J S Adams

Summary

Affiliation: Cedars-Sinai Medical Center
Country: USA

Publications

  1. ncbi Rapid recovery of bone mass in hypercalciuric, osteoporotic men treated with hydrochlorothiazide
    J S Adams
    Burns and Allen Research Institute and Cedars Sinai Medical Center, University of California, Los Angeles, School of Medicine 90048, USA
    Ann Intern Med 130:658-60. 1999
  2. ncbi Resolution of vitamin D insufficiency in osteopenic patients results in rapid recovery of bone mineral density
    J S Adams
    Bone Center and Burns and Allen Research Institute, Cedars Sinai Medical Center, University of California School of Medicine, Los Angeles 90048, USA
    J Clin Endocrinol Metab 84:2729-30. 1999
  3. ncbi Vitamin D in defense of the human immune response
    John S Adams
    Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Room B 131, Los Angeles, CA 90048, USA
    Ann N Y Acad Sci 1117:94-105. 2007
  4. ncbi Vitamin D as a defensin
    J S Adams
    Division of Endocrinology, Diabetes and Metabolism, Cedars Sinai Medical Center, University of California, Los Angeles, CA 90048, USA
    J Musculoskelet Neuronal Interact 6:344-6. 2006
  5. ncbi Cloning, sequencing, and functional characterization of the vitamin D receptor in vitamin D-resistant New World primates
    R F Chun
    Department of Endocrinology, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
    Am J Primatol 54:107-18. 2001
  6. ncbi Co-chaperone potentiation of vitamin D receptor-mediated transactivation: a role for Bcl2-associated athanogene-1 as an intracellular-binding protein for 1,25-dihydroxyvitamin D3
    R F Chun
    Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Mol Endocrinol 39:81-9. 2007
  7. pmc Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase
    J S Adams
    Orthopaedic Hospital Research Center, UCLA Orthopaedic Hospital Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7358, USA
    Arch Biochem Biophys 523:95-102. 2012
  8. pmc Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset of Crohn's disease patients with elevated 1,25-dihydroxyvitamin D and low bone mineral density
    M T Abreu
    Division of Gastroenterology, Inflammatory Bowel Disease Center, Steven Spielberg Pediatric Research Center, Burns and Allen Research Institute, Los Angeles, CA 90048, USA
    Gut 53:1129-36. 2004
  9. ncbi Splice variants of the CYP27b1 gene and the regulation of 1,25-dihydroxyvitamin D3 production
    S Wu
    Burns and Allen Research Institute, Division of Endocrinology, Diabetes and Metabolism, Cedars Sinai Medical Center, Los Angeles, School of Medicine, California 90048, USA
    Endocrinology 148:3410-8. 2007
  10. ncbi Novel regulators of vitamin D action and metabolism: Lessons learned at the Los Angeles zoo
    J S Adams
    Burns and Allen Research Institute, Division of Endocrinology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, California, USA
    J Cell Biochem 88:308-14. 2003

Collaborators

Detail Information

Publications35

  1. ncbi Rapid recovery of bone mass in hypercalciuric, osteoporotic men treated with hydrochlorothiazide
    J S Adams
    Burns and Allen Research Institute and Cedars Sinai Medical Center, University of California, Los Angeles, School of Medicine 90048, USA
    Ann Intern Med 130:658-60. 1999
    ..Chronic hypercalciuria can contribute to osteoporosis, particularly in men...
  2. ncbi Resolution of vitamin D insufficiency in osteopenic patients results in rapid recovery of bone mineral density
    J S Adams
    Bone Center and Burns and Allen Research Institute, Cedars Sinai Medical Center, University of California School of Medicine, Los Angeles 90048, USA
    J Clin Endocrinol Metab 84:2729-30. 1999
    ..001) and the femoral neck (P = 0.03), indicating that resolution of vitamin D insufficiency in a population of patients with low bone mass results in a rapid rebound increase in bone mineral density...
  3. ncbi Vitamin D in defense of the human immune response
    John S Adams
    Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Room B 131, Los Angeles, CA 90048, USA
    Ann N Y Acad Sci 1117:94-105. 2007
    ....
  4. ncbi Vitamin D as a defensin
    J S Adams
    Division of Endocrinology, Diabetes and Metabolism, Cedars Sinai Medical Center, University of California, Los Angeles, CA 90048, USA
    J Musculoskelet Neuronal Interact 6:344-6. 2006
  5. ncbi Cloning, sequencing, and functional characterization of the vitamin D receptor in vitamin D-resistant New World primates
    R F Chun
    Department of Endocrinology, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA
    Am J Primatol 54:107-18. 2001
    ....
  6. ncbi Co-chaperone potentiation of vitamin D receptor-mediated transactivation: a role for Bcl2-associated athanogene-1 as an intracellular-binding protein for 1,25-dihydroxyvitamin D3
    R F Chun
    Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Mol Endocrinol 39:81-9. 2007
    ....
  7. pmc Extrarenal expression of the 25-hydroxyvitamin D-1-hydroxylase
    J S Adams
    Orthopaedic Hospital Research Center, UCLA Orthopaedic Hospital Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7358, USA
    Arch Biochem Biophys 523:95-102. 2012
    ....
  8. pmc Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset of Crohn's disease patients with elevated 1,25-dihydroxyvitamin D and low bone mineral density
    M T Abreu
    Division of Gastroenterology, Inflammatory Bowel Disease Center, Steven Spielberg Pediatric Research Center, Burns and Allen Research Institute, Los Angeles, CA 90048, USA
    Gut 53:1129-36. 2004
    ..We further hypothesised that this was secondary to increased synthesis of 1,25(OH)(2)D by inflammatory cells in the intestine. The aim of this study was to examine the relationship between 1,25(OH)(2)D levels and BMD in patients with CD...
  9. ncbi Splice variants of the CYP27b1 gene and the regulation of 1,25-dihydroxyvitamin D3 production
    S Wu
    Burns and Allen Research Institute, Division of Endocrinology, Diabetes and Metabolism, Cedars Sinai Medical Center, Los Angeles, School of Medicine, California 90048, USA
    Endocrinology 148:3410-8. 2007
    ..01). These data indicate that noncoding splice variants of CYP27b1 are functionally active and may play a significant role in the regulation of 1,25(OH)2D3 synthesis during normal physiology...
  10. ncbi Novel regulators of vitamin D action and metabolism: Lessons learned at the Los Angeles zoo
    J S Adams
    Burns and Allen Research Institute, Division of Endocrinology, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, California, USA
    J Cell Biochem 88:308-14. 2003
    ....
  11. ncbi An Hsp27-related, dominant-negative-acting intracellular estradiol-binding protein
    Hong Chen
    Division of Endocrinology, Diabetes, and Metabolism, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, California 90048, USA
    J Biol Chem 279:29944-51. 2004
    ..In summary, by inhibiting the ERalpha-E2 interaction, IEBP acts to squelch ERalpha-directed ERE-regulated transactivation and promote estrogen resistance in NWP cells...
  12. pmc Increased expression of 25-hydroxyvitamin D-1alpha-hydroxylase in dysgerminomas: a novel form of humoral hypercalcemia of malignancy
    Katie N Evans
    Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham, Birmingham, United Kingdom
    Am J Pathol 165:807-13. 2004
    ..We further postulate that this autocrine/paracrine action of 1alpha-hydroxylase may lead to increased circulating levels of 1,25(OH)2D3 and a form of HHM which is distinct from that seen with PTHrP-secreting tumors...
  13. ncbi Creation of estrogen resistance in vivo by transgenic overexpression of the heterogeneous nuclear ribonucleoprotein-related estrogen response element binding protein
    Hong Chen
    Burns and Allen Research Institute and Division of Endocrinology, Diabetes, and Metabolism, Cedars Sinai Medical Center, David Geffen School of Medicine at the University of California, Los Angeles, California 90048, USA
    Endocrinology 146:4266-73. 2005
    ..This work confirms that tissue-targeted overexpression of the ERE-BP can effectively block estrogen-ERalpha-ERE-directed action in vivo...
  14. ncbi Purification and characterization of a novel intracellular 17 beta-estradiol binding protein in estrogen-resistant New World primate cells
    Hong Chen
    Division of Endocrinology, Diabetes and Metabolism, Cedars Sinai Burns and Allen Research Institute, UCLA School of Medicine, Los Angeles, California, USA
    J Clin Endocrinol Metab 88:501-4. 2003
    ..In conclusion, IEBP is a specific E2-interacting heat shock protein in the hsp-27 family that is relatively overexpressed in estrogen-resistant cells...
  15. ncbi Regulation of 1,25-dihydroxyvitamin d synthesis by intracellular vitamin d binding protein-1
    Shaoxing Wu
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars Sinai Medical Center, UCLA School of Medicine, 90048, USA
    Endocrinology 143:4135. 2002
    ....
  16. pmc Control of estradiol-directed gene transactivation by an intracellular estrogen-binding protein and an estrogen response element-binding protein
    Hong Chen
    Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mol Endocrinol 22:559-69. 2008
    ..This appears to involve a physical association between the two proteins to form a complex that is able to interact with both E(2) and ERalpha in cytosolic and nuclear compartments...
  17. ncbi Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
    Philip T Liu
    Department of Microbiology, Immunology, and Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Science 311:1770-3. 2006
    ..These data support a link between TLRs and vitamin D-mediated innate immunity and suggest that differences in ability of human populations to produce vitamin D may contribute to susceptibility to microbial infection...
  18. ncbi Increase in bone mass after correction of vitamin D insufficiency in bisphosphonate-treated patients
    Jordan L Geller
    Burns and Allen Research Institute and Cedars Sinai Medical Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90048, USA
    Endocr Pract 14:293-7. 2008
    ..To assess the relative contribution of vitamin D insufficiency to loss of bone mineral density (BMD) in patients taking bisphosphonates...
  19. ncbi Proton pump inhibitor therapy and hip fracture risk
    Jordan L Geller
    JAMA 297:1429; author reply 1429-30. 2007
  20. pmc Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity
    John S Adams
    Department of Endocrinology, Diabetes and Metabolism, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    Nat Clin Pract Endocrinol Metab 4:80-90. 2008
    ..Specific examples of this will be detailed in the current Review, with particular emphasis on the immunomodulatory properties of vitamin D...
  21. pmc Altered endocrine and autocrine metabolism of vitamin D in a mouse model of gastrointestinal inflammation
    Nancy Liu
    Department of Orthopaedic Surgery, David Geffen School of Medicine, UCLA, 615 Charles E Young Drive South, Los Angeles, California 90095, USA
    Endocrinology 149:4799-808. 2008
    ..These data indicate that both local and endocrine synthesis of 1,25(OH)2D3 affect colitis in DSS-treated mice. Lack of Cyp27b1 exacerbates disease in this model, suggesting that similar effects may occur with vitamin D deficiency...
  22. ncbi Vitamin D therapy
    Jordan L Geller
    Orthopaedic Hospital Research Center, UCLA Orthopaedic Hospital Department of Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Mail Stop 735822, 615 Charles E Young Drive South, Room 410E, Los Angeles, CA 90095, USA
    Curr Osteoporos Rep 6:5-11. 2008
    ..Patients who are taking bisphosphonates and those with coexisting primary hyperparathyroidism are not exempt from taking supplemental vitamin D...
  23. ncbi Substrate and enzyme trafficking as a means of regulating 1,25-dihydroxyvitamin D synthesis and action: the human innate immune response
    John S Adams
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Bone Miner Res 22:V20-4. 2007
    ..In this review, we use vitamin D-directed events in the human innate immune response to Mycobacterium tuberculosis as a physiologically relevant model system in which to highlight the importance of these intracellular traffic patterns...
  24. ncbi Extra-renal 25-hydroxyvitamin D3-1alpha-hydroxylase in human health and disease
    Martin Hewison
    Burns and Allen Research Institute, Division of Endocrinology, Cedars Sinai Medical Center and David Geffen School of Medicine at UCLA, Los Angeles, CA 90048, USA
    J Steroid Biochem Mol Biol 103:316-21. 2007
    ..Data suggest that local synthesis of 1,25(OH)(2)D(3) may be a preferred mode of response to antigenic challenge in many tissues...
  25. ncbi Cinacalcet in the management of tumor-induced osteomalacia
    Jordan L Geller
    Clinical Research Institute, Cedars Sinai Medical Center and the David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Bone Miner Res 22:931-7. 2007
    ..Cinacalcet treatment resulted in increased renal phosphate reabsorption, allowed for a decrease in phosphate supplementation, and showed evidence of bone healing in one of the two patients...
  26. ncbi Vitamin D and barrier function: a novel role for extra-renal 1 alpha-hydroxylase
    Martin Hewison
    Division of Medical Sciences, Institute of Clinical Research, The University of Birmingham, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Mol Cell Endocrinol 215:31-8. 2004
    ....
  27. ncbi Response element binding proteins and intracellular vitamin D binding proteins: novel regulators of vitamin D trafficking, action and metabolism
    John S Adams
    The Burns and Allen Research Institute, Cedars Sinai Medical Center, UCLA School of Medicine, B131, Cedars Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, USA
    J Steroid Biochem Mol Biol 89:461-5. 2004
    ..Our ongoing studies indicate directly or indirectly through a series of protein interactions that the IDBPs interact with hydroxylated vitamin D metabolites and facilitate their intracellular targeting...
  28. ncbi Alternative splicing of vitamin D-24-hydroxylase: a novel mechanism for the regulation of extrarenal 1,25-dihydroxyvitamin D synthesis
    Songyang Ren
    Department of Medicine, Division of Endocrinology, Burns and Allen Research Institute, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Biol Chem 280:20604-11. 2005
    ..We theorize that expression of the CYP24-SV may contribute to the extracellular accumulation of 1,25(OH)(2)D in human health and disease...
  29. ncbi Biological actions of extra-renal 25-hydroxyvitamin D-1alpha-hydroxylase and implications for chemoprevention and treatment
    Kelly Townsend
    Division of Medical Sciences, Institute of Biomedical Research, The University of Birmingham, Birmingham B15 2TH, UK
    J Steroid Biochem Mol Biol 97:103-9. 2005
    ..The role of 1alpha-hydroxylase in protection against cancer is likely to be more complicated and may involve anti-tumor immune responses...
  30. ncbi Adenosine 5'-triphosphate-dependent vitamin D sterol binding to heat shock protein-70 chaperones
    Rene Chun
    Burns and Allen Research Institute and Division of Endocrinology, Diabetes, and Metabolism, Cedars Sinai Medical Center, David Geffen School of Medicine at University of California, Los Angeles, 90048, USA
    Endocrinology 146:5540-4. 2005
    ....
  31. ncbi Vitamin D-mediated hypercalcemia in lymphoma: evidence for hormone production by tumor-adjacent macrophages
    Martin Hewison
    Division of Medical Sciences, University of Birmingham, Birmingham, United Kingdom
    J Bone Miner Res 18:579-82. 2003
    ..Based on this case study, we propose that the abnormal synthesis of 1,25(OH)2D3 associated with some lymphomas is because of paracrine regulation of tumor-associated macrophages...
  32. ncbi Vitamin D-mediated hypercalcemia in slack skin disease: evidence for involvement of extrarenal 25-hydroxyvitamin D 1alpha-hydroxylase
    Helen Karakelides
    Department of Endocrinology, Metabolism and Nutrition, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    J Bone Miner Res 21:1496-9. 2006
    ..Immunolocalization of 1alpha-OH in skin showed simultaneous dysregulation in epithelial and granulomatous cells...
  33. ncbi Functional characterization of heterogeneous nuclear ribonuclear protein C1/C2 in vitamin D resistance: a novel response element-binding protein
    Hong Chen
    Division of Endocrinology, Diabetes and Metabolism, Burns and Allen Research Institute, Cedars Sinai Medical Center, UCLA School of Medicine, Los Angeles, California 90048, USA
    J Biol Chem 281:39114-20. 2006
    ..In particular, chromatin immunoprecipitation data suggest that, in addition to its RNA-processing functions, hnRNP C1/C2 may be a key determinant of the temporal patterns of VDRE occupancy...
  34. pmc Heterogeneous nuclear ribonucleoprotein (hnRNP) binding to hormone response elements: a cause of vitamin D resistance
    Hong Chen
    Burns and Allen Research Institute and the Division of Endocrinology, Diabetes, and Metabolism, 8700 Beverly Boulevard, Room B 131, Los Angeles, CA 90048, USA
    Proc Natl Acad Sci U S A 100:6109-14. 2003
    ..That this protein is a member of the hnRNP family capable of interacting with double-stranded DNA highlights a potentially important new component of the complex machinery required for steroid hormone signal transduction...
  35. ncbi "Bound" to work: the free hormone hypothesis revisited
    John S Adams
    Burns and Allen Research Institute, Cedars Sinai Medical Center, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90048, USA
    Cell 122:647-9. 2005
    ..2005) show that resistance (insensitivity) to sex steroid hormones is encountered in animals lacking megalin. These data provide important insights into an endocytic mechanism for the uptake of sex steroids by mammalian cells...