David Underhill

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. pmc Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production
    David M Underhill
    Institute for Systems Biology, Seattle, WA 98103, USA
    Blood 106:2543-50. 2005
  2. ncbi request reprint Phagosome maturation: steady as she goes
    David M Underhill
    Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Immunity 23:343-4. 2005
  3. ncbi request reprint Dectin-1 and TLRs permit macrophages to distinguish between different Aspergillus fumigatus cellular states
    Geoffrey M Gersuk
    Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    J Immunol 176:3717-24. 2006
  4. ncbi request reprint Collaboration between the innate immune receptors dectin-1, TLRs, and Nods
    David M Underhill
    Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Immunol Rev 219:75-87. 2007
  5. ncbi request reprint The many faces of ITAMs
    David M Underhill
    Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Trends Immunol 28:66-73. 2007
  6. pmc Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling
    Pearl Gray
    Division of Pediatric Infectious Diseases and Immunology, Burns and Allen Research Institute, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90048, USA
    J Immunol 184:6359-66. 2010
  7. ncbi request reprint Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cells
    Helen S Goodridge
    Immunobiology Research Institute, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    J Immunol 178:3107-15. 2007
  8. pmc Lymphoid-related CD11c+ CD8alpha+ dendritic cells are involved in enhancing herpes simplex virus type 1 latency
    Kevin R Mott
    Center for Neurobiology and Vaccine Development, D2024, Cedars Sinai Burns and Allen Research Institute, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    J Virol 82:9870-9. 2008
  9. pmc A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages
    Kevin R Mott
    Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Virol J 6:56. 2009
  10. doi request reprint Beta-glucan recognition by the innate immune system
    Helen S Goodridge
    Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Immunol Rev 230:38-50. 2009

Research Grants

  1. Phagosomal targeting of CARD proteins
    David M Underhill; Fiscal Year: 2010
  2. Non-Toll-like receptor innate immune signaling
    David M Underhill; Fiscal Year: 2010
  3. TOLL-LIKE RECEPTORS: ACTIVATORS OF INNATE IMMUNITY
    David Underhill; Fiscal Year: 2005
  4. Phagosomal targeting of CARD proteins
    David M Underhill; Fiscal Year: 2010

Collaborators

  • A Aderem
  • S Akira
  • Kevin R Mott
  • Eicke Latz
  • Rosalinda Sorrentino
  • Terrence Town
  • David A Hume
  • Timothy Ravasi
  • THOMAS HAWN
  • K A Marr
  • Helen S Goodridge
  • Takahiro Shimada
  • Andrea J Wolf
  • Kenichi Shimada
  • Benjamin N Gantner
  • Randi M Simmons
  • Constantinos Brikos
  • Pearl Gray
  • Courtney A Becker
  • Timothy R Crother
  • Shuang Chen
  • Moshe Arditi
  • Masafumi Nakayama
  • Geoffrey M Gersuk
  • Christopher N Reyes
  • Cherilyn M Sirois
  • Edward A Miao
  • Emily Lowe
  • Yonca Bulut
  • Friedrich Götz
  • George Y Liu
  • Kathrin S Michelsen
  • Bong Goo Park
  • Anatoly V Slepenkin
  • Paul W Dempsey
  • Xin Lin
  • Ellena Peterson
  • Yen Michael S Hsu
  • Randa Alsabeh
  • Terence M Doherty
  • Toshiyuki Takai
  • Bin Li
  • Toshio Kitamura
  • Timothy W Petersen
  • Liqun Zhu
  • Scott J Canavera

Detail Information

Publications24

  1. pmc Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production
    David M Underhill
    Institute for Systems Biology, Seattle, WA 98103, USA
    Blood 106:2543-50. 2005
    ..The proportion of macrophages using this signaling pathway can be modulated by cytokine treatment. Thus, Dectin-1 signaling reveals dynamic macrophage heterogeneity in inflammatory activation potential...
  2. ncbi request reprint Phagosome maturation: steady as she goes
    David M Underhill
    Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Immunity 23:343-4. 2005
    ..However, in this issue of Immunity, Yates and Russell use carefully defined particles and quantitative methodology to measure phagosome maturation and find no effect of TLR signaling on the process...
  3. ncbi request reprint Dectin-1 and TLRs permit macrophages to distinguish between different Aspergillus fumigatus cellular states
    Geoffrey M Gersuk
    Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    J Immunol 176:3717-24. 2006
    ..These data demonstrate one mechanism by which the pulmonary inflammatory response is tailored toward metabolically active cells, thereby avoiding unnecessary tissue damage with frequent inhalation of ubiquitous spores...
  4. ncbi request reprint Collaboration between the innate immune receptors dectin-1, TLRs, and Nods
    David M Underhill
    Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Immunol Rev 219:75-87. 2007
    ..Studies on the molecular mechanisms of cross-talk and synergy between these receptors provide a framework in which to understand the importance of having multiple receptors recognize individual microbes...
  5. ncbi request reprint The many faces of ITAMs
    David M Underhill
    Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Trends Immunol 28:66-73. 2007
    ..Elucidating the diversity of ITAM-based signaling mechanisms will clarify how activating signals generated by ITAMs are tightly regulated and will open opportunities for specific therapeutic manipulation of ITAM-based signaling pathways...
  6. pmc Identification of a novel human MD-2 splice variant that negatively regulates Lipopolysaccharide-induced TLR4 signaling
    Pearl Gray
    Division of Pediatric Infectious Diseases and Immunology, Burns and Allen Research Institute, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90048, USA
    J Immunol 184:6359-66. 2010
    ....
  7. ncbi request reprint Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cells
    Helen S Goodridge
    Immunobiology Research Institute, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    J Immunol 178:3107-15. 2007
    ..These data establish NFAT activation in myeloid cells as a novel mechanism of regulation of the innate antimicrobial response...
  8. pmc Lymphoid-related CD11c+ CD8alpha+ dendritic cells are involved in enhancing herpes simplex virus type 1 latency
    Kevin R Mott
    Center for Neurobiology and Vaccine Development, D2024, Cedars Sinai Burns and Allen Research Institute, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    J Virol 82:9870-9. 2008
    ..Our results suggest that CD11c(+) CD8alpha(+) DCs directly or indirectly increase the amount of HSV-1 latency in mouse TGs...
  9. pmc A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages
    Kevin R Mott
    Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Virol J 6:56. 2009
    ..The aim of our study was to determine factor (s) that are involved in the resistance of DCs and macrophages to productive HSV-1 infection...
  10. doi request reprint Beta-glucan recognition by the innate immune system
    Helen S Goodridge
    Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Immunol Rev 230:38-50. 2009
    ....
  11. pmc The NOD/RIP2 pathway is essential for host defenses against Chlamydophila pneumoniae lung infection
    Kenichi Shimada
    Division of Pediatrics, Infectious Diseases, and Immunology, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    PLoS Pathog 5:e1000379. 2009
    ..pneumoniae from the lungs and survival of the infectious challenge...
  12. pmc Differential use of CARD9 by dectin-1 in macrophages and dendritic cells
    Helen S Goodridge
    Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Immunol 182:1146-54. 2009
    ..In such cells, Dectin-1, CARD9, and Bcl10 levels are not limiting, and data indicate that these cells express additional factors that restrict Dectin-1-CARD9 signaling for TNF-alpha induction...
  13. pmc Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1beta secretion
    Takahiro Shimada
    Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Cell Host Microbe 7:38-49. 2010
    ..aureus are functionally coupled to inflammasome activation and IL-1beta secretion and illustrate a case whereby a bacterium specifically subverts IL-1beta secretion through chemical modification of its cell wall PGN...
  14. ncbi request reprint Paired Ig-like receptors bind to bacteria and shape TLR-mediated cytokine production
    Masafumi Nakayama
    Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98103, USA
    J Immunol 178:4250-9. 2007
    ..aureus and enhanced TLR-mediated inflammatory responses to the bacteria. These data suggest a novel mechanism for innate immune regulation by paired Ig-like receptor family members...
  15. pmc Dectin-1 mediates macrophage recognition of Candida albicans yeast but not filaments
    Benjamin N Gantner
    The Department of Immunology, University of Washington, Seattle, WA, USA
    EMBO J 24:1277-86. 2005
    ..The data demonstrate a mechanism by which C. albicans shape alone directly contributes to the method by which phagocytes recognize the fungus...
  16. ncbi request reprint Phagocytosis of microbes: complexity in action
    David M Underhill
    Institute for Systems Biology, 1441 North 34 Street, Seattle, Washington 98103, USA
    Annu Rev Immunol 20:825-52. 2002
    ..Indeed, pathogenic microorganisms target many of these molecules in their attempts to evade destruction...
  17. pmc Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2
    Benjamin N Gantner
    Department of Immunology, University of Washington, Seattle, 98103, USA
    J Exp Med 197:1107-17. 2003
    ..The data demonstrate that collaborative recognition of distinct microbial components by different classes of innate immune receptors is crucial in orchestrating inflammatory responses...
  18. ncbi request reprint Toll-like receptors: key mediators of microbe detection
    David M Underhill
    Institute for Systems Biology, 4225 Roosevelt Way NE, Seattle, WA 98105, USA
    Curr Opin Immunol 14:103-10. 2002
    ..There has also been greater recognition of the importance of specific Toll-like receptors in host defense...
  19. ncbi request reprint Leishmania major activates IL-1 alpha expression in macrophages through a MyD88-dependent pathway
    Thomas R Hawn
    Division of Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Microbes Infect 4:763-71. 2002
    ..Examination of promoter activation is a powerful tool for understanding the early events in macrophage activation for anti-inflammatory pathogens such as Leishmania that have mechanisms to downregulate transcription and translation...
  20. ncbi request reprint Toll-like receptors: networking for success
    David M Underhill
    Institute for Systems Biology, 1441 North 34th Street, Seattle, WA 98105, USA
    Eur J Immunol 33:1767-75. 2003
    ..Useful models for these interacting signaling pathways are now emerging and should pave the way for understanding the molecular mechanisms that drive the rich diversity of inflammatory responses...
  21. ncbi request reprint Macrophage recognition of zymosan particles
    David M Underhill
    Institute for Systems Biology, 1441 N 34th Street, Seattle, WA 98103, USA
    J Endotoxin Res 9:176-80. 2003
    ..Further, ablation of the Toll-like receptor-stimulating activity of zymosan does not affect the ability of phagocytic receptors to internalise the particle...
  22. ncbi request reprint Toll-like receptors and microbes take aim at each other
    David M Underhill
    Institute for Systems Biology, 1441 N 34th St, Seattle, Washington 98103, USA
    Curr Opin Immunol 16:483-7. 2004
    ..Recent studies have improved our understanding of the various mechanisms by which pathogenic organisms manipulate the TLR recognition system...
  23. ncbi request reprint Integration of Toll-like receptor and phagocytic signaling for tailored immunity
    David M Underhill
    Institute for Systems Biology, 1441 N 34th Street, Seattle, WA 98103, USA
    Microbes Infect 6:1368-73. 2004
    ..In this review, we discuss the relationship between phagocytosis and TLRs from two additional perspectives: first, TLR signaling modulates phagocytosis; second, phagocytosis modulates the consequences of TLR activation...
  24. ncbi request reprint Generation of diversity in the innate immune system: macrophage heterogeneity arises from gene-autonomous transcriptional probability of individual inducible genes
    Timothy Ravasi
    Institute for Molecular Bioscience, and Cooperative Research Center for Chronic Inflammatory Diseases, University of Queensland, Brisbane, Queensland 4072, Australia
    J Immunol 168:44-50. 2002
    ..The results indicate that each LPS-inducible gene has its own inherent probability of activation in response to LPS...

Research Grants13

  1. Phagosomal targeting of CARD proteins
    David M Underhill; Fiscal Year: 2010
    ..Clinical manipulation of these pathways may help suppress unwanted inflammation, or stimulate effective immune defenses. ..
  2. Non-Toll-like receptor innate immune signaling
    David M Underhill; Fiscal Year: 2010
    ..In Aim 3 we will define the effect of the role of Dectin-1 and NFAT signaling in innate and adaptive immune responses in vivo. ..
  3. TOLL-LIKE RECEPTORS: ACTIVATORS OF INNATE IMMUNITY
    David Underhill; Fiscal Year: 2005
    ....
  4. Phagosomal targeting of CARD proteins
    David M Underhill; Fiscal Year: 2010
    ..Clinical manipulation of these pathways may help suppress unwanted inflammation, or stimulate effective immune defenses. ..