Gil Y Melmed

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. pmc Family history and serology predict Crohn's disease after ileal pouch-anal anastomosis for ulcerative colitis
    Gil Y Melmed
    Division of Gastroenterology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Dis Colon Rectum 51:100-8. 2008
  2. ncbi request reprint Quality indicators for inflammatory bowel disease: development of process and outcome measures
    Gil Y Melmed
    Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
    Inflamm Bowel Dis 19:662-8. 2013
  3. doi request reprint Future biologic targets for IBD: potentials and pitfalls
    Gil Y Melmed
    Inflammatory Bowel Disease Center, Division of Gastroenterology, Department of Medicine, Cedars Sinai Medical Center, 8635 West 3rd Street, 960 W Los Angeles, CA 90048, USA
    Nat Rev Gastroenterol Hepatol 7:110-7. 2010
  4. ncbi request reprint Vaccination strategies for patients with inflammatory bowel disease on immunomodulators and biologics
    Gil Y Melmed
    Division of Gastroenterology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Inflamm Bowel Dis 15:1410-6. 2009
  5. ncbi request reprint Immunosuppression impairs response to pneumococcal polysaccharide vaccination in patients with inflammatory bowel disease
    Gil Y Melmed
    Department of Medicine, Cedars Sinai Medical Center, University of California, Los Angeles, California 90048, USA
    Am J Gastroenterol 105:148-54. 2010
  6. ncbi request reprint The appropriateness of concomitant immunomodulators with anti-tumor necrosis factor agents for Crohn's disease: one size does not fit all
    Gil Y Melmed
    Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Clin Gastroenterol Hepatol 8:655-9. 2010
  7. ncbi request reprint A new method for endoscopic closure of gastrocolonic fistula: novel application of a cardiac septal defect closure device (with video)
    Gil Y Melmed
    Division of Gastroenterology, Department of Medicine, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California, Los Angeles, California 90048, USA
    Gastrointest Endosc 70:542-5. 2009
  8. pmc Anti-aging therapy with human growth hormone associated with metastatic colon cancer in a patient with Crohn's colitis
    Gil Y Melmed
    Department of Medicine, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California, Los Angeles, California 90048, USA
    Clin Gastroenterol Hepatol 6:360-3. 2008
  9. pmc Assessing health status in inflammatory bowel disease using a novel single-item numeric rating scale
    Bijal Surti
    F Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, 8635 W 3rd St 960 Wv, Los Angeles, CA 90048, USA
    Dig Dis Sci 58:1313-21. 2013
  10. ncbi request reprint A prospective analysis of clinical variables, serologic factors, and outcome of ileal pouch-anal anastomosis in patients with backwash ileitis
    Evan White
    Division of Colon and Rectal Surgery, Cedars Sinai Medical Center, Los Angeles, California, USA
    Dis Colon Rectum 53:987-94. 2010

Detail Information

Publications35

  1. pmc Family history and serology predict Crohn's disease after ileal pouch-anal anastomosis for ulcerative colitis
    Gil Y Melmed
    Division of Gastroenterology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Dis Colon Rectum 51:100-8. 2008
    ..Preoperative predictors for Crohn's disease post-ileal pouch-anal anastomosis have not been prospectively defined...
  2. ncbi request reprint Quality indicators for inflammatory bowel disease: development of process and outcome measures
    Gil Y Melmed
    Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
    Inflamm Bowel Dis 19:662-8. 2013
    ..The RAND/UCLA appropriateness method was used to develop a set of process and outcome QIs to define quality of care for IBD...
  3. doi request reprint Future biologic targets for IBD: potentials and pitfalls
    Gil Y Melmed
    Inflammatory Bowel Disease Center, Division of Gastroenterology, Department of Medicine, Cedars Sinai Medical Center, 8635 West 3rd Street, 960 W Los Angeles, CA 90048, USA
    Nat Rev Gastroenterol Hepatol 7:110-7. 2010
    ..Future biologic drug development will benefit from the early identification of subsets of patients who are most likely to respond to therapy by use of biological markers of genetic susceptibility or immunologic susceptibility...
  4. ncbi request reprint Vaccination strategies for patients with inflammatory bowel disease on immunomodulators and biologics
    Gil Y Melmed
    Division of Gastroenterology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Inflamm Bowel Dis 15:1410-6. 2009
    ..This review discusses the rationale for currently recommended vaccinations, as well as issues pertaining to vaccine safety and immunogenicity in immunosuppressed patients with inflammatory bowel disease and their household contacts...
  5. ncbi request reprint Immunosuppression impairs response to pneumococcal polysaccharide vaccination in patients with inflammatory bowel disease
    Gil Y Melmed
    Department of Medicine, Cedars Sinai Medical Center, University of California, Los Angeles, California 90048, USA
    Am J Gastroenterol 105:148-54. 2010
    ..We aimed to assess the impact of immunosuppression on immune responses to pneumococcal vaccination in patients with IBD...
  6. ncbi request reprint The appropriateness of concomitant immunomodulators with anti-tumor necrosis factor agents for Crohn's disease: one size does not fit all
    Gil Y Melmed
    Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Clin Gastroenterol Hepatol 8:655-9. 2010
    ..We applied the RAND/University of California Los Angeles Appropriateness Method toward establishing appropriateness of concomitant immunomodulators and anti-TNF therapies for Crohn's disease...
  7. ncbi request reprint A new method for endoscopic closure of gastrocolonic fistula: novel application of a cardiac septal defect closure device (with video)
    Gil Y Melmed
    Division of Gastroenterology, Department of Medicine, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California, Los Angeles, California 90048, USA
    Gastrointest Endosc 70:542-5. 2009
    ..Gastrocolonic fistula after percutaneous endoscopic gastrostomy PEG tube placement is an uncommon but serious complication. These fistulous tracts are often fibrotic and frequently require surgical intervention...
  8. pmc Anti-aging therapy with human growth hormone associated with metastatic colon cancer in a patient with Crohn's colitis
    Gil Y Melmed
    Department of Medicine, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California, Los Angeles, California 90048, USA
    Clin Gastroenterol Hepatol 6:360-3. 2008
    ..The nonapproved use of human growth hormone (HGH) for anti-aging has been increasing. Theoretical concerns for neoplastic potentiation by HGH have been raised, but not proven clinically...
  9. pmc Assessing health status in inflammatory bowel disease using a novel single-item numeric rating scale
    Bijal Surti
    F Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, 8635 W 3rd St 960 Wv, Los Angeles, CA 90048, USA
    Dig Dis Sci 58:1313-21. 2013
    ..A numeric rating scale (NRS) is a quick, inexpensive, and convenient patient-reported outcome that can capture the patient's overall perception of health...
  10. ncbi request reprint A prospective analysis of clinical variables, serologic factors, and outcome of ileal pouch-anal anastomosis in patients with backwash ileitis
    Evan White
    Division of Colon and Rectal Surgery, Cedars Sinai Medical Center, Los Angeles, California, USA
    Dis Colon Rectum 53:987-94. 2010
    ..We prospectively compared the outcomes of ileal pouch-anal anastomosis in colitis patients with backwash ileitis and colitis patients without backwash ileitis...
  11. ncbi request reprint NOD2 variants and antibody response to microbial antigens in Crohn's disease patients and their unaffected relatives
    Shane M Devlin
    Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Gastroenterology 132:576-86. 2007
    ..The aim of our study was to determine if defects in innate immunity are similarly associated with increased adaptive immune responses to microbial antigens in Crohn's disease patients...
  12. ncbi request reprint Predicting a change in diagnosis from ulcerative colitis to Crohn's disease: a nested, case-control study
    Gil Y Melmed
    Inflammatory Bowel Disease Center, Division of Gastroenterology, Department of Medicine, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California Los Angeles, California, USA
    Clin Gastroenterol Hepatol 5:602-8; quiz 525. 2007
    ..Identification of predictors of a diagnostic change could potentially impact the management of patients with colonic inflammation. Our aim was to characterize clinical and serologic predictors of a change in diagnosis from UC to CD...
  13. doi request reprint A prospective evaluation of the long-term outcome of ileal pouch-anal anastomosis in patients with inflammatory bowel disease-unclassified and indeterminate colitis
    Zuri A Murrell
    Department of Surgery, Division of Colon and Rectal Surgery, Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, California, USA
    Dis Colon Rectum 52:872-8. 2009
    ..The aim of this study was to prospectively evaluate the long-term outcome of ileal pouch-anal anastomosis in a closely monitored cohort of patients with ulcerative colitis or indeterminate colitis...
  14. ncbi request reprint Does preoperative immunosuppression influence unplanned hospital readmission after surgery in patients with Crohn's disease?
    Evan C White
    Division of Colon and Rectal Surgery, Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, California, USA
    Dis Colon Rectum 55:563-8. 2012
    ..Unplanned hospital readmission is considered to be an index of quality surgical care...
  15. ncbi request reprint Patients with inflammatory bowel disease are at risk for vaccine-preventable illnesses
    Gil Y Melmed
    Department of Medicine, Division of Gastroenterology, Cedars Sinai Medical Center Los Angeles, California 90048, USA
    Am J Gastroenterol 101:1834-40. 2006
    ..We aimed to assess exposure risk and immunization status among patients receiving care in an IBD specialty clinic...
  16. pmc Antibiotics for Treatment of Clostridium difficile Infection in Hospitalized Patients with Inflammatory Bowel Disease
    Henry A Horton
    F Widjaja Foundation, Inflammatory Bowel and Immunobiology Institute, Division of Gastroenterology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
    Antimicrob Agents Chemother 58:5054-9. 2014
    ..Patients with ulcerative colitis and CDI should be treated with vancomycin. ..
  17. ncbi request reprint A prospective, randomized, noninferiority trial of steroid dosing after major colorectal surgery
    Karen Zaghiyan
    Divisions of Colorectal Surgery and Gastroenterology and Department of Biostatistics and Bioinformatics, Cedars Sinai Medical Center, Los Angeles, CA
    Ann Surg 259:32-7. 2014
    ..To evaluate the safety of perioperative low-dose steroids (LDS) versus high-dose steroids (HDS) in steroid-treated patients with inflammatory bowel disease (IBD) undergoing major colorectal surgery...
  18. pmc Genetic predictors of medically refractory ulcerative colitis
    Talin Haritunians
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Inflamm Bowel Dis 16:1830-40. 2010
    ..The aim of this study was to use a genome-wide association study (GWAS) in a well-characterized cohort of UC patients to identify genetic variation that contributes to MR-UC...
  19. pmc Variants in ZNF365 isoform D are associated with Crohn's disease
    Talin Haritunians
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Gut 60:1060-7. 2011
    ..Genome-wide association studies have identified multiple Crohn's disease (CD) susceptibility loci, including association with non-coding intergenic single-nucleotide polymorphisms (SNPs) at 10q21...
  20. ncbi request reprint Vaccinations in older adults with gastrointestinal diseases
    Henry A Horton
    Division of Gastroenterology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Clin Geriatr Med 30:17-28. 2014
    ..Vaccinations also appear to be less effective in the elderly, warranting research into different vaccination strategies such as booster vaccines, higher doses of vaccine, and measurement of antibody titers to guide vaccination. ..
  21. doi request reprint Colorectal cancer screening and surveillance in Crohn's colitis
    Robert J Basseri
    Department of Medicine and Division of Gastroenterology, Cedars Sinai Medical Center, Los Angeles, CA, USA
    J Crohns Colitis 6:824-9. 2012
    ..To assess colonoscopic screening and surveillance for detecting neoplasia in patients with long-standing colonic Crohn's disease (CD)...
  22. doi request reprint New clinical method for distinguishing D-IBS from other gastrointestinal conditions causing diarrhea: the LA/IBS diagnostic strategy
    Mark Pimentel
    GI Motility Program, Cedars Sinai Medical Center, 8730 Alden Drive, Suite 225E, Los Angeles, CA 90048, USA
    Dig Dis Sci 55:145-9. 2010
    ..81; specificity = 0.60). The use of this simple tool that identifies an irregularly irregular bowel form and function is successful in separating D-IBS from non-IBS subjects...
  23. ncbi request reprint Significant variation in recommendation of care for women of reproductive age with ulcerative colitis postileal pouch-anal anastomosis
    Kara Bradford
    Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Dig Dis Sci 59:1115-20. 2014
    ..To better understand these issues, we surveyed gastroenterologists (GI), colorectal surgeons (CRS), and obstetricians (OB) to assess practice variation in recommendations for delivery post IPAA...
  24. doi request reprint Translating improved quality of care into an improved quality of life for patients with inflammatory bowel disease
    Corey A Siegel
    Section of Gastroenterology and Hepatology, Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    Clin Gastroenterol Hepatol 11:908-12. 2013
    ..All of this work is intended to make quality improvement programs both feasible and useful, with the ultimate goal of improving quality of life for our patients. ..
  25. pmc Clinical, serologic, and genetic factors associated with pyoderma gangrenosum and erythema nodosum in inflammatory bowel disease patients
    Adam Weizman
    F Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California Department of Pediatrics, Pediatric Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, California Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland Department of Internal Medicine, Section of Digestive Diseases, Yale School of Medicine, New Haven, Connecticut Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Universite de Montreal and the Montreal Heart Institute, Research Center, Montreal, Canada Mount Sinai Inflammatory Bowel Disease Center, University of Toronto, Toronto, Canada Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute and Department of Pediatrics, Harbor UCLA Medical Center, Torrance, California and Medical Genetics Research Institute, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California
    Inflamm Bowel Dis 20:525-33. 2014
    ..Pyoderma gangrenosum (PG) and erythema nodosum (EN) are the most common cutaneous manifestations of inflammatory bowel disease (IBD) but little is known regarding their etiopathogenesis...
  26. doi request reprint Are immunosuppressive medications associated with decreased responses to routine immunizations? A systematic review
    Nikhil Agarwal
    Division of Gastroenterology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA, United States
    Vaccine 30:1413-24. 2012
    ..Vaccination may be a way to prevent a variety of infections but vaccine responses among patients receiving immunosuppressive therapies have been variable...
  27. pmc Controversies in ulcerative colitis: a survey comparing decision making of experts versus community gastroenterologists
    Brennan M R Spiegel
    Veteran s Administration Greater Los Angeles Healthcare System, Los Angeles, California, USA
    Clin Gastroenterol Hepatol 7:168-74, 174.e1. 2009
    ..We performed a national vignette survey to measure variations in decision-making in areas of controversy...
  28. doi request reprint High-dose perioperative corticosteroids in steroid-treated patients undergoing major colorectal surgery: necessary or overkill?
    Karen N Zaghiyan
    Division of Colorectal Surgery, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Am J Surg 204:481-6. 2012
    ..However, there is no evidence to support this practice...
  29. ncbi request reprint Capsule endoscopy: practical applications
    Gil Y Melmed
    Divison of Gastroenterology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Clin Gastroenterol Hepatol 3:411-22. 2005
    ..We discuss safety concerns, optimal preparation for the procedure, diagnostic utility as compared to conventional methods, indications for capsule endoscopy, and outcomes...
  30. pmc Genome-wide association identifies multiple ulcerative colitis susceptibility loci
    Dermot P B McGovern
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Nat Genet 42:332-7. 2010
    ..These data implicate approximately 30 loci in ulcerative colitis, thereby providing insight into disease pathogenesis...
  31. ncbi request reprint Quality of life at the end of life: trends in patients with metastatic prostate cancer
    Gil Y Melmed
    Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095 1738, USA
    Urology 59:103-9. 2002
    ..To identify the rates of decline in health-related quality of life during the year before death in men with prostate cancer...
  32. ncbi request reprint New insights into the pathogenesis of inflammatory bowel disease
    Gil Y Melmed
    Department of Medicine, Division of Gastroenterology, Inflammatory Bowel Disease Center, Mount Sinai School of Medicine, 1190 Fifth Avenue, New York, NY 10029, USA
    Curr Gastroenterol Rep 6:474-81. 2004
    ..In this review we summarize these key developments in the pathophysiology of inflammatory bowel disease and attempt to ascribe clinical relevance where applicable...
  33. doi request reprint Proximal small intestinal CD detected by CE
    Gil Y Melmed
    Gastrointest Endosc 68:202-3; author reply 203-4. 2008
  34. doi request reprint Certolizumab pegol
    Gil Y Melmed
    Nat Rev Drug Discov 7:641-2. 2008
    ..In April 2008, certolizumab pegol (Cimzia; UCB), a tumour-necrosis factor blocker, was approved by the US FDA for the treatment of adult patients with moderate-to-severe Crohn's disease who have not responded to conventional therapies...
  35. doi request reprint The impact of medical therapy for inflammatory bowel disease on pregnancy outcome
    Peter W Simpson
    Am J Gastroenterol 103:805-6. 2008