Dermot P B McGovern

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. pmc Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease
    Dermot P B McGovern
    Medical Genetics Institute and Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Inflamm Bowel Dis 15:883-9. 2009
  2. pmc MAGI2 genetic variation and inflammatory bowel disease
    Dermot P B McGovern
    Medical Genetics Institute and Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Inflamm Bowel Dis 15:75-83. 2009
  3. pmc Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease
    Dermot P B McGovern
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Hum Mol Genet 19:3468-76. 2010
  4. pmc Genome-wide association identifies multiple ulcerative colitis susceptibility loci
    Dermot P B McGovern
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Nat Genet 42:332-7. 2010
  5. pmc IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein
    Kathrin S Michelsen
    Inflammatory Bowel Disease Center and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    PLoS ONE 4:e4719. 2009
  6. pmc Combination of innate and adaptive immune alterations increased the likelihood of fibrostenosis in Crohn's disease
    Andrew Ippoliti
    Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Inflamm Bowel Dis 16:1279-85. 2010
  7. pmc Multidimensional prognostic risk assessment identifies association between IL12B variation and surgery in Crohn's disease
    Marla C Dubinsky
    Departments of Pediatrics, Pediatric Inflammatory Bowel Disease Center and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Inflamm Bowel Dis 19:1662-70. 2013
  8. doi request reprint Assessing health status in inflammatory bowel disease using a novel single-item numeric rating scale
    Bijal Surti
    F Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, 8635 W 3rd St 960 Wv, Los Angeles, CA 90048, USA
    Dig Dis Sci 58:1313-21. 2013
  9. pmc Genetic predictors of medically refractory ulcerative colitis
    Talin Haritunians
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Inflamm Bowel Dis 16:1830-40. 2010
  10. pmc Variants in ZNF365 isoform D are associated with Crohn's disease
    Talin Haritunians
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Gut 60:1060-7. 2011

Detail Information

Publications15

  1. pmc Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease
    Dermot P B McGovern
    Medical Genetics Institute and Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Inflamm Bowel Dis 15:883-9. 2009
    ..Genetic variants in the IL23R and IL12B have been associated with CD susceptibility. We investigated 10 genes within the IL23/IL17 pathway in a case-control study of 763 CD cases and 254 healthy controls...
  2. pmc MAGI2 genetic variation and inflammatory bowel disease
    Dermot P B McGovern
    Medical Genetics Institute and Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Inflamm Bowel Dis 15:75-83. 2009
    ..Our aim was to test MAGI2 variants for association with IBD and also their role in determining intermediate hereditary phenotypes defined by antibody production to microbial antigens...
  3. pmc Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease
    Dermot P B McGovern
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Hum Mol Genet 19:3468-76. 2010
    ..001). These findings strongly implicate this locus in CD susceptibility and highlight the role of the mucus layer in the development of CD...
  4. pmc Genome-wide association identifies multiple ulcerative colitis susceptibility loci
    Dermot P B McGovern
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Nat Genet 42:332-7. 2010
    ..These data implicate approximately 30 loci in ulcerative colitis, thereby providing insight into disease pathogenesis...
  5. pmc IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein
    Kathrin S Michelsen
    Inflammatory Bowel Disease Center and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    PLoS ONE 4:e4719. 2009
    ..TL1A and its receptor DR3 are up-regulated during chronic intestinal inflammation in ulcerative colitis and Crohn's disease (CD). TL1A gene haplotypes increase CD susceptibility in Japanese, European, and US cohorts...
  6. pmc Combination of innate and adaptive immune alterations increased the likelihood of fibrostenosis in Crohn's disease
    Andrew Ippoliti
    Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Inflamm Bowel Dis 16:1279-85. 2010
    ....
  7. pmc Multidimensional prognostic risk assessment identifies association between IL12B variation and surgery in Crohn's disease
    Marla C Dubinsky
    Departments of Pediatrics, Pediatric Inflammatory Bowel Disease Center and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Inflamm Bowel Dis 19:1662-70. 2013
    ....
  8. doi request reprint Assessing health status in inflammatory bowel disease using a novel single-item numeric rating scale
    Bijal Surti
    F Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, 8635 W 3rd St 960 Wv, Los Angeles, CA 90048, USA
    Dig Dis Sci 58:1313-21. 2013
    ..A numeric rating scale (NRS) is a quick, inexpensive, and convenient patient-reported outcome that can capture the patient's overall perception of health...
  9. pmc Genetic predictors of medically refractory ulcerative colitis
    Talin Haritunians
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Inflamm Bowel Dis 16:1830-40. 2010
    ..The aim of this study was to use a genome-wide association study (GWAS) in a well-characterized cohort of UC patients to identify genetic variation that contributes to MR-UC...
  10. pmc Variants in ZNF365 isoform D are associated with Crohn's disease
    Talin Haritunians
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Gut 60:1060-7. 2011
    ..Genome-wide association studies have identified multiple Crohn's disease (CD) susceptibility loci, including association with non-coding intergenic single-nucleotide polymorphisms (SNPs) at 10q21...
  11. pmc Distinct IFNG methylation in a subset of ulcerative colitis patients based on reactivity to microbial antigens
    Rivkah Gonsky
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Inflamm Bowel Dis 17:171-8. 2011
    ..This study evaluated the relationship between IFNG methylation and serologic and clinical profiles in peripheral T cells from IBD patients...
  12. pmc Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis
    Iliyan D Iliev
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Science 336:1314-7. 2012
    ....
  13. pmc Clinical, serologic, and genetic factors associated with pyoderma gangrenosum and erythema nodosum in inflammatory bowel disease patients
    Adam Weizman
    F Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California Department of Pediatrics, Pediatric Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, California Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland Department of Internal Medicine, Section of Digestive Diseases, Yale School of Medicine, New Haven, Connecticut Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Universite de Montreal and the Montreal Heart Institute, Research Center, Montreal, Canada Mount Sinai Inflammatory Bowel Disease Center, University of Toronto, Toronto, Canada Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute and Department of Pediatrics, Harbor UCLA Medical Center, Torrance, California and Medical Genetics Research Institute, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California
    Inflamm Bowel Dis 20:525-33. 2014
    ..Pyoderma gangrenosum (PG) and erythema nodosum (EN) are the most common cutaneous manifestations of inflammatory bowel disease (IBD) but little is known regarding their etiopathogenesis...
  14. ncbi request reprint Human NK Cells Licensed by Killer Ig Receptor Genes Have an Altered Cytokine Program That Modifies CD4+ T Cell Function
    Lin Lin
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095 Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095
    J Immunol 193:940-9. 2014
    ....
  15. pmc A modular organization of the human intestinal mucosal microbiota and its association with inflammatory bowel disease
    Maomeng Tong
    Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 8:e80702. 2013
    ..Microbial modules thus provide an integrative view of microbial ecology relevant to IBD. ..