Michael I Lewis

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. ncbi request reprint Effect of severe short-term malnutrition on diaphragm muscle signal transduction pathways influencing protein turnover
    Michael I Lewis
    Division of Pulmonary Critical Care Medicine, Burns and Allen Research Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Rm 6732, Los Angeles, CA 90048, USA
    J Appl Physiol 100:1799-806. 2006
  2. pmc Metabolic and morphometric profile of muscle fibers in chronic hemodialysis patients
    Michael I Lewis
    Division of Pulmonary Critical Care Medicine, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Appl Physiol 112:72-8. 2012
  3. ncbi request reprint Role of IGF-I and IGF-binding proteins within diaphragm muscle in modulating the effects of nandrolone
    Michael I Lewis
    Division of Pulmonary Critical Care Medicine, The Burns and Allen Research Institute, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, California 90048, USA
    Am J Physiol Endocrinol Metab 282:E483-90. 2002
  4. ncbi request reprint Tumor necrosis factor-alpha and malnutrition-induced inhibition of diaphragm fiber growth in young rats
    Michael I Lewis
    Division of Pulmonary Critical Care Medicine, The Burns and Allen Research Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Rm 6732, Los Angeles, CA 90048, USA
    J Appl Physiol 99:1649-57. 2005
  5. ncbi request reprint Skeletal muscle adaptations to testosterone and resistance training in men with COPD
    Michael I Lewis
    Division of Pulmonary and Critical Care Medicine, The Burns and Allen Research Institute at Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Appl Physiol 103:1299-310. 2007
  6. ncbi request reprint Influence of varying degrees of malnutrition on IGF-I expression in the rat diaphragm
    Michael I Lewis
    Division of Pulmonary Critical Care Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Appl Physiol 95:555-62. 2003
  7. ncbi request reprint Insulin-like growth factor I prevents corticosteroid-induced diaphragm muscle atrophy in emphysematous hamsters
    Mario Fournier
    Cedars Sinai Medical Center, 8700 Beverly Blvd, Rm 6732, Los Angeles, CA 90048, USA
    Am J Physiol Regul Integr Comp Physiol 285:R34-43. 2003
  8. ncbi request reprint Exercise in maintenance hemodialysis patients induces transcriptional changes in genes favoring anabolic muscle
    Joel D Kopple
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Los Angeles, California, USA
    J Am Soc Nephrol 18:2975-86. 2007
  9. ncbi request reprint Short-term influences of lung volume reduction surgery on the diaphragm in emphysematous hamsters
    Michael I Lewis
    Division of Pulmonary Critical Care Medicine, Cedars Sinai Medical Center, David Geffen School of Medicine at University of California, Los Angeles, CA 90048, USA
    Am J Respir Crit Care Med 170:753-9. 2004
  10. pmc Time course expression of Foxo transcription factors in skeletal muscle following corticosteroid administration
    John E Cho
    Division of Pulmonary Critical Care Medicine, The Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Appl Physiol 108:137-45. 2010

Detail Information

Publications16

  1. ncbi request reprint Effect of severe short-term malnutrition on diaphragm muscle signal transduction pathways influencing protein turnover
    Michael I Lewis
    Division of Pulmonary Critical Care Medicine, Burns and Allen Research Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Rm 6732, Los Angeles, CA 90048, USA
    J Appl Physiol 100:1799-806. 2006
    ..This forms the framework for future studies aimed at identifying therapeutic targets in the management of short-term nutritionally induced cachectic states...
  2. pmc Metabolic and morphometric profile of muscle fibers in chronic hemodialysis patients
    Michael I Lewis
    Division of Pulmonary Critical Care Medicine, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Appl Physiol 112:72-8. 2012
    ..The enlarged CSA of muscle fibers may, in part, be accounted for by edema. We speculate that these changes contribute to reduce limb strength in MHD patients by reducing specific force...
  3. ncbi request reprint Role of IGF-I and IGF-binding proteins within diaphragm muscle in modulating the effects of nandrolone
    Michael I Lewis
    Division of Pulmonary Critical Care Medicine, The Burns and Allen Research Institute, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, California 90048, USA
    Am J Physiol Endocrinol Metab 282:E483-90. 2002
    ....
  4. ncbi request reprint Tumor necrosis factor-alpha and malnutrition-induced inhibition of diaphragm fiber growth in young rats
    Michael I Lewis
    Division of Pulmonary Critical Care Medicine, The Burns and Allen Research Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Rm 6732, Los Angeles, CA 90048, USA
    J Appl Physiol 99:1649-57. 2005
    ..Thus rat anti-TNF-alpha at a dose known to neutralize the cytokine failed to attenuate or reverse ND-induced inhibition of DIA fiber growth in our model...
  5. ncbi request reprint Skeletal muscle adaptations to testosterone and resistance training in men with COPD
    Michael I Lewis
    Division of Pulmonary and Critical Care Medicine, The Burns and Allen Research Institute at Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Appl Physiol 103:1299-310. 2007
    ..Our data suggest that the combined interventions produced an enhanced local anabolic milieu driven in large part by the muscle IGF system, despite potentially negative biochemical influences present in COPD patients...
  6. ncbi request reprint Influence of varying degrees of malnutrition on IGF-I expression in the rat diaphragm
    Michael I Lewis
    Division of Pulmonary Critical Care Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Appl Physiol 95:555-62. 2003
    ..This is particularly so in view of recent data demonstrating the importance of the autocrine/paracrine system in muscle growth and maintenance of fiber size...
  7. ncbi request reprint Insulin-like growth factor I prevents corticosteroid-induced diaphragm muscle atrophy in emphysematous hamsters
    Mario Fournier
    Cedars Sinai Medical Center, 8700 Beverly Blvd, Rm 6732, Los Angeles, CA 90048, USA
    Am J Physiol Regul Integr Comp Physiol 285:R34-43. 2003
    ..These results may have important clinical implications for treatment options to offset the adverse effects of CS on the respiratory muscles in patients with chronic lung disorders...
  8. ncbi request reprint Exercise in maintenance hemodialysis patients induces transcriptional changes in genes favoring anabolic muscle
    Joel D Kopple
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Los Angeles, California, USA
    J Am Soc Nephrol 18:2975-86. 2007
  9. ncbi request reprint Short-term influences of lung volume reduction surgery on the diaphragm in emphysematous hamsters
    Michael I Lewis
    Division of Pulmonary Critical Care Medicine, Cedars Sinai Medical Center, David Geffen School of Medicine at University of California, Los Angeles, CA 90048, USA
    Am J Respir Crit Care Med 170:753-9. 2004
    ..Acute fiber stretch predisposes to muscle fiber injury and may also be a necessary mechanotransductive stimulus for fiber remodeling as the diaphragm adapts to reduced lung volume...
  10. pmc Time course expression of Foxo transcription factors in skeletal muscle following corticosteroid administration
    John E Cho
    Division of Pulmonary Critical Care Medicine, The Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Appl Physiol 108:137-45. 2010
    ..Elucidating the dynamic catabolic responses to CS challenge is important in understanding the mechanisms underlying muscle atrophy and therapeutic measures to offset this...
  11. doi request reprint Effects of malnutrition with or without eicosapentaenoic acid on proteolytic pathways in diaphragm
    Joanne M Bando
    Division of Pulmonary Critical Care Medicine, The Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, United States
    Respir Physiol Neurobiol 180:14-24. 2012
    ..Our study provides unique data on proteolytic signals with ND and has important implications for future studies using EPA...
  12. doi request reprint Testosterone and resistance training effects on muscle nitric oxide synthase isoforms in COPD men
    Bahman Chavoshan
    Rehabilitation Clinical Trials Center, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Respir Med 106:269-75. 2012
    ..We hypothesized that resistance exercise training (R) and/or testosterone supplementation (T) would alter the transcription and expression of the NOS isoenzymes in COPD skeletal muscle...
  13. doi request reprint Do faculty intensivists have better outcomes when caring for patients directly in a closed ICU versus consulting in an open ICU?
    Dani Hackner
    Pulmonary Critical Care Medicine Division, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Hosp Pract (1995) 37:40-50. 2009
    ....
  14. ncbi request reprint Effects of testosterone and resistance training in men with chronic obstructive pulmonary disease
    Richard Casaburi
    Division of Respiratory and Critical Care Physiology and Medicine, Los Angeles Biomedical Research Institute, Building RB2, 1124 West Carson Street, Torrance, CA 90502, USA
    Am J Respir Crit Care Med 170:870-8. 2004
    ..Further studies are required to determine long-term benefits of adding testosterone supplementation and resistance training to rehabilitative programs for carefully screened men with COPD and low testosterone levels...
  15. ncbi request reprint Apoptosis as a potential mechanism of muscle cachexia in chronic obstructive pulmonary disease
    Michael I Lewis
    Am J Respir Crit Care Med 166:434-6. 2002
  16. ncbi request reprint Mechanisms underlying myogenesis: complex and likely to become more so!
    Michael I Lewis
    J Appl Physiol 101:1539-40. 2006