Research Topics
Species | ROBERT PECHNICKSummaryAffiliation: Cedars-Sinai Medical Center Country: USA Publications
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Publications
Comparison of the effects of dextromethorphan, dextrorphan, and levorphanol on the hypothalamo-pituitary-adrenal axisRobert N Pechnick
Department of Psychiatry and Mental Health, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
J Pharmacol Exp Ther 309:515-22. 2004..These results support the hypothesis that dextromethorphan has pharmacological activity aside from its biotransformation to dextrorphan and demonstrate that the effects of dextrorphan are not mediated by opioid receptors...
Eszopiclone stimulates the hypothalamo-pituitary-adrenal axis in the ratRobert N Pechnick
Department of Psychiatry and Behavioral Neurosciences, Cedars Sinai Medical Center, Los Angeles, CA, USA
Eur J Pharmacol 661:22-6. 2011..Pretreatment with eszopiclone did not affect stress-induced stimulation of the HPA axis. These results show that eszopiclone and the benzodiazepine-type drugs differentially affect the HPA axis...- Reduced immobility in the forced swim test in mice with a targeted deletion of the leukemia inhibitory factor (LIF) geneRobert N Pechnick
Department of Psychiatry and Mental Health, Cedars Sinai Medical Center, Los Angeles, CA 9048, USA
Neuropsychopharmacology 29:770-6. 2004..It was found that LIF knockout mice show reduced immobility in the forced swim test, suggesting that LIF might have a potential role in the etiology of some forms of depression... - Acamprosate attenuates cue-induced reinstatement of nicotine-seeking behavior in ratsRobert N Pechnick
Department of Psychiatry and Behavioral Neurosciences, Cedars Sinai Medical Center, UCLA, Los Angeles, California 90048, USA
Behav Pharmacol 22:222-7. 2011..These results show that acamprosate reduced cue-induced nicotine-seeking behavior and suggest that acamprosate might be efficacious in treating nicotine addiction in humans... - The role of antagonism of NMDA receptor-mediated neurotransmission and inhibition of the dopamine reuptake in the neuroendocrine effects of phencyclidineRobert N Pechnick
Department of Psychiatry and Mental Health, Cedars Sinai Medical Center, 8730 Alden Drive, Los Angeles, CA, 90048, USA
Life Sci 78:2006-11. 2006.... - Developmental exposure to corticosterone: behavioral changes and differential effects on leukemia inhibitory factor (LIF) and corticotropin-releasing hormone (CRH) gene expression in the mouseRobert N Pechnick
Department of Psychiatry and Mental Health, Cedars Sinai Medical Center, 8730 Alden Drive, Los Angeles, CA 90048, USA
Psychopharmacology (Berl) 185:76-83. 2006..Both the hypothalamic-pituitary-adrenal axis and the immune system, including cytokine-mediated responses, appear to be susceptible to long-term programming during fetal and neonatal development... 
Comparison of the effects of desmethylimipramine on behavior in the forced swim test in peripubertal and adult ratsRobert N Pechnick
Department of Psychiatry and Behavioral Neurosciences, Cedars Sinai Medical Center, Los Angeles, California 90034, USA
Behav Pharmacol 19:81-4. 2008..Owing to the discrepancy between the preclinical and clinical data, the predictive validity of the FST might need to be reevaluated across different age groups...- The role of dopaminergic agents in improving quality of life in major depressive disorderWaguih William Ishak
Department of Psychiatry, Cedars Sinai Medical Center and David Geffen School of Medicine at UCLA, 8730 Alden Drive, Thalians W 157, Los Angeles, CA 90048, USA
Curr Psychiatry Rep 11:503-8. 2009..Preliminary evidence suggests dopaminergic agents may have a positive effect on QOL for patients with MDD. Prospective, randomized, double-blind, placebo-controlled studies are needed to extend these findings... - Antidepressants and Cdk inhibitors: releasing the brake on neurogenesis?Vera Chesnokova
Department of Medicine, Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
Cell Cycle 7:2321-6. 2008..However, there is a possibility that long-term stimulation of neurogenesis might exhaust the proliferation potentials of neuronal progenitors... - Self-administration of 5-iodo-A-85380, a beta2-selective nicotinic receptor ligand, by operantly trained ratsXiu Liu
Department of Psychiatry, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Neuroreport 14:1503-5. 2003..This finding suggests that interaction with beta2-containing nAChRs, without direct involvement of alpha7 receptors, can produce reinforcement and thereby can support self-administration behavior... - Endotoxin exposure in utero increases ethanol consumption in adult male offspringXiu Liu
Department of Psychiatry, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Neuroreport 15:203-6. 2004..These data suggest that maternal infection during pregnancy might precipitate alcohol drinking behavior in adult offspring and this effect might be due, at least in part, to elevated levels of anxiety... - Gene therapy for brain cancer: combination therapies provide enhanced efficacy and safetyMarianela Candolfi
Gene Therapeutics Research Institute, Cedars Sinai Medical Center, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
Curr Gene Ther 9:409-21. 2009.... - p21Cip1 restricts neuronal proliferation in the subgranular zone of the dentate gyrus of the hippocampusRobert N Pechnick
Department of Medicine, Division of Endocrinology, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
Proc Natl Acad Sci U S A 105:1358-63. 2008..Because many antidepressants stimulate neurogenesis, it is possible that their shared common mechanism of action is suppression of p21... - A novel bicistronic high-capacity gutless adenovirus vector that drives constitutive expression of herpes simplex virus type 1 thymidine kinase and tet-inducible expression of Flt3L for glioma therapeuticsMariana Puntel
Gene Therapeutics Research Institute, Cedars Sinai Medical Center UCLA, 8700 Beverly Blvd, Davis Building Research Pavilion, Room 5090, Los Angeles, CA 90048, USA
J Virol 84:6007-17. 2010.... - Exogenous fms-like tyrosine kinase 3 ligand overrides brain immune privilege and facilitates recognition of a neo-antigen without causing autoimmune neuropathologyDaniel Larocque
Gene Therapeutics Research Institute, Cedars Sinai Biomedical Sciences Graduate Program, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Proc Natl Acad Sci U S A 107:14443-8. 2010.... - Flt3L in combination with HSV1-TK-mediated gene therapy reverses brain tumor-induced behavioral deficitsGwendalyn D King
Board of Governors Gene Therapeutics Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
Mol Ther 16:682-90. 2008..These findings can serve to underpin further developments of this therapeutic modality, leading toward implementation of a Phase I clinical trial...
Research Grants
- Differential Effects of Antidepressants in Adult and Developing AnimalsROBERT PECHNICK; Fiscal Year: 2007....
- Viral-Mediated CRH Expression and DepressionROBERT PECHNICK; Fiscal Year: 2007..abstract_text> ..
- Nicotine Addiction: Influence of Prenatal and Adolescent ExposureROBERT PECHNICK; Fiscal Year: 2009..Using a nicotine patch or nicotine gum to treat pregnant women might reduce their smoking, but increase the vulnerability of their offspring to develop nicotine addiction. ..
- Nicotine Addiction: Influence of Prenatal and Adolescent ExposureROBERT NELSON PECHNICK; Fiscal Year: 2010..Using a nicotine patch or nicotine gum to treat pregnant women might reduce their smoking, but increase the vulnerability of their offspring to develop nicotine addiction. ..
- Nicotine Addiction: Influence of Prenatal and Adolescent ExposureROBERT NELSON PECHNICK; Fiscal Year: 2010..Using a nicotine patch or nicotine gum to treat pregnant women might reduce their smoking, but increase the vulnerability of their offspring to develop nicotine addiction. ..