L K Medina-Kauwe

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. ncbi request reprint Endocytosis of adenovirus and adenovirus capsid proteins
    Lali K Medina-Kauwe
    Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Institute for Genetic Medicine, 2250 Alcazar Street, CSC240, Los Angeles, CA 90033, USA
    Adv Drug Deliv Rev 55:1485-96. 2003
  2. pmc Development of adenovirus capsid proteins for targeted therapeutic delivery
    Lali K Medina-Kauwe
    Department of Biomedical Sciences, Cedars Sinai Medical Center, Geffen School of Medicine, University of California Los Angeles, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Ther Deliv 4:267-77. 2013
  3. pmc "Alternative" endocytic mechanisms exploited by pathogens: new avenues for therapeutic delivery?
    L K Medina-Kauwe
    Adv Drug Deliv Rev 59:798-809. 2007
  4. ncbi request reprint Typical and atypical trafficking pathways of Ad5 penton base recombinant protein: implications for gene transfer
    A Rentsendorj
    Gene Therapeutics Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Gene Ther 13:821-36. 2006
  5. ncbi request reprint 3PO, a novel nonviral gene delivery system using engineered Ad5 penton proteins
    L K Medina-Kauwe
    Institute for Genetic Medicine and Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Gene Ther 8:795-803. 2001
  6. ncbi request reprint Intracellular trafficking of nonviral vectors
    L K Medina-Kauwe
    Gene Therapeutics Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Gene Ther 12:1734-51. 2005
  7. ncbi request reprint Nonviral gene delivery to human breast cancer cells by targeted Ad5 penton proteins
    L K Medina-Kauwe
    Institute for Genetic Medicine and Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Gene Ther 8:1753-61. 2001
  8. ncbi request reprint The Ad5 fiber mediates nonviral gene transfer in the absence of the whole virus, utilizing a novel cell entry pathway
    A Rentsendorj
    The Gene Therapeutics Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Gene Ther 12:225-37. 2005
  9. ncbi request reprint Modulation of secretory functions in epithelia by adenovirus capsid proteins
    Sarah F Hamm-Alvarez
    Department of Pharmaceutical Sciences, USC School of Pharmacy, Los Angeles, CA 90033, USA
    J Control Release 93:129-40. 2003
  10. ncbi request reprint Specific delivery of corroles to cells via noncovalent conjugates with viral proteins
    Hasmik Agadjanian
    The Gene Therapeutics Research Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Davis 5092, Los Angeles, California 90048, USA
    Pharm Res 23:367-77. 2006

Research Grants

  1. Heregulin-Targeted Protein Uptake for Breast Cancer
    Lali Medina Kauwe; Fiscal Year: 2006
  2. A NOVEL TARGETED THERAPEUTIC USING VIRAL CAPSID PROTEIN
    Lali Medina Kauwe; Fiscal Year: 2007
  3. Protein-DNA Drug Carriers for Tumor Targeting
    Lali K Medina Kauwe; Fiscal Year: 2010
  4. Tumor Targeted Corroles for Detection and Intervention
    Lali K Medina Kauwe; Fiscal Year: 2010

Collaborators

  • J Xie
  • X Chen
  • SARAH HAMM ALVAREZ
  • Lali Medina Kauwe
  • Lali K Medina Kauwe
  • A Rentsendorj
  • Hasmik Agadjanian
  • M Macveigh
  • H Agadjanian
  • Sarah F Hamm-Alvarez
  • Ivan J Dmochowski
  • Zeev Gross
  • Jihee Kim
  • Altan Rentsendorj
  • Harry B Gray
  • S Bass
  • D H Kim
  • Ruth Margalit
  • J Rossi
  • S F Hamm-Alvarez
  • Sam Bass
  • Jeremy J Weaver
  • Atif Mahammed
  • L Kedes
  • S Hamm-Alvarez
  • M Cirivello
  • Yanru Wang

Detail Information

Publications11

  1. ncbi request reprint Endocytosis of adenovirus and adenovirus capsid proteins
    Lali K Medina-Kauwe
    Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Institute for Genetic Medicine, 2250 Alcazar Street, CSC240, Los Angeles, CA 90033, USA
    Adv Drug Deliv Rev 55:1485-96. 2003
    ..A greater understanding of the highly effective Ad cell entry pathway may lend itself to the development of safer drug and gene delivery alternatives utilizing similar pathways...
  2. pmc Development of adenovirus capsid proteins for targeted therapeutic delivery
    Lali K Medina-Kauwe
    Department of Biomedical Sciences, Cedars Sinai Medical Center, Geffen School of Medicine, University of California Los Angeles, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Ther Deliv 4:267-77. 2013
    ..This review summarizes the findings to date of the protein-cell activities of these capsid proteins in the absence of the whole virus and their potential for therapeutic application with regard to the delivery of foreign molecules...
  3. pmc "Alternative" endocytic mechanisms exploited by pathogens: new avenues for therapeutic delivery?
    L K Medina-Kauwe
    Adv Drug Deliv Rev 59:798-809. 2007
    ..This review will provide an overview of such endocytic pathways, and discuss current and future possibilities in using these routes as a means to improve therapeutic delivery...
  4. ncbi request reprint Typical and atypical trafficking pathways of Ad5 penton base recombinant protein: implications for gene transfer
    A Rentsendorj
    Gene Therapeutics Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Gene Ther 13:821-36. 2006
    ....
  5. ncbi request reprint 3PO, a novel nonviral gene delivery system using engineered Ad5 penton proteins
    L K Medina-Kauwe
    Institute for Genetic Medicine and Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Gene Ther 8:795-803. 2001
    ..The addition of protamine to penton-DNA complexes allows gene delivery in the presence of serum...
  6. ncbi request reprint Intracellular trafficking of nonviral vectors
    L K Medina-Kauwe
    Gene Therapeutics Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Gene Ther 12:1734-51. 2005
    ..The tools used to study trafficking pathways will also be discussed...
  7. ncbi request reprint Nonviral gene delivery to human breast cancer cells by targeted Ad5 penton proteins
    L K Medina-Kauwe
    Institute for Genetic Medicine and Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Gene Ther 8:1753-61. 2001
    ..We demonstrate that delivery can be accomplished in the presence of serum, thus suggesting a potential use for in vivo delivery...
  8. ncbi request reprint The Ad5 fiber mediates nonviral gene transfer in the absence of the whole virus, utilizing a novel cell entry pathway
    A Rentsendorj
    The Gene Therapeutics Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Gene Ther 12:225-37. 2005
    ..Fiber uptake by HeLa cells is also actin-dependent, requires the fiber tail/shaft region, and is largely inhibited by heparin. This study raises the possibility that alternative pathways may enable both viral and nonviral cell entry...
  9. ncbi request reprint Modulation of secretory functions in epithelia by adenovirus capsid proteins
    Sarah F Hamm-Alvarez
    Department of Pharmaceutical Sciences, USC School of Pharmacy, Los Angeles, CA 90033, USA
    J Control Release 93:129-40. 2003
    ..These findings suggest that the adenovirus penton protein compromises normal acinar secretory compartment organization and function and that these changes are due at least partly to penton-integrin interactions...
  10. ncbi request reprint Specific delivery of corroles to cells via noncovalent conjugates with viral proteins
    Hasmik Agadjanian
    The Gene Therapeutics Research Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Davis 5092, Los Angeles, California 90048, USA
    Pharm Res 23:367-77. 2006
    ..In this work, we test the hypothesis that recombinant cell penetrating proteins of the adenovirus (Ad) capsid form noncovalent conjugates with corroles to facilitate target-specific delivery and cell death...
  11. ncbi request reprint Using GFP--ligand fusions to measure receptor-mediated endocytosis in living cells
    Lali K Medina-Kauwe
    Department of Biochemistry, Institute for Genetic Medicine, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA
    Vitam Horm 65:81-95. 2002
    ..Both its utility and limitations are discussed...

Research Grants9

  1. Heregulin-Targeted Protein Uptake for Breast Cancer
    Lali Medina Kauwe; Fiscal Year: 2006
    ..We will assess the contribution of individual capsid proteins to the immune response to Ad, compare immunogenicity to Ad, and test a method of immune evasion. ..
  2. A NOVEL TARGETED THERAPEUTIC USING VIRAL CAPSID PROTEIN
    Lali Medina Kauwe; Fiscal Year: 2007
    ..As HER2+ breast cancer does not respond well to conventional therapies, this alternative therapy could provide a significant contribution to breast cancer treatment. ..
  3. Protein-DNA Drug Carriers for Tumor Targeting
    Lali K Medina Kauwe; Fiscal Year: 2010
    ..As HER2+ breast cancer does not respond well to conventional therapies, this alternative therapy could provide a significant contribution to breast cancer treatment, and could be modified to target therapy to other types of cancer. ..
  4. Tumor Targeted Corroles for Detection and Intervention
    Lali K Medina Kauwe; Fiscal Year: 2010
    ..Moreover, this therapeutic can be imaged during treatment so that tumor targeting can be detectable. Thus, this technology combines both detection and intervention in a single self-assembled targeted complex. ..