Robert M Cohen

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. ncbi request reprint The application of positron-emitting molecular imaging tracers in Alzheimer's disease
    Robert M Cohen
    Department of Psychiatry and Behavioral Neurosciences, Cedars Sinai Medical Center, Thalians E 135, Los Angeles, CA 90048, USA
    Mol Imaging Biol 9:204-16. 2007
  2. ncbi request reprint Age and APOE-epsilon4 genotype influence the effect of physostigmine infusion on the in-vivo distribution volume of the muscarinic-2-receptor dependent tracer [18F]FP-TZTP
    Robert M Cohen
    Geriatric Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Synapse 60:86-92. 2006
  3. ncbi request reprint Stability of CSF beta-amyloid(1-42) and tau levels by APOE genotype in Alzheimer patients
    Edward D Huey
    Geriatric Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA
    Dement Geriatr Cogn Disord 22:48-53. 2006
  4. ncbi request reprint Higher in vivo muscarinic-2 receptor distribution volumes in aging subjects with an apolipoprotein E-epsilon4 allele
    Robert M Cohen
    Geriatric Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Synapse 49:150-6. 2003
  5. ncbi request reprint Cerebrospinal fluid beta-amyloid1-42 and tau in control subjects at risk for Alzheimer's disease: the effect of APOE epsilon4 allele
    Trey Sunderland
    National Institute of Mental Health, Geriatric Psychiatry Branch, Building 10, Room 3N228, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Biol Psychiatry 56:670-6. 2004
  6. pmc Failing compensatory mechanisms during working memory in older apolipoprotein E-epsilon4 healthy adults
    Francesca M Filbey
    Geriatric Psychiatry Branch, NIMH, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Brain Imaging Behav 4:177-88. 2010
  7. ncbi request reprint Hippocampal atrophy in the healthy is initially linear and independent of age
    Robert M Cohen
    Geriatric Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Clinical Research Center 2 5362, MSC 1274, 10 Center Drive, Bethesda MD 20892 1274, USA
    Neurobiol Aging 27:1385-94. 2006
  8. ncbi request reprint Biomarkers in the diagnosis of Alzheimer's disease: are we ready?
    Trey Sunderland
    Geriatric Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Geriatr Psychiatry Neurol 19:172-9. 2006
  9. ncbi request reprint Predicting relapse in major depressive disorder using patient-reported outcomes of depressive symptom severity, functioning, and quality of life in the Individual Burden of Illness Index for Depression (IBI-D)
    Waguih William Ishak
    Department of Psychiatry and Behavioral Neurosciences, Cedars Sinai Medical Center, Los Angeles, Los Angeles, CA, USA
    J Affect Disord 151:59-65. 2013
  10. pmc A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aβ, and frank neuronal loss
    Robert M Cohen
    Department of Psychiatry and Behavioral Neurosciences, S Mark Taper Imaging Center, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Neurosci 33:6245-56. 2013

Collaborators

Detail Information

Publications20

  1. ncbi request reprint The application of positron-emitting molecular imaging tracers in Alzheimer's disease
    Robert M Cohen
    Department of Psychiatry and Behavioral Neurosciences, Cedars Sinai Medical Center, Thalians E 135, Los Angeles, CA 90048, USA
    Mol Imaging Biol 9:204-16. 2007
    ..A more immediate impact on the diagnosis and treatment evaluation of AD patients in clinical trials is predicted while the possibility of personalized treatment or prevention of AD may not be that far away...
  2. ncbi request reprint Age and APOE-epsilon4 genotype influence the effect of physostigmine infusion on the in-vivo distribution volume of the muscarinic-2-receptor dependent tracer [18F]FP-TZTP
    Robert M Cohen
    Geriatric Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Synapse 60:86-92. 2006
    ....
  3. ncbi request reprint Stability of CSF beta-amyloid(1-42) and tau levels by APOE genotype in Alzheimer patients
    Edward D Huey
    Geriatric Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA
    Dement Geriatr Cogn Disord 22:48-53. 2006
    ..Cerebrospinal fluid (CSF) measures of beta-amyloid(1-42 )and tau differ between patients with Alzheimer's Disease (AD) and elderly normal controls. The effect of time and APOE genotype on these biomarkers continues to be elucidated...
  4. ncbi request reprint Higher in vivo muscarinic-2 receptor distribution volumes in aging subjects with an apolipoprotein E-epsilon4 allele
    Robert M Cohen
    Geriatric Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Synapse 49:150-6. 2003
    ..65, P < 0.06). A lower concentration of acetylcholine in the synapse of APOE-epsilon4+ older individuals is a likely explanation for the greater [(18)F]FP-TZTP distribution volumes...
  5. ncbi request reprint Cerebrospinal fluid beta-amyloid1-42 and tau in control subjects at risk for Alzheimer's disease: the effect of APOE epsilon4 allele
    Trey Sunderland
    National Institute of Mental Health, Geriatric Psychiatry Branch, Building 10, Room 3N228, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Biol Psychiatry 56:670-6. 2004
    ..We tested these CSF markers in groups of subjects with AD and healthy older control subjects, using the absence or presence of the APOE epsilon4 allele as a predictive variable in the search for possible prognostic biomarkers of AD...
  6. pmc Failing compensatory mechanisms during working memory in older apolipoprotein E-epsilon4 healthy adults
    Francesca M Filbey
    Geriatric Psychiatry Branch, NIMH, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Brain Imaging Behav 4:177-88. 2010
    ..This effect, however, appears to diminish with age...
  7. ncbi request reprint Hippocampal atrophy in the healthy is initially linear and independent of age
    Robert M Cohen
    Geriatric Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Clinical Research Center 2 5362, MSC 1274, 10 Center Drive, Bethesda MD 20892 1274, USA
    Neurobiol Aging 27:1385-94. 2006
    ....
  8. ncbi request reprint Biomarkers in the diagnosis of Alzheimer's disease: are we ready?
    Trey Sunderland
    Geriatric Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    J Geriatr Psychiatry Neurol 19:172-9. 2006
    ..The current biomarker approaches to diagnosis are reviewed along with a special emphasis on near-term recommendations and further research directions...
  9. ncbi request reprint Predicting relapse in major depressive disorder using patient-reported outcomes of depressive symptom severity, functioning, and quality of life in the Individual Burden of Illness Index for Depression (IBI-D)
    Waguih William Ishak
    Department of Psychiatry and Behavioral Neurosciences, Cedars Sinai Medical Center, Los Angeles, Los Angeles, CA, USA
    J Affect Disord 151:59-65. 2013
    ..This study examines the utility of a single multidimensional measure that captures variance in patient-reported Depressive Symptom Severity, Functioning, and Quality of Life (QOL), in predicting MDD relapse...
  10. pmc A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aβ, and frank neuronal loss
    Robert M Cohen
    Department of Psychiatry and Behavioral Neurosciences, S Mark Taper Imaging Center, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Neurosci 33:6245-56. 2013
    ..These results demonstrate progressive neurodegeneration of the Alzheimer type in these animals. The TgF344-AD rat fills a critical need for a next-generation animal model to enable basic and translational AD research...
  11. ncbi request reprint In vivo muscarinic 2 receptor imaging in cognitively normal young and older volunteers
    Teresa A Podruchny
    Geriatric Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Synapse 48:39-44. 2003
    ..41, P < 0.01). A lower concentration of acetylcholine in the synapse of some older subjects is one possible explanation for the data...
  12. ncbi request reprint Effects of previous major depressive illness on cognition in Alzheimer disease patients
    H Eleanor Cannon-Spoor
    Geriatric Psychiatry Branch, NIMH, Bethesda, MD 20892 1274, USA
    Am J Geriatr Psychiatry 13:312-8. 2005
    ....
  13. ncbi request reprint Functional magnetic resonance imaging and magnetoencephalography differences associated with APOEepsilon4 in young healthy adults
    Francesca M Filbey
    Geriatric Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA
    Neuroreport 17:1585-90. 2006
    ..The findings suggest that the presence of the APOEepsilon4 allele has physiological consequences before aging that may contribute to risk for Alzheimer's disease...
  14. ncbi request reprint A magnetoencephalography spatiotemporal analysis of neural activities during feature binding
    Francesca M Filbey
    Geriatric Psychiatry Branch, National Institute of Mental Health, Bethesda, Maryland, USA
    Neuroreport 16:1747-52. 2005
    ..Theta band synchronization was observed in many of these same areas, but also in other areas not noted to have increased theta band power suggesting a broad network of regions subserving the encoding phase of feature binding...
  15. doi request reprint Incorporating multidimensional patient-reported outcomes of symptom severity, functioning, and quality of life in the Individual Burden of Illness Index for Depression to measure treatment impact and recovery in MDD
    Robert M Cohen
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    JAMA Psychiatry 70:343-50. 2013
    ..The Individual Burden of Illness Index for Depression (IBI-D) metric was developed to meet this need...
  16. ncbi request reprint Decreased beta-amyloid1-42 and increased tau levels in cerebrospinal fluid of patients with Alzheimer disease
    Trey Sunderland
    Geriatric Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892, USA
    JAMA 289:2094-103. 2003
    ..The search for antemortem biomarkers is intense and has focused on cerebrospinal fluid (CSF) beta-amyloid1-42 and tau proteins...
  17. pmc Widespread decrease of nicotinic acetylcholine receptors in Parkinson's disease
    Masahiro Fujita
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 1, Room B3 10, I Center Drive, MSC 0135, Bethesda, MD, USA
    Ann Neurol 59:174-7. 2006
    ..Nicotinic acetylcholine receptors have close interactions with the dopaminergic system and play critical roles in cognitive function. The purpose of this study was to compare these receptors between living PD patients and healthy subjects...
  18. ncbi request reprint Noninvasive estimation of normalized distribution volume: application to the muscarinic-2 ligand [(18)F]FP-TZTP
    Masanori Ichise
    Kreitchman PET Center, Department of Radiology, Columbia University College of Physicians, New York, New York 10032, USA
    J Cereb Blood Flow Metab 28:420-30. 2008
    ..We conclude that MRTM2 V(T)(*) allows detection of group differences in receptor binding without arterial blood or a receptor-free reference region...
  19. ncbi request reprint PET imaging of brain with the beta-amyloid probe, [11C]6-OH-BTA-1, in a transgenic mouse model of Alzheimer's disease
    Hiroshi Toyama
    Department of Radiology, Fujita Health University, 1 98, Dengakugakubo, Kutsukake, Toyoake, 470 1192, Aichi, Japan
    Eur J Nucl Med Mol Imaging 32:593-600. 2005
    ..The purpose of this study was to evaluate the capacity of [11C]6-OH-BTA-1 and positron emission tomography (PET) to quantify beta-amyloid (Abeta) plaques in the Tg2576 mouse model of Alzheimer's disease (AD)...
  20. pmc Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease
    Navin Maswood
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 101:18171-6. 2004
    ....