Research Topics
Genomes and Genes
Species | Eric A VasiliauskasSummaryAffiliation: Cedars-Sinai Medical Center Country: USA Publications
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Detail Information
Publications
Case report: evidence for transplacental transfer of maternally administered infliximab to the newbornEric A Vasiliauskas
Inflammatory Bowel Disease Center, Division of Gastroenterology, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
Clin Gastroenterol Hepatol 4:1255-8. 2006..As a result of heightened maternal concern triggered by recent labeling changes, infliximab levels were measured in the newborn of a mother treated with infliximab...- Recent advances in the diagnosis and classification of inflammatory bowel diseaseEric Vasiliauskas
Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, 8631 West Third Street, Suite 245E, Los Angeles, CA 90048, USA
Curr Gastroenterol Rep 5:493-500. 2003.... - Anti-flagellin (CBir1) phenotypic and genetic Crohn's disease associationsKonstantinos A Papadakis
Cedars Sinai Inflammatory Bowel Disease Center, Los Angeles, California, USA
Inflamm Bowel Dis 13:524-30. 2007..We examined the association between anti-CBir1 and clinical phenotypes and NOD2 variants in a large cohort of adult CD patients... - NOD2 variants and antibody response to microbial antigens in Crohn's disease patients and their unaffected relativesShane M Devlin
Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
Gastroenterology 132:576-86. 2007..The aim of our study was to determine if defects in innate immunity are similarly associated with increased adaptive immune responses to microbial antigens in Crohn's disease patients... 
Combination of innate and adaptive immune alterations increased the likelihood of fibrostenosis in Crohn's diseaseAndrew Ippoliti
Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, CA, USA
Inflamm Bowel Dis 16:1279-85. 2010....- Association of antibody responses to microbial antigens and complications of small bowel Crohn's diseaseWilliam S Mow
Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
Gastroenterology 126:414-24. 2004.... 
Family history and serology predict Crohn's disease after ileal pouch-anal anastomosis for ulcerative colitisGil Y Melmed
Division of Gastroenterology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Dis Colon Rectum 51:100-8. 2008..Preoperative predictors for Crohn's disease post-ileal pouch-anal anastomosis have not been prospectively defined...- Antibodies to I2 predict clinical response to fecal diversion in Crohn's diseaseJacob Spivak
Division of Colon and Rectal Surgery, Department of Surgery, Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Inflamm Bowel Dis 12:1122-30. 2006..CONCLUSION: Expression of I2 antibodies against a bacterial antigen of Pseudomonas fluorescens was highly associated with clinical response to fecal diversion in CD patients... - A prospective analysis of clinical variables, serologic factors, and outcome of ileal pouch-anal anastomosis in patients with backwash ileitisEvan White
Division of Colon and Rectal Surgery, Cedars Sinai Medical Center, Los Angeles, California, USA
Dis Colon Rectum 53:987-94. 2010..We prospectively compared the outcomes of ileal pouch-anal anastomosis in colitis patients with backwash ileitis and colitis patients without backwash ileitis... - Familial expression of anti-Escherichia coli outer membrane porin C in relatives of patients with Crohn's diseaseLing Mei
Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
Gastroenterology 130:1078-85. 2006..That UC patients in mixed families had a higher response to OmpC than those in UC-only families indicates pathophysiologic heterogeneity within UC... - A prospective evaluation of the long-term outcome of ileal pouch-anal anastomosis in patients with inflammatory bowel disease-unclassified and indeterminate colitisZuri A Murrell
Department of Surgery, Division of Colon and Rectal Surgery, Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, California, USA
Dis Colon Rectum 52:872-8. 2009..The aim of this study was to prospectively evaluate the long-term outcome of ileal pouch-anal anastomosis in a closely monitored cohort of patients with ulcerative colitis or indeterminate colitis... - High incidence of anergy in inflammatory bowel disease patients limits the usefulness of PPD screening before infliximab therapyWilliam S Mow
Department of Medicine, Division of Gastroenterology, Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
Clin Gastroenterol Hepatol 2:309-13. 2004..Evaluation for TB risks should include not only a TST, but also a detailed history of travel, TB exposures, and such symptoms as chronic cough and weight loss, and a chest radiograph should be considered... - Serum immune responses predict rapid disease progression among children with Crohn's disease: immune responses predict disease progressionMarla C Dubinsky
Department of Pediatrics, Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
Am J Gastroenterol 101:360-7. 2006.... - Does infliximab influence surgical morbidity of ileal pouch-anal anastomosis in patients with ulcerative colitis?Stefanie J Schluender
Division of Colon and Rectal Surgery, Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, 8737 Beverly Boulevard, Suite 101, Los Angeles, California 90048, USA
Dis Colon Rectum 50:1747-53. 2007..This study was designed to compare short-term complications in patients with ulcerative colitis who were treated with and without infliximab before colectomy... - Initial experience with wireless capsule enteroscopy in the diagnosis and management of inflammatory bowel diseaseWilliam S Mow
Inflammatory Bowel Disease Center, Los Angeles, California, USA
Clin Gastroenterol Hepatol 2:31-40. 2004.... - Predicting a change in diagnosis from ulcerative colitis to Crohn's disease: a nested, case-control studyGil Y Melmed
Inflammatory Bowel Disease Center, Division of Gastroenterology, Department of Medicine, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California Los Angeles, California, USA
Clin Gastroenterol Hepatol 5:602-8; quiz 525. 2007..Identification of predictors of a diagnostic change could potentially impact the management of patients with colonic inflammation. Our aim was to characterize clinical and serologic predictors of a change in diagnosis from UC to CD... - Treatment with infliximab is associated with increased markers of bone formation in patients with Crohn's diseaseMaria T Abreu
Department of Medicine, Division of Gastroenterology, Inflammatory Bowel Disease Center, Mount Sinai School of Medicine, New York, NY, USA
J Clin Gastroenterol 40:55-63. 2006..Studies of longer duration are needed to assess the effect of infliximab on bone mineral density... - Safety and efficacy of adalimumab (D2E7) in Crohn's disease patients with an attenuated response to infliximabKonstantinos A Papadakis
Division of Gastroenterology, Department of Medicine, Inflammatory Bowel Disease Center, 8631 W. Third Street, Suite 430E, Los Angeles, CA 90048, USA
Am J Gastroenterol 100:75-9. 2005..CONCLUSIONS: Our preliminary data suggest that adalimumab may be a safe and effective therapy for patients with CD who have experienced an attenuated response to infliximab... - Early hepatic nodular hyperplasia and submicroscopic fibrosis associated with 6-thioguanine therapy in inflammatory bowel diseaseStephen A Geller
Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Am J Surg Pathol 28:1204-11. 2004..6-TG-related hepatotoxicity, including liver biochemistry value elevations, sinusoidal collagen deposition on electron microscopy, and veno-occlusive disease, have been described related to its use as therapy for neoplastic disease... - A pilot study of adalimumab in infliximab-allergic patientsAdrienne Youdim
Department of Medicine, Division of Gastroenterology, Inflammatory Bowel Disease Center, Los Angeles, CA 90048, USA
Inflamm Bowel Dis 10:333-8. 2004..Based on these preliminary data, adalimumab may be a safe and effective substitute for infliximab-allergic patients. Individuals who have been exposed to human antibodies may be sensitized to other human antibodies such as adalimumab... - Immunosuppression impairs response to pneumococcal polysaccharide vaccination in patients with inflammatory bowel diseaseGil Y Melmed
Department of Medicine, Cedars Sinai Medical Center, University of California, Los Angeles, California 90048, USA
Am J Gastroenterol 105:148-54. 2010..We aimed to assess the impact of immunosuppression on immune responses to pneumococcal vaccination in patients with IBD... - Genetic predictors of medically refractory ulcerative colitisTalin Haritunians
Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Inflamm Bowel Dis 16:1830-40. 2010..The aim of this study was to use a genome-wide association study (GWAS) in a well-characterized cohort of UC patients to identify genetic variation that contributes to MR-UC... - Thioguanine: a potential alternate thiopurine for IBD patients allergic to 6-mercaptopurine or azathioprineMarla C Dubinsky
Department of Medicine, Division of Gastroenterology, Cedars-Sinai Medical Center, UCLA, Los Angeles, California 90048, USA
Am J Gastroenterol 98:1058-63. 2003..Despite these favorable results, candidates for 6-TG should be selected with caution, and its use should be reserved for IBD patients well informed about potential toxicities... - Colorectal cancer screening and surveillance in Crohn's colitisRobert J Basseri
Department of Medicine and Division of Gastroenterology, Cedars Sinai Medical Center, Los Angeles, CA, USA
J Crohns Colitis 6:824-9. 2012..To assess colonoscopic screening and surveillance for detecting neoplasia in patients with long-standing colonic Crohn's disease (CD)... - Early nodular hyperplasia of the liver occurring with inflammatory bowel diseases in association with thioguanine therapySunita Shastri
Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
Arch Pathol Lab Med 128:49-53. 2004..Reticulin-stained histologic sections are necessary to recognize this change. Further studies are needed to determine the frequency and significance of this change... - The spectrum of gastrointestinal toxicity and effect on disease activity of selective cyclooxygenase-2 inhibitors in patients with inflammatory bowel diseaseRobin Matuk
Department of Medicine, Division of Gastroenterology, Cedars-Sinai Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
Inflamm Bowel Dis 10:352-6. 2004..Treatment with COX-2 inhibitors is associated with a high incidence of exacerbation of the underlying IBD and GI-related complications... - Capsule endoscopy in patients with Crohn's disease: diagnostic yield and safetyShahab Mehdizadeh
Division of Gastroenterology, Cedars Sinai Medical Center, Los Angeles, California, USA
Gastrointest Endosc 71:121-7. 2010..Capsule endoscopy (CE) is increasingly used in patients with suspected or known Crohn's disease (CD)... - 6-thioguanine can cause serious liver injury in inflammatory bowel disease patientsMarla C Dubinsky
Pediatric Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, 8635 West Third Street, Suite 1165W, Los Angeles, California 90048, USA
Gastroenterology 125:298-303. 2003..The aim of this study was to describe the association between 6-TG and NRH in IBD... - Elevated platelet count before ileal pouch-anal anastomosis for ulcerative colitis is associated with the development of chronic pouchitisAderet Okon
Division of Colon and Rectal Surgery, Department of Surgery, Inflammatory Bowel Disease Center, Cedars-Sinai Medical Center, Los Angeles, California, USA
Am Surg 71:821-6. 2005..03). The incidence of CP was significantly higher after IPAA in UC patients having thrombocytosis before surgery compared to UC patients having a normal platelet count before surgery... - Patients with inflammatory bowel disease are at risk for vaccine-preventable illnessesGil Y Melmed
Department of Medicine, Division of Gastroenterology, Cedars-Sinai Medical Center Los Angeles, California 90048, USA
Am J Gastroenterol 101:1834-40. 2006..Efforts to improve immunization status among patients with IBD and other chronic, immune-mediated conditions are needed... - Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's diseaseMaria T Abreu
Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
Gastroenterology 123:679-88. 2002..NOD2 gene mutations in CD have been described recently and may alter innate immune responses. We hypothesized that NOD2 mutations may be associated with distinct phenotypic expressions of CD... - MAGI2 genetic variation and inflammatory bowel diseaseDermot P B McGovern
Medical Genetics Institute and Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
Inflamm Bowel Dis 15:75-83. 2009..Our aim was to test MAGI2 variants for association with IBD and also their role in determining intermediate hereditary phenotypes defined by antibody production to microbial antigens... - Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's diseaseStephan R Targan
Cedars Sinai Inflammatory Bowel Disease Center, Los Angeles, California 90048, USA
Gastroenterology 128:2020-8. 2005.... - Increased immune reactivity predicts aggressive complicating Crohn's disease in childrenMarla C Dubinsky
Department of Pediatrics, IBD Center, Cedars Sinai Medical Center, Los Angeles, California, USA
Clin Gastroenterol Hepatol 6:1105-11. 2008..The aims of this study were to determine whether immune responses and/or CARD15 variants are associated with complicated disease phenotypes and predict disease progression... - Surgical outcome of ileal pouch-anal anastomosis when used intentionally for well-defined Crohn's diseaseQuy Le
Division of Colon and Rectal Surgery, Cedars Sinai Medical Center, Los Angeles, California, USA
Inflamm Bowel Dis 19:30-6. 2013..Crohn's disease (CD) is considered a contraindication to ileal pouch--anal anastomosis (IPAA). In this study, we compare outcomes of CD and ulcerative colitis (UC) patients undergoing IPAA... - Serologic responses in indeterminate colitis patients before ileal pouch-anal anastomosis may determine those at risk for continuous pouch inflammationThomas Hui
Division of Colon and Rectal Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA
Dis Colon Rectum 48:1254-62. 2005.... - Both preoperative perinuclear antineutrophil cytoplasmic antibody and anti-CBir1 expression in ulcerative colitis patients influence pouchitis development after ileal pouch-anal anastomosisPhillip Fleshner
Division of Colon and Rectal Surgery, Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, California, USA
Clin Gastroenterol Hepatol 6:561-8. 2008..The aim of this study was to assess associations of preoperative perinuclear antineutrophil cytoplasmic antibody (pANCA) and anti-CBir1 flagellin on AP or CP development... - Genome-wide association identifies multiple ulcerative colitis susceptibility lociDermot P B McGovern
Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
Nat Genet 42:332-7. 2010..These data implicate approximately 30 loci in ulcerative colitis, thereby providing insight into disease pathogenesis... - New clinical method for distinguishing D-IBS from other gastrointestinal conditions causing diarrhea: the LA/IBS diagnostic strategyMark Pimentel
GI Motility Program, Cedars Sinai Medical Center, 8730 Alden Drive, Suite 225E, Los Angeles, CA 90048, USA
Dig Dis Sci 55:145-9. 2010..81; specificity = 0.60). The use of this simple tool that identifies an irregularly irregular bowel form and function is successful in separating D-IBS from non-IBS subjects... - 6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel diseaseMarla C Dubinsky
Division of Gastroenterology and Genetics, Department of Medicine and Pediatrics, Cedars Sinai Medical Center, UCLA, Los Angeles, California 90048, USA
Gastroenterology 122:904-15. 2002..The objectives of this study were to determine whether dose escalation optimizes both 6-TGN levels and efficacy in patients failing therapy because of subtherapeutic 6-TGN levels and its effect on TPMT... - Genetic epistasis of IL23/IL17 pathway genes in Crohn's diseaseDermot P B McGovern
Medical Genetics Institute and Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Inflamm Bowel Dis 15:883-9. 2009..Genetic variants in the IL23R and IL12B have been associated with CD susceptibility. We investigated 10 genes within the IL23/IL17 pathway in a case-control study of 763 CD cases and 254 healthy controls... - Preoperative wireless capsule endoscopy does not predict outcome after ileal pouch-anal anastomosisZuri Murrell
Division of Colon and Rectal Surgery, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, California, USA
Dis Colon Rectum 53:293-300. 2010..This study examined the value of preoperative wireless capsule endoscopy in predicting outcome of ileal pouch-anal anastomosis in patients with ulcerative colitis or indeterminate colitis... - Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's diseaseDermot P B McGovern
Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Hum Mol Genet 19:3468-76. 2010..001). These findings strongly implicate this locus in CD susceptibility and highlight the role of the mucus layer in the development of CD... - A prospective multivariate analysis of clinical factors associated with pouchitis after ileal pouch-anal anastomosisPhillip Fleshner
Division of Colon and Rectal Surgery, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, California, USA
Clin Gastroenterol Hepatol 5:952-8; quiz 887. 2007..The aim of this study was to identify important clinical risk factors associated with AP or CP...