Research Topics
Genomes and Genes
| Norihiko KawamataSummaryAffiliation: Cedars-Sinai Medical Center Country: USA Publications
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Detail Information
Publications
Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarrayNorihiko Kawamata
Department of Hematology, Oncology, Cedars Sinai Medical Center University of California at Los Angeles School of Medicine 90048, USA
Blood 111:776-84. 2008..This technique was able to detect subgroups with a poor prognosis based on their genetic status...- Identified hidden genomic changes in mantle cell lymphoma using high-resolution single nucleotide polymorphism genomic arrayNorihiko Kawamata
Hematology Oncology, Cedars Sinai Medical Center UCLA School of Medicine, Los Angeles, Calif, USA
Exp Hematol 37:937-46. 2009..This technique allows detection of genomic changes with higher resolution, including loss of heterozygosity without changes of gene dosage, so-called acquired uniparental disomy (aUPD)... - Genetic profiling of myeloproliferative disorders by single-nucleotide polymorphism oligonucleotide microarrayNorihiko Kawamata
Hematology Oncology, Cedars Sinai Medical Center UCLA School of Medicine, Los Angeles, CA 90048, USA
Exp Hematol 36:1471-9. 2008..Mutations in JAK2 are present in many MPD patients. Additional genomic abnormalities are not fully examined in MPD... - Cloning of genes involved in chromosomal translocations by high-resolution single nucleotide polymorphism genomic microarrayNorihiko Kawamata
Hematology Oncology, Cedars Sinai Medical Center UCLA School of Medicine, Los Angeles, CA 90048, USA
Proc Natl Acad Sci U S A 105:11921-6. 2008..PAX5-fusion proteins may contribute to leukemogenesis by blocking differentiation of hematopoietic cells into mature B cells. SNP-chip is a powerful tool to identify fusion genes in human cancers... - Suberoylanilide hydroxamic acid (SAHA; vorinostat) suppresses translation of cyclin D1 in mantle cell lymphoma cellsNorihiko Kawamata
Division of Hematology Oncology, Cedars Sinai Medical Center University of California, Los Angeles UCLA School of Medicine, Los Angeles, CA 90048, USA
Blood 110:2667-73. 2007..Taken together, SAHA caused a rapid decrease of cyclin D1 in MCL by blocking the translation of cyclin D1 by inhibiting the phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR/eIF4E-BP pathway, probably by PI3K inhibition... - Methylation status analysis of cell cycle regulatory genes (p16INK4A, p15INK4B, p21Waf1/Cip1, p27Kip1 and p73) in natural killer cell disordersNorihiko Kawamata
Division of Hematology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
Eur J Haematol 74:424-9. 2005..These results suggested that inactivation of the cell cycle regulatory genes by DNA methylation could be associated with tumorigenesis in NK cell disorders, not only aggressive subtypes but also chronic subtype... - Mxi1 isoforms are expressed in hematological cell lines and normal bone marrowNorihiko Kawamata
Division of Hematology Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA
Int J Oncol 26:1369-75. 2005.... - Epigenetic regulation and molecular characterization of C/EBPalpha in pancreatic cancer cellsTakashi Kumagai
Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA, USA
Int J Cancer 124:827-33. 2009.... - Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemiaRyoko Okamoto
Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, 8700, Beverly Blvd, Los Angeles, CA90048, USA
Haematologica 95:1481-8. 2010..The inferior prognosis in adult acute lymphoblastic leukemia is not fully understood but could be attributed, in part, to differences in genomic alterations found in adult as compared to in pediatric acute lymphoblastic leukemia... - Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterationsTadayuki Akagi
Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, Los Angeles, CA, USA
Blood 113:1741-8. 2009..Here, we showed for the first time hidden abnormalities and novel disease-related genomic changes in t(15;17) APL... - Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell linesSakura Sakajiri
Division of Hematology/Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA
Exp Hematol 33:53-61. 2005..In nude mice, SAHA significantly inhibited growth of a mantle cell lymphoma without major toxic side effects. In summary, HDACIs are promising therapeutic agents for human lymphoid cancers... - Frequent genomic abnormalities in acute myeloid leukemia/myelodysplastic syndrome with normal karyotypeTadayuki Akagi
Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA
Haematologica 94:213-23. 2009..Here, we identified hidden genomic alterations and novel disease-related regions in normal karyotype acute myeloid leukemia/myelodysplastic syndrome samples... - Chromosomal abnormalities and novel disease-related regions in progression from Barrett's esophagus to esophageal adenocarcinomaTadayuki Akagi
Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA, USA
Int J Cancer 125:2349-59. 2009..Thus, this SNP-chip analysis has identified several early cytogenetic events and novel candidate cancer-related genes that are potentially involved in the evolution of BE to EAC... - Molecular allelokaryotyping of early-stage, untreated chronic lymphocytic leukemiaSoren Lehmann
Department of Hematology Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, Los Angeles, California 90048, USA
Cancer 112:1296-305. 2008..Single nucleotide polymorphism (SNP) genomic array (SNP-chip) is a new tool that can detect copy number changes and uniparental disomy (UPD) over the entire genome with very high resolution... - Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cellsTakashi Kumagai
Division of Hematology Oncology, UCLA School of Medicine, Cedars Sinai Medical Center, Los Angeles, CA, USA
Int J Cancer 121:656-65. 2007..SAHA is a novel, promising therapeutic agent for human pancreatic cancers... - Molecular allelokaryotyping of relapsed pediatric acute lymphoblastic leukemiaNorihiko Kawamata
Hematology Oncology, Cedars Sinai Medical Center UCLA School of Medicine, Los Angeles, CA 90048, USA
Int J Oncol 34:1603-12. 2009..In summary, additional genomic changes are very common events in ALL at relapse; whether these abnormalities are associated with resistance to treatment remains to clarified in further studies... - High-resolution genomic copy number profiling of glioblastoma multiforme by single nucleotide polymorphism DNA microarrayDong Yin
Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, Davis Building 5022 Room, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
Mol Cancer Res 7:665-77. 2009..1 (p53) deletion/AUPD. Taken together, these results suggest that this technique is a rapid, robust, and inexpensive method to profile genome-wide abnormalities in GBM... - Highly sensitive method for genomewide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genotyping microarraysGo Yamamoto
Departments of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Am J Hum Genet 81:114-26. 2007..In conclusion, AsCNAR should substantially improve our ability to dissect the complexity of cancer genomes and should contribute to our understanding of the genetic basis of human cancers... - Molecular analysis of oncogenes, ras family genes (N-ras, K-ras, H-ras), myc family genes (c-myc, N-myc) and mdm2 in natural killer cell neoplasmsKei-Ji Sugimoto
Division of Hematology, Department of Medicine, Juntendo University School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan
Jpn J Cancer Res 93:1270-7. 2002..In contrast, overexpression of MDM2 might be associated with tumorigenesis of NK cell neoplasms, especially aggressive subclasses... - ERCC5 is a novel biomarker of ovarian cancer prognosisChristine S Walsh
Department of Obstetrics and Gynecology, Cedars Sinai Women s Cancer Research Institute, Samuel Oschin Comprehensive Cancer Institute, David Geffen School of Medicine, University of California at Los Angeles, CA 90048, USA
J Clin Oncol 26:2952-8. 2008..Gene expression analyses were performed through microarray experiments. Candidate genes were tested for independent effects on survival using Cox proportional hazards models, Kaplan-Meier survival curves, and the log-rank test... - Genome-wide loss of heterozygosity and uniparental disomy in BRCA1/2-associated ovarian carcinomasChristine S Walsh
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Cedars Sinai Women s Cancer Research Institute, David Geffen School of Medicine at UCLA, Los Angeles, California 90048, USA
Clin Cancer Res 14:7645-51. 2008..The importance of the BRCA gene products in maintaining genomic stability led us to hypothesize that BRCA-associated and sporadic ovarian cancers would have distinctive genetic profiles despite similarities in histologic appearance... - Discovery of epigenetically masked tumor suppressor genes in endometrial cancerNoriyuki Takai
Division of Hematology/Oncology, Cedars-Sinai Medical Center/University of California at Los Angeles School of Medicine, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
Mol Cancer Res 3:261-9. 2005..Our data suggest that C/ebpalpha and Tig1 function as tumor suppressor proteins in endometrial cancers and that their reexpression may be a therapeutic target... - 2C4, a monoclonal antibody against HER2, disrupts the HER kinase signaling pathway and inhibits ovarian carcinoma cell growthNoriyuki Takai
Division of Hematology/Oncology, Cedars-Sinai Medical Center/UCLA School of Medicine, Los Angeles, CA 90048, USA
Cancer 104:2701-8. 2005..The response appears limited to lines in which HER2 heterodimers were able to transduce proliferative signals. Our findings suggest a strong rationale to conduct clinical trials of 2C4 in a subset of patients with ovarian tumors... - Molecular allelokaryotyping of T-cell prolymphocytic leukemia cells with high density single nucleotide polymorphism arrays identifies novel common genomic lesions and acquired uniparental disomyDaniel Nowak
Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
Haematologica 94:518-27. 2009.... - Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor: effects on gene expression and growth of glioma cells in vitro and in vivoDong Yin
Division of Hematology Oncology and Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, Los Angeles, California 90048, USA
Clin Cancer Res 13:1045-52. 2007..The aim of this study is to examine the effects of SAHA on gene expression and growth of glioblastoma multiforme (GBM) cells in vitro and in vivo... - SNP array analysis of tyrosine kinase inhibitor-resistant chronic myeloid leukemia identifies heterogeneous secondary genomic alterationsDaniel Nowak
Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California Los Angeles School of Medicine, CA 90048, USA
Blood 115:1049-53. 2010..This may support a hypothesis of TKI-induced selection of subclones differentiating into immature B-cell progenitors as a mechanism of disease progression and evasion of TKI sensitivity... - Absence of R24C mutation of the CDK4 gene in leukemias and solid tumorsNaoki Mori
Department of Medicine, Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, California, USA
Int J Hematol 77:259-62. 2003..Sequence analysis and in vitro kinase assays showed that most of the mutations that disrupted interactions with p16(INK4) also knocked out the activity of CDK4. This result may explain the rareness of CDK4 mutations in human tumors... - Adaptor protein Lnk negatively regulates the mutant MPL, MPLW515L associated with myeloproliferative disordersSigal Gery
Division of Hematology Oncology, UCLA School of Medicine, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
Blood 110:3360-4. 2007..Further elucidating the cellular pathways that attenuate MPLW515L will provide insight into the pathogenesis of MPD and could help develop specific therapeutic approaches... - Rare mutations of the PIK3CA gene in malignancies of the hematopoietic system as well as endometrium, ovary, prostate and osteosarcomas, and discovery of a PIK3CA pseudogeneClaudia I Muller
Division of Hematology Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA
Leuk Res 31:27-32. 2007..Additionally, a previously unidentified PIK3CA pseudogene spanning exons 9-13 on chromosome 22 was discovered... - A novel chromosomal translocation t(1;14)(q25;q32) in pre-B acute lymphoblastic leukemia involves the LIM homeodomain protein gene, Lhx4Norihiko Kawamata
Division of Hematology, Department of Medicine, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
Oncogene 21:4983-91. 2002..The Lhx4 gene is deregulated in the leukemic cells and Lhx4 protein may play an important role, possibly as an activator, in leukemogenesis... - Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasmsNils H Thoennissen
Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California Los Angeles School of Medicine, Los Angeles, CA 90048, USA
Blood 115:2882-90. 2010..01 and P = .016, respectively). Our high-density SNP-array analysis of MPN genomes in the chronic compared with leukemic stage identified novel target genes and provided prognostic insights associated with the evolution to leukemia... - Functional analysis of a novel DNA polymorphism of a tandem repeated sequence in the asparagine synthetase gene in acute lymphoblastic leukemia cellsTadayuki Akagi
Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
Leuk Res 33:991-6. 2009..Clinical significance in ALL requires further studies... - Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasmsMasashi Sanada
Cancer Genomics Project, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Nature 460:904-8. 2009..Our findings provide a new insight into a role of gain-of-function mutations of a tumour suppressor associated with aUPD in the pathogenesis of some myeloid cancer subsets... - Epigenetic silencing of the candidate tumor suppressor gene Per1 in non-small cell lung cancerSigal Gery
Division of Hematology Oncology, Cedars Sinai Medical Center, University of California, Los Angeles School of Medicine, Los Angeles, California 90048, USA
Clin Cancer Res 13:1399-404. 2007..Epigenetic events are a critical factor contributing to cancer development. The purpose of this study was to identify tumor suppressor genes silenced by DNA methylation and histone deacetylation in non-small cell lung cancer (NSCLC)... - Human ovarian carcinoma cells: histone deacetylase inhibitors exhibit antiproliferative activity and potently induce apoptosisNoriyuki Takai
Division of Hematology/Oncology, Cedars-Sinai Medical Center/University of California-Los Angeles School of Medicine, Los Angeles, California 90048, USA
Cancer 101:2760-70. 2004..CONCLUSIONS: The results of the current study suggest that HDACIs may be particularly effective in the treatment of ovarian tumors... - [Zygomycosis: two case reports and review of reported cases in the literature in Japan]Takeshi Mori
Division of Hematology, Department of Internal Medicine, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
Nippon Ishinkin Gakkai Zasshi 44:163-79. 2003..Five cases with allergic zygomycosis were all alive. There were only 14 cases in which isolated fungi were identified (Cunninghamella spp. from 5 cases, Mucor spp. from 2, Rhizomucor spp. from 2, and Rhizopus spp. from 5)... - Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3Atsushi Kato
Division of Hematology, Department of Internal Medicine and Division of Biochemical Analysis, Central Laboratory of Medical Sciences, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
J Biol Chem 277:28934-41. 2002..As Aup1 possesses domains related to signal transduction, these results suggest involvement of Aup1 in the integrin signaling... - Epstein-Barr virus-associated T-cell acute lymphoblastic leukaemiaSakura Sakajiri
Division of Hematology, Department of Medicine, Juntendo University School of Medicine, Hongo, Bunkyo-ku, Tokyo, Japan
Br J Haematol 117:127-9. 2002..The leukaemic cells, massively infiltrated into the liver and spleen, were resistant to chemotherapy. EBV might be associated with tumorigenesis of T-ALL, and characteristic clinical features of the patient... - SAHA, a HDAC inhibitor, has profound anti-growth activity against non-small cell lung cancer cellsNaoki Komatsu
Department of Hematology Respiratory, Cedars Sinai Medical Center University of California at Los Angeles School of Medicine, 90048, USA
Oncol Rep 15:187-91. 2006..Protein assay by Western blot analysis showed that SAHA induced expression of p21WAF1. These results demonstrated that administration of SAHA may be a novel approach to the treatment of non-small cell lung cancer... - Chronic phase of ETV6-ABL1 positive CML responds to imatinibNorihiko Kawamata
Genes Chromosomes Cancer 47:919-21. 2008