Cathryn M Kolka

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. pmc Lipid-induced insulin resistance does not impair insulin access to skeletal muscle
    Cathryn M Kolka
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California
    Am J Physiol Endocrinol Metab 308:E1001-9. 2015
  2. pmc Modest hyperglycemia prevents interstitial dispersion of insulin in skeletal muscle
    Cathryn M Kolka
    Department of Physiology and Biophysics, University of Southern California, Los Angeles, CA Electronic address
    Metabolism 64:330-7. 2015
  3. pmc The endothelium in diabetes: its role in insulin access and diabetic complications
    Cathryn M Kolka
    Diabetes and Obesity Research Institute, Department of Biomedical Science, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Rev Endocr Metab Disord 14:13-9. 2013
  4. pmc The barrier within: endothelial transport of hormones
    Cathryn M Kolka
    Diabetes and Obesity Research Institute, Department of Biomedical Science, Cedars Sinai Medical Center, Los Angeles, California, USA
    Physiology (Bethesda) 27:237-47. 2012
  5. pmc Diet-induced obesity prevents interstitial dispersion of insulin in skeletal muscle
    Cathryn M Kolka
    Department of Physiology and Biophysics, University of Southern California, Los Angeles, California, USA
    Diabetes 59:619-26. 2010
  6. pmc Experimental hyperlipidemia dramatically reduces access of insulin to canine skeletal muscle
    Jenny D Chiu
    Department of Physiology and Biophysics, University of Southern California, Los Angeles, California, USA
    Obesity (Silver Spring) 17:1486-92. 2009
  7. pmc High-fat diet-induced insulin resistance does not increase plasma anandamide levels or potentiate anandamide insulinotropic effect in isolated canine islets
    Orison O Woolcott
    Diabetes and Obesity Research Institute, Cedars Sinai Medical Center, Los Angeles, California, United States of America
    PLoS ONE 10:e0123558. 2015
  8. doi request reprint Rapid development of cardiac dysfunction in a canine model of insulin resistance and moderate obesity
    Josiane L Broussard
    Diabetes and Obesity Research Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA
    Diabetologia 59:197-207. 2016
  9. doi request reprint Elevated nocturnal NEFA are an early signal for hyperinsulinaemic compensation during diet-induced insulin resistance in dogs
    Josiane L Broussard
    Diabetes and Obesity Research Institute, Cedars Sinai Medical Center, Los Angeles, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA
    Diabetologia 58:2663-70. 2015
  10. doi request reprint Failure of homeostatic model assessment of insulin resistance to detect marked diet-induced insulin resistance in dogs
    Marilyn Ader
    Diabetes and Obesity Research Institute, Cedars Sinai Medical Center, Los Angeles, CA
    Diabetes 63:1914-9. 2014

Collaborators

  • Darko Stefanovski
  • Viorica Ionut
  • Lidia S Szczepaniak
  • Marilyn Ader
  • Kristen L Knutson
  • Richard N Bergman
  • Josiane L Broussard
  • Jenny D Chiu
  • Erlinda L Kirkman
  • Edward W Szczepaniak
  • Rebecca L Paszkiewicz
  • Ana V B Castro
  • Orison O Woolcott
  • Stella P Kim
  • Maya Lottati
  • Joyce M Richey
  • Isaac Asare Bediako
  • Qiang Wu
  • Morvarid Kabir
  • Malini S Iyer
  • L Nicole Harrison
  • Edward Zuniga
  • Laura Smith
  • Michael D Nelson
  • Hasmik Mkrtchyan
  • Hernan C Rios
  • Karyn J Catalano
  • Isabel R Hsu
  • Isaac Asare-Bediako
  • Dan Zheng
  • Robert H Chow
  • Heather Bradshaw
  • Lisa N Harrison
  • Martin Ellmerer
  • Erlinda Kirkman

Detail Information

Publications14

  1. pmc Lipid-induced insulin resistance does not impair insulin access to skeletal muscle
    Cathryn M Kolka
    Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California
    Am J Physiol Endocrinol Metab 308:E1001-9. 2015
    ....
  2. pmc Modest hyperglycemia prevents interstitial dispersion of insulin in skeletal muscle
    Cathryn M Kolka
    Department of Physiology and Biophysics, University of Southern California, Los Angeles, CA Electronic address
    Metabolism 64:330-7. 2015
    ..Here we asked whether interstitial insulin diffusion is reduced in modest hyperglycemia, similar to that induced by a high fat diet...
  3. pmc The endothelium in diabetes: its role in insulin access and diabetic complications
    Cathryn M Kolka
    Diabetes and Obesity Research Institute, Department of Biomedical Science, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Rev Endocr Metab Disord 14:13-9. 2013
    ..We will focus on the most recent developments in the field, including current treatment possibilities...
  4. pmc The barrier within: endothelial transport of hormones
    Cathryn M Kolka
    Diabetes and Obesity Research Institute, Department of Biomedical Science, Cedars Sinai Medical Center, Los Angeles, California, USA
    Physiology (Bethesda) 27:237-47. 2012
    ..Here, we review the structure and function of the endothelium, its contribution to the function of hormones, and its involvement in disease...
  5. pmc Diet-induced obesity prevents interstitial dispersion of insulin in skeletal muscle
    Cathryn M Kolka
    Department of Physiology and Biophysics, University of Southern California, Los Angeles, California, USA
    Diabetes 59:619-26. 2010
    ..Here we asked whether interstitial insulin diffusion is reduced in physiological obesity induced by a high-fat diet (HFD)...
  6. pmc Experimental hyperlipidemia dramatically reduces access of insulin to canine skeletal muscle
    Jenny D Chiu
    Department of Physiology and Biophysics, University of Southern California, Los Angeles, California, USA
    Obesity (Silver Spring) 17:1486-92. 2009
    ..The diversion of insulin from the interstitium under hyperlipidemic conditions may play a role in the insulin resistance observed coincident with elevated nocturnal FFAs as is observed in obesity...
  7. pmc High-fat diet-induced insulin resistance does not increase plasma anandamide levels or potentiate anandamide insulinotropic effect in isolated canine islets
    Orison O Woolcott
    Diabetes and Obesity Research Institute, Cedars Sinai Medical Center, Los Angeles, California, United States of America
    PLoS ONE 10:e0123558. 2015
    ..Obesity has been associated with elevated plasma anandamide levels. In addition, anandamide has been shown to stimulate insulin secretion in vitro, suggesting that anandamide might be linked to hyperinsulinemia...
  8. doi request reprint Rapid development of cardiac dysfunction in a canine model of insulin resistance and moderate obesity
    Josiane L Broussard
    Diabetes and Obesity Research Institute, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA
    Diabetologia 59:197-207. 2016
    ..A major cause of the morbidity and mortality associated with obesity and diabetes is heart disease, yet the mechanisms that lead to cardiovascular complications remain unclear...
  9. doi request reprint Elevated nocturnal NEFA are an early signal for hyperinsulinaemic compensation during diet-induced insulin resistance in dogs
    Josiane L Broussard
    Diabetes and Obesity Research Institute, Cedars Sinai Medical Center, Los Angeles, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA
    Diabetologia 58:2663-70. 2015
    ..We therefore designed this study to test the hypothesis that elevated nocturnal NEFA are an early signal for hyperinsulinaemic compensation for insulin resistance...
  10. doi request reprint Failure of homeostatic model assessment of insulin resistance to detect marked diet-induced insulin resistance in dogs
    Marilyn Ader
    Diabetes and Obesity Research Institute, Cedars Sinai Medical Center, Los Angeles, CA
    Diabetes 63:1914-9. 2014
    ..Caution should be exercised when using HOMA-IR to detect insulin resistance when pancreatic function is compromised. It is necessary to use other accurate indices to detect longitudinal changes in insulin resistance with any confidence...
  11. pmc Greater omentectomy improves insulin sensitivity in nonobese dogs
    Maya Lottati
    Department of Physiology and Biophysics, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Obesity (Silver Spring) 17:674-80. 2009
    ..postsurgery: 6.7 +/- 1.2 pmol/l/mg/dl, P = 0.9). These findings provide new evidence for the deleterious role of visceral fat in insulin resistance, and suggest that a greater OM procedure may effectively improve insulin sensitivity...
  12. pmc Hepatic insulin clearance is the primary determinant of insulin sensitivity in the normal dog
    Marilyn Ader
    Diabetes and Obesity Research Institute, Cedars Sinai Medical Center, Los Angeles, California
    Obesity (Silver Spring) 22:1238-45. 2014
    ..We examined if factors other than obesity are more substantial predictors of insulin sensitivity under baseline, nonstimulated conditions...
  13. doi request reprint Direct administration of insulin into skeletal muscle reveals that the transport of insulin across the capillary endothelium limits the time course of insulin to activate glucose disposal
    Jenny D Chiu
    Department of Physiology and Biophysics, University of Southern California, Keck School of Medicine, 1333 San Pablo St, MMR 626, Los Angeles, CA 90033, USA
    Diabetes 57:828-35. 2008
    ....
  14. pmc Increase in visceral fat per se does not induce insulin resistance in the canine model
    Ana V B Castro
    Diabetes and Obesity Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Obesity (Silver Spring) 23:105-11. 2015
    ..To determine whether a selective increase of visceral adipose tissue content will result in insulin resistance...