Vera M Chesnokova

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. pmc Antidepressants stimulate hippocampal neurogenesis by inhibiting p21 expression in the subgranular zone of the hipppocampus
    Robert N Pechnick
    Department of Psychiatry and Behavioral Neurosciences, Cedars Sinai Medical Center, Los Angeles, California, United States of America
    PLoS ONE 6:e27290. 2011
  2. pmc Pituitary senescence: the evolving role of Pttg
    Vera Chesnokova
    Department of Medicine, Division of Endocrinology and Metabolism, Cedars Sinai Medical Center David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90048, USA
    Mol Cell Endocrinol 326:55-9. 2010
  3. pmc Antidepressants and Cdk inhibitors: releasing the brake on neurogenesis?
    Vera Chesnokova
    Department of Medicine, Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Cell Cycle 7:2321-6. 2008
  4. ncbi request reprint Hypothalamic-pituitary cytokine network
    Anastasia Kariagina
    Cedars Sinai Medical Center University of California, Los Angeles School of Medicine, California 90048, USA
    Endocrinology 145:104-12. 2004
  5. ncbi request reprint Developmental exposure to corticosterone: behavioral changes and differential effects on leukemia inhibitory factor (LIF) and corticotropin-releasing hormone (CRH) gene expression in the mouse
    Robert N Pechnick
    Department of Psychiatry and Mental Health, Cedars Sinai Medical Center, 8730 Alden Drive, Los Angeles, CA 90048, USA
    Psychopharmacology (Berl) 185:76-83. 2006
  6. ncbi request reprint Opposing effects of pituitary leukemia inhibitory factor and SOCS-3 on the ACTH axis response to inflammation
    Vera Chesnokova
    Cedars Sinai Research Institute University of California Los Angeles School of Medicine, Los Angeles, California 90048, USA
    Am J Physiol Endocrinol Metab 282:E1110-8. 2002
  7. ncbi request reprint Leukemia inhibitory factor regulates glucocorticoid receptor expression in the hypothalamic-pituitary-adrenal axis
    Anastasia Kariagina
    Cedars Sinai Medical Center and David Geffen School of Medicine at University of California, Los Angeles, CA, USA
    Am J Physiol Endocrinol Metab 289:E857-63. 2005
  8. ncbi request reprint Minireview: Neuro-immuno-endocrine modulation of the hypothalamic-pituitary-adrenal (HPA) axis by gp130 signaling molecules
    Vera Chesnokova
    Cedars Sinai Research Institute, University of California Los Angeles School of Medicine, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Endocrinology 143:1571-4. 2002
  9. ncbi request reprint Reduced immobility in the forced swim test in mice with a targeted deletion of the leukemia inhibitory factor (LIF) gene
    Robert N Pechnick
    Department of Psychiatry and Mental Health, Cedars Sinai Medical Center, Los Angeles, CA 9048, USA
    Neuropsychopharmacology 29:770-6. 2004
  10. pmc p21Cip1 restricts neuronal proliferation in the subgranular zone of the dentate gyrus of the hippocampus
    Robert N Pechnick
    Department of Medicine, Division of Endocrinology, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Proc Natl Acad Sci U S A 105:1358-63. 2008

Research Grants

  1. LIF MEDIATES ACTH AXIS RESPONSE TO INFLAMMATION
    Vera Chesnokova; Fiscal Year: 2003

Collaborators

Detail Information

Publications14

  1. pmc Antidepressants stimulate hippocampal neurogenesis by inhibiting p21 expression in the subgranular zone of the hipppocampus
    Robert N Pechnick
    Department of Psychiatry and Behavioral Neurosciences, Cedars Sinai Medical Center, Los Angeles, California, United States of America
    PLoS ONE 6:e27290. 2011
    ....
  2. pmc Pituitary senescence: the evolving role of Pttg
    Vera Chesnokova
    Department of Medicine, Division of Endocrinology and Metabolism, Cedars Sinai Medical Center David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90048, USA
    Mol Cell Endocrinol 326:55-9. 2010
    ..These observations point to senescence as a target for effective therapy for both tumor silencing and growth restraint towards development of pituitary malignancy...
  3. pmc Antidepressants and Cdk inhibitors: releasing the brake on neurogenesis?
    Vera Chesnokova
    Department of Medicine, Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Cell Cycle 7:2321-6. 2008
    ..However, there is a possibility that long-term stimulation of neurogenesis might exhaust the proliferation potentials of neuronal progenitors...
  4. ncbi request reprint Hypothalamic-pituitary cytokine network
    Anastasia Kariagina
    Cedars Sinai Medical Center University of California, Los Angeles School of Medicine, California 90048, USA
    Endocrinology 145:104-12. 2004
    ..Our results suggest that increased central proinflammatory cytokine expression can compensate for the impaired HPA axis function and activates inflammatory ACTH and corticosterone responses in mice-deficient in both CRH and LIF...
  5. ncbi request reprint Developmental exposure to corticosterone: behavioral changes and differential effects on leukemia inhibitory factor (LIF) and corticotropin-releasing hormone (CRH) gene expression in the mouse
    Robert N Pechnick
    Department of Psychiatry and Mental Health, Cedars Sinai Medical Center, 8730 Alden Drive, Los Angeles, CA 90048, USA
    Psychopharmacology (Berl) 185:76-83. 2006
    ..Both the hypothalamic-pituitary-adrenal axis and the immune system, including cytokine-mediated responses, appear to be susceptible to long-term programming during fetal and neonatal development...
  6. ncbi request reprint Opposing effects of pituitary leukemia inhibitory factor and SOCS-3 on the ACTH axis response to inflammation
    Vera Chesnokova
    Cedars Sinai Research Institute University of California Los Angeles School of Medicine, Los Angeles, California 90048, USA
    Am J Physiol Endocrinol Metab 282:E1110-8. 2002
    ..05). The results indicate that, although LIF induces ACTH, SOCS-3 acts to counterregulate the HPA axis response to inflammation...
  7. ncbi request reprint Leukemia inhibitory factor regulates glucocorticoid receptor expression in the hypothalamic-pituitary-adrenal axis
    Anastasia Kariagina
    Cedars Sinai Medical Center and David Geffen School of Medicine at University of California, Los Angeles, CA, USA
    Am J Physiol Endocrinol Metab 289:E857-63. 2005
    ..These data suggest that LIF maintains the HPA axis activation by decreasing GR expression and raise the possibility that LIF might contribute to the development of central glucocorticoid resistance during inflammation...
  8. ncbi request reprint Minireview: Neuro-immuno-endocrine modulation of the hypothalamic-pituitary-adrenal (HPA) axis by gp130 signaling molecules
    Vera Chesnokova
    Cedars Sinai Research Institute, University of California Los Angeles School of Medicine, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Endocrinology 143:1571-4. 2002
    ..At the same time, gp130 cytokines stimulate pituitary suppressor of cytokine signaling (SOCS)-3, which represses cytokine signaling and abrogates cytokine-induced corticotroph POMC gene transcription and ACTH secretion...
  9. ncbi request reprint Reduced immobility in the forced swim test in mice with a targeted deletion of the leukemia inhibitory factor (LIF) gene
    Robert N Pechnick
    Department of Psychiatry and Mental Health, Cedars Sinai Medical Center, Los Angeles, CA 9048, USA
    Neuropsychopharmacology 29:770-6. 2004
    ..It was found that LIF knockout mice show reduced immobility in the forced swim test, suggesting that LIF might have a potential role in the etiology of some forms of depression...
  10. pmc p21Cip1 restricts neuronal proliferation in the subgranular zone of the dentate gyrus of the hippocampus
    Robert N Pechnick
    Department of Medicine, Division of Endocrinology, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Proc Natl Acad Sci U S A 105:1358-63. 2008
    ..Because many antidepressants stimulate neurogenesis, it is possible that their shared common mechanism of action is suppression of p21...
  11. ncbi request reprint Discordant proliferation and differentiation in pituitary tumor-transforming gene-null bone marrow stem cells
    Tami Rubinek
    Academic Affairs, Rm 2015, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    Am J Physiol Cell Physiol 293:C1082-92. 2007
    ..The results indicate that Pttg deletion reduces BMSC proliferation, renders cells more sensitive to hypoxia, and enhances senescent features, thus pointing to a role for Pttg in the maintenance and proliferation of BMSCs...
  12. pmc p21(Cip1) restrains pituitary tumor growth
    Vera Chesnokova
    Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Proc Natl Acad Sci U S A 105:17498-503. 2008
    ..Aneuploid pituitary cell p21 may constrain pituitary tumor growth, thus accounting for the very low incidence of pituitary carcinomas...
  13. doi request reprint Pituitary tumour-transforming gene (PTTG) and pituitary senescence
    Vera Chesnokova
    Cedars Sinai Medical Center, David Geffen School of Medicine, Los Angeles, CA 90048, USA
    Horm Res 71:82-7. 2009
    ..These results improve our understanding of pituitary syndromes associated with infertility, growth disorders, hypercortisolism or adrenal, thyroid and gonadal failure due to abrogated pituitary function...
  14. pmc Senescence mediates pituitary hypoplasia and restrains pituitary tumor growth
    Vera Chesnokova
    Department of Medicine, Cedars Sinai Medical Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90048, USA
    Cancer Res 67:10564-72. 2007
    ....

Research Grants2

  1. LIF MEDIATES ACTH AXIS RESPONSE TO INFLAMMATION
    Vera Chesnokova; Fiscal Year: 2003
    ..This study will provide insights into the cytokine-mediated neuro-immuno-endocrine interface. ..