JULIA LJUBIMOVA

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. ncbi request reprint Antisense inhibition of laminin-8 expression reduces invasion of human gliomas in vitro
    Natalya M Khazenzon
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Mol Cancer Ther 2:985-94. 2003
  2. ncbi request reprint Gene expression changes in rat brain after short and long exposures to particulate matter in Los Angeles basin air: Comparison with human brain tumors
    Julia Y Ljubimova
    Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, United States Electronic address
    Exp Toxicol Pathol . 2013
  3. pmc Overexpression of beta1-chain-containing laminins in capillary basement membranes of human breast cancer and its metastases
    Manabu Fujita
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Breast Cancer Res 7:R411-21. 2005
  4. pmc Poly(malic acid) nanoconjugates containing various antibodies and oligonucleotides for multitargeting drug delivery
    Julia Y Ljubimova
    Cedars Sinai Medical Center, Department of Neurosurgery, 8631 West Third Street, Suite 800E, Los Angeles, CA 90048, USA
    Nanomedicine (Lond) 3:247-65. 2008
  5. pmc Nanoconjugate based on polymalic acid for tumor targeting
    Julia Y Ljubimova
    Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, USA
    Chem Biol Interact 171:195-203. 2008
  6. ncbi request reprint Gene expression abnormalities in human glial tumors identified by gene array
    J Y Ljubimova
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, 8631 West Third Street, Suite 800 E, Los Angeles, CA 90048, USA
    Int J Oncol 18:287-95. 2001
  7. pmc Changes in laminin isoforms associated with brain tumor invasion and angiogenesis
    Julia Y Ljubimova
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Front Biosci 11:81-8. 2006
  8. ncbi request reprint Association between laminin-8 and glial tumor grade, recurrence, and patient survival
    Julia Y Ljubimova
    Department of Surgery, Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Cancer 101:604-12. 2004
  9. ncbi request reprint Overexpression of alpha4 chain-containing laminins in human glial tumors identified by gene microarray analysis
    J Y Ljubimova
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Cancer Res 61:5601-10. 2001
  10. pmc Brain tumor tandem targeting using a combination of monoclonal antibodies attached to biopoly(beta-L-malic acid)
    Manabu Fujita
    Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Control Release 122:356-63. 2007

Research Grants

  1. Tumor drug delivery systems based on polymalic acid
    JULIA LJUBIMOVA; Fiscal Year: 2007
  2. Tumor drug delivery systems based on polymalic acid
    JULIA LJUBIMOVA; Fiscal Year: 2009
  3. Tumor drug delivery systems based on polymalic acid
    Julia Y Ljubimova; Fiscal Year: 2010

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Antisense inhibition of laminin-8 expression reduces invasion of human gliomas in vitro
    Natalya M Khazenzon
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Mol Cancer Ther 2:985-94. 2003
    ..The results show that laminin-8 may contribute to glioma progression and recurrence not only as part of the neovascularization process but also by directly increasing the invasive potential of tumor cells...
  2. ncbi request reprint Gene expression changes in rat brain after short and long exposures to particulate matter in Los Angeles basin air: Comparison with human brain tumors
    Julia Y Ljubimova
    Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, United States Electronic address
    Exp Toxicol Pathol . 2013
    ..In summary, exposure to air PM leads to distinct changes in rodent brain gene expression similar to those observed in human brain tumors...
  3. pmc Overexpression of beta1-chain-containing laminins in capillary basement membranes of human breast cancer and its metastases
    Manabu Fujita
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Breast Cancer Res 7:R411-21. 2005
    ..Here, differential expression of laminins was studied in blood vessels and ductal epithelium of the breast...
  4. pmc Poly(malic acid) nanoconjugates containing various antibodies and oligonucleotides for multitargeting drug delivery
    Julia Y Ljubimova
    Cedars Sinai Medical Center, Department of Neurosurgery, 8631 West Third Street, Suite 800E, Los Angeles, CA 90048, USA
    Nanomedicine (Lond) 3:247-65. 2008
    ..Delivery of antisense oligonucleotides to a tumor-specific angiogenic marker using Polycefin resulted in significant inhibition of tumor angiogenesis and increase of animal survival...
  5. pmc Nanoconjugate based on polymalic acid for tumor targeting
    Julia Y Ljubimova
    Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, USA
    Chem Biol Interact 171:195-203. 2008
    ..The results of live imaging were corroborated histologically by fluorescence microscopic examination of various organs. In addition to tumors, only kidney and liver showed some fluorescent signal...
  6. ncbi request reprint Gene expression abnormalities in human glial tumors identified by gene array
    J Y Ljubimova
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, 8631 West Third Street, Suite 800 E, Los Angeles, CA 90048, USA
    Int J Oncol 18:287-95. 2001
    ..The validity of gene arrays for tumor-specific gene discovery is discussed. Study of differential gene expression in glial tumors should help identify the mechanism/s of transformation of normal glial cells to malignant...
  7. pmc Changes in laminin isoforms associated with brain tumor invasion and angiogenesis
    Julia Y Ljubimova
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Front Biosci 11:81-8. 2006
    ..Laminin-8 may be thus used as a predictor of tumor recurrence, patient survival and as a potential molecular target for glioma therapy...
  8. ncbi request reprint Association between laminin-8 and glial tumor grade, recurrence, and patient survival
    Julia Y Ljubimova
    Department of Surgery, Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Cancer 101:604-12. 2004
    ....
  9. ncbi request reprint Overexpression of alpha4 chain-containing laminins in human glial tumors identified by gene microarray analysis
    J Y Ljubimova
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Cancer Res 61:5601-10. 2001
    ..0007). Up-regulation of alpha4 chain-containing laminins could be important for the development of glioma-induced neovascularization and glial tumor progression. Overexpression of laminin-8 may be predictive of glioma recurrence...
  10. pmc Brain tumor tandem targeting using a combination of monoclonal antibodies attached to biopoly(beta-L-malic acid)
    Manabu Fujita
    Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Control Release 122:356-63. 2007
    ..The results suggest improved efficacy for tandem configuration of antibodies than for single configurations carried by a drug delivery vehicle...
  11. pmc Inhibition of laminin-8 in vivo using a novel poly(malic acid)-based carrier reduces glioma angiogenesis
    Manabu Fujita
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, 8631 W Third Street, Suite 800E, Los Angeles, CA, 90048, USA
    Angiogenesis 9:183-91. 2006
    ..This system may hold promise for future clinical applications...
  12. pmc Polycefin, a new prototype of a multifunctional nanoconjugate based on poly(beta-L-malic acid) for drug delivery
    Bong Seop Lee
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Bioconjug Chem 17:317-26. 2006
    ..Polycefin was nontoxic to normal and tumor astrocytes in a wide range of concentrations, accumulated in brain tumor, and could be used for specific targeting of several biomarkers simultaneously...
  13. pmc Inhibition of brain tumor growth by intravenous poly (β-L-malic acid) nanobioconjugate with pH-dependent drug release [corrected]
    Hui Ding
    Department of Neurosurgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Proc Natl Acad Sci U S A 107:18143-8. 2010
    ..This delivery system with drug release into the brain-specific cell type could be useful for treatment of various brain pathologies...
  14. pmc A multimode optical imaging system for preclinical applications in vivo: technology development, multiscale imaging, and chemotherapy assessment
    Jae Youn Hwang
    Minimally Invasive Surgical Technologies Institute and Department of Surgery, Cedars Sinai Medical Center, 8700 Beverly Blvd D6061, Los Angeles, CA 90048, USA
    Mol Imaging Biol 14:431-42. 2012
    ..We developed a new multimode optical imaging system designed to be application-versatile, yielding high sensitivity, and specificity molecular imaging...
  15. pmc Proteinase and growth factor alterations revealed by gene microarray analysis of human diabetic corneas
    Mehrnoosh Saghizadeh
    Ophthalmology Research Laboratories, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Invest Ophthalmol Vis Sci 46:3604-15. 2005
    ..To identify proteinases and growth factors abnormally expressed in human corneas of donors with diabetic retinopathy (DR), additional to previously described matrix metalloproteinase (MMP)-10 and -3 and insulin-like growth factor (IGF)-I...

Research Grants5

  1. Tumor drug delivery systems based on polymalic acid
    JULIA LJUBIMOVA; Fiscal Year: 2007
    ..Aim 4. Evaluation of the effects of lead compounds on animal survival, tumor size, vascularity, apoptosis, and expression of their molecular targets, EGFR and laminin-8, in xenotransplanted human tumors. ..
  2. Tumor drug delivery systems based on polymalic acid
    JULIA LJUBIMOVA; Fiscal Year: 2009
    ..Aim 4. Evaluation of the effects of lead compounds on animal survival, tumor size, vascularity, apoptosis, and expression of their molecular targets, EGFR and laminin-8, in xenotransplanted human tumors. ..
  3. Tumor drug delivery systems based on polymalic acid
    Julia Y Ljubimova; Fiscal Year: 2010
    ..Aim 4. Evaluation of the effects of lead compounds on animal survival, tumor size, vascularity, apoptosis, and expression of their molecular targets, EGFR and laminin-8, in xenotransplanted human tumors. ..