Patrick Lyden

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. ncbi request reprint Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers
    Patrick Lyden
    Department of Neurology, 8700 Beverly Blvd, Los Angeles, CA 90048
    Curr Pharm Des 19:7479-85. 2013
  2. doi request reprint Hemorrhagic transformation during thrombolytic therapy and reperfusion: effects of age, blood pressure, and matrix metalloproteinases
    Patrick D Lyden
    Department of Neurology, Cedars Sinai Medical Center, Los Angeles, CA 90036, USA
    J Stroke Cerebrovasc Dis 22:532-8. 2013
  3. doi request reprint Sisyphus and translational stroke research
    Patrick Lyden
    Department of Neurology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Sci Transl Med 4:156ps20. 2012
  4. pmc Determinants of effective cooling during endovascular hypothermia
    Patrick Lyden
    Department of Neurology, Cedars Sinai Medical Center, Thalians E240, 8730 Alden Drive, Los Angeles, CA 90048, USA
    Neurocrit Care 16:413-20. 2012
  5. doi request reprint Validation assessment of risk scores to predict postthrombolysis intracerebral haemorrhage
    Brett Cucchiara
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Int J Stroke 6:109-11. 2011
  6. doi request reprint Factors associated with intracerebral hemorrhage after thrombolytic therapy for ischemic stroke: pooled analysis of placebo data from the Stroke-Acute Ischemic NXY Treatment (SAINT) I and SAINT II Trials
    Brett Cucchiara
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Stroke 40:3067-72. 2009
  7. doi request reprint Serum calcium as prognosticator in ischemic stroke
    Bruce Ovbiagele
    Stroke Center and Department of Neurology, University of California at Los Angeles Medical Center, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Stroke 39:2231-6. 2008
  8. doi request reprint Direct thrombin inhibitor argatroban reduces stroke damage in 2 different models
    Patrick Lyden
    From the Department of Neurology, Cedars Sinai Medical Center, Los Angeles, CA
    Stroke 45:896-9. 2014
  9. doi request reprint The effect of transfer and hospital volume in subarachnoid hemorrhage patients
    Miriam Nuno
    Department of Neurosurgery, Cedars Sinai Medical Center, Center for Neurosurgical Outcomes Research, Maxine Dunitz Neurosurgical Institute, 8631 W Third Street, Suite 800E, Los Angeles, CA 90048, USA
    Neurocrit Care 17:312-23. 2012
  10. doi request reprint Eagle syndrome revisited: cerebrovascular complications
    Tsuyoshi Todo
    Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Ann Vasc Surg 26:729.e1-5. 2012

Research Grants

  1. Angiogenesis Following Stroke
    Patrick Lyden; Fiscal Year: 2003
  2. Role of Angiogenesis Following Stroke
    Patrick Lyden; Fiscal Year: 2006

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers
    Patrick Lyden
    Department of Neurology, 8700 Beverly Blvd, Los Angeles, CA 90048
    Curr Pharm Des 19:7479-85. 2013
    ..3K3A-APC was designed for preserved activity at PAR-1 with reduced anticoagulation. This Phase 1 trial characterized pharmacokinetics and anticoagulation effects of 3K3A-APC...
  2. doi request reprint Hemorrhagic transformation during thrombolytic therapy and reperfusion: effects of age, blood pressure, and matrix metalloproteinases
    Patrick D Lyden
    Department of Neurology, Cedars Sinai Medical Center, Los Angeles, CA 90036, USA
    J Stroke Cerebrovasc Dis 22:532-8. 2013
    ..We sought to test the effects of age, hypertension, and matrix metalloproteinases during recombinant tissue plasminogen activator (rt-PA) treatment in a standard model of filament occlusion of the middle cerebral artery...
  3. doi request reprint Sisyphus and translational stroke research
    Patrick Lyden
    Department of Neurology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Sci Transl Med 4:156ps20. 2012
    ..New preclinical and clinical approaches conceived outside of the current paradigm exist and should be carefully considered. Now, Tymianski and colleagues report on results obtained during translation of a new neuroprotectant...
  4. pmc Determinants of effective cooling during endovascular hypothermia
    Patrick Lyden
    Department of Neurology, Cedars Sinai Medical Center, Thalians E240, 8730 Alden Drive, Los Angeles, CA 90048, USA
    Neurocrit Care 16:413-20. 2012
    ..We demonstrated the feasibility of thrombolysis combined with endovascular hypothermia, but not all patients achieved effective cooling. We sought to identify the factors that determined effective cooling...
  5. doi request reprint Validation assessment of risk scores to predict postthrombolysis intracerebral haemorrhage
    Brett Cucchiara
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Int J Stroke 6:109-11. 2011
    ..Two clinical risk scores, the Haemorrhage After Thrombolysis and Multicentre Stroke Survey scores, have been proposed to predict the risk of intracerebral haemorrhage following thrombolysis in acute ischaemic stroke...
  6. doi request reprint Factors associated with intracerebral hemorrhage after thrombolytic therapy for ischemic stroke: pooled analysis of placebo data from the Stroke-Acute Ischemic NXY Treatment (SAINT) I and SAINT II Trials
    Brett Cucchiara
    Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Stroke 40:3067-72. 2009
    ..A number of factors have been associated with postthrombolysis intracerebral hemorrhage, but these have varied across studies...
  7. doi request reprint Serum calcium as prognosticator in ischemic stroke
    Bruce Ovbiagele
    Stroke Center and Department of Neurology, University of California at Los Angeles Medical Center, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Stroke 39:2231-6. 2008
    ..Calcium (Ca(2+)) plays a role in the cellular and molecular pathways of ischemic neuronal death. We evaluated the impact of both early and delayed Ca(2+) levels on clinical outcomes from acute ischemic stroke...
  8. doi request reprint Direct thrombin inhibitor argatroban reduces stroke damage in 2 different models
    Patrick Lyden
    From the Department of Neurology, Cedars Sinai Medical Center, Los Angeles, CA
    Stroke 45:896-9. 2014
    ..We showed previously robust neuroprotection with the thrombin inhibitor argatroban and now sought additional support for its neuroprotective potential...
  9. doi request reprint The effect of transfer and hospital volume in subarachnoid hemorrhage patients
    Miriam Nuno
    Department of Neurosurgery, Cedars Sinai Medical Center, Center for Neurosurgical Outcomes Research, Maxine Dunitz Neurosurgical Institute, 8631 W Third Street, Suite 800E, Los Angeles, CA 90048, USA
    Neurocrit Care 17:312-23. 2012
    ..Providers are often unclear about the safety of transferring critical patients. This study evaluated the "transfer effect" in a large sample of aneurysmal SAH patients undergoing treatment...
  10. doi request reprint Eagle syndrome revisited: cerebrovascular complications
    Tsuyoshi Todo
    Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Ann Vasc Surg 26:729.e1-5. 2012
    ..Although rare, Eagle syndrome should be considered in the differential diagnosis in patients with cerebrovascular symptoms, especially those induced by positional change...
  11. doi request reprint Hematoma growth in oral anticoagulant related intracerebral hemorrhage
    Brett Cucchiara
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Stroke 39:2993-6. 2008
    ..Limited data suggest that intracerebral hemorrhage related to oral anticoagulant therapy (OAT ICH) is associated with more hemorrhage expansion and a worse prognosis than spontaneous ICH (SICH)...

Research Grants4

  1. Angiogenesis Following Stroke
    Patrick Lyden; Fiscal Year: 2003
    ..abstract_text> ..
  2. Role of Angiogenesis Following Stroke
    Patrick Lyden; Fiscal Year: 2006
    ..abstract_text> ..