Benedick A Fraass

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. doi request reprint Impact of complexity and computer control on errors in radiation therapy
    B A Fraass
    Department of Radiation Oncology, Cedars Sinai Medical Center, 8700 Beverly Blvd, AC1085, Los Angeles, CA 90048, USA
    Ann ICRP 41:188-96. 2012
  2. pmc Inverse-optimized 3D conformal planning: minimizing complexity while achieving equivalence with beamlet IMRT in multiple clinical sites
    Benedick A Fraass
    Department of Radiation Oncology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Med Phys 39:3361-74. 2012
  3. doi request reprint Quality, technology and outcomes: evolution and evaluation of new treatments and/or new technology
    Benedick A Fraass
    Department of Radiation Oncology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Semin Radiat Oncol 22:3-10. 2012
  4. ncbi request reprint The influence of beam model differences in the comparison of dose calculation algorithms for lung cancer treatment planning
    Indrin J Chetty
    Department of Radiation Oncology, The University of Michigan, Ann Arbor, MI 48109 0010, USA
    Phys Med Biol 50:801-15. 2005
  5. ncbi request reprint Accounting for center-of-mass target motion using convolution methods in Monte Carlo-based dose calculations of the lung
    Indrin J Chetty
    Department of Radiation Oncology, The University of Michigan, Ann Arbor, Michigan 48109 0010, USA
    Med Phys 31:925-32. 2004
  6. ncbi request reprint Experimental verification of a Monte Carlo-based MLC simulation model for IMRT dose calculation
    Neelam Tyagi
    Department of Radiation Oncology, The University of Michigan, Ann Arbor, Michigan 48109 0010, USA
    Med Phys 34:651-63. 2007
  7. ncbi request reprint Photon beam relative dose validation of the DPM Monte Carlo code in lung-equivalent media
    Indrin J Chetty
    The University of Michigan, Department of Radiation Oncology, Ann Arbor, Michigan 48109 0010, USA
    Med Phys 30:563-73. 2003
  8. ncbi request reprint Reporting and analyzing statistical uncertainties in Monte Carlo-based treatment planning
    Indrin J Chetty
    Department of Radiation Oncology, The University of Michigan, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 65:1249-59. 2006
  9. ncbi request reprint Potential for dose-escalation and reduction of risk in pancreatic cancer using IMRT optimization with lexicographic ordering and gEUD-based cost functions
    Aaron C Spalding
    Department of Radiation Oncology, University of Michigan, Ann Arbor Michigan 48109 0010, USA
    Med Phys 34:521-9. 2007
  10. pmc Evaluation of multiple breathing states using a multiple instance geometry approximation (MIGA) in inverse-planned optimization for locoregional breast treatment
    Alexander Lin
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 72:610-6. 2008

Detail Information

Publications40

  1. doi request reprint Impact of complexity and computer control on errors in radiation therapy
    B A Fraass
    Department of Radiation Oncology, Cedars Sinai Medical Center, 8700 Beverly Blvd, AC1085, Los Angeles, CA 90048, USA
    Ann ICRP 41:188-96. 2012
    ..Clinical implications of these results are discussed, as are some of the ways in which the field should respond to the ongoing concerns about errors and complexity in radiation therapy...
  2. pmc Inverse-optimized 3D conformal planning: minimizing complexity while achieving equivalence with beamlet IMRT in multiple clinical sites
    Benedick A Fraass
    Department of Radiation Oncology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Med Phys 39:3361-74. 2012
    ....
  3. doi request reprint Quality, technology and outcomes: evolution and evaluation of new treatments and/or new technology
    Benedick A Fraass
    Department of Radiation Oncology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Semin Radiat Oncol 22:3-10. 2012
    ..Design of appropriate studies can help us improve patient care while at the same time documenting which new clinical strategies, enabled by new technology, lead to improved patient outcomes...
  4. ncbi request reprint The influence of beam model differences in the comparison of dose calculation algorithms for lung cancer treatment planning
    Indrin J Chetty
    Department of Radiation Oncology, The University of Michigan, Ann Arbor, MI 48109 0010, USA
    Phys Med Biol 50:801-15. 2005
    ..This may ultimately hinder our ability to accurately correlate dose with clinical outcome...
  5. ncbi request reprint Accounting for center-of-mass target motion using convolution methods in Monte Carlo-based dose calculations of the lung
    Indrin J Chetty
    Department of Radiation Oncology, The University of Michigan, Ann Arbor, Michigan 48109 0010, USA
    Med Phys 31:925-32. 2004
    ..This increase is not unexpected considering that the target spends relatively more time at inhale as the asymmetry decreases (note that the treatment plans were generated using the exhale CT scans)...
  6. ncbi request reprint Experimental verification of a Monte Carlo-based MLC simulation model for IMRT dose calculation
    Neelam Tyagi
    Department of Radiation Oncology, The University of Michigan, Ann Arbor, Michigan 48109 0010, USA
    Med Phys 34:651-63. 2007
    ..Various sources of uncertainties in these comparisons are discussed...
  7. ncbi request reprint Photon beam relative dose validation of the DPM Monte Carlo code in lung-equivalent media
    Indrin J Chetty
    The University of Michigan, Department of Radiation Oncology, Ann Arbor, Michigan 48109 0010, USA
    Med Phys 30:563-73. 2003
    ..This work demonstrates that the DPM Monte Carlo code is capable of accurate photon beam dose calculations in situations where lateral electron disequilibrium effects are pronounced...
  8. ncbi request reprint Reporting and analyzing statistical uncertainties in Monte Carlo-based treatment planning
    Indrin J Chetty
    Department of Radiation Oncology, The University of Michigan, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 65:1249-59. 2006
    ..To investigate methods of reporting and analyzing statistical uncertainties in doses to targets and normal tissues in Monte Carlo (MC)-based treatment planning...
  9. ncbi request reprint Potential for dose-escalation and reduction of risk in pancreatic cancer using IMRT optimization with lexicographic ordering and gEUD-based cost functions
    Aaron C Spalding
    Department of Radiation Oncology, University of Michigan, Ann Arbor Michigan 48109 0010, USA
    Med Phys 34:521-9. 2007
    ..We conclude that LO-IMRT with gEUD cost functions could allow dose escalation in pancreas tumors with concomitant reduction in doses to organs at risk as compared with traditional 3DCRT...
  10. pmc Evaluation of multiple breathing states using a multiple instance geometry approximation (MIGA) in inverse-planned optimization for locoregional breast treatment
    Alexander Lin
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 72:610-6. 2008
    ..This study assessed whether optimization based on multiple instance geometry approximation (MIGA) could derive an IMRT plan that is less sensitive to known respiratory motions...
  11. ncbi request reprint Enhanced spectral discrimination through the exploitation of interface effects in photon dose data
    Paule M Charland
    Department of Radiation Oncology, The University of Michigan, Ann Arbor, Michigan 48109, USA
    Med Phys 31:264-76. 2004
    ..Consequently, we suggest that as part of a beam-commissioning methodology, designated electronic disequilibrium test cases be implemented in unambiguously determining the correct energy spectrum to be used...
  12. ncbi request reprint Improving IMRT delivery efficiency using intensity limits during inverse planning
    Martha M Coselmon
    Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Med Phys 32:1234-45. 2005
    ..Constraining the maximum intensity in an inverse IMRT plan is a simple way to improve delivery efficiency without compromising plan objectives...
  13. ncbi request reprint Experimental validation of the DPM Monte Carlo code using minimally scattered electron beams in heterogeneous media
    Indrin J Chetty
    Department of Radiation Oncology, The University of Michigan, Ann Arbor 48109 0010, USA
    Phys Med Biol 47:1837-51. 2002
    ....
  14. pmc Adaptive diffusion smoothing: a diffusion-based method to reduce IMRT field complexity
    Martha M Matuszak
    Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Med Phys 35:1532-46. 2008
    ..In summary, adaptive diffusion smoothing is a promising tool for ensuring that only the necessary amount of beam modulation is used, promoting more efficient and accurate IMRT planning, QA, and delivery...
  15. ncbi request reprint A fluence convolution method to account for respiratory motion in three-dimensional dose calculations of the liver: a Monte Carlo study
    Indrin J Chetty
    Department of Radiation Oncology, The University of Michigan, Ann Arbor, Michigan 48109 0010, USA
    Med Phys 30:1776-80. 2003
    ....
  16. ncbi request reprint Reduction of IMRT beam complexity through the use of beam modulation penalties in the objective function
    Martha M Matuszak
    Department of Radiation Oncology, University of Michigan, Ann Arbor Michigan 48109, USA
    Med Phys 34:507-20. 2007
    ..However, the penalty based upon the plan intensity map variation consistently produced the most delivery-efficient plans with the fewest computations...
  17. ncbi request reprint Multiple fields may offer better esophagus sparing without increased probability of lung toxicity in optimized IMRT of lung tumors
    Olivier Chapet
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 65:255-65. 2006
    ..To evaluate whether increasing numbers of intensity-modulated radiation therapy (IMRT) fields enhance lung-tumor dose without additional predicted toxicity for difficult planning geometries...
  18. ncbi request reprint Lexicographic ordering: intuitive multicriteria optimization for IMRT
    Kyung Wook Jee
    Department of Radiation Oncology, University of Michigan, UH B2C432, Box 0010, 1500 E Medical Ctr Dr, Ann Arbor, MI 48109, USA
    Phys Med Biol 52:1845-61. 2007
    ..This method produces encouraging results for difficult IMRT planning cases in a highly intuitive manner...
  19. pmc Penalization of aperture complexity in inversely planned volumetric modulated arc therapy
    Kelly C Younge
    Department of Radiation Oncology, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Med Phys 39:7160-70. 2012
    ....
  20. ncbi request reprint A dose gradient analysis tool for IMRT QA
    Jean M Moran
    Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0010, USA
    J Appl Clin Med Phys 6:62-73. 2005
    ..The remaining dose differences not explained by the geometric tolerance can then be evaluated graphically (dose difference display) or analytically (dose difference dose-volume histograms)over the entire comparison region...
  21. ncbi request reprint Surface buildup dose dependence on photon field delivery technique for IMRT
    Shigeru Yokoyama
    Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0010, USA
    J Appl Clin Med Phys 5:71-81. 2004
    ..An example IMRT field was also studied to assess variations due to delivery technique (static vs. dynamic) and intensity level. Buildup dose is weakly dependent on the multileaf delivery technique for efficient IMRT fields...
  22. ncbi request reprint Potential gains for irradiation of chest wall and regional nodes with intensity modulated radiotherapy
    Editha A Krueger
    Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    Int J Radiat Oncol Biol Phys 56:1023-37. 2003
    ..To develop an intensity modulated radiotherapy (IMRT) technique for postmastectomy RT that improves target coverage while sparing all appropriate normal tissues...
  23. pmc FusionArc optimization: a hybrid volumetric modulated arc therapy (VMAT) and intensity modulated radiation therapy (IMRT) planning strategy
    Martha M Matuszak
    Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Med Phys 40:071713. 2013
    ....
  24. doi request reprint Contralateral breast dose after whole-breast irradiation: an analysis by treatment technique
    Terence M Williams
    Department of Radiation Oncology, University of Michigan Health System, Ann Arbor, MI, USA
    Int J Radiat Oncol Biol Phys 82:2079-85. 2012
    ..To investigate the contralateral breast dose (CBD) across a continuum of breast-conservation therapy techniques...
  25. ncbi request reprint Performance of a direct-detection active matrix flat panel dosimeter (AMFPD) for IMRT measurements
    Yu Chen
    Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Med Phys 34:4911-22. 2007
    ....
  26. ncbi request reprint Accuracy of rapid radiographic film calibration for intensity-modulated radiation therapy verification
    Ravi Kulasekere
    Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0010, USA
    J Appl Clin Med Phys 7:86-95. 2006
    ..Using a single calibration film exposed at the time of experiment, the total uncertainty of film response was estimated to be <2% (1%) for XV (EDR) film at 50 (100) cGy and higher, respectively...
  27. ncbi request reprint Summary and recommendations of a National Cancer Institute workshop on issues limiting the clinical use of Monte Carlo dose calculation algorithms for megavoltage external beam radiation therapy
    Benedick A Fraass
    Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA
    Med Phys 30:3206-16. 2003
    ..Based on these discussions, the workshop developed recommendations for future NCI-funded research and development efforts. This paper briefly summarizes the issues presented at the workshop and the recommendations developed by the group...
  28. doi request reprint A method for evaluating quality assurance needs in radiation therapy
    M Saiful Huq
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    Int J Radiat Oncol Biol Phys 71:S170-3. 2008
    ..Recommendations on how to apply this new approach to individual clinics and further research and development will also be discussed...
  29. pmc QA issues for computer-controlled treatment delivery: this is not your old R/V system any more!
    Benedick A Fraass
    Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, MI 48109 5010, USA
    Int J Radiat Oncol Biol Phys 71:S98-S102. 2008
    ..The potential for improved quality assurance for computer-controlled delivery is discussed...
  30. ncbi request reprint An Active Matrix Flat Panel Dosimeter (AMFPD) for in-phantom dosimetric measurements
    Jean M Moran
    Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109 0010, USA
    Med Phys 32:466-72. 2005
    ..The device also compares well to film for 2-D planar dose distributions. It is expected that the AMFPD system will be useful for beam commissioning, algorithm verification test data, and routine IMRT quality assurance dosimetry...
  31. ncbi request reprint Esophagus sparing with IMRT in lung tumor irradiation: an EUD-based optimization technique
    Olivier Chapet
    University of Michigan, Department of Radiation Oncology, Ann Arbor, MI 48109 0010, USA
    Int J Radiat Oncol Biol Phys 63:179-87. 2005
    ....
  32. pmc Use of plan quality degradation to evaluate tradeoffs in delivery efficiency and clinical plan metrics arising from IMRT optimizer and sequencer compromises
    Joel R Wilkie
    Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Med Phys 40:071708. 2013
    ....
  33. pmc Practice-based evidence to evidence-based practice: building the National Radiation Oncology Registry
    Jason A Efstathiou
    Massachusetts General Hospital, Department of Radiation Oncology, Boston, MA 02114 2606, USA
    J Oncol Pract 9:e90-5. 2013
    ..The NROR pilot study will provide the framework for expansion to a nationwide electronic registry for radiation oncology. ..
  34. ncbi request reprint Benchmarking of the dose planning method (DPM) Monte Carlo code using electron beams from a racetrack microtron
    Indrin J Chetty
    The University of Michigan, Department of Radiation Oncology, Ann Arbor 48109 0010, USA
    Med Phys 29:1035-41. 2002
    ..The accuracy of the DPM code illustrated in this work suggests that DPM may be used as a valuable tool for electron beam dose calculations...
  35. doi request reprint Errors in radiotherapy: motivation for development of new radiotherapy quality assurance paradigms
    Benedick A Fraass
    Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, MI 48109 5010, USA
    Int J Radiat Oncol Biol Phys 71:S162-5. 2008
    ....
  36. ncbi request reprint Incorporation of realistic delivery limitations into dynamic MLC treatment delivery
    Dale W Litzenberg
    Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor 48109 0010, USA
    Med Phys 29:810-20. 2002
    ....
  37. ncbi request reprint Clinical aspects of intensity-modulated radiotherapy in the treatment of breast cancer
    Editha A Krueger
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA
    Semin Radiat Oncol 12:250-9. 2002
    ..Furthermore, IMRT may be able to reduce doses delivered to the heart and lungs, and may potentially minimize further the probability of complications from radiotherapy...
  38. ncbi request reprint Dosimetric comparison of extended dose range film with ionization measurements in water and lung equivalent heterogeneous media exposed to megavoltage photons
    Paule M Charland
    Department of Radiation Oncology, The University of Michigan, Ann Arbor, Michigan 48109 0010, USA
    J Appl Clin Med Phys 4:25-39. 2003
    ..From this investigation EDR film appears to be a useful medium for relative dosimetry in higher dose ranges in both water and lung equivalent material for moderate field sizes and depths...
  39. doi request reprint Safety considerations for IMRT: executive summary
    Jean M Moran
    Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 5010, USA
    Med Phys 38:5067-72. 2011
    ....
  40. ncbi request reprint Verification of dynamic and segmental IMRT delivery by dynamic log file analysis
    Dale W Litzenberg
    Department of Radiation Oncology, University of Michigan Medical Center, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 0010, USA
    J Appl Clin Med Phys 3:63-72. 2002
    ..This program is part of a semi-automated quality assurance (QA) system for pretreatment fluence verification and daily treatment verification of dynamic multileaf collimation (DMLC) delivery...