Research Topics
| Benedick A FraassSummaryAffiliation: Cedars-Sinai Medical Center Country: USA Publications
| Collaborators
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Detail Information
Publications
Impact of complexity and computer control on errors in radiation therapyB A Fraass
Department of Radiation Oncology, Cedars Sinai Medical Center, 8700 Beverly Blvd, AC1085, Los Angeles, CA 90048, USA
Ann ICRP 41:188-96. 2012..Clinical implications of these results are discussed, as are some of the ways in which the field should respond to the ongoing concerns about errors and complexity in radiation therapy...
Inverse-optimized 3D conformal planning: minimizing complexity while achieving equivalence with beamlet IMRT in multiple clinical sitesBenedick A Fraass
Department of Radiation Oncology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Med Phys 39:3361-74. 2012....- Quality, technology and outcomes: evolution and evaluation of new treatments and/or new technologyBenedick A Fraass
Department of Radiation Oncology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
Semin Radiat Oncol 22:3-10. 2012..Design of appropriate studies can help us improve patient care while at the same time documenting which new clinical strategies, enabled by new technology, lead to improved patient outcomes... 
The influence of beam model differences in the comparison of dose calculation algorithms for lung cancer treatment planningIndrin J Chetty
Department of Radiation Oncology, The University of Michigan, Ann Arbor, MI 48109 0010, USA
Phys Med Biol 50:801-15. 2005..This may ultimately hinder our ability to accurately correlate dose with clinical outcome...- Experimental verification of a Monte Carlo-based MLC simulation model for IMRT dose calculationNeelam Tyagi
Department of Radiation Oncology, The University of Michigan, Ann Arbor, Michigan 48109 0010, USA
Med Phys 34:651-63. 2007..Various sources of uncertainties in these comparisons are discussed... - Accounting for center-of-mass target motion using convolution methods in Monte Carlo-based dose calculations of the lungIndrin J Chetty
Department of Radiation Oncology, The University of Michigan, Ann Arbor, Michigan 48109 0010, USA
Med Phys 31:925-32. 2004..This increase is not unexpected considering that the target spends relatively more time at inhale as the asymmetry decreases (note that the treatment plans were generated using the exhale CT scans)... - Potential for dose-escalation and reduction of risk in pancreatic cancer using IMRT optimization with lexicographic ordering and gEUD-based cost functionsAaron C Spalding
Department of Radiation Oncology, University of Michigan, Ann Arbor Michigan 48109 0010, USA
Med Phys 34:521-9. 2007..We conclude that LO-IMRT with gEUD cost functions could allow dose escalation in pancreas tumors with concomitant reduction in doses to organs at risk as compared with traditional 3DCRT... - Reporting and analyzing statistical uncertainties in Monte Carlo-based treatment planningIndrin J Chetty
Department of Radiation Oncology, The University of Michigan, Ann Arbor, MI 48109 0010, USA
Int J Radiat Oncol Biol Phys 65:1249-59. 2006..To investigate methods of reporting and analyzing statistical uncertainties in doses to targets and normal tissues in Monte Carlo (MC)-based treatment planning... - Photon beam relative dose validation of the DPM Monte Carlo code in lung-equivalent mediaIndrin J Chetty
The University of Michigan, Department of Radiation Oncology, Ann Arbor, Michigan 48109 0010, USA
Med Phys 30:563-73. 2003..This work demonstrates that the DPM Monte Carlo code is capable of accurate photon beam dose calculations in situations where lateral electron disequilibrium effects are pronounced... - Evaluation of multiple breathing states using a multiple instance geometry approximation (MIGA) in inverse-planned optimization for locoregional breast treatmentAlexander Lin
Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 0010, USA
Int J Radiat Oncol Biol Phys 72:610-6. 2008..This study assessed whether optimization based on multiple instance geometry approximation (MIGA) could derive an IMRT plan that is less sensitive to known respiratory motions... - Enhanced spectral discrimination through the exploitation of interface effects in photon dose dataPaule M Charland
Department of Radiation Oncology, The University of Michigan, Ann Arbor, Michigan 48109, USA
Med Phys 31:264-76. 2004..Consequently, we suggest that as part of a beam-commissioning methodology, designated electronic disequilibrium test cases be implemented in unambiguously determining the correct energy spectrum to be used... - Improving IMRT delivery efficiency using intensity limits during inverse planningMartha M Coselmon
Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109, USA
Med Phys 32:1234-45. 2005..Constraining the maximum intensity in an inverse IMRT plan is a simple way to improve delivery efficiency without compromising plan objectives... - Adaptive diffusion smoothing: a diffusion-based method to reduce IMRT field complexityMartha M Matuszak
Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109, USA
Med Phys 35:1532-46. 2008..In summary, adaptive diffusion smoothing is a promising tool for ensuring that only the necessary amount of beam modulation is used, promoting more efficient and accurate IMRT planning, QA, and delivery... - Experimental validation of the DPM Monte Carlo code using minimally scattered electron beams in heterogeneous mediaIndrin J Chetty
Department of Radiation Oncology, The University of Michigan, Ann Arbor 48109 0010, USA
Phys Med Biol 47:1837-51. 2002.... - A fluence convolution method to account for respiratory motion in three-dimensional dose calculations of the liver: a Monte Carlo studyIndrin J Chetty
Department of Radiation Oncology, The University of Michigan, Ann Arbor, Michigan 48109 0010, USA
Med Phys 30:1776-80. 2003.... - Reduction of IMRT beam complexity through the use of beam modulation penalties in the objective functionMartha M Matuszak
Department of Radiation Oncology, University of Michigan, Ann Arbor Michigan 48109, USA
Med Phys 34:507-20. 2007..However, the penalty based upon the plan intensity map variation consistently produced the most delivery-efficient plans with the fewest computations... - Lexicographic ordering: intuitive multicriteria optimization for IMRTKyung Wook Jee
Department of Radiation Oncology, University of Michigan, UH B2C432, Box 0010, 1500 E Medical Ctr Dr, Ann Arbor, MI 48109, USA
Phys Med Biol 52:1845-61. 2007..This method produces encouraging results for difficult IMRT planning cases in a highly intuitive manner... - Multiple fields may offer better esophagus sparing without increased probability of lung toxicity in optimized IMRT of lung tumorsOlivier Chapet
Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109-0010, USA
Int J Radiat Oncol Biol Phys 65:255-65. 2006..CONCLUSION: Optimized many-field IMRT plans can lead to escalated lung-tumor dose in the special case of esophagus overlapping PTV, without unacceptable alteration in the dose distribution to normal lung... - Penalization of aperture complexity in inversely planned volumetric modulated arc therapyKelly C Younge
Department of Radiation Oncology, University of Michigan Health System, Ann Arbor, MI 48109, USA
Med Phys 39:7160-70. 2012.... - A dose gradient analysis tool for IMRT QAJean M Moran
Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0010, USA
J Appl Clin Med Phys 6:62-73. 2005..The remaining dose differences not explained by the geometric tolerance can then be evaluated graphically (dose difference display) or analytically (dose difference dose-volume histograms)over the entire comparison region... - Surface buildup dose dependence on photon field delivery technique for IMRTShigeru Yokoyama
Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0010, USA
J Appl Clin Med Phys 5:71-81. 2004..An example IMRT field was also studied to assess variations due to delivery technique (static vs. dynamic) and intensity level. Buildup dose is weakly dependent on the multileaf delivery technique for efficient IMRT fields... - Potential gains for irradiation of chest wall and regional nodes with intensity modulated radiotherapyEditha A Krueger
Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
Int J Radiat Oncol Biol Phys 56:1023-37. 2003..To develop an intensity modulated radiotherapy (IMRT) technique for postmastectomy RT that improves target coverage while sparing all appropriate normal tissues... - Contralateral breast dose after whole-breast irradiation: an analysis by treatment techniqueTerence M Williams
Department of Radiation Oncology, University of Michigan Health System, Ann Arbor, MI, USA
Int J Radiat Oncol Biol Phys 82:2079-85. 2012..To investigate the contralateral breast dose (CBD) across a continuum of breast-conservation therapy techniques... - Summary and recommendations of a National Cancer Institute workshop on issues limiting the clinical use of Monte Carlo dose calculation algorithms for megavoltage external beam radiation therapyBenedick A Fraass
Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA
Med Phys 30:3206-16. 2003..Based on these discussions, the workshop developed recommendations for future NCI-funded research and development efforts. This paper briefly summarizes the issues presented at the workshop and the recommendations developed by the group... - Accuracy of rapid radiographic film calibration for intensity-modulated radiation therapy verificationRavi Kulasekere
Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0010, USA
J Appl Clin Med Phys 7:86-95. 2006..Using a single calibration film exposed at the time of experiment, the total uncertainty of film response was estimated to be <2% (1%) for XV (EDR) film at 50 (100) cGy and higher, respectively... - Performance of a direct-detection active matrix flat panel dosimeter (AMFPD) for IMRT measurementsYu Chen
Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109, USA
Med Phys 34:4911-22. 2007.... - Esophagus sparing with IMRT in lung tumor irradiation: an EUD-based optimization techniqueOlivier Chapet
University of Michigan, Department of Radiation Oncology, Ann Arbor, MI 48109-0010, USA
Int J Radiat Oncol Biol Phys 63:179-87. 2005.... - QA issues for computer-controlled treatment delivery: this is not your old R/V system any more!Benedick A Fraass
Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, MI 48109 5010, USA
Int J Radiat Oncol Biol Phys 71:S98-S102. 2008..The potential for improved quality assurance for computer-controlled delivery is discussed... - A method for evaluating quality assurance needs in radiation therapyM Saiful Huq
Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
Int J Radiat Oncol Biol Phys 71:S170-3. 2008..Recommendations on how to apply this new approach to individual clinics and further research and development will also be discussed... - An Active Matrix Flat Panel Dosimeter (AMFPD) for in-phantom dosimetric measurementsJean M Moran
Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109 0010, USA
Med Phys 32:466-72. 2005..The device also compares well to film for 2-D planar dose distributions. It is expected that the AMFPD system will be useful for beam commissioning, algorithm verification test data, and routine IMRT quality assurance dosimetry... - Benchmarking of the dose planning method (DPM) Monte Carlo code using electron beams from a racetrack microtronIndrin J Chetty
The University of Michigan, Department of Radiation Oncology, Ann Arbor 48109 0010, USA
Med Phys 29:1035-41. 2002..The accuracy of the DPM code illustrated in this work suggests that DPM may be used as a valuable tool for electron beam dose calculations... - Errors in radiotherapy: motivation for development of new radiotherapy quality assurance paradigmsBenedick A Fraass
Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, MI 48109 5010, USA
Int J Radiat Oncol Biol Phys 71:S162-5. 2008.... - Incorporation of realistic delivery limitations into dynamic MLC treatment deliveryDale W Litzenberg
Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor 48109 0010, USA
Med Phys 29:810-20. 2002.... - Clinical aspects of intensity-modulated radiotherapy in the treatment of breast cancerEditha A Krueger
Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109, USA
Semin Radiat Oncol 12:250-9. 2002..Furthermore, IMRT may be able to reduce doses delivered to the heart and lungs, and may potentially minimize further the probability of complications from radiotherapy... - Dosimetric comparison of extended dose range film with ionization measurements in water and lung equivalent heterogeneous media exposed to megavoltage photonsPaule M Charland
Department of Radiation Oncology, The University of Michigan, Ann Arbor, Michigan 48109 0010, USA
J Appl Clin Med Phys 4:25-39. 2003..From this investigation EDR film appears to be a useful medium for relative dosimetry in higher dose ranges in both water and lung equivalent material for moderate field sizes and depths... - Safety considerations for IMRT: executive summaryJean M Moran
Department of Radiation Oncology, University of Michigan, Ann Arbor, MI 48109 5010, USA
Med Phys 38:5067-72. 2011.... - Verification of dynamic and segmental IMRT delivery by dynamic log file analysisDale W Litzenberg
Department of Radiation Oncology, University of Michigan Medical Center, 1500 East Medical Center Drive, Ann Arbor, Michigan 48109 0010, USA
J Appl Clin Med Phys 3:63-72. 2002..This program is part of a semi-automated quality assurance (QA) system for pretreatment fluence verification and daily treatment verification of dynamic multileaf collimation (DMLC) delivery...