Armando E Giuliano

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. doi request reprint Should ACOSOG Z0011 change practice with respect to axillary lymph node dissection for a positive sentinel lymph node biopsy in breast cancer?
    Armando E Giuliano
    Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Clin Exp Metastasis 29:687-92. 2012
  2. doi request reprint Association of occult metastases in sentinel lymph nodes and bone marrow with survival among women with early-stage invasive breast cancer
    Armando E Giuliano
    Division of Surgical Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, California, USA
    JAMA 306:385-93. 2011
  3. doi request reprint Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial
    Armando E Giuliano
    John Wayne Cancer Institute at Saint John s Health Center, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
    JAMA 305:569-75. 2011
  4. pmc Adherence to the National Quality Forum (NQF) breast cancer measures within cancer clinical trials: a review from ACOSOG Z0010
    Lee G Wilke
    Department of Surgery, Duke University Medical Center, Durham, NC, USA
    Ann Surg Oncol 17:1989-94. 2010
  5. ncbi request reprint Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs
    Valerie Gouaze
    John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, California 90404, USA
    Cancer Res 65:3861-7. 2005
  6. doi request reprint Locoregional recurrence after sentinel lymph node dissection with or without axillary dissection in patients with sentinel lymph node metastases: the American College of Surgeons Oncology Group Z0011 randomized trial
    Armando E Giuliano
    John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA 90404, USA
    Ann Surg 252:426-32; discussion 432-3. 2010
  7. ncbi request reprint Detection of circulating tumor cells in early-stage breast cancer metastasis to axillary lymph nodes
    Taku Nakagawa
    Department of Molecular Oncology, John Wayne Cancer Institute, Saint John s Health Center, Santa Monica, California 90404, USA
    Clin Cancer Res 13:4105-10. 2007
  8. doi request reprint Hypomethylation of LINE-1 in primary tumor has poor prognosis in young breast cancer patients: a retrospective cohort study
    Anneke Q van Hoesel
    Department of Molecular Oncology, John Wayne Cancer Institute JWCI at St John s Health Center, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
    Breast Cancer Res Treat 134:1103-14. 2012
  9. pmc Sentinel node skills verification and surgeon performance: data from a multicenter clinical trial for early-stage breast cancer
    Katherine E Posther
    Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    Ann Surg 242:593-9; discussion 599-602. 2005
  10. doi request reprint Impact of immediate versus delayed axillary node dissection on surgical outcomes in breast cancer patients with positive sentinel nodes: results from American College of Surgeons Oncology Group Trials Z0010 and Z0011
    John A Olson
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 26:3530-5. 2008

Detail Information

Publications75

  1. doi request reprint Should ACOSOG Z0011 change practice with respect to axillary lymph node dissection for a positive sentinel lymph node biopsy in breast cancer?
    Armando E Giuliano
    Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Clin Exp Metastasis 29:687-92. 2012
    ..SLNR has its role in the management of early stage breast cancer, but whether SLNR alone should replace ALND is yet to be determined...
  2. doi request reprint Association of occult metastases in sentinel lymph nodes and bone marrow with survival among women with early-stage invasive breast cancer
    Armando E Giuliano
    Division of Surgical Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, California, USA
    JAMA 306:385-93. 2011
    ..Immunochemical staining of sentinel lymph nodes (SLNs) and bone marrow identifies breast cancer metastases not seen with routine pathological or clinical examination...
  3. doi request reprint Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: a randomized clinical trial
    Armando E Giuliano
    John Wayne Cancer Institute at Saint John s Health Center, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
    JAMA 305:569-75. 2011
    ..Sentinel lymph node dissection (SLND) accurately identifies nodal metastasis of early breast cancer, but it is not clear whether further nodal dissection affects survival...
  4. pmc Adherence to the National Quality Forum (NQF) breast cancer measures within cancer clinical trials: a review from ACOSOG Z0010
    Lee G Wilke
    Department of Surgery, Duke University Medical Center, Durham, NC, USA
    Ann Surg Oncol 17:1989-94. 2010
    ..We proposed to study the degree of adherence with these measures among participating institutions in a multi-institutional trial...
  5. ncbi request reprint Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs
    Valerie Gouaze
    John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, California 90404, USA
    Cancer Res 65:3861-7. 2005
    ..The data suggest that lipids play a role in the expression of multidrug resistance...
  6. doi request reprint Locoregional recurrence after sentinel lymph node dissection with or without axillary dissection in patients with sentinel lymph node metastases: the American College of Surgeons Oncology Group Z0011 randomized trial
    Armando E Giuliano
    John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA 90404, USA
    Ann Surg 252:426-32; discussion 432-3. 2010
    ..Few studies have examined the outcome of patients who do not undergo ALND for positive SNs. We now report local and regional recurrence information from the American College of Surgeons Oncology Group Z0011 trial...
  7. ncbi request reprint Detection of circulating tumor cells in early-stage breast cancer metastasis to axillary lymph nodes
    Taku Nakagawa
    Department of Molecular Oncology, John Wayne Cancer Institute, Saint John s Health Center, Santa Monica, California 90404, USA
    Clin Cancer Res 13:4105-10. 2007
    ....
  8. doi request reprint Hypomethylation of LINE-1 in primary tumor has poor prognosis in young breast cancer patients: a retrospective cohort study
    Anneke Q van Hoesel
    Department of Molecular Oncology, John Wayne Cancer Institute JWCI at St John s Health Center, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
    Breast Cancer Res Treat 134:1103-14. 2012
    ..LINE-1 analysis of primary breast cancer demonstrated cancer-related age-dependent hypomethylation. In patients ≤55 years, LINE-1 hypomethylation portends a high-risk of DR...
  9. pmc Sentinel node skills verification and surgeon performance: data from a multicenter clinical trial for early-stage breast cancer
    Katherine E Posther
    Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    Ann Surg 242:593-9; discussion 599-602. 2005
    ..Based on previous reports and expert opinion, we predicted that 20 to 30 cases of SLND with axillary lymph node dissection (ALND) would enable surgeons to identify sentinel lymph nodes (SLN)...
  10. doi request reprint Impact of immediate versus delayed axillary node dissection on surgical outcomes in breast cancer patients with positive sentinel nodes: results from American College of Surgeons Oncology Group Trials Z0010 and Z0011
    John A Olson
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    J Clin Oncol 26:3530-5. 2008
    ..The impact of the timing of cALND on pathologic results and complications in these patients has not been examined...
  11. ncbi request reprint Patterns of participation and successful patient recruitment to American College of Surgeons Oncology Group Z0010, a phase II trial for patients with early-stage breast cancer
    A Marilyn Leitch
    Department of Surgery, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9155, USA
    Am J Surg 190:539-42. 2005
    ..This report elucidates factors influencing patient accrual...
  12. ncbi request reprint The current role of sentinel node biopsy in the treatment of breast cancer
    Baiba J Grube
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas, USA
    Adv Surg 38:121-66. 2004
  13. ncbi request reprint Proteomic profiling of primary breast cancer predicts axillary lymph node metastasis
    Taku Nakagawa
    Department of Molecular Oncology, Division of Biostatistics, and Joyce Eisenberg Keefer Breast Center, John Wayne Cancer Institute, Santa Monica, CA 90404, USA
    Cancer Res 66:11825-30. 2006
    ..016 and 0.0083, respectively). ProteinChip array analysis identified differential protein peaks in primary breast cancers that predict the presence and number of ALN metastases and non-SLN status...
  14. ncbi request reprint Distinct hypermethylation profile of primary breast cancer is associated with sentinel lymph node metastasis
    Masaru Shinozaki
    Department of Molecular Oncology, John Wayne Cancer Institute and St John s Health Center, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
    Clin Cancer Res 11:2156-62. 2005
    ..Gene promoter region hypermethylation is a significant event in primary breast cancer. However, its impact on tumor progression and potential predictive implications remain relatively unknown...
  15. doi request reprint Prognostic value of basal phenotype in HER2-overexpressing breast cancer
    Sanjay P Bagaria
    Department of Surgical Oncology, John Wayne Cancer Institute, Santa Monica, CA, USA
    Ann Surg Oncol 19:935-40. 2012
    ..We investigated the clinical relevance of this basal-HER2+ subtype within HER2-overexpressing breast tumors...
  16. ncbi request reprint Hypermethylation of adenosine triphosphate-binding cassette transporter genes in primary hyperparathyroidism and its effect on sestamibi imaging
    Hiroya Takeuchi
    Department of Molecular Oncology, John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
    J Clin Endocrinol Metab 92:1785-90. 2007
    ....
  17. ncbi request reprint Preliminary results: double lumpectomies for multicentric breast carcinoma
    Nimmi S Kapoor
    John Wayne Cancer Institute, Santa Monica, California, USA
    Am Surg 78:1345-8. 2012
    ..This small series suggests that "double lumpectomy" may be considered for multicentric invasive breast carcinoma in carefully selected patients with favorable tumors who desire breast conservation...
  18. ncbi request reprint Outcomes for women with ductal carcinoma-in-situ and a positive sentinel node: a multi-institutional audit
    Katrina H Moore
    Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, MRI 1026, New York, NY 10021, USA
    Ann Surg Oncol 14:2911-7. 2007
    ..Although it is well established that nodal status for invasive disease is prognostically important, the clinical relevance of a positive SLN in patients with DCIS remains undetermined...
  19. doi request reprint Basal-like breast cancer defined by FOXC1 expression offers superior prognostic value: a retrospective immunohistochemical study
    PARTHA S RAY
    Department of Surgical Oncology, John Wayne Cancer Institute, Santa Monica, CA, USA
    Ann Surg Oncol 18:3839-47. 2011
    ..We investigated the prognostic value of FOXC1 protein expression in invasive breast cancer and compared its prognostic significance to that of TNP and basal CKs...
  20. pmc Lymphatic mapping establishes the role of BRAF gene mutation in papillary thyroid carcinoma
    Joseph Kim
    Department of Molecular Oncology, John Wayne Cancer Institute at Saint Johns Hospital, Santa Monica, CA 90404, USA
    Ann Surg 244:799-804. 2006
    ..To define the role of BRAF gene mutation in the progression of papillary thyroid carcinoma...
  21. doi request reprint Invasive lobular vs. ductal breast cancer: a stage-matched comparison of outcomes
    Nabil Wasif
    John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA, USA
    Ann Surg Oncol 17:1862-9. 2010
    ..Does delayed diagnosis of ILC affect survival? We used a national registry to compare outcomes of patients with stage-matched ILC and IDC...
  22. pmc Ceramide and glucosylceramide upregulate expression of the multidrug resistance gene MDR1 in cancer cells
    Valerie Gouaze-Andersson
    John Wayne Cancer Institute at Saint John s Health Center, Department of Experimental Therapeutics, Santa Monica, CA 90404, USA
    Biochim Biophys Acta 1771:1407-17. 2007
    ..Therefore, ceramide's role as a messenger of cytotoxic response might be linked to the multidrug resistance pathway...
  23. ncbi request reprint An update on prognosis in breast cancer patients with extensive axillary disease
    Francesca Hoehne
    Joyce Eisenberg Keefer Breast Center, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, California 90404, USA
    Breast J 14:76-80. 2008
    ..14 (95% confidence interval: 0.04-0.46). In our study, patients with at least 10 positive axillary LN had a 5-year survival of 71.9% which may be due to the improvements in local and systemic therapy...
  24. ncbi request reprint Prediction of breast tumor progression by integrity of free circulating DNA in serum
    Naoyuki Umetani
    Department of Molecular Oncology and the Joyce Eisenberg Breast Center, John Wayne Cancer Institute, Santa Monica, CA 90404, USA
    J Clin Oncol 24:4270-6. 2006
    ..Serum DNA integrity, the ratio of longer fragments to total DNA, may be clinically useful for detecting breast cancer progression...
  25. doi request reprint Epigenetic regulation of cancer stem cell genes in triple-negative breast cancer
    Naofumi Kagara
    Department of Molecular Oncology, John Wayne Cancer Institute, Saint John s Health Center, Santa Monica, CA 90404, USA
    Am J Pathol 181:257-67. 2012
    ..Assessment of epigenetic changes in BCSC genes may provide a more accurate classification of TNBC and could be developed as potential therapeutic targets...
  26. ncbi request reprint Sentinel lymph node biopsy for local recurrence of breast cancer after breast-conserving therapy
    Bret Taback
    Division of Surgical Oncology, Columbia University Medical Center, 177 Fort Washington Avenue, New York, New York 10032, USA
    Ann Surg Oncol 13:1099-104. 2006
    ....
  27. ncbi request reprint Surgical complications associated with sentinel lymph node biopsy: results from a prospective international cooperative group trial
    Lee Gravatt Wilke
    Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA
    Ann Surg Oncol 13:491-500. 2006
    ..Surgical complications associated with the sentinel lymph node biopsy surgical procedure are reported...
  28. pmc Estrogen receptor and HER2/neu status affect epigenetic differences of tumor-related genes in primary breast tumors
    Eiji Sunami
    Department of Molecular Oncology, The John Wayne Cancer Institute, Saint John s Health Center, Santa Monica Blvd, Santa Monica, California 90404, USA
    Breast Cancer Res 10:R46. 2008
    ....
  29. doi request reprint Quantification of LINE1 in circulating DNA as a molecular biomarker of breast cancer
    Eiji Sunami
    Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, California, USA
    Ann N Y Acad Sci 1137:171-4. 2008
    ..This preliminary study demonstrates the potential clinical utility of LINE1 copy numbers in breast cancer patients...
  30. doi request reprint Impact of micrometastases in the sentinel node of patients with invasive breast cancer
    Nora M Hansen
    John Wayne Cancer Institute, Santa Monica, CA 90404, USA
    J Clin Oncol 27:4679-84. 2009
    ..This study is based on the new sixth edition of the American Joint Committee on Cancer (AJCC) staging criteria...
  31. ncbi request reprint Tumor characteristics predictive of sentinel node metastases in 105 consecutive patients with invasive lobular carcinoma
    Baiba J Grube
    Joyce Eisenberg Keefer Breast Center, John Wayne Cancer Institute, Saint John s Health Center, Santa Monica, CA 90404, USA
    Am J Surg 184:372-6. 2002
    ..Identification of nodal metastases in invasive lobular carcinoma (ILC) is difficult. Sentinel node (SN) biopsy offers a potential advantage. This study reports the feasibility of SN identification and predictors of SN metastases for ILC...
  32. ncbi request reprint Sentinel node mapping for breast cancer: progress to date and prospects for the future
    Helen Mabry
    John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
    Surg Oncol Clin N Am 16:55-70. 2007
    ..SNB has become the new standard of care for the treatment of early breast cancer...
  33. ncbi request reprint Manipulation of the primary breast tumor and the incidence of sentinel node metastases from invasive breast cancer
    Nora M Hansen
    Joyce Eisenberg Keefer Breast Center, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, Calif, USA
    Arch Surg 139:634-9; discussion 639-40. 2004
    ..The incidence of sentinel node (SN) metastases from invasive breast cancer might be affected by the technique used to obtain biopsy specimens from the primary tumor before sentinel lymph node dissection...
  34. doi request reprint Survey of ASCO members on management of sentinel node micrometastases in breast cancer: variation in treatment recommendations according to specialty
    Nabil Wasif
    John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA, USA
    Ann Surg Oncol 16:2442-9. 2009
    ..We hypothesized that variation exists in adherence to these guidelines and management of SNMM as a result of the medical specialty of the treating physician...
  35. doi request reprint FOXC1 is a potential prognostic biomarker with functional significance in basal-like breast cancer
    PARTHA S RAY
    Department of Surgical Oncology, John Wayne Cancer Institute, Santa Monica, California 90404, USA
    Cancer Res 70:3870-6. 2010
    ..Our findings identify FOXC1 as a theranostic biomarker that is specific for BLBC, offering not only a potential prognostic candidate but also a potential molecular therapeutic target in this breast cancer subtype...
  36. doi request reprint Long-term morbidity of sentinel node biopsy versus complete axillary dissection for unilateral breast cancer
    Rebecca Crane-Okada
    Department of Surgical Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA, USA
    Ann Surg Oncol 15:1996-2005. 2008
    ..The purpose of this study was to compare long-term morbidity after SLNB or ALND and breast-conservation surgery...
  37. doi request reprint Underuse of axillary dissection for the management of sentinel node micrometastases in breast cancer
    Nabil Wasif
    John Wayne Cancer Institute at Saint John s Health Center, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
    Arch Surg 145:161-6. 2010
    ..Current American Society of Clinical Oncology guidelines for management of sentinel node micrometastases (SNMM) in breast cancer recommend axillary lymph node dissection (ALND) for all patients...
  38. ncbi request reprint Detection of tumor-specific genetic alterations in bone marrow from early-stage breast cancer patients
    Bret Taback
    Department of Molecular Oncology, Joyce Eisenberg Keefer Breast Center, John Wayne Cancer Institute, Santa Monica, California 90404, USA
    Cancer Res 63:1884-7. 2003
    ....
  39. ncbi request reprint Epigenetic analysis of body fluids and tumor tissues: application of a comprehensive molecular assessment for early-stage breast cancer patients
    Bret Taback
    Division of Surgical Oncology, Columbia University Medical Center, New York, New York 10032, USA
    Ann N Y Acad Sci 1075:211-21. 2006
    ..This study demonstrates the novel finding of tumor-associated epigenetic markers in BM aspirates/blood and their potential role as targets for molecular detection...
  40. doi request reprint Predicting nipple-areolar involvement using preoperative breast MRI and primary tumor characteristics
    Shawn T Steen
    Gonda Goldschmied Research Laboratories of the John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA, USA
    Ann Surg Oncol 20:633-9. 2013
    ..Preoperative assessment of the nipple-areolar complex (NAC) is invaluable when considering nipple-sparing mastectomy. Our hypothesis is that breast magnetic resonance imaging (MRI) may predict involvement of the NAC with tumor...
  41. ncbi request reprint Axillary dissection is not required for all patients with breast cancer and positive sentinel nodes
    J Michael Guenther
    Kaiser Los Angeles Medical Center, Los Angeles, CA, USA
    Arch Surg 138:52-6. 2003
    ..When SN metastasis is present, the value of additional axillary dissection is unclear and not all patients benefit from axillary lymph node dissection (ALND)...
  42. ncbi request reprint MRI versus ultrasonography and mammography for preoperative assessment of breast cancer
    Nabil Wasif
    John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, California 90404, USA
    Am Surg 75:970-5. 2009
    ..We conclude that MRI is more accurate than either ultrasonography or mammography for assessment of the size of primary breast cancer presenting as a mass...
  43. ncbi request reprint The prognostic significance of micrometastases in breast cancer: a SEER population-based analysis
    Steven L Chen
    Joyce Eisenberg Keefer Breast Center, John Wayne Cancer Institute, Saint John s Health Center, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
    Ann Surg Oncol 14:3378-84. 2007
    ..We hypothesized that the survival of patients with solely micrometastatic disease (N1mi) would be intermediate to patients with 1-3 tumor-positive lymph nodes (N1) and those with no positive lymph nodes (N0)...
  44. ncbi request reprint Nonsentinel node metastases in breast cancer patients with isolated tumor cells in the sentinel node: implications for completion axillary node dissection
    Kristine E Calhoun
    The Joyce Eisenberg Keefer Breast Center, John Wayne Cancer Institute at Saint John s Health Center, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
    Am J Surg 190:588-91. 2005
    ..We hypothesized that the number of positive non-SLNs is low and ALND is unnecessary for most patients with ITC...
  45. doi request reprint N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing
    Hongtao Wang
    Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Mol Cancer Ther 7:2967-76. 2008
    ..These studies suggest that enhanced clinical efficacy of 4-HPR may be realized through regimens containing agents that modulate sphingoid base metabolism...
  46. doi request reprint The florid subtype of lobular carcinoma in situ: marker or precursor for invasive lobular carcinoma?
    Sanjay P Bagaria
    Department of Surgical Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA, USA
    Ann Surg Oncol 18:1845-51. 2011
    ..Since DCIS is considered a precursor to invasive ductal carcinoma, should F-LCIS be considered a precursor to invasive lobular carcinoma (ILC)?..
  47. ncbi request reprint Overexpression of glucosylceramide synthase and P-glycoprotein in cancer cells selected for resistance to natural product chemotherapy
    Valerie Gouaze
    John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, California 90404, USA
    Mol Cancer Ther 3:633-9. 2004
    ..A possible connection between glucosylceramide synthase and P-gp in drug resistance biology is suggested...
  48. doi request reprint Sentinel lymph node biopsy for papillary thyroid cancer: 12 years of experience at a single institution
    Deborah K Cunningham
    Department of Surgical Oncology, John Wayne Cancer Institute, Saint John s Health Center, Santa Monica, CA, USA
    Ann Surg Oncol 17:2970-5. 2010
    ....
  49. ncbi request reprint What is the value of axillary dissection or sentinel node biopsy in patients with ductal carcinoma in situ?
    Helen Mabry
    Joyce Eisenberg Keefer Breast Center, John Wayne Cancer Institute, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
    Am J Surg 192:455-7. 2006
    ..Some surgeons have advocated sentinel node biopsy (SNB) for ductal carcinoma in situ (DCIS). The value of the information obtained is not clear...
  50. doi request reprint Direct serum assay for microRNA-21 concentrations in early and advanced breast cancer
    Sota Asaga
    Department of Molecular Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA 90404, USA
    Clin Chem 57:84-91. 2011
    ..We hypothesized that serum concentrations of miR-21, a biomarker increased in breast tumors, would correlate with the presence and extent of breast cancer...
  51. ncbi request reprint Society of Surgical Oncology: position statement on prophylactic mastectomy. Approved by the Society of Surgical Oncology Executive Council, March 2007
    Armando E Giuliano
    John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
    Ann Surg Oncol 14:2425-7. 2007
  52. doi request reprint Surgical delay of the nipple-areolar complex: a powerful technique to maximize nipple viability following nipple-sparing mastectomy
    J Arthur Jensen
    Division of Plastic Surgery, Geffen School of Medicine at U C L A, Los Angeles, CA, USA
    Ann Surg Oncol 19:3171-6. 2012
    ..We used a surgical delay procedure to improve nipple viability in patients who were identified to be at high risk for nipple necrosis following NSM...
  53. doi request reprint Primary tumor classification according to methylation pattern is prognostic in patients with early stage ER-negative breast cancer
    Anneke Q van Hoesel
    Department of Molecular Oncology, John Wayne Cancer Institute JWCI at St John s Health Center, 2200 Santa Monica Boulevard, Santa Monica, CA, 90404, USA
    Breast Cancer Res Treat 131:859-69. 2012
    ..0, P = 0.003). Methylation classification of primary breast cancer is an independent prognostic factor for disease outcome in patients with ER-negative tumors. The study's findings will have to be confirmed in an independent dataset...
  54. doi request reprint A novel automated assay for the rapid identification of metastatic breast carcinoma in sentinel lymph nodes
    Sheldon Feldman
    Department of Surgery, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Cancer 117:2599-607. 2011
    ....
  55. doi request reprint Nipple-sparing mastectomy in 99 patients with a mean follow-up of 5 years
    J Arthur Jensen
    Department of Surgical Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA, USA
    Ann Surg Oncol 18:1665-70. 2011
    ..The safety and practicality of nipple-sparing mastectomy (NSM) are controversial...
  56. pmc Metabolism of short-chain ceramide by human cancer cells--implications for therapeutic approaches
    Jacqueline V Chapman
    John Wayne Cancer Institute at Saint John s Health Center, Department of Experimental Therapeutics, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
    Biochem Pharmacol 80:308-15. 2010
    ..We propose that use of tamoxifen and other P-glycoprotein antagonists can be an effective means for enhancing cytotoxic potential of short-chain ceramides in the treatment of cancer...
  57. ncbi request reprint Sentinel lymph node mapping for primary breast cancer
    Lori L Wilson
    Joyce Eisenberg Keefer Breast Center, John Wayne Cancer Institute at St John s Health Center, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
    Curr Oncol Rep 7:12-7. 2005
    ..We address the current status and future directions of SLND for primary breast cancer...
  58. ncbi request reprint Sentinel node in the era of neoadjuvant therapy and locally advanced breast cancer
    Steven D Trocha
    Joyce Eisenberg Keefer Breast Center, John Wayne Cancer Institute at Saint John s Health Center, 2200 Santa Monica Blvd Suite, 113, Santa Monica, CA, 90404, USA
    Surg Oncol 12:271-6. 2003
    ....
  59. ncbi request reprint Aberrant hypermethylation of ID4 gene promoter region increases risk of lymph node metastasis in T1 breast cancer
    Naoyuki Umetani
    Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, CA 90404, USA
    Oncogene 24:4721-7. 2005
    ..ID4 mRNA level was suppressed in hypermethylated cancer specimens (P=0.014). ID4 may play an important suppressive role in tumor progression, and its silencing by hypermethylation may increase the risk of regional lymph node metastasis...
  60. doi request reprint B7-h3 ligand expression by primary breast cancer and associated with regional nodal metastasis
    Takaaki Arigami
    Department of Molecular Oncology, John Wayne Cancer Institute, Saint John s Health Center, Santa Monica, CA, USA
    Ann Surg 252:1044-51. 2010
    ..We hypothesized that B7-H3, a coinhibitory factor, is expressed by primary breast cancer cells and associated with metastasis to regional tumor-draining lymph nodes...
  61. doi request reprint Nodal stage classification for breast carcinoma: improving interobserver reproducibility through standardized histologic criteria and image-based training
    Roderick R Turner
    Department of Pathology, Saint John s Health Center, 1328 Twenty Second St, Santa Monica, CA 90404, USA
    J Clin Oncol 26:258-63. 2008
    ..We sought to determine whether a set of clearly defined histologic criteria could lead to reproducible nodal classification by pathologists...
  62. doi request reprint Comparison of outcomes of breast conserving therapy in multifocal and unifocal invasive breast cancer
    Alice P Chung
    Department of Surgery, Division of Surgical Oncology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    J Am Coll Surg 215:137-46; discussion 146-7. 2012
    ..There is controversy about whether breast conserving therapy (BCT) should be contraindicated in multifocal (MF) breast cancer. Few studies have reported on the oncologic safety of BCT in MF breast cancer...
  63. ncbi request reprint Sentinel lymph node dissection and the current status of American trials on breast lymphatic mapping
    Katherine E Posther
    Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Semin Oncol 31:426-36. 2004
    ..Surgeon participation is crucial to the ongoing success of clinical trials in the field of breast cancer surgery...
  64. doi request reprint Preoperative breast MRI in the surgical treatment of ductal carcinoma in situ
    Luisa C Kropcho
    Departments of Surgical Oncology, John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA, USA
    Breast J 18:151-6. 2012
    ..In this study, MRI did not improve the surgeon's ability to achieve clear margins following BCS...
  65. ncbi request reprint Local and regional control in breast cancer: role of sentinel node biopsy
    Armando E Giuliano
    Margie and Robert E Petersen Breast Cancer Research Program, John Wayne Cancer Institute at Saint John s Health Center, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
    Adv Surg 45:101-16. 2011
    ....
  66. ncbi request reprint The effects of adjuvant chemotherapy on bone density in postmenopausal women with early breast cancer
    Nancy C Greep
    Department of Skeletal Health, The John Wayne Cancer Institute at Saint John s Hospital, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
    Am J Med 114:653-9. 2003
    ..Adjuvant chemotherapy for breast cancer can have adverse effects on bone. We investigated the effects of adjuvant chemotherapy on bone mineral density in postmenopausal women with early-stage breast cancer...
  67. ncbi request reprint Skin-sparing mastectomy. specialty bias and worldwide lack of consensus
    Richard J Bleicher
    John Wayne Cancer Institute, Saint John s Hospital and Health Center, Santa Monica, California 90404, USA
    Cancer 98:2316-21. 2003
    ..Skin-sparing mastectomy (SSM) is a variation of modified radical mastectomy (MRM) optimized for reconstruction. The authors attempted to determine SSM attitudes and biases within different specialties and countries throughout the world...
  68. ncbi request reprint Stanniocalcin-1: a novel molecular blood and bone marrow marker for human breast cancer
    Robert A Wascher
    Department of Molecular Oncology, John Wayne Cancer Institute, Santa Monica, California 90404, USA
    Clin Cancer Res 9:1427-35. 2003
    ..We investigated STC-1 mRNA as a potential molecular marker for detection of breast cancer metastasis in the blood and BM...
  69. doi request reprint Senior peer counseling by telephone for psychosocial support after breast cancer surgery: effects at six months
    Rebecca Crane-Okada
    John Wayne Cancer Institute, Saint John s Health Center, Santa Monica, CA, USA
    Oncol Nurs Forum 39:78-89. 2012
    ..To evaluate the efficacy of senior peer counseling by telephone for supplemental psychosocial support of older women after breast cancer surgery...
  70. pmc Molecular lymphatic mapping of the sentinel lymph node
    Bret Taback
    Department of Molecular Oncology, John Wayne Cancer Institute, Saint John s Health Center, Santa Monica, California 90404, USA
    Am J Pathol 161:1153-61. 2002
    ..MLM in conjunction with a conventional mapping agent can be used as a valuable asset for molecular assessment of the SLN and retrospective analysis of paraffin-embedded specimens...
  71. ncbi request reprint The selective use of sentinel node biopsy in ductal carcinoma in situ
    Richard J Bleicher
    John Wayne Cancer Institute, Santa Monica, CA 90404, USA
    Arch Surg 138:489. 2003
  72. ncbi request reprint Weight of normal parathyroid glands in patients with parathyroid adenomas
    Kathy Yao
    Department of Breast and Endocrine Disease, John Wayne Cancer Institute at Saint John s Health Center, 2200 Santa Monica Boulevard, Santa Monica, CA 90404, USA
    J Clin Endocrinol Metab 89:3208-13. 2004
    ..Therefore, certain histological features are a better measure than weight in determining whether a gland is normal, and intraoperative identification of slightly enlarged glands should not lead to immediate subtotal parathyroidectomy...
  73. ncbi request reprint The utility of estrogen receptor, progesterone receptor, and Her-2/neu status to predict survival in patients undergoing hepatic resection for breast cancer metastases
    Steve R Martinez
    Department of Surgical Oncology, Division of Gastrointestinal Surgery, John Wayne Cancer Institute, 2200 Santa Monica Blvd, Santa Monica, CA 90404, USA
    Am J Surg 191:281-3. 2006
    ..Hepatic metastases from breast cancer signal a dismal prognosis, with a median survival of 9.5 months...
  74. ncbi request reprint Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells
    Yong Yu Liu
    John Wayne Cancer Institute at Saint John s Health Center, Santa Monica, CA, USA
    J Lipid Res 45:933-40. 2004
    ..This study demonstrates that a 20-mer asGCS oligonucleotide effectively reverses MDR in human cancer cells...
  75. ncbi request reprint The time has come to change the algorithm for the surgical management of early breast cancer
    Nora M Hansen
    Joyce Eisenberg Keefer Breast Center, John Wayne Cancer Institute at St John s Health Center, Santa Monica, CA 90404, USA
    Arch Surg 137:1131-5. 2002
    ..If the sentinel lymph nodes (SNs) draining a primary invasive breast cancer are free of tumor, then axillary lymph node dissection is not necessary for management of disease...