Adrian F Gombart

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. ncbi request reprint Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1
    Adrian F Gombart
    Division of Hematology Oncology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Blood 101:3265-73. 2003
  2. ncbi request reprint Phenotypic and functional alterations of peripheral blood monocytes in neutrophil-specific granule deficiency
    Masaaki Shiohara
    Shinshu University School of Medicine, 3 1 1, Asahi, Matsumoto, 390 8621 Japan
    J Leukoc Biol 75:190-7. 2004
  3. ncbi request reprint Expression of bactericidal/permeability-increasing protein requires C/EBP epsilon
    Miyuki Tanaka
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Int J Hematol 85:304-11. 2007
  4. ncbi request reprint Neutrophil-specific granule deficiency: homozygous recessive inheritance of a frameshift mutation in the gene encoding transcription factor CCAAT/enhancer binding protein--epsilon
    A F Gombart
    Cedars Sinai Medical Center, Burns and Allen Research Institute, Division of Hematology Oncology, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Blood 97:2561-7. 2001
  5. ncbi request reprint Aberrant expression of neutrophil and macrophage-related genes in a murine model for human neutrophil-specific granule deficiency
    Adrian F Gombart
    Cedars Sinai Medical Center, Division of Hematology Oncology, Burns and Allen Research Institute and David Geffen School of Medicine at University of California Los Angeles, USA
    J Leukoc Biol 78:1153-65. 2005
  6. ncbi request reprint Vitamin D compounds: activity against microbes and cancer
    Adrian F Gombart
    Division of Hematology Oncology, Cedars Sinai Medical Center, Burns and Allen Research Institute, David Geffen School of Medicine at UCLA, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    Anticancer Res 26:2531-42. 2006
  7. ncbi request reprint ATF4 differentially regulates transcriptional activation of myeloid-specific genes by C/EBPepsilon and C/EBPalpha
    Adrian F Gombart
    Cedars Sinai Medical Center, Division of Hematology Oncology, Davis Bldg 5019, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    J Leukoc Biol 81:1535-47. 2007
  8. ncbi request reprint Regulation of the CAMP gene by 1,25(OH)2D3 in various tissues
    Adrian F Gombart
    Cedars Sinai Medical Center, Department of Medicine, Division of Hematology Oncology, Burns and Allen Research Institute, David Geffen School of Medicine at UCLA, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    J Steroid Biochem Mol Biol 103:552-7. 2007
  9. ncbi request reprint Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias
    Adrian F Gombart
    Cedars Sinai Medical Center, Burns and Allen Research Institute, Division of Hematology Oncology, University of California Los Angeles School of Medicine, 90048, USA
    Blood 99:1332-40. 2002
  10. ncbi request reprint Neutrophil specific granule deficiency and mutations in the gene encoding transcription factor C/EBP(epsilon)
    Adrian F Gombart
    Division of Hematology Oncology, Cedars Sinai Medical Center, Burns and Allen Research Institute, UCLA School of Medicine, Los Angeles, California 90048, USA
    Curr Opin Hematol 9:36-42. 2002

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1
    Adrian F Gombart
    Division of Hematology Oncology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Blood 101:3265-73. 2003
    ..Furthermore, it indicates the importance of PU.1 in the cooperative activation of eosinophil granule genes...
  2. ncbi request reprint Phenotypic and functional alterations of peripheral blood monocytes in neutrophil-specific granule deficiency
    Masaaki Shiohara
    Shinshu University School of Medicine, 3 1 1, Asahi, Matsumoto, 390 8621 Japan
    J Leukoc Biol 75:190-7. 2004
    ..This study implicates abnormalities in monocytes/macrophages and neutrophils in the onset and development of SGD...
  3. ncbi request reprint Expression of bactericidal/permeability-increasing protein requires C/EBP epsilon
    Miyuki Tanaka
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan
    Int J Hematol 85:304-11. 2007
    ..Expression of BPI in human cord blood cells was increased by incubation with 10-7 MATRA for 48 hours. These results demonstrate the requirement for C/EBP epsilon in mediating BPI gene expression in myeloid cells in vitro and in vivo...
  4. ncbi request reprint Neutrophil-specific granule deficiency: homozygous recessive inheritance of a frameshift mutation in the gene encoding transcription factor CCAAT/enhancer binding protein--epsilon
    A F Gombart
    Cedars Sinai Medical Center, Burns and Allen Research Institute, Division of Hematology Oncology, UCLA School of Medicine, Los Angeles, CA 90048, USA
    Blood 97:2561-7. 2001
    ..This study strongly implicates mutation of the C/EBPepsilon gene as the primary genetic defect involved in the development of neutrophil SGD and defines its mechanism of inheritance...
  5. ncbi request reprint Aberrant expression of neutrophil and macrophage-related genes in a murine model for human neutrophil-specific granule deficiency
    Adrian F Gombart
    Cedars Sinai Medical Center, Division of Hematology Oncology, Burns and Allen Research Institute and David Geffen School of Medicine at University of California Los Angeles, USA
    J Leukoc Biol 78:1153-65. 2005
    ..In summary, dysregulation of numerous, novel C/EBPepsilon target genes impairs innate immune response and possibly other important biological processes mediated by neutrophils and macrophages...
  6. ncbi request reprint Vitamin D compounds: activity against microbes and cancer
    Adrian F Gombart
    Division of Hematology Oncology, Cedars Sinai Medical Center, Burns and Allen Research Institute, David Geffen School of Medicine at UCLA, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    Anticancer Res 26:2531-42. 2006
    ..In this report, the anticancer and newly discovered antimicrobial actions of 1,25(OH)2D3 and deltanoids are reviewed...
  7. ncbi request reprint ATF4 differentially regulates transcriptional activation of myeloid-specific genes by C/EBPepsilon and C/EBPalpha
    Adrian F Gombart
    Cedars Sinai Medical Center, Division of Hematology Oncology, Davis Bldg 5019, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    J Leukoc Biol 81:1535-47. 2007
    ..We propose that ATF4 may regulate myeloid gene expression differentially by potentiating C/EBPepsilon but inhibiting C/EBPalpha-mediated transcriptional activation...
  8. ncbi request reprint Regulation of the CAMP gene by 1,25(OH)2D3 in various tissues
    Adrian F Gombart
    Cedars Sinai Medical Center, Department of Medicine, Division of Hematology Oncology, Burns and Allen Research Institute, David Geffen School of Medicine at UCLA, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    J Steroid Biochem Mol Biol 103:552-7. 2007
    ..The data suggest that regulation of CAMP by 1,25(OH)(2)D(3) is potentially important in a wide range of tissues...
  9. ncbi request reprint Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias
    Adrian F Gombart
    Cedars Sinai Medical Center, Burns and Allen Research Institute, Division of Hematology Oncology, University of California Los Angeles School of Medicine, 90048, USA
    Blood 99:1332-40. 2002
    ..These results suggest that mutation of C/EBPalpha is involved in specific subtypes of AML and in MDS, but may occur rarely in other types of leukemias or nonhematologic malignancies...
  10. ncbi request reprint Neutrophil specific granule deficiency and mutations in the gene encoding transcription factor C/EBP(epsilon)
    Adrian F Gombart
    Division of Hematology Oncology, Cedars Sinai Medical Center, Burns and Allen Research Institute, UCLA School of Medicine, Los Angeles, California 90048, USA
    Curr Opin Hematol 9:36-42. 2002
    ..Deficiencies in multiple myeloid lineages, in addition to neutrophils, indicate the importance of C/EBP(epsilon) in regulating important innate immune and inflammatory responses critical for host defense...
  11. ncbi request reprint Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3
    Adrian F Gombart
    Department of Medicine, Division of Hematology Oncology, Cedars Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, California 90048, USA
    FASEB J 19:1067-77. 2005
    ..Our findings reveal a novel activity of 1,25-dihydroxyvitamin D3 and the VDR in regulation of primate innate immunity...
  12. ncbi request reprint Restoration of C/EBPalpha expression in a BCR-ABL+ cell line induces terminal granulocytic differentiation
    Sigal Tavor
    Division of Hematology Oncology, Cedars Sinai Medical Center, School of Medicine, UCLA, Los Angeles, California 90048, USA
    J Biol Chem 278:52651-9. 2003
    ....
  13. pmc In vivo deficiency of both C/EBPβ and C/EBPε results in highly defective myeloid differentiation and lack of cytokine response
    Tadayuki Akagi
    Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California Los Angeles School of Medicine, Los Angeles, California, United States of America
    PLoS ONE 5:e15419. 2010
    ....
  14. pmc Transcription profiling of C/EBP targets identifies Per2 as a gene implicated in myeloid leukemia
    Sigal Gery
    Cedars Sinai Medical Center, Davis Bldg 5066, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    Blood 106:2827-36. 2005
    ..These results suggest that Per2 is a downstream C/EBPalpha-target gene involved in AML, and its disruption might be involved in initiation and/or progression of AML...
  15. ncbi request reprint Macrophage functional maturation and cytokine production are impaired in C/EBP epsilon-deficient mice
    Sigal Tavor
    Division of Hematology Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Blood 99:1794-801. 2002
    ..Taken together, this study implicates the C/EBP epsilon gene as an important transcription factor required for normal function and development of macrophages...
  16. pmc Impaired response to GM-CSF and G-CSF, and enhanced apoptosis in C/EBPbeta-deficient hematopoietic cells
    Tadayuki Akagi
    Division of Hematology and Oncology, Cedars Sinai Medical Center, University of California Los Angeles School of Medicine, Los Angeles, CA 90048, USA
    Blood 111:2999-3004. 2008
    ..Our present results indicate that C/EBPbeta helps regulate survival of neutrophils, downstream of the granulocyte colony stimulating factor receptor...
  17. ncbi request reprint C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis
    Sigal Gery
    Cedars Sinai Medical Center, Davis Bldg 5066, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    Blood 103:828-35. 2004
    ..We propose that the interactions between C/EBPepsilon, a tissue-specific transcription factor, and the broad-spectrum proteins, Rb and E2F1, are important in C/EBPepsilon-induced terminal granulocytic differentiation...
  18. pmc C/EBPε mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice
    Pierre Kyme
    Department of Biomedical Sciences, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Clin Invest 122:3316-29. 2012
    ..Nicotinamide was efficacious in both prophylactic and therapeutic settings. Our findings suggest that C/EBPε is an important target to boost killing of bacteria by the innate immune system...
  19. ncbi request reprint Identifying progression-associated genes in adult T-cell leukemia/lymphoma by using oligonucleotide microarrays
    Kunihiro Tsukasaki
    Division of Hematology Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, CA, USA
    Int J Cancer 109:875-81. 2004
    ..These results demonstrated that distinct sets of genes that are known to be critical in cellular transformation and/or activation are up- or down-regulated during the transition to the acute phase of ATL...
  20. pmc MyD88 and TRIF mediate the cyclic adenosine monophosphate (cAMP) induced corticotropin releasing hormone (CRH) expression in JEG3 choriocarcinoma cell line
    Andy Uh
    Ahmanson Department of Pediatrics, Steven Spielberg Pediatric Research Center, Burns and Allen Research Institute, David Geffen School of Medicine at UCLA, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Reprod Biol Endocrinol 7:74. 2009
    ..Here we investigated the role of MyD88, TRIF and IRAK2 on cAMP-induced CRH promoter activation in JEG3 cells in the absence of LPS/TLR4 stimulation...
  21. doi request reprint Low plasma level of cathelicidin antimicrobial peptide (hCAP18) predicts increased infectious disease mortality in patients undergoing hemodialysis
    Adrian F Gombart
    Department of Medicine, Division of Hematology Oncology, Cedars Sinai Medical Center, David Geffen School of Medicine at Univeristy of California, Los Angeles, USA
    Clin Infect Dis 48:418-24. 2009
    ....
  22. ncbi request reprint Establishment of the acute myeloid leukemia cell line Kasumi-6 from a patient with a dominant-negative mutation in the DNA-binding region of the C/EBPalpha gene
    Hiroya Asou
    Department of Molecular Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
    Genes Chromosomes Cancer 36:167-74. 2003
    ..The Kasumi-6 cell line can serve as a model to study the cellular and molecular biology of the non-t(8;21) M2 type of myeloid leukemia and can elucidate the role of mutated C/EBPalpha in leukemogenesis...
  23. ncbi request reprint Haptoglobin is synthesized during granulocyte differentiation, stored in specific granules, and released by neutrophils in response to activation
    Kim Theilgaard-Monch
    Granulocyte Research Laboratory Department of Hematology, Rigshospitalet, the Laboratory for Gene Therapy Research Department of Clinical Biochemistry, University of Copenhagen, Copenhagen Ø, Denmark
    Blood 108:353-61. 2006
    ..Hence, neutrophil-derived Hp might reduce tissue damage and bacterial growth at sites of infection or injury by propagating anti-inflammatory activities and Hb clearance...
  24. ncbi request reprint Highly glycosylated alpha1-acid glycoprotein is synthesized in myelocytes, stored in secondary granules, and released by activated neutrophils
    Kim Theilgaard-Monch
    Granulocyte Research Laboratory, Department of Hematology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    J Leukoc Biol 78:462-70. 2005
    ..Hence, neutrophils, which constitute the first line of defense, are likely to serve as the primary local source of AGP at sites of infection or injury...
  25. ncbi request reprint CCAAT/enhancer binding protein alpha (C/EBPalpha) and C/EBPalpha myeloid oncoproteins induce bcl-2 via interaction of their basic regions with nuclear factor-kappaB p50
    Ido Paz-Priel
    Division of Pediatric Oncology, Johns Hopkins University, CRB 253, 1650 Orleans Street, Baltimore, Maryland 21231, USA
    Mol Cancer Res 3:585-96. 2005
    ..Targeting interaction between C/EBPalpha basic region and NF-kappaB p50 may contribute to the therapy of AML and other malignancies expressing C/EBPs...