Mark Pimentel

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. ncbi request reprint A 14-day elemental diet is highly effective in normalizing the lactulose breath test
    Mark Pimentel
    GI Motility Program, Division of Gastroenterology, Department of Medicine, Cedars Sinai Medical Center, CSMC Burns and Allen Research Institute, Los Angeles, California 90048, USA
    Dig Dis Sci 49:73-7. 2004
  2. ncbi request reprint Methane, a gas produced by enteric bacteria, slows intestinal transit and augments small intestinal contractile activity
    Mark Pimentel
    Cedars Sinai Medical Center, Burns and Allen Research Institute, Los Angeles, CA 90048, USA
    Am J Physiol Gastrointest Liver Physiol 290:G1089-95. 2006
  3. ncbi request reprint Neomycin improves constipation-predominant irritable bowel syndrome in a fashion that is dependent on the presence of methane gas: subanalysis of a double-blind randomized controlled study
    Mark Pimentel
    Cedars Sinai Medical Center, Burns and Allen Research Institute, UCLA Geffen School of Medicine, 8635 W 3rd St, Suite 770, Los Angeles, California 90034, USA
    Dig Dis Sci 51:1297-301. 2006
  4. ncbi request reprint Rifaximin versus other antibiotics in the primary treatment and retreatment of bacterial overgrowth in IBS
    Janet Yang
    GI Motility Program, GI Motility Laboratory, Cedars Sinai Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Dig Dis Sci 53:169-74. 2008
  5. ncbi request reprint Bacterial concepts in irritable bowel syndrome
    Henry C Lin
    Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Rev Gastroenterol Disord 5:S3-9. 2005
  6. doi request reprint Gas and the microbiome
    Mark Pimentel
    GI Motility Program, Division of Gastroenterology, Cedars Sinai Medical Center, 8730 Alden Drive, Suite 201E, Los Angeles, CA, 90048, USA
    Curr Gastroenterol Rep 15:356. 2013
  7. doi request reprint Report from the multinational irritable bowel syndrome initiative 2012
    Mark Pimentel
    Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Gastroenterology 144:e1-5. 2013
  8. ncbi request reprint Irritable Bowel Syndrome: Bacterial Overgrowth--What's Known and What to Do
    Mark Pimentel
    Mark Pimentel, MD, FRCP C GI Motility Program, Cedars Sinai Medical Center, 8730 Alden Drive, Suite 225E, Los Angeles, CA 90048, USA
    Curr Treat Options Gastroenterol 10:328-37. 2007
  9. ncbi request reprint A new rat model links two contemporary theories in irritable bowel syndrome
    Mark Pimentel
    GI Motilty Program, Cedars Sinai Medical Center, Burns and Allen Research Institute, 8730 Alden Drive, Suite 225E, Los Angeles, CA 90048, USA
    Dig Dis Sci 53:982-9. 2008
  10. doi request reprint New clinical method for distinguishing D-IBS from other gastrointestinal conditions causing diarrhea: the LA/IBS diagnostic strategy
    Mark Pimentel
    GI Motility Program, Cedars Sinai Medical Center, 8730 Alden Drive, Suite 225E, Los Angeles, CA 90048, USA
    Dig Dis Sci 55:145-9. 2010

Collaborators

Detail Information

Publications54

  1. ncbi request reprint A 14-day elemental diet is highly effective in normalizing the lactulose breath test
    Mark Pimentel
    GI Motility Program, Division of Gastroenterology, Department of Medicine, Cedars Sinai Medical Center, CSMC Burns and Allen Research Institute, Los Angeles, California 90048, USA
    Dig Dis Sci 49:73-7. 2004
    ..9 +/- 22.0% in those who failed to normalize (P < 0.001). An elemental diet is highly effective in normalizing an abnormal LBT in IBS subjects, with a concomitant improvement in clinical symptoms...
  2. ncbi request reprint Methane, a gas produced by enteric bacteria, slows intestinal transit and augments small intestinal contractile activity
    Mark Pimentel
    Cedars Sinai Medical Center, Burns and Allen Research Institute, Los Angeles, CA 90048, USA
    Am J Physiol Gastrointest Liver Physiol 290:G1089-95. 2006
    ..05). Therefore, methane, a gaseous by-product of intestinal bacteria, slows small intestinal transit and appears to do so by augmenting small bowel contractile activity...
  3. ncbi request reprint Neomycin improves constipation-predominant irritable bowel syndrome in a fashion that is dependent on the presence of methane gas: subanalysis of a double-blind randomized controlled study
    Mark Pimentel
    Cedars Sinai Medical Center, Burns and Allen Research Institute, UCLA Geffen School of Medicine, 8635 W 3rd St, Suite 770, Los Angeles, California 90034, USA
    Dig Dis Sci 51:1297-301. 2006
    ..0+/-12.3%) compared to placebo (5.0+/-5.1%) (P < .05). Treatment with neomycin improves constipation in C-IBS. This improvement depends on the presence and elimination of methane on breath test...
  4. ncbi request reprint Rifaximin versus other antibiotics in the primary treatment and retreatment of bacterial overgrowth in IBS
    Janet Yang
    GI Motility Program, GI Motility Laboratory, Cedars Sinai Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Dig Dis Sci 53:169-74. 2008
    ..The purpose of this study was to compare the efficacy of rifaximin in both the treatment and retreatment of IBS...
  5. ncbi request reprint Bacterial concepts in irritable bowel syndrome
    Henry C Lin
    Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Rev Gastroenterol Disord 5:S3-9. 2005
    ..Once a good clinical response and normalization of the lactulose breath test are achieved, a prokinetic agent may be used to stimulate phase III of interdigestive motility to delay relapse of bacterial overgrowth...
  6. doi request reprint Gas and the microbiome
    Mark Pimentel
    GI Motility Program, Division of Gastroenterology, Cedars Sinai Medical Center, 8730 Alden Drive, Suite 201E, Los Angeles, CA, 90048, USA
    Curr Gastroenterol Rep 15:356. 2013
    ..g., hydrogen production as measured by breath testing can be used to diagnose bacterial overgrowth. In this article, we review the roles and effects of hydrogen (H2), methane (CH4) and hydrogen sulfide (H2S) in the human gut. ..
  7. doi request reprint Report from the multinational irritable bowel syndrome initiative 2012
    Mark Pimentel
    Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Gastroenterology 144:e1-5. 2013
    ..Together, the discussions held at this workshop form a framework to address future research in IBS...
  8. ncbi request reprint Irritable Bowel Syndrome: Bacterial Overgrowth--What's Known and What to Do
    Mark Pimentel
    Mark Pimentel, MD, FRCP C GI Motility Program, Cedars Sinai Medical Center, 8730 Alden Drive, Suite 225E, Los Angeles, CA 90048, USA
    Curr Treat Options Gastroenterol 10:328-37. 2007
    ..A treatment algorithm also is proposed based on these findings. New areas of research in IBS such as gut bacteria are changing the treatment approach in IBS from a symptom-based style to one that is hypothesis driven...
  9. ncbi request reprint A new rat model links two contemporary theories in irritable bowel syndrome
    Mark Pimentel
    GI Motilty Program, Cedars Sinai Medical Center, Burns and Allen Research Institute, 8730 Alden Drive, Suite 225E, Los Angeles, CA 90048, USA
    Dig Dis Sci 53:982-9. 2008
    ..We studied whether acute infection with Campylobacter could precipitate bacterial overgrowth in a rat model in order to link the two hypotheses...
  10. doi request reprint New clinical method for distinguishing D-IBS from other gastrointestinal conditions causing diarrhea: the LA/IBS diagnostic strategy
    Mark Pimentel
    GI Motility Program, Cedars Sinai Medical Center, 8730 Alden Drive, Suite 225E, Los Angeles, CA 90048, USA
    Dig Dis Sci 55:145-9. 2010
    ..81; specificity = 0.60). The use of this simple tool that identifies an irregularly irregular bowel form and function is successful in separating D-IBS from non-IBS subjects...
  11. doi request reprint Effects of rifaximin treatment and retreatment in nonconstipated IBS subjects
    Mark Pimentel
    GI Motility Program, Cedars Sinai Medical Center, 8730 Alden Drive, Suite 225E, Los Angeles, CA 90048, USA
    Dig Dis Sci 56:2067-72. 2011
    ..In this retrospective study, subjects with nonconstipated IBS who were retreated with rifaximin were examined...
  12. doi request reprint Inflammation and microflora
    Mark Pimentel
    GI Motility Program, Cedars Sinai Medical Center, 8730 Alden Drive, Suite 225E, Los Angeles, CA 90048, USA
    Gastroenterol Clin North Am 40:69-85. 2011
    ..Data suggesting an interaction between this gut flora and inflammation in the context of IBS is also presented...
  13. doi request reprint Evaluating a bacterial hypothesis in IBS using a modification of Koch's postulates: part 1
    Mark Pimentel
    GI Motility Program, Cedars Sinai Medical Center, Los Angeles, California, USA
    Am J Gastroenterol 105:718-21. 2010
    ..On the basis of proof of a bacterial cause of IBS, antibiotics may be a good choice of therapy...
  14. doi request reprint Antibiotic prophylaxis prevents the development of a post-infectious phenotype in a new rat model of post-infectious IBS
    Mark Pimentel
    GI Motility Program, Division of Gastroenterology, Cedars Sinai Medical Center, 8730 Alden Drive, Suite 225E, Los Angeles, CA 90048, USA
    Dig Dis Sci 56:1962-6. 2011
    ..In this study, we test whether prophylactic treatment with the antibiotic rifaximin will prevent the development of long-term altered bowel function in this model...
  15. ncbi request reprint The effect of a nonabsorbed oral antibiotic (rifaximin) on the symptoms of the irritable bowel syndrome: a randomized trial
    Mark Pimentel
    Cedars Sinai Medical Center, Burns and Allen Research Institute, and University of California, Los Angeles, Geffen School of Medicine, Los Angeles, California 90048, USA
    Ann Intern Med 145:557-63. 2006
    ..Alterations in gut flora may be important in the pathophysiology of the irritable bowel syndrome (IBS)...
  16. ncbi request reprint IBS subjects with methane on lactulose breath test have lower postprandial serotonin levels than subjects with hydrogen
    Mark Pimentel
    GI Motility Program, Department of Medicine, CSMC Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Dig Dis Sci 49:84-7. 2004
    ..Methane producing IBS subjects have reduced postprandial serotonin. Whether methane is a surrogate marker of constipation or contributing to the reduced serotonin remains to be determined...
  17. pmc ICC density predicts bacterial overgrowth in a rat model of post-infectious IBS
    Sam Ryong Jee
    GI Motility Program, Division of Gastroenterology, Cedars Sinai Medical Center, 8730 Alden Drive, Los Angeles, CA 90048, USA
    World J Gastroenterol 16:3680-6. 2010
    ..To investigate the interstitial cells of Cajal (ICC) number using a new rat model...
  18. doi request reprint Methanobrevibacter smithii is the predominant methanogen in patients with constipation-predominant IBS and methane on breath
    Gene Kim
    GI Motility Program, Division of Gastroenterology, Cedars Sinai Medical Center, 8730, Alden Dr, Suite 225 E, Los Angeles, CA 90048, USA
    Dig Dis Sci 57:3213-8. 2012
    ..Although the most common methanogen in humans is Methanobrevibacter smithii, incidence and type of methanogenic bacteria in C-IBS patients are unknown...
  19. doi request reprint Acute and chronic histological changes of the small bowel secondary to C. jejuni infection in a rat model for post-infectious IBS
    Walter Morales
    GI Motility Program, Division of Gastroenterology, Cedars Sinai Medical Center, 8730 Alden Drive, Suite, 2 East, Los Angeles, CA 90048, USA
    Dig Dis Sci 56:2575-84. 2011
    ..In this study, we characterized both acute and chronic-phase histological changes of the small bowel in rats exposed to wild-type C. jejuni 81-176, or a strain that does not produce CDT, by using a validated rat model of PI-IBS...
  20. ncbi request reprint Methane production during lactulose breath test is associated with gastrointestinal disease presentation
    Mark Pimentel
    GI Motility Program, Bums and Allen Research Center, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Dig Dis Sci 48:86-92. 2003
    ..In fact, methane was almost nonexistent in the predominantly diarrheal conditions of Crohn's and UC. In conclusion, a methane positive breath test is associated with constipation as a symptom...
  21. doi request reprint Evaluating breath methane as a diagnostic test for constipation-predominant IBS
    Laura Hwang
    GI Motility Program, Division of Gastroenterology, Cedars Sinai Medical Center, 8730 Alden Drive, Suite 225E, Los Angeles, CA 90048, USA
    Dig Dis Sci 55:398-403. 2010
    ..7% and a specificity of 81.3% (OR = 47.7, CI = 9.4-232, P < 0.00001). In conclusion, methane is a potential diagnostic test for the identification of C-IBS and may guide treatment...
  22. ncbi request reprint The degree of breath methane production in IBS correlates with the severity of constipation
    Soumya Chatterjee
    Cedars Sinai Medical Center, Burns and Allen Research Institute, Los Angeles, California, USA
    Am J Gastroenterol 102:837-41. 2007
    ..This work has been based on subjective constipation outcomes. In this study, methane is compared to constipation in another population of IBS subjects with constipation being determined both subjectively and objectively...
  23. doi request reprint A combination of rifaximin and neomycin is most effective in treating irritable bowel syndrome patients with methane on lactulose breath test
    Kimberly Low
    GI Motility Program, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Clin Gastroenterol 44:547-50. 2010
    ..In this study, we evaluate 3 different antibiotic treatments in patients who have a methane-positive breath test: rifaximin only, neomycin only, and the combination of neomycin and rifaximin...
  24. doi request reprint Factor analysis demonstrates a symptom cluster related to methane and non-methane production in irritable bowel syndrome
    Marc Makhani
    GI Motility Program, Division of Gastroenterology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Clin Gastroenterol 45:40-4. 2011
    ..The goal of this study was to conduct a factor analysis to determine whether there is a cluster of symptoms associated with methane production...
  25. pmc Pathogen-specific risk of chronic gastrointestinal disorders following bacterial causes of foodborne illness
    Chad K Porter
    Enteric Diseases Department, Naval Medical Research Center, Silver Spring, MD, USA
    BMC Gastroenterol 13:46. 2013
    ..We utilized a US Department of Defense medical encounter database to evaluate the risk of several gastrointestinal disorders following select foodborne infections...
  26. doi request reprint Pathogen-specific risk of celiac disease following bacterial causes of foodborne illness: a retrospective cohort study
    Mark S Riddle
    Enteric Diseases Department, Infectious Disease Directorate, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD, 20910 7500, USA
    Dig Dis Sci 58:3242-5. 2013
    ..We utilized a US Department of Defense medical encounter database to evaluate the risk of CD following select foodborne infections...
  27. doi request reprint Importance of diarrhea in evaluating constipation in irritable bowel syndrome clinical studies
    Robert J Basseri
    GI Motility Program, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Clin Gastroenterol 45:790-3. 2011
    ..In this study, we examine "constipation minus diarrhea" score (C-D) to account for the contribution of diarrhea and to create a reliable method for predicting constipation predominance in IBS...
  28. ncbi request reprint Normalization of lactulose breath testing correlates with symptom improvement in irritable bowel syndrome. a double-blind, randomized, placebo-controlled study
    Mark Pimentel
    GI Motility Program, Department of Medicine, CSMC Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Am J Gastroenterol 98:412-9. 2003
    ..We have recently found an association between abnormal lactulose breath test (LBT) findings and irritable bowel syndrome (IBS). The current study was designed to test the effect of antibiotic treatment for IBS in a double-blind fashion...
  29. pmc Role of Cytolethal Distending Toxin in Altered Stool Form and Bowel Phenotypes in a Rat Model of Post-infectious Irritable Bowel Syndrome
    Venkata Pokkunuri
    GI Motility Program, Cedars Sinai Medical Center, Los Angeles, California, USA
    J Neurogastroenterol Motil 18:434-42. 2012
    ..Cytolethal distending toxin (CDT) is expressed by enteric pathogens that cause PI-IBS. We used a rat model of PI-IBS to investigate the role of CDT in long-term altered stool form and bowel phenotypes...
  30. doi request reprint Intestinal Methanobrevibacter smithii but not total bacteria is related to diet-induced weight gain in rats
    Ruchi Mathur
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
    Obesity (Silver Spring) 21:748-54. 2013
    ..It is increasingly understood that gastrointestinal (GI) methanogens, including Methanobrevibacter smithii, influence host metabolism...
  31. doi request reprint "Pre-cebo": an unrecognized issue in the interpretation of adequate relief during irritable bowel syndrome drug trials
    Sharon E Kim
    GI Motility Program, Cedars Sinai Medical Center, Division of Gastroenterology, Los Angeles, CA 90048, USA
    J Clin Gastroenterol 46:686-90. 2012
    ..In this study, we utilized consent language from prior studies of diarrhea predominant IBS (D-IBS) drug trials to determine whether the knowledge imparted during this process affects the response to different therapies...
  32. ncbi request reprint Breath testing to evaluate lactose intolerance in irritable bowel syndrome correlates with lactulose testing and may not reflect true lactose malabsorption
    Mark Pimentel
    GI Motility Program, Department of Medicine, CSMC Burns and Allen Research Institute, Cedars Sinai Medical Center, 8635 W 3rd Street, Suite 770, Los Angeles, CA 90048, USA
    Am J Gastroenterol 98:2700-4. 2003
    ..Because symptoms of lactose intolerance result from bacterial fermentation, the purpose of this study was to determine whether an abnormal lactose breath test is reflective of malabsorption or early presentation to bacteria...
  33. ncbi request reprint Measurement of gastrointestinal transit
    Henry C Lin
    Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Dig Dis Sci 50:989-1004. 2005
    ..As we make progress in our understanding of the pathophysiology of transit disorders, the clinical usefulness of these diagnostic tests will be further enhanced...
  34. doi request reprint Esophageal motor dysfunction and gastroesophageal reflux are prevalent in lung transplant candidates
    Benjamin Basseri
    GI Motility Program, Division of Gastroenterology, Cedars Sinai Medical Center, Los Angeles, California, USA
    Ann Thorac Surg 90:1630-6. 2010
    ..We evaluated LTx candidates for esophageal motor abnormalities and gastroesophageal reflux...
  35. doi request reprint Severity of dyspeptic symptoms correlates with delayed and early variables of gastric emptying
    Andres Ardila-Hani
    Division of Gastroenterology, GI Motility Program, Cedars Sinai Medical Center, 8730 Alden Drive, Los Angeles, CA 90048, USA
    Dig Dis Sci 58:478-87. 2013
    ..A simplified report of gastric retention values at select times is now recommended for scintigraphic gastric emptying test (GET)...
  36. pmc Apple sauce improves detection of esophageal motor dysfunction during high-resolution manometry evaluation of dysphagia
    Benjamin Basseri
    GI Motility Program, Division of Gastroenterology, Cedars Sinai Medical Center, 8730 Alden Drive, Suite 225E, Los Angeles, CA 90048, USA
    Dig Dis Sci 56:1723-8. 2011
    ..Although manometry is the gold standard for evaluation of these symptoms, patients with dysphagia often have normal results in manometry studies...
  37. ncbi request reprint A systematic review of diagnostic tests for small intestinal bacterial overgrowth
    Reza Khoshini
    Division of Gastroenterology, Harbor UCLA Medical Center, Torrance, CA, USA
    Dig Dis Sci 53:1443-54. 2008
    ..In this systematic review, the validity of culture and other diagnostic testing for SIBO is evaluated...
  38. ncbi request reprint Studying the overlap between IBS and GERD: a systematic review of the literature
    Igor Nastaskin
    Cedars Sinai Medical Center, Burns and Allen Research Institute, and UCLA Geffen School of Medicine, Los Angeles, California, USA
    Dig Dis Sci 51:2113-20. 2006
    ..1%. There is a strong overlap between GERD and IBS that exceeds the individual presence of each condition. In the absence of GERD, IBS is relatively uncommon...
  39. doi request reprint A high-resolution view of achalasia
    Sam Ryong Jee
    GI Motility Program, Division of Gastroenterology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Clin Gastroenterol 43:644-51. 2009
    ..This technology is revealing new observations regarding disordered motor function in esophageal diseases...
  40. doi request reprint Gender distribution in irritable bowel syndrome is proportional to the severity of constipation relative to diarrhea
    Jeremy Herman
    GI Motility Program, Division of Gastroenterology, Cedars Sinai Medical Center, 8730 Alden Drive, Los Angeles, CA 90048, USA
    Gend Med 7:240-6. 2010
    ..However, this observation is based on Rome criteria categorization and does not take into account the severity of constipation or diarrhea...
  41. ncbi request reprint Lower frequency of MMC is found in IBS subjects with abnormal lactulose breath test, suggesting bacterial overgrowth
    Mark Pimentel
    GI Motility Program, Department of Medicine, CSMC Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Dig Dis Sci 47:2639-43. 2002
    ..05). In conclusion, phase III is reduced in subjects with IBS and SIBO. Eradication of bacterial overgrowth seems to result in some normalization of motility...
  42. doi request reprint Methane on breath testing is associated with constipation: a systematic review and meta-analysis
    David Kunkel
    GI Motility Program, Cedars Sinai Medical Center, 8730 Alden Drive, Thalians Building, 2nd Floor East, Los Angeles, CA, 90048, USA
    Dig Dis Sci 56:1612-8. 2011
    ..A growing body of literature suggests an association between methane and constipation. Studies also link degree of methane production to severity of constipation and have shown constipation is improved following antibiotics...
  43. doi request reprint Methane and the gastrointestinal tract
    Ara B Sahakian
    Division of Gastroenterology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Dig Dis Sci 55:2135-43. 2010
    ..Carbon dioxide, hydrogen, hydrogen sulfide, and methane are thought to be the most common of these. Recent evidence suggests that methane may not be inert. In this review article, we summarize the findings with methane...
  44. ncbi request reprint Bacteria and irritable bowel syndrome: the evidence for small intestinal bacterial overgrowth
    Hyo Rang Lee
    GI Motility Laboratory, Cedars Sinai Medical Center, 8730 Alden Drive, 2nd Floor, Los Angeles, CA 90048, USA
    Curr Gastroenterol Rep 8:305-11. 2006
    ..In this review, these topics are discussed and outlined...
  45. doi request reprint Proton pump inhibitor therapy does not affect hydrogen production on lactulose breath test in subjects with IBS
    David Law
    GI Motility Program, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Dig Dis Sci 55:2302-8. 2010
    ..Recently, the question has arisen whether the lactulose breath test (LBT) is abnormal in IBS subjects due to overlapping GERD and proton-pump inhibitor (PPI) usage...
  46. pmc Risk of inflammatory bowel disease following a diagnosis of irritable bowel syndrome
    Chad K Porter
    Enteric Diseases Department, Infectious Disease Directorate, Naval Medical Research Center, 503 Robert Grant Avenue, Silver Spring, MD, USA
    BMC Gastroenterol 12:55. 2012
    ..In some IBS cases there are subtle inflammatory changes similar to the immune-mediated pathophysiology of IBD, and the risk of both increases after infectious gastroenteritis (IGE)...
  47. doi request reprint Antibiotics for irritable bowel syndrome: rationale and current evidence
    Amit H Sachdev
    GI Motility Laboratory, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Curr Gastroenterol Rep 14:439-45. 2012
    ..In this article, we review the different mechanisms by which gut flora and, specifically, SIBO may contribute to IBS and the evidence supporting the use of various antibiotic therapies in treating IBS...
  48. doi request reprint Polycystic ovary syndrome is associated with an increased prevalence of irritable bowel syndrome
    Ruchi Mathur
    Department of Obstetrics Gynecology, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Dig Dis Sci 55:1085-9. 2010
    ..Irritable bowel syndrome (IBS) is a chronic intestinal disorder that affects up to 20% of adults, more often women. We evaluate if there is a relationship between these common conditions...
  49. ncbi request reprint Increased prevalence of irritable bowel syndrome in patients with gastroesophageal reflux
    Mark Pimentel
    GI Motility Program, Department of Medicine, Cedars Sinai Medical Center, CSMC Burns and Allen Research Institute, Los Angeles, California 90048, USA
    J Clin Gastroenterol 34:221-4. 2002
    ..To determine the prevalence of irritable bowel syndrome (IBS) in subjects with gastroesophageal reflux disease (GERD) compared with non-GERD controls...
  50. doi request reprint Rifaximin therapy for patients with irritable bowel syndrome without constipation
    Mark Pimentel
    Cedars Sinai Medical Center, Los Angeles, USA
    N Engl J Med 364:22-32. 2011
    ..Evidence suggests that gut flora may play an important role in the pathophysiology of the irritable bowel syndrome (IBS). We evaluated rifaximin, a minimally absorbed antibiotic, as treatment for IBS...
  51. doi request reprint Irritable bowel syndrome and small intestinal bacterial overgrowth
    David Yamini
    GI Motility Program, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Clin Gastroenterol 44:672-5. 2010
    ..In this review, the current evidence for bacteria in irritable bowel syndrome will be examined...
  52. ncbi request reprint Review of rifaximin as treatment for SIBO and IBS
    Mark Pimentel
    GI Motility Program, Cedars Sinai Medical Center, 8730 Alden Dr, Suite 225E, Los Angeles, CA 90048, USA
    Expert Opin Investig Drugs 18:349-58. 2009
    ..Therefore, rifaximin may be useful in the treatment of gastrointestinal disorders associated with altered bacterial flora, including irritable bowel syndrome (IBS) and small intestinal bacterial overgrowth (SIBO)...
  53. ncbi request reprint Do antibiotics influence IBS?
    Mark Pimentel
    Am J Gastroenterol 97:2681. 2002
  54. doi request reprint Prevention of traveler's diarrhea: a call to reconvene
    Mark Pimentel
    Clin Infect Dis 46:151-2. 2008