Talin Haritunians

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. pmc Genetic predictors of medically refractory ulcerative colitis
    Talin Haritunians
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Inflamm Bowel Dis 16:1830-40. 2010
  2. pmc Variants in ZNF365 isoform D are associated with Crohn's disease
    Talin Haritunians
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Gut 60:1060-7. 2011
  3. pmc Genetic association of COL5A1 variants in keratoconus patients suggests a complex connection between corneal thinning and keratoconus
    Xiaohui Li
    Cornea Genetic Eye Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 54:2696-704. 2013
  4. pmc Variation in the lysyl oxidase (LOX) gene is associated with keratoconus in family-based and case-control studies
    Yelena Bykhovskaya
    Regenerative Medicine Institute, Ophthalmology Research, Department of Surgery, Division of Surgical Research, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Invest Ophthalmol Vis Sci 53:4152-7. 2012
  5. pmc Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease
    Dermot P B McGovern
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Hum Mol Genet 19:3468-76. 2010
  6. pmc Multidimensional prognostic risk assessment identifies association between IL12B variation and surgery in Crohn's disease
    Marla C Dubinsky
    Departments of Pediatrics, Pediatric Inflammatory Bowel Disease Center and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Inflamm Bowel Dis 19:1662-70. 2013
  7. pmc An association between the calpastatin (CAST) gene and keratoconus
    Xiaohui Li
    Cornea Genetic Eye Institute, Los Angeles, CA, USA
    Cornea 32:696-701. 2013
  8. pmc Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease
    Marla C Dubinsky
    Department of Pediatrics and Medicine, Inflammatory Bowel Disease Program, Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Inflamm Bowel Dis 16:1357-66. 2010
  9. pmc Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease
    Dermot P B McGovern
    Medical Genetics Institute and Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Inflamm Bowel Dis 15:883-9. 2009
  10. pmc A genome-wide association study of central corneal thickness in Latinos
    Xiaoyi Gao
    Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Invest Ophthalmol Vis Sci 54:2435-43. 2013

Detail Information

Publications17

  1. pmc Genetic predictors of medically refractory ulcerative colitis
    Talin Haritunians
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Inflamm Bowel Dis 16:1830-40. 2010
    ..The aim of this study was to use a genome-wide association study (GWAS) in a well-characterized cohort of UC patients to identify genetic variation that contributes to MR-UC...
  2. pmc Variants in ZNF365 isoform D are associated with Crohn's disease
    Talin Haritunians
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Gut 60:1060-7. 2011
    ..Genome-wide association studies have identified multiple Crohn's disease (CD) susceptibility loci, including association with non-coding intergenic single-nucleotide polymorphisms (SNPs) at 10q21...
  3. pmc Genetic association of COL5A1 variants in keratoconus patients suggests a complex connection between corneal thinning and keratoconus
    Xiaohui Li
    Cornea Genetic Eye Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Invest Ophthalmol Vis Sci 54:2696-704. 2013
    ..Using family linkage analysis, we identified a keratoconus susceptibility locus at 9q34. These findings led us to perform an association study between COL5A1 variation and keratoconus susceptibility...
  4. pmc Variation in the lysyl oxidase (LOX) gene is associated with keratoconus in family-based and case-control studies
    Yelena Bykhovskaya
    Regenerative Medicine Institute, Ophthalmology Research, Department of Surgery, Division of Surgical Research, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Invest Ophthalmol Vis Sci 53:4152-7. 2012
    ..To determine whether LOX is a genetic determinant of the pathogenesis of keratoconus, we analyzed association results of LOX polymorphisms in two independent case-control samples and in keratoconus families...
  5. pmc Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease
    Dermot P B McGovern
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Hum Mol Genet 19:3468-76. 2010
    ..001). These findings strongly implicate this locus in CD susceptibility and highlight the role of the mucus layer in the development of CD...
  6. pmc Multidimensional prognostic risk assessment identifies association between IL12B variation and surgery in Crohn's disease
    Marla C Dubinsky
    Departments of Pediatrics, Pediatric Inflammatory Bowel Disease Center and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Inflamm Bowel Dis 19:1662-70. 2013
    ....
  7. pmc An association between the calpastatin (CAST) gene and keratoconus
    Xiaohui Li
    Cornea Genetic Eye Institute, Los Angeles, CA, USA
    Cornea 32:696-701. 2013
    ..To test whether variants in CAST gene are involved in genetic susceptibility to KC, we performed genetic testing of polymorphic markers in CAST gene in family and case-control panels of patients with KC...
  8. pmc Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease
    Marla C Dubinsky
    Department of Pediatrics and Medicine, Inflammatory Bowel Disease Program, Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Inflamm Bowel Dis 16:1357-66. 2010
    ..The aim was to test associations of known IBD susceptibility loci and novel "pharmacogenetic" GWAS identified loci with primary nonresponse to anti-TNFalpha in pediatric IBD patients and develop a predictive model of primary nonresponse...
  9. pmc Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease
    Dermot P B McGovern
    Medical Genetics Institute and Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Inflamm Bowel Dis 15:883-9. 2009
    ..Genetic variants in the IL23R and IL12B have been associated with CD susceptibility. We investigated 10 genes within the IL23/IL17 pathway in a case-control study of 763 CD cases and 254 healthy controls...
  10. pmc A genome-wide association study of central corneal thickness in Latinos
    Xiaoyi Gao
    Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Invest Ophthalmol Vis Sci 54:2435-43. 2013
    ..Genetic factors controlling CCT in Latinos, the most populous minority population in the United States, are unclear. Here we describe the first genome-wide association study (GWAS) report of CCT in Latinos...
  11. pmc Genome-wide association identifies multiple ulcerative colitis susceptibility loci
    Dermot P B McGovern
    Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Nat Genet 42:332-7. 2010
    ..These data implicate approximately 30 loci in ulcerative colitis, thereby providing insight into disease pathogenesis...
  12. doi request reprint Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells
    Talin Haritunians
    Division of Hematology Oncology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Leuk Res 32:1366-73. 2008
    ..These encouraging results suggest the appropriateness of clinical trials of cucurbitacins for the treatment of hematopoietic malignancies...
  13. doi request reprint Clinical, serologic, and genetic factors associated with pyoderma gangrenosum and erythema nodosum in inflammatory bowel disease patients
    Adam Weizman
    F Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California Department of Pediatrics, Pediatric Inflammatory Bowel Disease Center, Cedars Sinai Medical Center, Los Angeles, California Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, Maryland Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland Department of Internal Medicine, Section of Digestive Diseases, Yale School of Medicine, New Haven, Connecticut Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Universite de Montreal and the Montreal Heart Institute, Research Center, Montreal, Canada Mount Sinai Inflammatory Bowel Disease Center, University of Toronto, Toronto, Canada Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute and Department of Pediatrics, Harbor UCLA Medical Center, Torrance, California and Medical Genetics Research Institute, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California
    Inflamm Bowel Dis 20:525-33. 2014
    ..Pyoderma gangrenosum (PG) and erythema nodosum (EN) are the most common cutaneous manifestations of inflammatory bowel disease (IBD) but little is known regarding their etiopathogenesis...
  14. pmc A genome-wide association study identifies a potential novel gene locus for keratoconus, one of the commonest causes for corneal transplantation in developed countries
    Xiaohui Li
    Cornea Genetic Eye Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Hum Mol Genet 21:421-9. 2012
    ..6 × 10(-7) (unadjusted P= 1.2 × 10(-9)). These findings suggest SNP rs4954218, located near the RAB3GAP1 gene, previously reported to be associated with corneal malformation, is a potential susceptibility locus for keratoconus...
  15. ncbi request reprint Lipoprotein lipase locus and progression of atherosclerosis in coronary-artery bypass grafts
    Kent D Taylor
    Medical Genetics Institute, and Division of Cardiology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California, USA
    Genet Med 6:481-6. 2004
    ..Our aim was to test whether polymorphisms in the lipoprotein lipase (LPL) gene were associated with the progression of atherosclerosis in grafts examined in the Post-Coronary Artery Bypass Graft Trial (Post-CABG Trial)...
  16. pmc Novel acyl sulfonamide LY573636-sodium: effect on hematopoietic malignant cells
    Talin Haritunians
    Division of Hematology Oncology, Cedars Sinai Medical Center and UCLA School of Medicine, Los Angeles, CA 90048, USA
    Oncol Rep 20:1237-42. 2008
    ..LY573636, as shown before in solid tumors, is effective in hematopoietic cell lines as well. These data suggest the use of LY573636 alone or in combination with conventional chemotherapeutic regimens in hematopoietic malignancies...
  17. pmc Novel Gemini vitamin D(3) analogs have potent antitumor activity
    Tsuyako Saito
    Division of Hematology and Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90048, USA
    J Steroid Biochem Mol Biol 112:151-6. 2008
    ..05) more apoptosis than 1,25(OH)(2)D(3). In summary, these analogs have a unique structure resulting in extremely potent inhibition of clonal proliferation of various types of cancer cells, especially HL-60 cells...