David M Underhill

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. doi request reprint Beta-glucan recognition by the innate immune system
    Helen S Goodridge
    Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Immunol Rev 230:38-50. 2009
  2. doi request reprint Information processing during phagocytosis
    David M Underhill
    Inflammatory Bowel and Immunobiology Research Institute, Department of Biomedical Sciences, Cedars Sinai Medical Center, 8, 700 Beverly Boulevard, Los Angeles, California 90048, USA
    Nat Rev Immunol 12:492-502. 2012
  3. pmc Phagosomal degradation increases TLR access to bacterial ligands and enhances macrophage sensitivity to bacteria
    Andrea J Wolf
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Immunol 187:6002-10. 2011
  4. pmc Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'
    Helen S Goodridge
    IBD and Immunobiology Research Institute, 8700 Beverly Boulevard, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Nature 472:471-5. 2011
  5. pmc Detection of a TLR2 agonist by hematopoietic stem and progenitor cells impacts the function of the macrophages they produce
    Alberto Yáñez
    Regenerative Medicine Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Eur J Immunol 43:2114-25. 2013
  6. pmc Failure to induce IFN-β production during Staphylococcus aureus infection contributes to pathogenicity
    Amber Kaplan
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Immunol 189:4537-45. 2012
  7. pmc Dectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived antigens
    Jun Ma
    Division of Immunology, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Biol Chem 287:34149-56. 2012
  8. ncbi request reprint Collaboration between the innate immune receptors dectin-1, TLRs, and Nods
    David M Underhill
    Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Immunol Rev 219:75-87. 2007
  9. pmc Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1beta secretion
    Takahiro Shimada
    Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Cell Host Microbe 7:38-49. 2010
  10. pmc Differential use of CARD9 by dectin-1 in macrophages and dendritic cells
    Helen S Goodridge
    Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Immunol 182:1146-54. 2009

Collaborators

Detail Information

Publications17

  1. doi request reprint Beta-glucan recognition by the innate immune system
    Helen S Goodridge
    Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Immunol Rev 230:38-50. 2009
    ....
  2. doi request reprint Information processing during phagocytosis
    David M Underhill
    Inflammatory Bowel and Immunobiology Research Institute, Department of Biomedical Sciences, Cedars Sinai Medical Center, 8, 700 Beverly Boulevard, Los Angeles, California 90048, USA
    Nat Rev Immunol 12:492-502. 2012
    ..In this Review, we discuss how such information is acquired during phagocytosis and how it is processed to coordinate an immune response...
  3. pmc Phagosomal degradation increases TLR access to bacterial ligands and enhances macrophage sensitivity to bacteria
    Andrea J Wolf
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Immunol 187:6002-10. 2011
    ..aureus more susceptible to degradation and resulted in increased inflammatory responses, similar to those observed for mutant degradation-sensitive bacteria...
  4. pmc Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'
    Helen S Goodridge
    IBD and Immunobiology Research Institute, 8700 Beverly Boulevard, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Nature 472:471-5. 2011
    ....
  5. pmc Detection of a TLR2 agonist by hematopoietic stem and progenitor cells impacts the function of the macrophages they produce
    Alberto Yáñez
    Regenerative Medicine Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Eur J Immunol 43:2114-25. 2013
    ..Our data demonstrate that macrophage function can be influenced by TLR signaling in the HSPCs from which they are derived, and that this may impact the clinical utility of targeting TLRs on HSPCs to boost myelopoiesis. ..
  6. pmc Failure to induce IFN-β production during Staphylococcus aureus infection contributes to pathogenicity
    Amber Kaplan
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Immunol 189:4537-45. 2012
    ..aureus infection (in vitro and in vivo) was protective. Together, the data demonstrate that failure to induce IFN-β production during S. aureus infection contributes to pathogenicity...
  7. pmc Dectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived antigens
    Jun Ma
    Division of Immunology, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Biol Chem 287:34149-56. 2012
    ....
  8. ncbi request reprint Collaboration between the innate immune receptors dectin-1, TLRs, and Nods
    David M Underhill
    Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Immunol Rev 219:75-87. 2007
    ..Studies on the molecular mechanisms of cross-talk and synergy between these receptors provide a framework in which to understand the importance of having multiple receptors recognize individual microbes...
  9. pmc Staphylococcus aureus evades lysozyme-based peptidoglycan digestion that links phagocytosis, inflammasome activation, and IL-1beta secretion
    Takahiro Shimada
    Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Cell Host Microbe 7:38-49. 2010
    ..aureus are functionally coupled to inflammasome activation and IL-1beta secretion and illustrate a case whereby a bacterium specifically subverts IL-1beta secretion through chemical modification of its cell wall PGN...
  10. pmc Differential use of CARD9 by dectin-1 in macrophages and dendritic cells
    Helen S Goodridge
    Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Immunol 182:1146-54. 2009
    ..In such cells, Dectin-1, CARD9, and Bcl10 levels are not limiting, and data indicate that these cells express additional factors that restrict Dectin-1-CARD9 signaling for TNF-alpha induction...
  11. pmc Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis
    Kenichi Shimada
    Division of Pediatrics Infectious Disease and Immunology, Cedars Sinai Medical Center and David Geffen School of Medicine, UCLA, Los Angeles, CA 90048, USA
    Immunity 36:401-14. 2012
    ..These results provide a missing link between apoptosis and inflammasome activation, via binding of cytosolic oxidized mtDNA to the NLRP3 inflammasome...
  12. pmc Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis
    Iliyan D Iliev
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Science 336:1314-7. 2012
    ....
  13. doi request reprint Cutting Edge: FYCO1 Recruitment to Dectin-1 Phagosomes Is Accelerated by Light Chain 3 Protein and Regulates Phagosome Maturation and Reactive Oxygen Production
    Jun Ma
    F Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048
    J Immunol 192:1356-60. 2014
    ..During LC3-associated phagocytosis, FYCO1 recruitment facilitates maturation of early p40phox(+) phagosomes into late LAMP1(+) phagosomes. When FYCO1 is lacking, phagosomes stay p40phox(+) longer and produce more reactive oxygen. ..
  14. doi request reprint Mechanisms of Fc receptor and dectin-1 activation for phagocytosis
    Helen S Goodridge
    Regenerative Medicine Institute, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Traffic 13:1062-71. 2012
    ..We will examine how these receptors detect their ligands, how signal transduction is initiated and regulated, and how internalization is instructed to achieve rapid and yet controlled uptake of their targets...
  15. ncbi request reprint Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cells
    Helen S Goodridge
    Immunobiology Research Institute, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    J Immunol 178:3107-15. 2007
    ..These data establish NFAT activation in myeloid cells as a novel mechanism of regulation of the innate antimicrobial response...
  16. pmc β-Glucan signaling connects phagocytosis to autophagy
    Jun Ma
    Research Division of Immunology, Department of Biomedical Sciences, F Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Glycobiology 23:1047-51. 2013
    ..Studies documenting LC3's recruitment to phagosomes containing β-glucan and other nonsugar particles suggest that LC3 plays a role in regulating phagocytosis and its related immunological responses. ..
  17. pmc Striking a balance: fungal commensalism versus pathogenesis
    Iliyan D Iliev
    F Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Department of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Curr Opin Microbiol 16:366-73. 2013
    ..Recent studies have begun to shed light on how this balance is established and maintained, and suggest future studies on the role of fungi in homeostatic conditions. ..