Lin Pei

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. ncbi request reprint Phosphorylation modulates the function of the vasoactive intestinal polypeptide receptor transcriptional repressor protein
    L Pei
    Division of Endocrinology and Metabolism, Cedars Sinai Research Institute UCLA School of Medicine, Los Angeles, California 90048, USA
    J Biol Chem 275:1176-82. 2000
  2. ncbi request reprint Molecular characterization of the VIP receptor transcriptional repressor protein
    L Pei
    Division of Endocrinology and Metabolism, Cedars Sinai Research Institute UCLA School of Medicine, Los Angeles, California 90048, USA
    Ann N Y Acad Sci 921:157-64. 2000
  3. ncbi request reprint Activation of mitogen-activated protein kinase cascade regulates pituitary tumor-transforming gene transactivation function
    L Pei
    Division of Endocrinology and Metabolism, Cedars Sinai Research Institute UCLA School of Medicine, Los Angeles, California 90048, USA
    J Biol Chem 275:31191-8. 2000
  4. ncbi request reprint Identification of c-myc as a down-stream target for pituitary tumor-transforming gene
    L Pei
    Division of Endocrinology and Metabolism, Cedars Sinai Research Institute, UCLA School of Medicine, Los Angeles, California 90048, USA
    J Biol Chem 276:8484-91. 2001
  5. pmc Transcriptional repressor of vasoactive intestinal peptide receptor mediates repression through interactions with TFIIB and TFIIEbeta
    L Pei
    Division of Endocrinology and Metabolism, Cedars Sinai Research Institute UCLA School of Medicine, 8700 Beverly Boulevard, Los Angeles, CA 90048, U S A
    Biochem J 360:633-8. 2001
  6. ncbi request reprint Genomic organization and identification of an enhancer element containing binding sites for multiple proteins in rat pituitary tumor-transforming gene
    L Pei
    Division of Endocrinology, Cedars Sinai Research Institute, UCLA School of Medicine, Los Angeles, California 90048, USA
    J Biol Chem 273:5219-25. 1998
  7. ncbi request reprint Molecular cloning of a novel transcriptional repressor protein of the rat type 1 vasoactive intestinal peptide receptor gene
    L Pei
    Division of Endocrinology, Cedars Sinai Research Institute, UCLA School of Medicine, Los Angeles, California 90048, USA
    J Biol Chem 273:19902-8. 1998
  8. pmc Autoregulation of the human liver X receptor alpha promoter
    B A Laffitte
    Howard Hughes Medical Institute, University of California, Los Angeles, 90095-1662, USA
    Mol Cell Biol 21:7558-68. 2001
  9. ncbi request reprint A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product
    W Chien
    Division of Endocrinology and Metabolism, Cedars Sinai Research Institute, UCLA School of Medicine, Los Angeles, California 90048, USA
    J Biol Chem 275:19422-7. 2000
  10. ncbi request reprint Isolation and characterization of a pituitary tumor-transforming gene (PTTG)
    L Pei
    Division of Endocrinology and Metabolism, Cedars Sinai Research Institute UCLA School of Medicine, Los Angeles, California 90048, USA
    Mol Endocrinol 11:433-41. 1997

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Phosphorylation modulates the function of the vasoactive intestinal polypeptide receptor transcriptional repressor protein
    L Pei
    Division of Endocrinology and Metabolism, Cedars Sinai Research Institute UCLA School of Medicine, Los Angeles, California 90048, USA
    J Biol Chem 275:1176-82. 2000
    ..These observations suggest that phosphorylation plays an important role in regulating VIPR-RP function...
  2. ncbi request reprint Molecular characterization of the VIP receptor transcriptional repressor protein
    L Pei
    Division of Endocrinology and Metabolism, Cedars Sinai Research Institute UCLA School of Medicine, Los Angeles, California 90048, USA
    Ann N Y Acad Sci 921:157-64. 2000
    ..The results showed that VIPR-RP contains two separate transcriptional repression domains located between amino acids 50 to 101 and 470 to 527...
  3. ncbi request reprint Activation of mitogen-activated protein kinase cascade regulates pituitary tumor-transforming gene transactivation function
    L Pei
    Division of Endocrinology and Metabolism, Cedars Sinai Research Institute UCLA School of Medicine, Los Angeles, California 90048, USA
    J Biol Chem 275:31191-8. 2000
    ..Together, our data establish that a growth factor-stimulated MAP kinase plays an important role in modulating PTTG function...
  4. ncbi request reprint Identification of c-myc as a down-stream target for pituitary tumor-transforming gene
    L Pei
    Division of Endocrinology and Metabolism, Cedars Sinai Research Institute, UCLA School of Medicine, Los Angeles, California 90048, USA
    J Biol Chem 276:8484-91. 2001
    ..These results definitively established the role of PTTG as a transcription activator and indicate that PTTG is involved in cellular transformation and tumorigenesis through activation of c-myc oncogene...
  5. pmc Transcriptional repressor of vasoactive intestinal peptide receptor mediates repression through interactions with TFIIB and TFIIEbeta
    L Pei
    Division of Endocrinology and Metabolism, Cedars Sinai Research Institute UCLA School of Medicine, 8700 Beverly Boulevard, Los Angeles, CA 90048, U S A
    Biochem J 360:633-8. 2001
    ..My results indicate that VIPR-RP mediates transcriptional repression through direct interactions with the general transcription machinery...
  6. ncbi request reprint Genomic organization and identification of an enhancer element containing binding sites for multiple proteins in rat pituitary tumor-transforming gene
    L Pei
    Division of Endocrinology, Cedars Sinai Research Institute, UCLA School of Medicine, Los Angeles, California 90048, USA
    J Biol Chem 273:5219-25. 1998
    ..These results suggest that PTTG transcriptional activation in testicular cell lines involves interactions of multiple nuclear factors with the PTTG 5' enhancer sequence...
  7. ncbi request reprint Molecular cloning of a novel transcriptional repressor protein of the rat type 1 vasoactive intestinal peptide receptor gene
    L Pei
    Division of Endocrinology, Cedars Sinai Research Institute, UCLA School of Medicine, Los Angeles, California 90048, USA
    J Biol Chem 273:19902-8. 1998
    ..These results indicate that VIPR-RP is a novel transcriptional repressor protein that regulates VIPR expression...
  8. pmc Autoregulation of the human liver X receptor alpha promoter
    B A Laffitte
    Howard Hughes Medical Institute, University of California, Los Angeles, 90095-1662, USA
    Mol Cell Biol 21:7558-68. 2001
    ..The ability of LXR alpha to regulate its own promoter is likely to be an integral part of the macrophage physiologic response to lipid loading...
  9. ncbi request reprint A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product
    W Chien
    Division of Endocrinology and Metabolism, Cedars Sinai Research Institute, UCLA School of Medicine, Los Angeles, California 90048, USA
    J Biol Chem 275:19422-7. 2000
    ..In summary, we have characterized a novel PTTG-binding protein that facilitates PTTG nuclear translocation and potentiates its transcriptional activation function...
  10. ncbi request reprint Isolation and characterization of a pituitary tumor-transforming gene (PTTG)
    L Pei
    Division of Endocrinology and Metabolism, Cedars Sinai Research Institute UCLA School of Medicine, Los Angeles, California 90048, USA
    Mol Endocrinol 11:433-41. 1997
    ..These results indicate that pituitary tumor cells express a unique and potent transforming gene (PTTG), which may play a role in pituitary tumorigenesis...
  11. ncbi request reprint Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells
    L Pei
    Division of Endocrinology, Cedars Sinai Research Institute, UCLA School of Medicine, Los Angeles, California 90048, USA
    J Biol Chem 274:3151-8. 1999
    ..Moreover, the binding sites for both proteins were located within the C-terminal 75 amino acids of the PTTG protein. These results suggest that PTTG may play a role in spermatogenesis...