Research Topics
| Janet R CaseySummaryCountry: USA Publications
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Publications
Higher dosages of azithromycin are more effective in treatment of group A streptococcal tonsillopharyngitisJanet R Casey
Department of Pediatrics, Elmwood Pediatric Group, University of Rochester Medical Center, New York, USA
Clin Infect Dis 40:1748-55. 2005..In this study, our objective was to determine the optimal dose of azithromycin for treatment of GAS tonsillopharyngitis in children and adults by analyzing trials that used different dose regimens...- Metaanalysis of short course antibiotic treatment for group a streptococcal tonsillopharyngitisJanet R Casey
Department of Pediatrics, Elmwood Pediatric Group, University of Rochester Medical Center, NY, USA
Pediatr Infect Dis J 24:909-17. 2005..To compare bacterial and clinical cure rates in patients with group A streptococcal (GAS) tonsillopharyngitis treated with oral beta-lactam or macrolide antibiotics for 4-5 days versus 10-day comparators... - The evidence base for cephalosporin superiority over penicillin in streptococcal pharyngitisJanet R Casey
Elmwood Pediatric Group, University of Rochester, Rochester, NY 14642, USA
Diagn Microbiol Infect Dis 57:39S-45S. 2007..This review examines the evidence supporting the use of cephalosporins as a first choice of treatment for many patients with GABHS pharyngitis... 
Treating acute otitis media post-PCV-7: judicious antibiotic therapyJanet R Casey
Elmwood Pediatric Group, Rochester, NY 14620, USA
Postgrad Med 118:32-3, 24-31. 2005..Improved patient outcomes will result in fewer AOM episodes, decreased antibiotic resistance, and reduced direct and indirect health care costs...- Meta-analysis of cephalosporins versus penicillin for treatment of group A streptococcal tonsillopharyngitis in adultsJanet R Casey
University of Rochester, Elmwood Pediatric Group, Rochester, New York 14620, USA
Clin Infect Dis 38:1526-34. 2004..This meta-analysis indicates that the likelihood of bacteriologic and clinical failure in the treatment of GABHS tonsillopharyngitis is 2 times higher for oral penicillin than for oral cephalosporins... - Meta-analysis of cephalosporin versus penicillin treatment of group A streptococcal tonsillopharyngitis in childrenJanet R Casey
Department of Pediatrics, Elmwood Pediatric Group, University of Rochester, Rochester, New York 14620, USA
Pediatrics 113:866-82. 2004..To conduct a meta-analysis of randomized, controlled trials of cephalosporin versus penicillin treatment of group A beta-hemolytic streptococcal (GABHS) tonsillopharyngitis in children... - Symptomatic relapse of group A beta-hemolytic streptococcal tonsillopharyngitis in childrenJanet R Casey
University of Rochester School of Medicine, Elmwood Pediatric Group, Rochester, New York, USA
Clin Pediatr (Phila) 46:307-10. 2007..02). Clinicians should be aware that the rate of symptomatic failures after antibiotic therapy for group A beta-hemolytic streptococcal tonsillopharyngitis differs by drug and is not an uncommon event... - Efficacy of cephalexin two vs. three times daily vs. cefadroxil once daily for streptococcal tonsillopharyngitisCorrene D Curtin
Elmwood Pediatric Group, Rochester, New York 14642, USA
Clin Pediatr (Phila) 42:519-26. 2003..Cephalexin dosed twice daily or three times daily and cefadroxil dosed once daily appear equivalent in bacteriologic and clinical cure of GABHS tonsillopharyngitis... 
Identification of Streptococcus pneumoniae and Haemophilus influenzae in culture-negative middle ear fluids from children with acute otitis media by combination of multiplex PCR and multi-locus sequencing typingQingfu Xu
Rochester General Hospital Research Institute, 1425 Portland Avenue, Rochester, NY 14621, USA
Int J Pediatr Otorhinolaryngol 75:239-44. 2011..This study aimed to develop a combined molecular method to accurately detect these otopathogens...- Frequency of symptomatic relapses of group A beta-hemolytic streptococcal tonsillopharyngitis in children from 4 pediatric practices following penicillin, amoxicillin, and cephalosporin antibiotic treatmentJanet R Casey
Legacy Pediatrics, University of Rochester, Rochester, New York, USA
Clin Pediatr (Phila) 47:549-54. 2008.... - Antibody response to Streptococcus pneumoniae proteins PhtD, LytB, PcpA, PhtE and Ply after nasopharyngeal colonization and acute otitis media in childrenMichael E Pichichero
Rochester General Hospital Research Institute, Rochester, NY, USA
Hum Vaccin Immunother 8:799-805. 2012.... - When co-colonizing the nasopharynx haemophilus influenzae predominates over Streptococcus pneumoniae except serotype 19A strains to cause acute otitis mediaQingfu Xu
Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester, NY, USA
Pediatr Infect Dis J 31:638-40. 2012..Haemophilus influenzae and Streptococcus pneumoniae both predominated over Moraxella catarrhalis to cause AOM... - Phylogenetic relatedness and diversity of non-typable Haemophilus influenzae in the nasopharynx and middle ear fluid of children with acute otitis mediaRavinder Kaur
Rochester General Hospital, Research Institute, Center for Infectious Diseases and Immunology, Rochester, NY, USA
J Med Microbiol 60:1841-8. 2011..In this first study of its type to our knowledge, we could not identify predominant MLST types among strains colonizing the NP versus those causing AOM or expressing a β-lactamase enzyme conferring penicillin resistance in children... - Antibody response to Haemophilus influenzae outer membrane protein D, P6, and OMP26 after nasopharyngeal colonization and acute otitis media in childrenMichael E Pichichero
Rochester General Hospital Research Institue, 1425 Portland Avenue, Rochester, NY 14621, USA
Vaccine 28:7184-92. 2010..For all 3 proteins serum antibody levels in the convalescent phase of AOM infection were not as high as after NP colonization. Antibodies to protein D and P6 but not OMP26 were bactericidal... - Changes in frequency and pathogens causing acute otitis media in 1995-2003Janet R Casey
Elmwood Pediatric Group, Department of Pediatrics, University of Rochester, Rochester, NY, USA
Pediatr Infect Dis J 23:824-8. 2004..Fewer S. pneumoniae AOM isolates are penicillin-resistant and more H. influenzae are beta-lactamase-producing... - Efficacy of penicillin vs. amoxicillin in children with group A beta hemolytic streptococcal tonsillopharyngitisCorrene Curtin-Wirt
Elmwood Pediatric Group, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Clin Pediatr (Phila) 42:219-25. 2003..84, 95% confidence interval 1.02-3.29); the same was true for dinical cure (OR = 1.99, 95% CI = 1.02-3.87). Amoxicillin may be superior to penicillin for bacteriologic and clinical cure of GABHS tonsillopharyngitis... - Reduced serum IgG responses to pneumococcal antigens in otitis-prone children may be due to poor memory B-cell generationSharad K Sharma
Center for Infectious Diseases and Vaccine Immunology, Research Institute, Rochester General Hospital, Rochester, NY, USA
J Infect Dis 205:1225-9. 2012.... - New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccineJanet R Casey
Department of Pediatrics, University of Rochester, Rochester, NY, USA
Pediatr Infect Dis J 29:304-9. 2010.... - Nontypeable Streptococcus pneumoniae as an otopathogenQingfu Xu
Rochester General Hospital Research Institute, Rochester, NY 14621, USA
Diagn Microbiol Infect Dis 69:200-4. 2011..pneumoniae (NT-Spn) in a child with acute otitis media (AOM). The strain was pneumolysin PCR positive and capsule gene PCR negative. Virulence of the NT-Spn was confirmed in a chinchilla model of AOM... - Bacterial eradication rates with shortened courses of 2nd- and 3rd-generation cephalosporins versus 10 days of penicillin for treatment of group A streptococcal tonsillopharyngitis in adultsMichael E Pichichero
University of Rochester, and Elmwood Pediatric Group, Rochester, NY 14642, USA
Diagn Microbiol Infect Dis 59:127-30. 2007..46; 95% confidence interval, 0.96-2.22, P = 0.08)... - Systematic review of factors contributing to penicillin treatment failure in Streptococcus pyogenes pharyngitisMichael E Pichichero
University of Rochester Medical Center, Rochester, NY 14642, USA
Otolaryngol Head Neck Surg 137:851-857. 2007..Review the evidence for various explanations for microbiologic treatment failure following use of penicillin in group A streptococcal (GAS) tonsillopharyngitis... - Evolving microbiology and molecular epidemiology of acute otitis media in the pneumococcal conjugate vaccine eraMichael E Pichichero
Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA urmc rochester edu
Pediatr Infect Dis J 26:S12-6. 2007..Expansion of the number of serotypes included in pneumococcal conjugate vaccines is needed to sustain a long-term benefit from immunization against these bacteria... - Serum antibody response to three non-typeable Haemophilus influenzae outer membrane proteins during acute otitis media and nasopharyngeal colonization in otitis prone and non-otitis prone childrenRavinder Kaur
Rochester General Hospital Research Institute, 1425 Portland Avenue, Rochester, NY 14621, USA
Vaccine 29:1023-8. 2011..Moreover, the data suggest that otitis prone children should be evaluated for their responses to Protein D, P6 and OMP26 vaccine antigens of NTHi... - Pathogens causing recurrent and difficult-to-treat acute otitis media, 2003-2006Michael E Pichichero
University of Rochester Medical Center and Legacy Pediatrics, Rochester, New York 14642, USA
Clin Pediatr (Phila) 47:901-6. 2008..influenzae produced beta-lactamase, respectively. Although H. influenzae remains the most frequently isolated pathogen in children with AOMTF or recurrent AOM, S. pneumoniae that are PNSP are reemerging as important organisms... - Simultaneous assay for four bacterial species including Alloiococcus otitidis using multiplex-PCR in children with culture negative acute otitis mediaRavinder Kaur
Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, University of Rochester School of Medicine, Rochester, NY, USA
Pediatr Infect Dis J 29:741-5. 2010..Conventional culture methods detect these pathogens in only 60% to 70% of cases of AOM. Alloiococcus otitidis, another potential pathogen, has often been ignored... - Novel type of Streptococcus pneumoniae causing multidrug-resistant acute otitis media in childrenQingfu Xu
University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Emerg Infect Dis 15:547-51. 2009..pneumoniae in which all strains had 6 of the same alleles as ST-156. The multidrug-resistant strains related to ST-156 expressed different capsular serotypes: 9V, 14, 11A, 15C, and 19F... - Comparison of amoxicillin/clavulanic acid high dose with cefdinir in the treatment of acute otitis mediaJanet R Casey
Legacy Pediatrics, Rochester, NY, USA
Drugs 72:1991-7. 2012.... - Serum antibody response to five Streptococcus pneumoniae proteins during acute otitis media in otitis-prone and non-otitis-prone childrenRavinder Kaur
Rochester General Hospital Research Institute, Center for Infectious Diseases and Immunology, Rochester, NY 14621, USA
Pediatr Infect Dis J 30:645-50. 2011..Streptococcus pneumoniae (Spn) is one of the common bacteria responsible for episodic acute otitis media (AOM; non-otitis-prone), recurrent AOM (otitis-prone), and AOM treatment failure (AOMTF) in children... - Azithromycin for the treatment of pertussisMichael E Pichichero
Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
Pediatr Infect Dis J 22:847-9. 2003 - Reduced memory CD4+ T-cell generation in the circulation of young children may contribute to the otitis-prone conditionSharad K Sharma
Center for Infectious Disease and Vaccine Immunology, Research Institute, Rochester General Hospital, Rochester, New York 14621, USA
J Infect Dis 204:645-53. 2011..Poor antibody response has been associated with the otitis-prone condition; however, there is no precise mechanistic explanation for this condition... - Acute otitis media: making sense of recent guidelines on antimicrobial treatmentMichael E Pichichero
University of Rochester Medical Center, Elmwood Pediatric Group, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
J Fam Pract 54:313-22. 2005..Key factors for enhancing compliance are taste of suspension, dosing frequency, and duration of therapy... - Emergence of a multiresistant serotype 19A pneumococcal strain not included in the 7-valent conjugate vaccine as an otopathogen in childrenMichael E Pichichero
University of Rochester and Legacy Pediatrics, Rochester, New York, USA
JAMA 298:1772-8. 2007..Concern has been raised about the possible emergence of a bacterial strain that is untreatable by US Food and Drug Administration (FDA)-approved antibiotics and that causes acute otitis media (AOM) in children... - Acellular pertussis vaccine boosters combined with diphtheria and tetanus toxoid boosters for adolescents: safety and immunogenicity assessment when preceded by different 5-dose DTaP/DTwP schedulesMichael E Pichichero
Microbiology and Immunology, Pediatrics and Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
Clin Pediatr (Phila) 45:613-20. 2006..Seroprotective levels and antibody concentrations were comparable regardless of prior DTaP/DTwP vaccine history. A sixth sequential dose of Tdap after 5 doses of DTaP appears safe and immunogenic... - Safe use of selected cephalosporins in penicillin-allergic patients: a meta-analysisMichael E Pichichero
Department of Microbiology and Immunology, University of Rochester, Elmwood Pediatric Group, Otolaryngology, University of Rochester Medical Center, Rochester, NY, USA
Otolaryngol Head Neck Surg 136:340-7. 2007.... - Antibody in middle ear fluid of children originates predominantly from sera and nasopharyngeal secretionsRavinder Kaur
Rochester General Hospital Research Institute, Center for Infectious Diseases and Immunology, Rochester, New York, USA
Clin Vaccine Immunol 19:1593-6. 2012.... - A simple scoring system to improve clinical assessment of acute otitis mediaJanet R Casey
Legacy Pediatrics, Rochester, NY, USA
Clin Pediatr (Phila) 50:623-9. 2011..Study design. Symptoms of AOM observed by validated otoscopists were tabulated and scored with a 10-point and a 30-point system at acute onset of illness and at the test-of-cure (TOC) 3 weeks later... - Diagnostic inaccuracy and subject exclusions render placebo and observational studies of acute otitis media inconclusiveMichael E Pichichero
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
Pediatr Infect Dis J 27:958-62. 2008..Diagnostic accuracy and appropriate inclusion/exclusion criteria representative of children at greatest risk is of paramount importance in trials to evaluate placebo or observation as an option for acute otitis media (AOM) management... - Haemophilus influenzae vaccine candidate outer membrane protein P6 is not conserved in all strainsArthur Chang
Rochester General Hospital, Rochester General Research Institute, Center for Infectious Diseases and Immunology, Rochester, NY, USA
Hum Vaccin 7:102-5. 2011..These results show that NTHi omp P6 is not invariant in its structure among respiratory isolates from children... - White blood cell count can aid judicious antibiotic prescribing in acute upper respiratory infections in childrenJanet R Casey
Elmwood Pediatric Group, Rochester, NY 14642, USA
Clin Pediatr (Phila) 42:113-9. 2003..With this approach, return office visits in the following 2 weeks were infrequent (13% of 737 patients), and no child had significant bacterial illness that was missed. With selective use of WBC count testing.. - A comparison of 2 white blood cell count devices to aid judicious antibiotic prescribingJanet R Casey
Legacy Pediatrics, Department of Pediatrics, University of Rochester, Rochester, New York, 14642, USA
Clin Pediatr (Phila) 48:291-4. 2009..A simple and quick point-of-care WBC count device produces similar results as achievable with a Cell-Dyn counter for total WBCs and may assist in judicious antibiotic prescribing... - Comparison of study designs for acute otitis media trialsMichael E Pichichero
University of Rochester, School of Medicine, Department of Microbiology Immunology, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, United States
Int J Pediatr Otorhinolaryngol 72:737-50. 2008..A framework for evaluating the efficacy of antibiotics in development as well as those currently approved for acute otitis media (AOM) is needed... - Acellular pertussis vaccine safety and efficacy in children, adolescents and adultsJanet R Casey
Elmwood Pediatric Group, University of Rochester, Rochester, New York 14620, USA
Drugs 65:1367-89. 2005..The economic impact of pertussis and transmission from adults to vulnerable infants provides a cost-benefit justification for widespread use of DTaP vaccines in all age groups with routine boosting every 10 years... - Breast-feeding is associated with a reduced frequency of acute otitis media and high serum antibody levels against NTHi and outer membrane protein vaccine antigen candidate P6Albert Sabirov
Department of Microbiology Immunology, University of Rochester, Rochester, New York 14627, USA
Pediatr Res 66:565-70. 2009..Higher serum IgG might facilitate protection against AOM and NP colonization in breast-fed children... - Acellular pertussis vaccines for adolescentsMichael E Pichichero
Elmwood Pediatric Group, University of Rochester, Rochester, NY 14642, USA
Pediatr Infect Dis J 24:S117-26. 2005..This development has spurred studies and anticipated licensure of safer diphtheria, tetanus, acellular pertussis combined (Tdap) vaccines for this older population... - Otitis mediaMichael E Pichichero
Elmwood Pediatric Group, University of Rochester Medical Center, Rochester, NY 14642, USA
Expert Opin Pharmacother 3:1073-90. 2002..Best-practice for management of acute OM continues to advocate antibiotic therapy with careful, accurate diagnosis and consideration of the major pathogens and their mechanisms of resistance... - Does group A beta-hemolytic streptococcal infection increase risk for behavioral and neuropsychiatric symptoms in children?Eliana Miller Perrin
Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, University of North Carolina at Chapel Hill, 200 Mason Farm Road, Chapel Hill, NC 27599 7220, USA
Arch Pediatr Adolesc Med 158:848-56. 2004..To determine whether group A beta-hemolytic streptococcal infections increase the risk of developing symptoms characteristic of the diagnosis pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS)...