Janet R Casey

Summary

Country: USA

Publications

  1. ncbi request reprint Meta-analysis of cephalosporins versus penicillin for treatment of group A streptococcal tonsillopharyngitis in adults
    Janet R Casey
    University of Rochester, Elmwood Pediatric Group, Rochester, New York 14620, USA
    Clin Infect Dis 38:1526-34. 2004
  2. doi request reprint Treating acute otitis media post-PCV-7: judicious antibiotic therapy
    Janet R Casey
    Elmwood Pediatric Group, Rochester, NY 14620, USA
    Postgrad Med 118:32-3, 24-31. 2005
  3. ncbi request reprint Symptomatic relapse of group A beta-hemolytic streptococcal tonsillopharyngitis in children
    Janet R Casey
    University of Rochester School of Medicine, Elmwood Pediatric Group, Rochester, New York, USA
    Clin Pediatr (Phila) 46:307-10. 2007
  4. ncbi request reprint The evidence base for cephalosporin superiority over penicillin in streptococcal pharyngitis
    Janet R Casey
    Elmwood Pediatric Group, University of Rochester, Rochester, NY 14642, USA
    Diagn Microbiol Infect Dis 57:39S-45S. 2007
  5. ncbi request reprint Metaanalysis of short course antibiotic treatment for group a streptococcal tonsillopharyngitis
    Janet R Casey
    Department of Pediatrics, Elmwood Pediatric Group, University of Rochester Medical Center, NY, USA
    Pediatr Infect Dis J 24:909-17. 2005
  6. ncbi request reprint Higher dosages of azithromycin are more effective in treatment of group A streptococcal tonsillopharyngitis
    Janet R Casey
    Department of Pediatrics, Elmwood Pediatric Group, University of Rochester Medical Center, New York, USA
    Clin Infect Dis 40:1748-55. 2005
  7. ncbi request reprint Meta-analysis of cephalosporin versus penicillin treatment of group A streptococcal tonsillopharyngitis in children
    Janet R Casey
    Department of Pediatrics, Elmwood Pediatric Group, University of Rochester, Rochester, New York 14620, USA
    Pediatrics 113:866-82. 2004
  8. ncbi request reprint Efficacy of cephalexin two vs. three times daily vs. cefadroxil once daily for streptococcal tonsillopharyngitis
    Correne D Curtin
    Elmwood Pediatric Group, Rochester, New York 14642, USA
    Clin Pediatr (Phila) 42:519-26. 2003
  9. pmc Identification of Streptococcus pneumoniae and Haemophilus influenzae in culture-negative middle ear fluids from children with acute otitis media by combination of multiplex PCR and multi-locus sequencing typing
    Qingfu Xu
    Rochester General Hospital Research Institute, 1425 Portland Avenue, Rochester, NY 14621, USA
    Int J Pediatr Otorhinolaryngol 75:239-44. 2011
  10. ncbi request reprint Frequency of symptomatic relapses of group A beta-hemolytic streptococcal tonsillopharyngitis in children from 4 pediatric practices following penicillin, amoxicillin, and cephalosporin antibiotic treatment
    Janet R Casey
    Legacy Pediatrics, University of Rochester, Rochester, New York, USA
    Clin Pediatr (Phila) 47:549-54. 2008

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Meta-analysis of cephalosporins versus penicillin for treatment of group A streptococcal tonsillopharyngitis in adults
    Janet R Casey
    University of Rochester, Elmwood Pediatric Group, Rochester, New York 14620, USA
    Clin Infect Dis 38:1526-34. 2004
    ..This meta-analysis indicates that the likelihood of bacteriologic and clinical failure in the treatment of GABHS tonsillopharyngitis is 2 times higher for oral penicillin than for oral cephalosporins...
  2. doi request reprint Treating acute otitis media post-PCV-7: judicious antibiotic therapy
    Janet R Casey
    Elmwood Pediatric Group, Rochester, NY 14620, USA
    Postgrad Med 118:32-3, 24-31. 2005
    ..Improved patient outcomes will result in fewer AOM episodes, decreased antibiotic resistance, and reduced direct and indirect health care costs...
  3. ncbi request reprint Symptomatic relapse of group A beta-hemolytic streptococcal tonsillopharyngitis in children
    Janet R Casey
    University of Rochester School of Medicine, Elmwood Pediatric Group, Rochester, New York, USA
    Clin Pediatr (Phila) 46:307-10. 2007
    ..02). Clinicians should be aware that the rate of symptomatic failures after antibiotic therapy for group A beta-hemolytic streptococcal tonsillopharyngitis differs by drug and is not an uncommon event...
  4. ncbi request reprint The evidence base for cephalosporin superiority over penicillin in streptococcal pharyngitis
    Janet R Casey
    Elmwood Pediatric Group, University of Rochester, Rochester, NY 14642, USA
    Diagn Microbiol Infect Dis 57:39S-45S. 2007
    ..This review examines the evidence supporting the use of cephalosporins as a first choice of treatment for many patients with GABHS pharyngitis...
  5. ncbi request reprint Metaanalysis of short course antibiotic treatment for group a streptococcal tonsillopharyngitis
    Janet R Casey
    Department of Pediatrics, Elmwood Pediatric Group, University of Rochester Medical Center, NY, USA
    Pediatr Infect Dis J 24:909-17. 2005
    ..To compare bacterial and clinical cure rates in patients with group A streptococcal (GAS) tonsillopharyngitis treated with oral beta-lactam or macrolide antibiotics for 4-5 days versus 10-day comparators...
  6. ncbi request reprint Higher dosages of azithromycin are more effective in treatment of group A streptococcal tonsillopharyngitis
    Janet R Casey
    Department of Pediatrics, Elmwood Pediatric Group, University of Rochester Medical Center, New York, USA
    Clin Infect Dis 40:1748-55. 2005
    ..In this study, our objective was to determine the optimal dose of azithromycin for treatment of GAS tonsillopharyngitis in children and adults by analyzing trials that used different dose regimens...
  7. ncbi request reprint Meta-analysis of cephalosporin versus penicillin treatment of group A streptococcal tonsillopharyngitis in children
    Janet R Casey
    Department of Pediatrics, Elmwood Pediatric Group, University of Rochester, Rochester, New York 14620, USA
    Pediatrics 113:866-82. 2004
    ..To conduct a meta-analysis of randomized, controlled trials of cephalosporin versus penicillin treatment of group A beta-hemolytic streptococcal (GABHS) tonsillopharyngitis in children...
  8. ncbi request reprint Efficacy of cephalexin two vs. three times daily vs. cefadroxil once daily for streptococcal tonsillopharyngitis
    Correne D Curtin
    Elmwood Pediatric Group, Rochester, New York 14642, USA
    Clin Pediatr (Phila) 42:519-26. 2003
    ..Cephalexin dosed twice daily or three times daily and cefadroxil dosed once daily appear equivalent in bacteriologic and clinical cure of GABHS tonsillopharyngitis...
  9. pmc Identification of Streptococcus pneumoniae and Haemophilus influenzae in culture-negative middle ear fluids from children with acute otitis media by combination of multiplex PCR and multi-locus sequencing typing
    Qingfu Xu
    Rochester General Hospital Research Institute, 1425 Portland Avenue, Rochester, NY 14621, USA
    Int J Pediatr Otorhinolaryngol 75:239-44. 2011
    ..This study aimed to develop a combined molecular method to accurately detect these otopathogens...
  10. ncbi request reprint Frequency of symptomatic relapses of group A beta-hemolytic streptococcal tonsillopharyngitis in children from 4 pediatric practices following penicillin, amoxicillin, and cephalosporin antibiotic treatment
    Janet R Casey
    Legacy Pediatrics, University of Rochester, Rochester, New York, USA
    Clin Pediatr (Phila) 47:549-54. 2008
    ....
  11. pmc Antibody response to Streptococcus pneumoniae proteins PhtD, LytB, PcpA, PhtE and Ply after nasopharyngeal colonization and acute otitis media in children
    Michael E Pichichero
    Rochester General Hospital Research Institute, Rochester, NY, USA
    Hum Vaccin Immunother 8:799-805. 2012
    ....
  12. pmc When co-colonizing the nasopharynx haemophilus influenzae predominates over Streptococcus pneumoniae except serotype 19A strains to cause acute otitis media
    Qingfu Xu
    Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, Rochester, NY, USA
    Pediatr Infect Dis J 31:638-40. 2012
    ..Haemophilus influenzae and Streptococcus pneumoniae both predominated over Moraxella catarrhalis to cause AOM...
  13. pmc Phylogenetic relatedness and diversity of non-typable Haemophilus influenzae in the nasopharynx and middle ear fluid of children with acute otitis media
    Ravinder Kaur
    Rochester General Hospital, Research Institute, Center for Infectious Diseases and Immunology, Rochester, NY, USA
    J Med Microbiol 60:1841-8. 2011
    ..In this first study of its type to our knowledge, we could not identify predominant MLST types among strains colonizing the NP versus those causing AOM or expressing a β-lactamase enzyme conferring penicillin resistance in children...
  14. pmc Relationship with original pathogen in recurrence of acute otitis media after completion of amoxicillin/clavulanate: bacterial relapse or new pathogen
    Ravinder Kaur
    From the Rochester General Hospital Research Institute and Legacy Pediatrics, Rochester, NY
    Pediatr Infect Dis J 32:1159-62. 2013
    ..We sought to determine whether recurrent acute otitis media (rAOM) occurring within 30 days of amoxicillin/clavulanate treatment was caused by bacterial relapse or new pathogens...
  15. ncbi request reprint Efficacy of penicillin vs. amoxicillin in children with group A beta hemolytic streptococcal tonsillopharyngitis
    Correne Curtin-Wirt
    Elmwood Pediatric Group, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Clin Pediatr (Phila) 42:219-25. 2003
    ..84, 95% confidence interval 1.02-3.29); the same was true for dinical cure (OR = 1.99, 95% CI = 1.02-3.87). Amoxicillin may be superior to penicillin for bacteriologic and clinical cure of GABHS tonsillopharyngitis...
  16. pmc Antibody response to Haemophilus influenzae outer membrane protein D, P6, and OMP26 after nasopharyngeal colonization and acute otitis media in children
    Michael E Pichichero
    Rochester General Hospital Research Institue, 1425 Portland Avenue, Rochester, NY 14621, USA
    Vaccine 28:7184-92. 2010
    ..For all 3 proteins serum antibody levels in the convalescent phase of AOM infection were not as high as after NP colonization. Antibodies to protein D and P6 but not OMP26 were bactericidal...
  17. ncbi request reprint Changes in frequency and pathogens causing acute otitis media in 1995-2003
    Janet R Casey
    Elmwood Pediatric Group, Department of Pediatrics, University of Rochester, Rochester, NY, USA
    Pediatr Infect Dis J 23:824-8. 2004
    ....
  18. pmc Reduced serum IgG responses to pneumococcal antigens in otitis-prone children may be due to poor memory B-cell generation
    Sharad K Sharma
    Center for Infectious Diseases and Vaccine Immunology, Research Institute, Rochester General Hospital, Rochester, NY, USA
    J Infect Dis 205:1225-9. 2012
    ....
  19. pmc New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccine
    Janet R Casey
    Department of Pediatrics, University of Rochester, Rochester, NY, USA
    Pediatr Infect Dis J 29:304-9. 2010
    ....
  20. ncbi request reprint Bacterial eradication rates with shortened courses of 2nd- and 3rd-generation cephalosporins versus 10 days of penicillin for treatment of group A streptococcal tonsillopharyngitis in adults
    Michael E Pichichero
    University of Rochester, and Elmwood Pediatric Group, Rochester, NY 14642, USA
    Diagn Microbiol Infect Dis 59:127-30. 2007
    ..46; 95% confidence interval, 0.96-2.22, P = 0.08)...
  21. pmc Nontypeable Streptococcus pneumoniae as an otopathogen
    Qingfu Xu
    Rochester General Hospital Research Institute, Rochester, NY 14621, USA
    Diagn Microbiol Infect Dis 69:200-4. 2011
    ..pneumoniae (NT-Spn) in a child with acute otitis media (AOM). The strain was pneumolysin PCR positive and capsule gene PCR negative. Virulence of the NT-Spn was confirmed in a chinchilla model of AOM...
  22. pmc Novel type of Streptococcus pneumoniae causing multidrug-resistant acute otitis media in children
    Qingfu Xu
    University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Emerg Infect Dis 15:547-51. 2009
    ..pneumoniae in which all strains had 6 of the same alleles as ST-156. The multidrug-resistant strains related to ST-156 expressed different capsular serotypes: 9V, 14, 11A, 15C, and 19F...
  23. pmc Simultaneous assay for four bacterial species including Alloiococcus otitidis using multiplex-PCR in children with culture negative acute otitis media
    Ravinder Kaur
    Center for Infectious Diseases and Immunology, Rochester General Hospital Research Institute, University of Rochester School of Medicine, Rochester, NY, USA
    Pediatr Infect Dis J 29:741-5. 2010
    ..Conventional culture methods detect these pathogens in only 60% to 70% of cases of AOM. Alloiococcus otitidis, another potential pathogen, has often been ignored...
  24. doi request reprint Pathogens causing recurrent and difficult-to-treat acute otitis media, 2003-2006
    Michael E Pichichero
    University of Rochester Medical Center and Legacy Pediatrics, Rochester, New York 14642, USA
    Clin Pediatr (Phila) 47:901-6. 2008
    ..influenzae produced beta-lactamase, respectively. Although H. influenzae remains the most frequently isolated pathogen in children with AOMTF or recurrent AOM, S. pneumoniae that are PNSP are reemerging as important organisms...
  25. pmc Serum antibody response to three non-typeable Haemophilus influenzae outer membrane proteins during acute otitis media and nasopharyngeal colonization in otitis prone and non-otitis prone children
    Ravinder Kaur
    Rochester General Hospital Research Institute, 1425 Portland Avenue, Rochester, NY 14621, USA
    Vaccine 29:1023-8. 2011
    ..Moreover, the data suggest that otitis prone children should be evaluated for their responses to Protein D, P6 and OMP26 vaccine antigens of NTHi...
  26. ncbi request reprint Evolving microbiology and molecular epidemiology of acute otitis media in the pneumococcal conjugate vaccine era
    Michael E Pichichero
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA urmc rochester edu
    Pediatr Infect Dis J 26:S12-6. 2007
    ..Expansion of the number of serotypes included in pneumococcal conjugate vaccines is needed to sustain a long-term benefit from immunization against these bacteria...
  27. ncbi request reprint Systematic review of factors contributing to penicillin treatment failure in Streptococcus pyogenes pharyngitis
    Michael E Pichichero
    University of Rochester Medical Center, Rochester, NY 14642, USA
    Otolaryngol Head Neck Surg 137:851-857. 2007
    ..Review the evidence for various explanations for microbiologic treatment failure following use of penicillin in group A streptococcal (GAS) tonsillopharyngitis...
  28. pmc Acute otitis media otopathogens during 2008 to 2010 in Rochester, New York
    Janet R Casey
    Legacy Pediatrics, Rochester, NY, USA
    Pediatr Infect Dis J 32:805-9. 2013
    ..The otopathogen distribution colonizing the nasopharynx (NP) and causing acute otitis media (AOM) is in flux following the introduction of pneumococcal conjugate vaccine 7 (PCV7) and will continue to change...
  29. pmc Comparison of amoxicillin/clavulanic acid high dose with cefdinir in the treatment of acute otitis media
    Janet R Casey
    Legacy Pediatrics, Rochester, NY, USA
    Drugs 72:1991-7. 2012
    ....
  30. ncbi request reprint Azithromycin for the treatment of pertussis
    Michael E Pichichero
    Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    Pediatr Infect Dis J 22:847-9. 2003
  31. pmc Serum antibody response to five Streptococcus pneumoniae proteins during acute otitis media in otitis-prone and non-otitis-prone children
    Ravinder Kaur
    Rochester General Hospital Research Institute, Center for Infectious Diseases and Immunology, Rochester, NY 14621, USA
    Pediatr Infect Dis J 30:645-50. 2011
    ..Streptococcus pneumoniae (Spn) is one of the common bacteria responsible for episodic acute otitis media (AOM; non-otitis-prone), recurrent AOM (otitis-prone), and AOM treatment failure (AOMTF) in children...
  32. pmc Reduced memory CD4+ T-cell generation in the circulation of young children may contribute to the otitis-prone condition
    Sharad K Sharma
    Center for Infectious Disease and Vaccine Immunology, Research Institute, Rochester General Hospital, Rochester, New York 14621, USA
    J Infect Dis 204:645-53. 2011
    ..Poor antibody response has been associated with the otitis-prone condition; however, there is no precise mechanistic explanation for this condition...
  33. ncbi request reprint Emergence of a multiresistant serotype 19A pneumococcal strain not included in the 7-valent conjugate vaccine as an otopathogen in children
    Michael E Pichichero
    University of Rochester and Legacy Pediatrics, Rochester, New York, USA
    JAMA 298:1772-8. 2007
    ..Concern has been raised about the possible emergence of a bacterial strain that is untreatable by US Food and Drug Administration (FDA)-approved antibiotics and that causes acute otitis media (AOM) in children...
  34. ncbi request reprint Safe use of selected cephalosporins in penicillin-allergic patients: a meta-analysis
    Michael E Pichichero
    Department of Microbiology and Immunology, University of Rochester, Elmwood Pediatric Group, Otolaryngology, University of Rochester Medical Center, Rochester, NY, USA
    Otolaryngol Head Neck Surg 136:340-7. 2007
    ....
  35. ncbi request reprint Acellular pertussis vaccine boosters combined with diphtheria and tetanus toxoid boosters for adolescents: safety and immunogenicity assessment when preceded by different 5-dose DTaP/DTwP schedules
    Michael E Pichichero
    Microbiology and Immunology, Pediatrics and Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    Clin Pediatr (Phila) 45:613-20. 2006
    ..Seroprotective levels and antibody concentrations were comparable regardless of prior DTaP/DTwP vaccine history. A sixth sequential dose of Tdap after 5 doses of DTaP appears safe and immunogenic...
  36. ncbi request reprint Acute otitis media: making sense of recent guidelines on antimicrobial treatment
    Michael E Pichichero
    University of Rochester Medical Center, Elmwood Pediatric Group, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, USA
    J Fam Pract 54:313-22. 2005
    ..Key factors for enhancing compliance are taste of suspension, dosing frequency, and duration of therapy...
  37. pmc Antibody in middle ear fluid of children originates predominantly from sera and nasopharyngeal secretions
    Ravinder Kaur
    Rochester General Hospital Research Institute, Center for Infectious Diseases and Immunology, Rochester, New York, USA
    Clin Vaccine Immunol 19:1593-6. 2012
    ....
  38. doi request reprint A simple scoring system to improve clinical assessment of acute otitis media
    Janet R Casey
    Legacy Pediatrics, Rochester, NY, USA
    Clin Pediatr (Phila) 50:623-9. 2011
    ..Study design. Symptoms of AOM observed by validated otoscopists were tabulated and scored with a 10-point and a 30-point system at acute onset of illness and at the test-of-cure (TOC) 3 weeks later...
  39. doi request reprint Diagnostic inaccuracy and subject exclusions render placebo and observational studies of acute otitis media inconclusive
    Michael E Pichichero
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Pediatr Infect Dis J 27:958-62. 2008
    ..Diagnostic accuracy and appropriate inclusion/exclusion criteria representative of children at greatest risk is of paramount importance in trials to evaluate placebo or observation as an option for acute otitis media (AOM) management...
  40. pmc Haemophilus influenzae vaccine candidate outer membrane protein P6 is not conserved in all strains
    Arthur Chang
    Rochester General Hospital, Rochester General Research Institute, Center for Infectious Diseases and Immunology, Rochester, NY, USA
    Hum Vaccin 7:102-5. 2011
    ..These results show that NTHi omp P6 is not invariant in its structure among respiratory isolates from children...
  41. pmc Nonprotective responses to pediatric vaccines occur in children who are otitis prone
    Michael E Pichichero
    From the Center for Infectious Disease and Immunology, Research Institute, Rochester General Hospital Legacy Pediatrics and Department of Biostatistics and Computational Biology, University of Rochester, Rochester, NY
    Pediatr Infect Dis J 32:1163-8. 2013
    ..Here we sought to determine if these same children also failed to develop antibody to routine pediatric vaccinations...
  42. ncbi request reprint White blood cell count can aid judicious antibiotic prescribing in acute upper respiratory infections in children
    Janet R Casey
    Elmwood Pediatric Group, Rochester, NY 14642, USA
    Clin Pediatr (Phila) 42:113-9. 2003
    ..With this approach, return office visits in the following 2 weeks were infrequent (13% of 737 patients), and no child had significant bacterial illness that was missed. With selective use of WBC count testing..
  43. ncbi request reprint Acellular pertussis vaccines for adolescents
    Michael E Pichichero
    Elmwood Pediatric Group, University of Rochester, Rochester, NY 14642, USA
    Pediatr Infect Dis J 24:S117-26. 2005
    ..This development has spurred studies and anticipated licensure of safer diphtheria, tetanus, acellular pertussis combined (Tdap) vaccines for this older population...
  44. doi request reprint Comparison of study designs for acute otitis media trials
    Michael E Pichichero
    University of Rochester, School of Medicine, Department of Microbiology Immunology, 601 Elmwood Avenue, Box 672, Rochester, NY 14642, United States
    Int J Pediatr Otorhinolaryngol 72:737-50. 2008
    ..A framework for evaluating the efficacy of antibiotics in development as well as those currently approved for acute otitis media (AOM) is needed...
  45. ncbi request reprint Acellular pertussis vaccine safety and efficacy in children, adolescents and adults
    Janet R Casey
    Elmwood Pediatric Group, University of Rochester, Rochester, New York 14620, USA
    Drugs 65:1367-89. 2005
    ..The economic impact of pertussis and transmission from adults to vulnerable infants provides a cost-benefit justification for widespread use of DTaP vaccines in all age groups with routine boosting every 10 years...
  46. doi request reprint A comparison of 2 white blood cell count devices to aid judicious antibiotic prescribing
    Janet R Casey
    Legacy Pediatrics, Department of Pediatrics, University of Rochester, Rochester, New York, 14642, USA
    Clin Pediatr (Phila) 48:291-4. 2009
    ..A simple and quick point-of-care WBC count device produces similar results as achievable with a Cell-Dyn counter for total WBCs and may assist in judicious antibiotic prescribing...
  47. pmc Breast-feeding is associated with a reduced frequency of acute otitis media and high serum antibody levels against NTHi and outer membrane protein vaccine antigen candidate P6
    Albert Sabirov
    Department of Microbiology Immunology, University of Rochester, Rochester, New York 14627, USA
    Pediatr Res 66:565-70. 2009
    ..Higher serum IgG might facilitate protection against AOM and NP colonization in breast-fed children...
  48. ncbi request reprint Otitis media
    Michael E Pichichero
    Elmwood Pediatric Group, University of Rochester Medical Center, Rochester, NY 14642, USA
    Expert Opin Pharmacother 3:1073-90. 2002
    ..Best-practice for management of acute OM continues to advocate antibiotic therapy with careful, accurate diagnosis and consideration of the major pathogens and their mechanisms of resistance...
  49. ncbi request reprint Does group A beta-hemolytic streptococcal infection increase risk for behavioral and neuropsychiatric symptoms in children?
    Eliana Miller Perrin
    Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, University of North Carolina at Chapel Hill, 200 Mason Farm Road, Chapel Hill, NC 27599 7220, USA
    Arch Pediatr Adolesc Med 158:848-56. 2004
    ..To determine whether group A beta-hemolytic streptococcal infections increase the risk of developing symptoms characteristic of the diagnosis pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS)...