Armando E Giuliano

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. ncbi Should ACOSOG Z0011 change practice with respect to axillary lymph node dissection for a positive sentinel lymph node biopsy in breast cancer?
    Armando E Giuliano
    Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Clin Exp Metastasis 29:687-92. 2012
  2. ncbi Association of occult metastases in sentinel lymph nodes and bone marrow with survival among women with early-stage invasive breast cancer
    Armando E Giuliano
    Division of Surgical Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, California, USA
    JAMA 306:385-93. 2011
  3. ncbi Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial
    Armando E Giuliano
    John Wayne Cancer Institute at Saint John s Health Center, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
    JAMA 305:569-75. 2011
  4. ncbi Adherence to the National Quality Forum (NQF) breast cancer measures within cancer clinical trials: a review from ACOSOG Z0010
    Lee G Wilke
    Department of Surgery, Duke University Medical Center, Durham, NC, USA
    Ann Surg Oncol 17:1989-94. 2010
  5. ncbi Locoregional recurrence after sentinel lymph node dissection with or without axillary dissection in patients with sentinel lymph node metastases: the American College of Surgeons Oncology Group Z0011 randomized trial
    Armando E Giuliano
    John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA 90404, USA
    Ann Surg 252:426-32; discussion 432-3. 2010
  6. ncbi Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs
    Valerie Gouaze
    John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, California 90404, USA
    Cancer Res 65:3861-7. 2005
  7. ncbi Detection of circulating tumor cells in early-stage breast cancer metastasis to axillary lymph nodes
    Taku Nakagawa
    Department of Molecular Oncology, John Wayne Cancer Institute, Saint John s Health Center, Santa Monica, California 90404, USA
    Clin Cancer Res 13:4105-10. 2007
  8. ncbi Hypomethylation of LINE-1 in primary tumor has poor prognosis in young breast cancer patients: a retrospective cohort study
    Anneke Q van Hoesel
    Department of Molecular Oncology, John Wayne Cancer Institute JWCI at St John s Health Center, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
    Breast Cancer Res Treat 134:1103-14. 2012
  9. ncbi Sentinel node skills verification and surgeon performance: data from a multicenter clinical trial for early-stage breast cancer
    Katherine E Posther
    Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    Ann Surg 242:593-9; discussion 599-602. 2005
  10. ncbi Patterns of participation and successful patient recruitment to American College of Surgeons Oncology Group Z0010, a phase II trial for patients with early-stage breast cancer
    A Marilyn Leitch
    Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9155, USA
    Am J Surg 190:539-42. 2005

Detail Information

Publications73

  1. ncbi Should ACOSOG Z0011 change practice with respect to axillary lymph node dissection for a positive sentinel lymph node biopsy in breast cancer?
    Armando E Giuliano
    Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Clin Exp Metastasis 29:687-92. 2012
    ..SLNR has its role in the management of early stage breast cancer, but whether SLNR alone should replace ALND is yet to be determined...
  2. ncbi Association of occult metastases in sentinel lymph nodes and bone marrow with survival among women with early-stage invasive breast cancer
    Armando E Giuliano
    Division of Surgical Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, California, USA
    JAMA 306:385-93. 2011
    ..Immunochemical staining of sentinel lymph nodes (SLNs) and bone marrow identifies breast cancer metastases not seen with routine pathological or clinical examination...
  3. ncbi Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial
    Armando E Giuliano
    John Wayne Cancer Institute at Saint John s Health Center, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
    JAMA 305:569-75. 2011
    ..Sentinel lymph node dissection (SLND) accurately identifies nodal metastasis of early breast cancer, but it is not clear whether further nodal dissection affects survival...
  4. ncbi Adherence to the National Quality Forum (NQF) breast cancer measures within cancer clinical trials: a review from ACOSOG Z0010
    Lee G Wilke
    Department of Surgery, Duke University Medical Center, Durham, NC, USA
    Ann Surg Oncol 17:1989-94. 2010
    ..We proposed to study the degree of adherence with these measures among participating institutions in a multi-institutional trial...
  5. ncbi Locoregional recurrence after sentinel lymph node dissection with or without axillary dissection in patients with sentinel lymph node metastases: the American College of Surgeons Oncology Group Z0011 randomized trial
    Armando E Giuliano
    John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA 90404, USA
    Ann Surg 252:426-32; discussion 432-3. 2010
    ..Few studies have examined the outcome of patients who do not undergo ALND for positive SNs. We now report local and regional recurrence information from the American College of Surgeons Oncology Group Z0011 trial...
  6. ncbi Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs
    Valerie Gouaze
    John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, California 90404, USA
    Cancer Res 65:3861-7. 2005
    ..The data suggest that lipids play a role in the expression of multidrug resistance...
  7. ncbi Detection of circulating tumor cells in early-stage breast cancer metastasis to axillary lymph nodes
    Taku Nakagawa
    Department of Molecular Oncology, John Wayne Cancer Institute, Saint John s Health Center, Santa Monica, California 90404, USA
    Clin Cancer Res 13:4105-10. 2007
    ....
  8. ncbi Hypomethylation of LINE-1 in primary tumor has poor prognosis in young breast cancer patients: a retrospective cohort study
    Anneke Q van Hoesel
    Department of Molecular Oncology, John Wayne Cancer Institute JWCI at St John s Health Center, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
    Breast Cancer Res Treat 134:1103-14. 2012
    ..LINE-1 analysis of primary breast cancer demonstrated cancer-related age-dependent hypomethylation. In patients ≤55 years, LINE-1 hypomethylation portends a high-risk of DR...
  9. ncbi Sentinel node skills verification and surgeon performance: data from a multicenter clinical trial for early-stage breast cancer
    Katherine E Posther
    Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    Ann Surg 242:593-9; discussion 599-602. 2005
    ....
  10. ncbi Patterns of participation and successful patient recruitment to American College of Surgeons Oncology Group Z0010, a phase II trial for patients with early-stage breast cancer
    A Marilyn Leitch
    Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9155, USA
    Am J Surg 190:539-42. 2005
    ..This report elucidates factors influencing patient accrual...
  11. ncbi Impact of immediate versus delayed axillary node dissection on surgical outcomes in breast cancer patients with positive sentinel nodes: results from American College of Surgeons Oncology Group Trials Z0010 and Z0011
    John A Olson
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 26:3530-5. 2008
    ..The impact of the timing of cALND on pathologic results and complications in these patients has not been examined...
  12. ncbi The current role of sentinel node biopsy in the treatment of breast cancer
    Baiba J Grube
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas, USA
    Adv Surg 38:121-66. 2004
  13. ncbi Proteomic profiling of primary breast cancer predicts axillary lymph node metastasis
    Taku Nakagawa
    Department of Molecular Oncology, Division of Biostatistics, and Joyce Eisenberg Keefer Breast Center, John Wayne Cancer Institute, Santa Monica, CA 90404, USA
    Cancer Res 66:11825-30. 2006
    ..016 and 0.0083, respectively). ProteinChip array analysis identified differential protein peaks in primary breast cancers that predict the presence and number of ALN metastases and non-SLN status...
  14. ncbi Distinct hypermethylation profile of primary breast cancer is associated with sentinel lymph node metastasis
    Masaru Shinozaki
    Department of Molecular Oncology, John Wayne Cancer Institute and St. John's Health Center, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
    Clin Cancer Res 11:2156-62. 2005
    ....
  15. ncbi Prognostic value of basal phenotype in HER2-overexpressing breast cancer
    Sanjay P Bagaria
    Department of Surgical Oncology, John Wayne Cancer Institute, Santa Monica, CA, USA
    Ann Surg Oncol 19:935-40. 2012
    ..We investigated the clinical relevance of this basal-HER2+ subtype within HER2-overexpressing breast tumors...
  16. ncbi Hypermethylation of adenosine triphosphate-binding cassette transporter genes in primary hyperparathyroidism and its effect on sestamibi imaging
    Hiroya Takeuchi
    Department of Molecular Oncology, John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
    J Clin Endocrinol Metab 92:1785-90. 2007
    ....
  17. ncbi Outcomes for women with ductal carcinoma-in-situ and a positive sentinel node: a multi-institutional audit
    Katrina H Moore
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, MRI 1026, New York, NY 10021, USA
    Ann Surg Oncol 14:2911-7. 2007
    ..Although it is well established that nodal status for invasive disease is prognostically important, the clinical relevance of a positive SLN in patients with DCIS remains undetermined...
  18. ncbi Basal-like breast cancer defined by FOXC1 expression offers superior prognostic value: a retrospective immunohistochemical study
    PARTHA S RAY
    Department of Surgical Oncology, John Wayne Cancer Institute, Santa Monica, CA, USA
    Ann Surg Oncol 18:3839-47. 2011
    ..We investigated the prognostic value of FOXC1 protein expression in invasive breast cancer and compared its prognostic significance to that of TNP and basal CKs...
  19. ncbi An update on prognosis in breast cancer patients with extensive axillary disease
    Francesca Hoehne
    Joyce Eisenberg Keefer Breast Center, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, California 90404, USA
    Breast J 14:76-80. 2008
    ..14 (95% confidence interval: 0.04-0.46). In our study, patients with at least 10 positive axillary LN had a 5-year survival of 71.9% which may be due to the improvements in local and systemic therapy...
  20. ncbi Ceramide and glucosylceramide upregulate expression of the multidrug resistance gene MDR1 in cancer cells
    Valerie Gouaze-Andersson
    John Wayne Cancer Institute at Saint John s Health Center, Department of Experimental Therapeutics, Santa Monica, CA 90404, USA
    Biochim Biophys Acta 1771:1407-17. 2007
    ..Therefore, ceramide's role as a messenger of cytotoxic response might be linked to the multidrug resistance pathway...
  21. ncbi Lymphatic mapping establishes the role of BRAF gene mutation in papillary thyroid carcinoma
    Joseph Kim
    Department of Molecular Oncology, John Wayne Cancer Institute at Saint Johns Hospital, Santa Monica, CA 90404, USA
    Ann Surg 244:799-804. 2006
    ..To define the role of BRAF gene mutation in the progression of papillary thyroid carcinoma...
  22. ncbi Prediction of breast tumor progression by integrity of free circulating DNA in serum
    Naoyuki Umetani
    Department of Molecular Oncology and the Joyce Eisenberg Breast Center, John Wayne Cancer Institute, Santa Monica, CA 90404, USA
    J Clin Oncol 24:4270-6. 2006
    ..0002 and P < .0001, respectively). CONCLUSION: Integrity of serum circulating DNA is a promising molecular biomarker for detecting breast cancer tumor progression and regional LN metastases...
  23. ncbi Invasive lobular vs. ductal breast cancer: a stage-matched comparison of outcomes
    Nabil Wasif
    John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA, USA
    Ann Surg Oncol 17:1862-9. 2010
    ..Does delayed diagnosis of ILC affect survival? We used a national registry to compare outcomes of patients with stage-matched ILC and IDC...
  24. ncbi Surgical complications associated with sentinel lymph node biopsy: results from a prospective international cooperative group trial
    Lee Gravatt Wilke
    Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    Ann Surg Oncol 13:491-500. 2006
    ..CONCLUSIONS: This study provides a prospective assessment of the sentinel lymph node biopsy procedure, as performed by a wide range of surgeons, demonstrating a low complication rate...
  25. ncbi Sentinel lymph node biopsy for local recurrence of breast cancer after breast-conserving therapy
    Bret Taback
    Division of Surgical Oncology, Columbia University Medical Center, 177 Fort Washington Avenue, New York, New York 10032, USA
    Ann Surg Oncol 13:1099-104. 2006
    ..This approach illustrates variations in the lymphatic drainage of recurrent breast tumors and may permit the identification of regional metastasis not noted with conventional imaging techniques...
  26. ncbi Epigenetic regulation of cancer stem cell genes in triple-negative breast cancer
    Naofumi Kagara
    Department of Molecular Oncology, John Wayne Cancer Institute, Saint John s Health Center, Santa Monica, CA 90404, USA
    Am J Pathol 181:257-67. 2012
    ..Assessment of epigenetic changes in BCSC genes may provide a more accurate classification of TNBC and could be developed as potential therapeutic targets...
  27. ncbi Quantification of LINE1 in circulating DNA as a molecular biomarker of breast cancer
    Eiji Sunami
    Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, California, USA
    Ann N Y Acad Sci 1137:171-4. 2008
    ..This preliminary study demonstrates the potential clinical utility of LINE1 copy numbers in breast cancer patients...
  28. ncbi Impact of micrometastases in the sentinel node of patients with invasive breast cancer
    Nora M Hansen
    John Wayne Cancer Institute, Santa Monica, CA 90404, USA
    J Clin Oncol 27:4679-84. 2009
    ..This study is based on the new sixth edition of the American Joint Committee on Cancer (AJCC) staging criteria...
  29. ncbi Estrogen receptor and HER2/neu status affect epigenetic differences of tumor-related genes in primary breast tumors
    Eiji Sunami
    Department of Molecular Oncology, The John Wayne Cancer Institute, Saint John s Health Center, Santa Monica Blvd, Santa Monica, California 90404, USA
    Breast Cancer Res 10:R46. 2008
    ....
  30. ncbi Tumor characteristics predictive of sentinel node metastases in 105 consecutive patients with invasive lobular carcinoma
    Baiba J Grube
    Joyce Eisenberg Keefer Breast Center, John Wayne Cancer Institute, Saint John's Health Center, Santa Monica, CA 90404, USA
    Am J Surg 184:372-6. 2002
    ..CONCLUSIONS: SN staging for ILC is feasible and accurate. Receptor status and proliferative indices are not useful markers for metastases. However, large tumor size and presence of angiolymphatic invasion are positive predictors...
  31. ncbi Sentinel node mapping for breast cancer: progress to date and prospects for the future
    Helen Mabry
    John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
    Surg Oncol Clin N Am 16:55-70. 2007
    ..SNB has become the new standard of care for the treatment of early breast cancer...
  32. ncbi Long-term morbidity of sentinel node biopsy versus complete axillary dissection for unilateral breast cancer
    Rebecca Crane-Okada
    Department of Surgical Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA, USA
    Ann Surg Oncol 15:1996-2005. 2008
    ..The purpose of this study was to compare long-term morbidity after SLNB or ALND and breast-conservation surgery...
  33. ncbi Detection of tumor-specific genetic alterations in bone marrow from early-stage breast cancer patients
    Bret Taback
    Department of Molecular Oncology, Joyce Eisenberg-Keefer Breast Center, John Wayne Cancer Institute, Santa Monica, California 90404, USA
    Cancer Res 63:1884-7. 2003
    ....
  34. ncbi Underuse of axillary dissection for the management of sentinel node micrometastases in breast cancer
    Nabil Wasif
    John Wayne Cancer Institute at Saint John s Health Center, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
    Arch Surg 145:161-6. 2010
    ..Current American Society of Clinical Oncology guidelines for management of sentinel node micrometastases (SNMM) in breast cancer recommend axillary lymph node dissection (ALND) for all patients...
  35. ncbi Manipulation of the primary breast tumor and the incidence of sentinel node metastases from invasive breast cancer
    Nora M Hansen
    Joyce Eisenberg Keefer Breast Center, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, Calif, USA
    Arch Surg 139:634-9; discussion 639-40. 2004
    ..The incidence of sentinel node (SN) metastases from invasive breast cancer might be affected by the technique used to obtain biopsy specimens from the primary tumor before sentinel lymph node dissection...
  36. ncbi FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer
    PARTHA S RAY
    Department of Surgical Oncology, John Wayne Cancer Institute, Santa Monica, California 90404, USA
    Cancer Res 70:3870-6. 2010
    ..Our findings identify FOXC1 as a theranostic biomarker that is specific for BLBC, offering not only a potential prognostic candidate but also a potential molecular therapeutic target in this breast cancer subtype...
  37. ncbi Epigenetic analysis of body fluids and tumor tissues: application of a comprehensive molecular assessment for early-stage breast cancer patients
    Bret Taback
    Division of Surgical Oncology, Columbia University Medical Center, New York, New York 10032, USA
    Ann N Y Acad Sci 1075:211-21. 2006
    ..This study demonstrates the novel finding of tumor-associated epigenetic markers in BM aspirates/blood and their potential role as targets for molecular detection...
  38. ncbi Survey of ASCO members on management of sentinel node micrometastases in breast cancer: variation in treatment recommendations according to specialty
    Nabil Wasif
    John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA, USA
    Ann Surg Oncol 16:2442-9. 2009
    ..We hypothesized that variation exists in adherence to these guidelines and management of SNMM as a result of the medical specialty of the treating physician...
  39. ncbi Axillary dissection is not required for all patients with breast cancer and positive sentinel nodes
    J Michael Guenther
    Kaiser Los Angeles Medical Center, Los Angeles, CA, USA
    Arch Surg 138:52-6. 2003
    ..To confirm this observation, we suggest that patients with SN metastases are ideal candidates for trials evaluating the necessity of ALND...
  40. ncbi The florid subtype of lobular carcinoma in situ: marker or precursor for invasive lobular carcinoma?
    Sanjay P Bagaria
    Department of Surgical Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA, USA
    Ann Surg Oncol 18:1845-51. 2011
    ..Since DCIS is considered a precursor to invasive ductal carcinoma, should F-LCIS be considered a precursor to invasive lobular carcinoma (ILC)?..
  41. ncbi MRI versus ultrasonography and mammography for preoperative assessment of breast cancer
    Nabil Wasif
    John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, California 90404, USA
    Am Surg 75:970-5. 2009
    ..We conclude that MRI is more accurate than either ultrasonography or mammography for assessment of the size of primary breast cancer presenting as a mass...
  42. ncbi N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing
    Hongtao Wang
    Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Mol Cancer Ther 7:2967-76. 2008
    ..These studies suggest that enhanced clinical efficacy of 4-HPR may be realized through regimens containing agents that modulate sphingoid base metabolism...
  43. ncbi Nonsentinel node metastases in breast cancer patients with isolated tumor cells in the sentinel node: implications for completion axillary node dissection
    Kristine E Calhoun
    The Joyce Eisenberg Keefer Breast Center, John Wayne Cancer Institute at Saint John's Health Center, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
    Am J Surg 190:588-91. 2005
    ..3% had micrometastases. When ALND was not performed, axillary recurrence was not seen. The low risk of non-SLN disease in this study fails to support the routine use of ALND for ITC-positive SLNs...
  44. ncbi The prognostic significance of micrometastases in breast cancer: a SEER population-based analysis
    Steven L Chen
    Joyce Eisenberg Keefer Breast Center, John Wayne Cancer Institute, Saint John s Health Center, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
    Ann Surg Oncol 14:3378-84. 2007
    ..We hypothesized that the survival of patients with solely micrometastatic disease (N1mi) would be intermediate to patients with 1-3 tumor-positive lymph nodes (N1) and those with no positive lymph nodes (N0)...
  45. ncbi Overexpression of glucosylceramide synthase and P-glycoprotein in cancer cells selected for resistance to natural product chemotherapy
    Valerie Gouaze
    John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, California 90404, USA
    Mol Cancer Ther 3:633-9. 2004
    ..A possible connection between glucosylceramide synthase and P-gp in drug resistance biology is suggested...
  46. ncbi Direct serum assay for microRNA-21 concentrations in early and advanced breast cancer
    Sota Asaga
    Department of Molecular Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA 90404, USA
    Clin Chem 57:84-91. 2011
    ..We hypothesized that serum concentrations of miR-21, a biomarker increased in breast tumors, would correlate with the presence and extent of breast cancer...
  47. ncbi What is the value of axillary dissection or sentinel node biopsy in patients with ductal carcinoma in situ?
    Helen Mabry
    Joyce Eisenberg Keefer Breast Center, John Wayne Cancer Institute, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
    Am J Surg 192:455-7. 2006
    ..Some surgeons have advocated sentinel node biopsy (SNB) for ductal carcinoma in situ (DCIS). The value of the information obtained is not clear...
  48. ncbi Society of Surgical Oncology: position statement on prophylactic mastectomy. Approved by the Society of Surgical Oncology Executive Council, March 2007
    Armando E Giuliano
    John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
    Ann Surg Oncol 14:2425-7. 2007
  49. ncbi Sentinel lymph node biopsy for papillary thyroid cancer: 12 years of experience at a single institution
    Deborah K Cunningham
    Department of Surgical Oncology, John Wayne Cancer Institute, Saint John s Health Center, Santa Monica, CA, USA
    Ann Surg Oncol 17:2970-5. 2010
    ....
  50. ncbi Surgical delay of the nipple-areolar complex: a powerful technique to maximize nipple viability following nipple-sparing mastectomy
    J Arthur Jensen
    Division of Plastic Surgery, Geffen School of Medicine at U C L A, Los Angeles, CA, USA
    Ann Surg Oncol 19:3171-6. 2012
    ..We used a surgical delay procedure to improve nipple viability in patients who were identified to be at high risk for nipple necrosis following NSM...
  51. ncbi Primary tumor classification according to methylation pattern is prognostic in patients with early stage ER-negative breast cancer
    Anneke Q van Hoesel
    Department of Molecular Oncology, John Wayne Cancer Institute JWCI at St John s Health Center, 2200 Santa Monica Boulevard, Santa Monica, CA, 90404, USA
    Breast Cancer Res Treat 131:859-69. 2012
    ..0, P = 0.003). Methylation classification of primary breast cancer is an independent prognostic factor for disease outcome in patients with ER-negative tumors. The study's findings will have to be confirmed in an independent dataset...
  52. ncbi A novel automated assay for the rapid identification of metastatic breast carcinoma in sentinel lymph nodes
    Sheldon Feldman
    Department of Surgery, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Cancer 117:2599-607. 2011
    ....
  53. ncbi B7-h3 ligand expression by primary breast cancer and associated with regional nodal metastasis
    Takaaki Arigami
    Department of Molecular Oncology, John Wayne Cancer Institute, Saint John s Health Center, Santa Monica, CA, USA
    Ann Surg 252:1044-51. 2010
    ..We hypothesized that B7-H3, a coinhibitory factor, is expressed by primary breast cancer cells and associated with metastasis to regional tumor-draining lymph nodes...
  54. ncbi Nipple-sparing mastectomy in 99 patients with a mean follow-up of 5 years
    J Arthur Jensen
    Department of Surgical Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA, USA
    Ann Surg Oncol 18:1665-70. 2011
    ..The safety and practicality of nipple-sparing mastectomy (NSM) are controversial...
  55. ncbi Sentinel node in the era of neoadjuvant therapy and locally advanced breast cancer
    Steven D Trocha
    Joyce Eisenberg Keefer Breast Center, John Wayne Cancer Institute at Saint John s Health Center, 2200 Santa Monica Blvd Suite, 113, Santa Monica, CA, 90404, USA
    Surg Oncol 12:271-6. 2003
    ....
  56. ncbi Nodal stage classification for breast carcinoma: improving interobserver reproducibility through standardized histologic criteria and image-based training
    Roderick R Turner
    Department of Pathology, Saint John s Health Center, 1328 Twenty Second St, Santa Monica, CA 90404, USA
    J Clin Oncol 26:258-63. 2008
    ..We sought to determine whether a set of clearly defined histologic criteria could lead to reproducible nodal classification by pathologists...
  57. ncbi Metabolism of short-chain ceramide by human cancer cells--implications for therapeutic approaches
    Jacqueline V Chapman
    John Wayne Cancer Institute at Saint John s Health Center, Department of Experimental Therapeutics, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
    Biochem Pharmacol 80:308-15. 2010
    ..We propose that use of tamoxifen and other P-glycoprotein antagonists can be an effective means for enhancing cytotoxic potential of short-chain ceramides in the treatment of cancer...
  58. ncbi Sentinel lymph node mapping for primary breast cancer
    Lori L Wilson
    Joyce Eisenberg Keefer Breast Center, John Wayne Cancer Institute at St. John's Health Center, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
    Curr Oncol Rep 7:12-7. 2005
    ..We address the current status and future directions of SLND for primary breast cancer...
  59. ncbi Aberrant hypermethylation of ID4 gene promoter region increases risk of lymph node metastasis in T1 breast cancer
    Naoyuki Umetani
    Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, CA 90404, USA
    Oncogene 24:4721-7. 2005
    ..ID4 mRNA level was suppressed in hypermethylated cancer specimens (P=0.014). ID4 may play an important suppressive role in tumor progression, and its silencing by hypermethylation may increase the risk of regional lymph node metastasis...
  60. ncbi Sentinel lymph node dissection and the current status of American trials on breast lymphatic mapping
    Katherine E Posther
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Semin Oncol 31:426-36. 2004
    ..Surgeon participation is crucial to the ongoing success of clinical trials in the field of breast cancer surgery...
  61. ncbi Comparison of outcomes of breast conserving therapy in multifocal and unifocal invasive breast cancer
    Alice P Chung
    Department of Surgery, Division of Surgical Oncology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Am Coll Surg 215:137-46; discussion 146-7. 2012
    ..There is controversy about whether breast conserving therapy (BCT) should be contraindicated in multifocal (MF) breast cancer. Few studies have reported on the oncologic safety of BCT in MF breast cancer...
  62. ncbi Preoperative breast MRI in the surgical treatment of ductal carcinoma in situ
    Luisa C Kropcho
    Departments of Surgical Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA, USA
    Breast J 18:151-6. 2012
    ..In this study, MRI did not improve the surgeon's ability to achieve clear margins following BCS...
  63. ncbi Local and regional control in breast cancer: role of sentinel node biopsy
    Armando E Giuliano
    Margie and Robert E Petersen Breast Cancer Research Program, John Wayne Cancer Institute at Saint John s Health Center, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
    Adv Surg 45:101-16. 2011
    ....
  64. ncbi Stanniocalcin-1: a novel molecular blood and bone marrow marker for human breast cancer
    Robert A Wascher
    Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, California 90404, USA
    Clin Cancer Res 9:1427-35. 2003
    ..CONCLUSIONS: STC-1 is proposed as a novel, specific, and clinically useful molecular marker for detecting occult breast cancer cells in the BM and blood...
  65. ncbi The effects of adjuvant chemotherapy on bone density in postmenopausal women with early breast cancer
    Nancy C Greep
    Department of Skeletal Health, The John Wayne Cancer Institute at Saint John's Hospital, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
    Am J Med 114:653-9. 2003
    ..Whether this effect is caused by adjuvant chemotherapy remains to be determined...
  66. ncbi Skin-sparing mastectomy. specialty bias and worldwide lack of consensus
    Richard J Bleicher
    John Wayne Cancer Institute, Saint John's Hospital and Health Center, Santa Monica, California 90404, USA
    Cancer 98:2316-21. 2003
    ..Although these results were indicative of only those responding, education about SSM is needed across specialties and in other countries if the procedure is to be widely accepted...
  67. ncbi Senior peer counseling by telephone for psychosocial support after breast cancer surgery: effects at six months
    Rebecca Crane-Okada
    John Wayne Cancer Institute, Saint John s Health Center, Santa Monica, CA, USA
    Oncol Nurs Forum 39:78-89. 2012
    ..To evaluate the efficacy of senior peer counseling by telephone for supplemental psychosocial support of older women after breast cancer surgery...
  68. ncbi Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells
    Yong Yu Liu
    John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA, USA
    J Lipid Res 45:933-40. 2004
    ..This study demonstrates that a 20-mer asGCS oligonucleotide effectively reverses MDR in human cancer cells...
  69. ncbi The selective use of sentinel node biopsy in ductal carcinoma in situ
    Richard J Bleicher
    John Wayne Cancer Institute, Santa Monica, CA 90404, USA
    Arch Surg 138:489. 2003
  70. ncbi Weight of normal parathyroid glands in patients with parathyroid adenomas
    Kathy Yao
    Department of Breast and Endocrine Disease, John Wayne Cancer Institute at Saint John's Health Center, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
    J Clin Endocrinol Metab 89:3208-13. 2004
    ..Therefore, certain histological features are a better measure than weight in determining whether a gland is normal, and intraoperative identification of slightly enlarged glands should not lead to immediate subtotal parathyroidectomy...
  71. ncbi The utility of estrogen receptor, progesterone receptor, and Her-2/neu status to predict survival in patients undergoing hepatic resection for breast cancer metastases
    Steve R Martinez
    Department of Surgical Oncology, Division of Gastrointestinal Surgery, John Wayne Cancer Institute, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
    Am J Surg 191:281-3. 2006
    ..Hepatic metastases from breast cancer signal a dismal prognosis, with a median survival of 9.5 months...
  72. ncbi Molecular lymphatic mapping of the sentinel lymph node
    Bret Taback
    Department of Molecular Oncology, John Wayne Cancer Institute, Saint John's Health Center, Santa Monica, California 90404, USA
    Am J Pathol 161:1153-61. 2002
    ..MLM in conjunction with a conventional mapping agent can be used as a valuable asset for molecular assessment of the SLN and retrospective analysis of paraffin-embedded specimens...
  73. ncbi The time has come to change the algorithm for the surgical management of early breast cancer
    Nora M Hansen
    Joyce Eisenberg Keefer Breast Center, John Wayne Cancer Institute at St John s Health Center, Santa Monica, CA 90404, USA
    Arch Surg 137:1131-5. 2002
    ..If the sentinel lymph nodes (SNs) draining a primary invasive breast cancer are free of tumor, then axillary lymph node dissection is not necessary for management of disease...