Research Topics
Genomes and Genes | Adrian F GombartSummaryAffiliation: Cedars-Sinai Medical Center Country: USA Publications
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Publications
Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1Adrian F Gombart
Division of Hematology Oncology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Blood 101:3265-73. 2003..Furthermore, it indicates the importance of PU.1 in the cooperative activation of eosinophil granule genes...- Phenotypic and functional alterations of peripheral blood monocytes in neutrophil-specific granule deficiencyMasaaki Shiohara
Shinshu University School of Medicine, 3 1 1, Asahi, Matsumoto, 390 8621 Japan
J Leukoc Biol 75:190-7. 2004..This study implicates abnormalities in monocytes/macrophages and neutrophils in the onset and development of SGD... - Expression of bactericidal/permeability-increasing protein requires C/EBP epsilonMiyuki Tanaka
Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
Int J Hematol 85:304-11. 2007..Expression of BPI in human cord blood cells was increased by incubation with 10-7 MATRA for 48 hours. These results demonstrate the requirement for C/EBP epsilon in mediating BPI gene expression in myeloid cells in vitro and in vivo... - Neutrophil-specific granule deficiency: homozygous recessive inheritance of a frameshift mutation in the gene encoding transcription factor CCAAT/enhancer binding protein--epsilonA F Gombart
Cedars Sinai Medical Center, Burns and Allen Research Institute, Division of Hematology Oncology, UCLA School of Medicine, Los Angeles, CA 90048, USA
Blood 97:2561-7. 2001..This study strongly implicates mutation of the C/EBPepsilon gene as the primary genetic defect involved in the development of neutrophil SGD and defines its mechanism of inheritance... - Aberrant expression of neutrophil and macrophage-related genes in a murine model for human neutrophil-specific granule deficiencyAdrian F Gombart
Cedars Sinai Medical Center, Division of Hematology Oncology, Burns and Allen Research Institute and David Geffen School of Medicine at University of California Los Angeles, USA
J Leukoc Biol 78:1153-65. 2005..In summary, dysregulation of numerous, novel C/EBPepsilon target genes impairs innate immune response and possibly other important biological processes mediated by neutrophils and macrophages... - Vitamin D compounds: activity against microbes and cancerAdrian F Gombart
Division of Hematology Oncology, Cedars Sinai Medical Center, Burns and Allen Research Institute, David Geffen School of Medicine at UCLA, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
Anticancer Res 26:2531-42. 2006..In this report, the anticancer and newly discovered antimicrobial actions of 1,25(OH)2D3 and deltanoids are reviewed... - ATF4 differentially regulates transcriptional activation of myeloid-specific genes by C/EBPepsilon and C/EBPalphaAdrian F Gombart
Cedars Sinai Medical Center, Division of Hematology Oncology, Davis Bldg 5019, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
J Leukoc Biol 81:1535-47. 2007..We propose that ATF4 may regulate myeloid gene expression differentially by potentiating C/EBPepsilon but inhibiting C/EBPalpha-mediated transcriptional activation... - Regulation of the CAMP gene by 1,25(OH)2D3 in various tissuesAdrian F Gombart
Cedars Sinai Medical Center, Department of Medicine, Division of Hematology Oncology, Burns and Allen Research Institute, David Geffen School of Medicine at UCLA, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
J Steroid Biochem Mol Biol 103:552-7. 2007..The data suggest that regulation of CAMP by 1,25(OH)(2)D(3) is potentially important in a wide range of tissues... - Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemiasAdrian F Gombart
Cedars Sinai Medical Center, Burns and Allen Research Institute, Division of Hematology Oncology, University of California Los Angeles School of Medicine, 90048, USA
Blood 99:1332-40. 2002..These results suggest that mutation of C/EBPalpha is involved in specific subtypes of AML and in MDS, but may occur rarely in other types of leukemias or nonhematologic malignancies... - Neutrophil specific granule deficiency and mutations in the gene encoding transcription factor C/EBP(epsilon)Adrian F Gombart
Division of Hematology Oncology, Cedars Sinai Medical Center, Burns and Allen Research Institute, UCLA School of Medicine, Los Angeles, California 90048, USA
Curr Opin Hematol 9:36-42. 2002..Deficiencies in multiple myeloid lineages, in addition to neutrophils, indicate the importance of C/EBP(epsilon) in regulating important innate immune and inflammatory responses critical for host defense... - Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3Adrian F Gombart
Department of Medicine, Division of Hematology Oncology, Cedars Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California 90048, USA
FASEB J 19:1067-77. 2005..Our findings reveal a novel activity of 1,25-dihydroxyvitamin D3 and the VDR in regulation of primate innate immunity... - Restoration of C/EBPalpha expression in a BCR-ABL+ cell line induces terminal granulocytic differentiationSigal Tavor
Division of Hematology Oncology, Cedars Sinai Medical Center, School of Medicine, UCLA, Los Angeles, California 90048, USA
J Biol Chem 278:52651-9. 2003.... 
In vivo deficiency of both C/EBPβ and C/EBPε results in highly defective myeloid differentiation and lack of cytokine responseTadayuki Akagi
Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California Los Angeles School of Medicine, Los Angeles, California, United States of America
PLoS ONE 5:e15419. 2010....- Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemiaSigal Gery
Cedars Sinai Medical Center, Davis Bldg 5066, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
Blood 106:2827-36. 2005..These results suggest that Per2 is a downstream C/EBPalpha-target gene involved in AML, and its disruption might be involved in initiation and/or progression of AML... - Macrophage functional maturation and cytokine production are impaired in C/EBP epsilon-deficient miceSigal Tavor
Division of Hematology Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90095, USA
Blood 99:1794-801. 2002..Taken together, this study implicates the C/EBP epsilon gene as an important transcription factor required for normal function and development of macrophages... - Impaired response to GM-CSF and G-CSF, and enhanced apoptosis in C/EBPbeta-deficient hematopoietic cellsTadayuki Akagi
Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California Los Angeles School of Medicine, Los Angeles, CA 90048, USA
Blood 111:2999-3004. 2008..Our present results indicate that C/EBPbeta helps regulate survival of neutrophils, downstream of the granulocyte colony stimulating factor receptor... - C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesisSigal Gery
Cedars Sinai Medical Center, Davis Bldg 5066, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
Blood 103:828-35. 2004..We propose that the interactions between C/EBPepsilon, a tissue-specific transcription factor, and the broad-spectrum proteins, Rb and E2F1, are important in C/EBPepsilon-induced terminal granulocytic differentiation... - C/EBPε mediates nicotinamide-enhanced clearance of Staphylococcus aureus in micePierre Kyme
Department of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
J Clin Invest 122:3316-29. 2012..Nicotinamide was efficacious in both prophylactic and therapeutic settings. Our findings suggest that C/EBPε is an important target to boost killing of bacteria by the innate immune system... - Identifying progression-associated genes in adult T-cell leukemia/lymphoma by using oligonucleotide microarraysKunihiro Tsukasaki
Division of Hematology Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, CA, USA
Int J Cancer 109:875-81. 2004..These results demonstrated that distinct sets of genes that are known to be critical in cellular transformation and/or activation are up- or down-regulated during the transition to the acute phase of ATL... - MyD88 and TRIF mediate the cyclic adenosine monophosphate (cAMP) induced corticotropin releasing hormone (CRH) expression in JEG3 choriocarcinoma cell lineAndy Uh
Ahmanson Department of Pediatrics, Steven Spielberg Pediatric Research Center, Burns and Allen Research Institute, David Geffen School of Medicine at UCLA, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Reprod Biol Endocrinol 7:74. 2009..Here we investigated the role of MyD88, TRIF and IRAK2 on cAMP-induced CRH promoter activation in JEG3 cells in the absence of LPS/TLR4 stimulation... 
Low plasma level of cathelicidin antimicrobial peptide (hCAP18) predicts increased infectious disease mortality in patients undergoing hemodialysisAdrian F Gombart
Department of Medicine, Division of Hematology Oncology, Cedars Sinai Medical Center, David Geffen School of Medicine at Univeristy of California, Los Angeles, USA
Clin Infect Dis 48:418-24. 2009....- Establishment of the acute myeloid leukemia cell line Kasumi-6 from a patient with a dominant-negative mutation in the DNA-binding region of the C/EBPalpha geneHiroya Asou
Department of Molecular Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
Genes Chromosomes Cancer 36:167-74. 2003..The Kasumi-6 cell line can serve as a model to study the cellular and molecular biology of the non-t(8;21) M2 type of myeloid leukemia and can elucidate the role of mutated C/EBPalpha in leukemogenesis... - Haptoglobin is synthesized during granulocyte differentiation, stored in specific granules, and released by neutrophils in response to activationKim Theilgaard-Monch
Granulocyte Research Laboratory Department of Hematology, Rigshospitalet, the Laboratory for Gene Therapy Research Department of Clinical Biochemistry, University of Copenhagen, Copenhagen Ø, Denmark
Blood 108:353-61. 2006..Hence, neutrophil-derived Hp might reduce tissue damage and bacterial growth at sites of infection or injury by propagating anti-inflammatory activities and Hb clearance... - Highly glycosylated alpha1-acid glycoprotein is synthesized in myelocytes, stored in secondary granules, and released by activated neutrophilsKim Theilgaard-Monch
Granulocyte Research Laboratory, Department of Hematology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
J Leukoc Biol 78:462-70. 2005..Hence, neutrophils, which constitute the first line of defense, are likely to serve as the primary local source of AGP at sites of infection or injury... - CCAAT/enhancer binding protein alpha (C/EBPalpha) and C/EBPalpha myeloid oncoproteins induce bcl-2 via interaction of their basic regions with nuclear factor-kappaB p50Ido Paz Priel
Division of Pediatric Oncology, Johns Hopkins University, CRB 253, 1650 Orleans Street, Baltimore, Maryland 21231, USA
Mol Cancer Res 3:585-96. 2005..Targeting interaction between C/EBPalpha basic region and NF-kappaB p50 may contribute to the therapy of AML and other malignancies expressing C/EBPs...