in an experimental rodent glioma model. ..