Shikha Bose

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. ncbi request reprint Anaplastic large cell lymphoma associated with a breast implant capsule: a case report and review of the literature
    Anna K Wong
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Am J Surg Pathol 32:1265-8. 2008
  2. ncbi request reprint Thyroid fine needle aspirate: a post-Bethesda update
    Shikha Bose
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Adv Anat Pathol 19:160-9. 2012
  3. ncbi request reprint The Akt pathway in human breast cancer: a tissue-array-based analysis
    Shikha Bose
    Department of Pathology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Mod Pathol 19:238-45. 2006
  4. ncbi request reprint p16(INK4A) is a surrogate biomarker for a subset of human papilloma virus-associated dysplasias of the uterine cervix as determined on the Pap smear
    Shikha Bose
    Department of Pathology, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Diagn Cytopathol 32:21-4. 2005
  5. doi request reprint BD ProEx C immunostaining in extramammary Paget's disease and perineal melanoma
    Ann E Walts
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Mod Pathol 22:246-51. 2009
  6. ncbi request reprint Unmasking of epigenetically silenced genes reveals DNA promoter methylation and reduced expression of PTCH in breast cancer
    Ido Wolf
    Division of Hematology Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA, USA
    Breast Cancer Res Treat 105:139-55. 2007
  7. doi request reprint Human papillomavirus genotypes in anal intraepithelial neoplasia and anal carcinoma as detected in tissue biopsies
    Anna K Wong
    Department of Pathology and Laboratory Medicine, George Burns and Gracie Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Mod Pathol 23:144-50. 2010
  8. doi request reprint Is the expression pattern of BD ProExC the same as Ki-67? A comparative analysis in cervical biopsies
    Ann E Walts
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Appl Immunohistochem Mol Morphol 18:262-7. 2010
  9. pmc Higher levels of GATA3 predict better survival in women with breast cancer
    Nam K Yoon
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1747, USA
    Hum Pathol 41:1794-801. 2010
  10. doi request reprint Invader human papillomavirus (HPV) type 16 and 18 assays as adjuncts to HPV screening of cervical papanicolaou smears with atypical squamous cells of undetermined significance
    Anna K Wong
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Cancer 115:823-32. 2009

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Anaplastic large cell lymphoma associated with a breast implant capsule: a case report and review of the literature
    Anna K Wong
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Am J Surg Pathol 32:1265-8. 2008
    ..Of interest is that 11 of these cases were T-cell lymphomas with 8 specifically of the CD30-positive anaplastic large cell lymphoma type. This rare case highlights the importance of histologic examination of breast capsule specimens...
  2. ncbi request reprint Thyroid fine needle aspirate: a post-Bethesda update
    Shikha Bose
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Adv Anat Pathol 19:160-9. 2012
    ..Recent and ongoing morphologic and molecular studies that aim to resolve these issues are summarized...
  3. ncbi request reprint The Akt pathway in human breast cancer: a tissue-array-based analysis
    Shikha Bose
    Department of Pathology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Mod Pathol 19:238-45. 2006
    ..Overall, a large proportion of in-situ and invasive breast cancers overexpressed cyclinD1 and S6. Our results may have significant implications in the development and application of targeted therapy...
  4. ncbi request reprint p16(INK4A) is a surrogate biomarker for a subset of human papilloma virus-associated dysplasias of the uterine cervix as determined on the Pap smear
    Shikha Bose
    Department of Pathology, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Diagn Cytopathol 32:21-4. 2005
    ..Additional studies are required for confirmation...
  5. doi request reprint BD ProEx C immunostaining in extramammary Paget's disease and perineal melanoma
    Ann E Walts
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Mod Pathol 22:246-51. 2009
    ..Currently neither of these lesions is known to be HPV related although according to the literature the possibility of a role for HPV in melanoma is still unsettled. Relevant literature is reviewed...
  6. ncbi request reprint Unmasking of epigenetically silenced genes reveals DNA promoter methylation and reduced expression of PTCH in breast cancer
    Ido Wolf
    Division of Hematology Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA, USA
    Breast Cancer Res Treat 105:139-55. 2007
    ..Thus, unmasking of epigenetic silencing in breast cancer enabled us to discover a large number of candidate tumor suppressor genes. Further analysis suggested a role of one of these genes, PTCH, in breast cancer tumorigenesis...
  7. doi request reprint Human papillomavirus genotypes in anal intraepithelial neoplasia and anal carcinoma as detected in tissue biopsies
    Anna K Wong
    Department of Pathology and Laboratory Medicine, George Burns and Gracie Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Mod Pathol 23:144-50. 2010
    ..In addition, a subset of these that were associated with type 16 or 18 showed progression, whereas those associated with non-16/18 subtypes regressed, thereby raising the possibility of conservative management for these lesions...
  8. doi request reprint Is the expression pattern of BD ProExC the same as Ki-67? A comparative analysis in cervical biopsies
    Ann E Walts
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Appl Immunohistochem Mol Morphol 18:262-7. 2010
    ..Fourteen cases were ProExC+ (7 of which were strongly p16+) and 11 were Ki-67+ (6 of which were strongly p16+)...
  9. pmc Higher levels of GATA3 predict better survival in women with breast cancer
    Nam K Yoon
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1747, USA
    Hum Pathol 41:1794-801. 2010
    ..GATA3 is an important predictor of disease outcome in breast cancer patients. This finding has been validated in a diverse set of populations. Thus, GATA3 expression has utility as a prognostic indicator in breast cancer...
  10. doi request reprint Invader human papillomavirus (HPV) type 16 and 18 assays as adjuncts to HPV screening of cervical papanicolaou smears with atypical squamous cells of undetermined significance
    Anna K Wong
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Cancer 115:823-32. 2009
    ..The current study was designed to determine the prevalence of HPV-16 and HPV-18 in ASC-US Pap smears and to determine whether further typing would enhance the risk stratification of patients for CIN-2/CIN-3...
  11. doi request reprint BD ProEx C: a sensitive and specific marker of HPV-associated squamous lesions of the cervix
    Riem E Badr
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Am J Surg Pathol 32:899-906. 2008
    ..ProEx C may also have a potential role in triaging patients with low-grade CIN. ProEx C expression patterns are similar to those for p16 and Ki67 with most discrepancies occurring in the CIN I category...
  12. ncbi request reprint P16 and Ki67 immunostaining is a useful adjunct in the assessment of biopsies for HPV-associated anal intraepithelial neoplasia
    Ann E Walts
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Am J Surg Pathol 30:795-801. 2006
    ..One was positive for high-risk HPV DNA. We conclude that when used together and evaluated in conjunction with H&E stained sections, p16 and Ki67 immunoexpression is a useful adjunct in the diagnosis and grading of AIN...
  13. doi request reprint A simplified Bethesda System for reporting thyroid cytopathology using only four categories improves intra- and inter-observer diagnostic agreement and provides non-overlapping estimates of malignancy risks
    Ann E Walts
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Diagn Cytopathol 40:E62-8. 2012
    ....
  14. ncbi request reprint Down-regulation and growth inhibitory role of C/EBPalpha in breast cancer
    Sigal Gery
    Division of Hematology Oncology, Cedars Sinai Medical Center, University of California at Los Angeles School of Medicine, USA
    Clin Cancer Res 11:3184-90. 2005
    ..The purpose of this study was to explore the possibility that C/EBPalpha is involved in breast cancer...
  15. ncbi request reprint FOXA1: Growth inhibitor and a favorable prognostic factor in human breast cancer
    Ido Wolf
    Division of Hematology Oncology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA, USA
    Int J Cancer 120:1013-22. 2007
    ..Yet, FOXA1 expression was noted in a subset of the ER-negative tumors. Taken together, our findings suggest a growth inhibitory role for FOXA1, and identify it as a novel, potential prognostic factor in breast cancer...
  16. pmc Human papillomavirus (HPV) in atypical squamous cervical cytology: the Invader HPV test as a new screening assay
    Anna K Wong
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA 90048, USA
    J Clin Microbiol 46:869-75. 2008
    ....
  17. ncbi request reprint Follicular lesion of undetermined significance in thyroid FNA revisited
    Ann E Walts
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, California
    Diagn Cytopathol 42:18-22. 2014
    ..FLUS cases lacking these atypical nuclear features have a risk for malignancy that approximates the risk BSRTC has assigned to FLUS...
  18. ncbi request reprint BRAF genetic heterogeneity in papillary thyroid carcinoma and its metastasis
    Ann E Walts
    Departments of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA Electronic address
    Hum Pathol 45:935-41. 2014
    ..Discordant BRAF status was detected in only 4.8% of the pairs studied and most frequently involved cases with recurrent metastasis thus suggesting a need for additional testing of these lesions before instituting therapy. ..
  19. ncbi request reprint CINtec® PLUS dual immunostain: a triage tool for cervical pap smears with atypical squamous cells of undetermined significance and low grade squamous intraepithelial lesion
    Sanam Loghavi
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Diagn Cytopathol 41:582-7. 2013
    ..CINtec® PLUS was more specific than HR HPV testing and Ki-67 and p16 immunostains alone in detecting an U or S HG CIN. CINtec® PLUS is a helpful adjunct in identifying U or S HG CIN when applied to SurePath Pap smears with ASC or LSIL...
  20. pmc Higher expression levels of 14-3-3sigma in ductal carcinoma in situ of the breast predict poorer outcome
    Nam K Yoon
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1747, USA
    Cancer Biomark 5:215-24. 2009
    ..To our knowledge this is the first published study associating 14-3-3sigma protein expression with breast cancer survival...
  21. ncbi request reprint PTEN promoter is methylated in a proportion of invasive breast cancers
    Salma Khan
    Department of Pathology, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Int J Cancer 112:407-10. 2004
    ..None of the breast cancer cell lines and normal breast tissues showed methylation. In summary, methylation of the PTEN promoter leads to PTEN inactivation in a subset of human breast cancers...
  22. pmc Automated detection of dual p16/Ki67 nuclear immunoreactivity in liquid-based Pap tests for improved cervical cancer risk stratification
    Arkadiusz Gertych
    Bioinformatics Laboratory, Department of Surgery, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Ann Biomed Eng 40:1192-204. 2012
    ..3 and 89.4%, respectively. We found that the quantitative characterization of immunoreactivity provided by the additional highlighting of classified nuclei can positively impact the efficacy and screening outcome of the Pap test...
  23. ncbi request reprint Securin is overexpressed in breast cancer
    Selam Ogbagabriel
    Department of Medicine, Cedars Sinai Research Institute, UCLA School of Medicine, Los Angeles, CA, USA
    Mod Pathol 18:985-90. 2005
    ..We propose immunohistochemical tumor securin expression as a potential invasive marker, and novel therapeutic target in breast cancer...
  24. ncbi request reprint Decreased expression of annexin A1 is correlated with breast cancer development and progression as determined by a tissue microarray analysis
    Dejun Shen
    Gonda UCLA Breast Cancer Research Laboratory, Revlon UCLA Breast Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Hum Pathol 37:1583-91. 2006
    ..These results suggest that suppressed ANXA1 expression in breast tissue is correlated with breast cancer development and progression...
  25. doi request reprint Clinicopathological significance of HER2/neu genetic heterogeneity in HER2/neu non-amplified invasive breast carcinomas and its concurrent axillary metastasis
    Hedyeh Shafi
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Clin Pathol 66:649-54. 2013
    ..HER2/neu (HER2) is a significant prognostic marker for breast carcinomas. Recently, new guidelines defining HER2 genetic heterogeneity (GH) were published by the College of American Pathologists...
  26. pmc WNT10B/β-catenin signalling induces HMGA2 and proliferation in metastatic triple-negative breast cancer
    Peter Wend
    Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA
    EMBO Mol Med 5:264-79. 2013
    ..We demonstrate that WNT10B has epistatic activity on HMGA2, which is necessary and sufficient for proliferation of TNBC cells. Furthermore, HMGA2 expression predicts relapse-free-survival and metastasis in TNBC patients...
  27. pmc P16 and Ki67 Immunostains Decrease Intra- and Interobserver Variability in the Diagnosis and Grading of Anal Intraepithelial Neoplasia (AIN)
    Ann E Walts
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA
    Clin Med Pathol 1:7-13. 2008
    ..This study was undertaken to determine if addition of p16 and Ki67 immunostaining would reduce inter- and intraobserver variability in diagnosis and grading of AIN...
  28. pmc Overexpression of beta1-chain-containing laminins in capillary basement membranes of human breast cancer and its metastases
    Manabu Fujita
    Maxine Dunitz Neurosurgical Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Breast Cancer Res 7:R411-21. 2005
    ..Here, differential expression of laminins was studied in blood vessels and ductal epithelium of the breast...
  29. doi request reprint p16, Ki-67, and BD ProExC immunostaining: a practical approach for diagnosis of cervical intraepithelial neoplasia
    Ann E Walts
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Hum Pathol 40:957-64. 2009
    ..Performing p16 and BD ProExC initially followed by Ki-67 only when p16 and BD ProExC yielded discordant results provided similar diagnostic accuracy at reduced cost because only one third of the cases required the additional stain...
  30. ncbi request reprint Paget's disease of the nipple with parenchymal ductal carcinoma in situ is associated with worse prognosis than Paget's disease alone
    Brandice Durkan
    Department of Surgery, Cedars Sinai Medical Center, Los Angeles, California, USA
    Am Surg 79:1009-12. 2013
    ..1 to 15.2 years). Thus, Paget's disease with parenchymal DCIS may confer worse survival than isolated Paget's disease of the nipple, suggesting the difficulty of identifying invasive carcinoma within a background of DCIS. ..
  31. ncbi request reprint Prediction of additional axillary metastasis of breast cancer following sentinel lymph node surgery
    Channikarn Changsri
    Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Breast J 10:392-7. 2004
    ..Primary tumor characteristics did not correlate with the incidence of NSLN metastasis in our series...
  32. doi request reprint Comparative analysis of size estimation by mapping and counting number of blocks with ductal carcinoma in situ in breast excision specimens
    Farnaz Dadmanesh
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Arch Pathol Lab Med 133:26-30. 2009
    ..The size of ductal carcinoma in situ (DCIS) is a significant predictor of local tumor recurrence and is used for selection of patients for conservative versus aggressive therapy. A standardized method for size assessment is lacking...
  33. pmc P16/Ki-67 Immunostaining is Useful in Stratification of Atypical Metaplastic Epithelium of the Cervix
    Ann E Walts
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048
    Clin Med Pathol 1:35-42. 2008
    ..The remaining 30% of the ASM cases showed variable positivity for p16 and Ki-67 and could not be stratified into the two categories. Thus p16/Ki-67 staining is helpful in stratification of ASM as reactive or CIN...
  34. doi request reprint Polyomavirus infection and urothelial carcinoma
    Sanam Loghavi
    Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, 8700 Beverly Blvd Los Angeles, CA 90048, USA
    Diagn Cytopathol 39:531-5. 2011
    ..Polyomavirus infections are common in the general (adult) population with a reported prevalence of more than 80%. Polyomavirus can infect urothelial carcinoma and change the morphology of these malignant cells, as is shown in this paper...
  35. ncbi request reprint Reduced expression of PTEN correlates with breast cancer progression
    Shikha Bose
    Department of Pathology, University of California, Los Angeles, California 90048, USA
    Hum Pathol 33:405-9. 2002
    ..These data suggest that PTEN expression is frequently reduced in advanced breast cancers...
  36. ncbi request reprint Adenomyoepithelioma of the breast: a cytologic dilemma. Report of a case and review of the literature
    Andrea Chang
    Department of Pathology, School of Medicine, University of California, Los Angeles, CA, USA
    Diagn Cytopathol 26:191-6. 2002
    ....
  37. ncbi request reprint Interobserver reproducibility in the diagnosis of flat epithelial atypia of the breast
    Frances P O'Malley
    Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada
    Mod Pathol 19:172-9. 2006
    ..1-97.4%), than for determining its presence (90.4%: 95% CI, 79.9-96.7%). We conclude that the diagnosis of FEA and its distinction from CCLs without atypia is highly reproducible with the use of available diagnostic criteria...