Wen Quan Zou

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc Recombinant human prion protein inhibits prion propagation in vitro
    Jue Yuan
    1 Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA 2 National Prion Disease Pathology Surveillance Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA 3
    Sci Rep 3:2911. 2013
  2. pmc Characterization of spontaneously generated prion-like conformers in cultured cells
    Roger S Zou
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Aging (Albany NY) 3:968-84. 2011
  3. pmc Protease-sensitive prions with 144-bp insertion mutations
    Xiangzhu Xiao
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Aging (Albany NY) 5:155-73. 2013
  4. pmc Glycoform-selective prion formation in sporadic and familial forms of prion disease
    Xiangzhu Xiao
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
    PLoS ONE 8:e58786. 2013
  5. pmc Insoluble cellular prion protein and its association with prion and Alzheimer diseases
    Wen Quan Zou
    Department of Pathology, National Prion Disease Pathology Surveillance Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Prion 5:172-8. 2011
  6. pmc Sporadic fatal insomnia in a young woman: a diagnostic challenge: case report
    Karen M Moody
    Texas Department of State Health Services, Austin, TX 78756 3199, USA
    BMC Neurol 11:136. 2011
  7. pmc Variably protease-sensitive prionopathy: a new sporadic disease of the prion protein
    Wen Quan Zou
    Department of Pathology, National Prion Disease Pathology Surveillance Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Ann Neurol 68:162-72. 2010
  8. pmc PrP conformational transitions alter species preference of a PrP-specific antibody
    Wen Quan Zou
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 4410, USA
    J Biol Chem 285:13874-84. 2010
  9. pmc Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain
    Wen Quan Zou
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Biol Chem 286:15095-105. 2011
  10. ncbi request reprint Prion: the chameleon protein
    W Q Zou
    Department of Pathology and National Prion Disease Pathology Surveillance Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Cell Mol Life Sci 64:3266-70. 2007

Collaborators

Detail Information

Publications30

  1. pmc Recombinant human prion protein inhibits prion propagation in vitro
    Jue Yuan
    1 Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA 2 National Prion Disease Pathology Surveillance Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA 3
    Sci Rep 3:2911. 2013
    ..Our findings suggest a new avenue for treating prion diseases, in which a patient's own unglycosylated and anchorless PrP is used to inhibit PrP(Sc) propagation without inducing immune response side effects. ..
  2. pmc Characterization of spontaneously generated prion-like conformers in cultured cells
    Roger S Zou
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Aging (Albany NY) 3:968-84. 2011
    ..Our results indicate that iPrPC may be formed more readily in an intracellular compartment and that a significant increase in PrPT183A aggregation may be attributable to the inhibition of autophagy...
  3. pmc Protease-sensitive prions with 144-bp insertion mutations
    Xiangzhu Xiao
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Aging (Albany NY) 5:155-73. 2013
    ....
  4. pmc Glycoform-selective prion formation in sporadic and familial forms of prion disease
    Xiangzhu Xiao
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
    PLoS ONE 8:e58786. 2013
    ....
  5. pmc Insoluble cellular prion protein and its association with prion and Alzheimer diseases
    Wen Quan Zou
    Department of Pathology, National Prion Disease Pathology Surveillance Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Prion 5:172-8. 2011
    ....
  6. pmc Sporadic fatal insomnia in a young woman: a diagnostic challenge: case report
    Karen M Moody
    Texas Department of State Health Services, Austin, TX 78756 3199, USA
    BMC Neurol 11:136. 2011
    ..Sporadic fatal insomnia (sFI) and fatal familial insomnia (FFI) are rare human prion diseases...
  7. pmc Variably protease-sensitive prionopathy: a new sporadic disease of the prion protein
    Wen Quan Zou
    Department of Pathology, National Prion Disease Pathology Surveillance Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Ann Neurol 68:162-72. 2010
    ..The 2 new PSPr forms affect individuals who are either homozygous for methionine (129MM) or heterozygous for methionine/valine (129MV)...
  8. pmc PrP conformational transitions alter species preference of a PrP-specific antibody
    Wen Quan Zou
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 4410, USA
    J Biol Chem 285:13874-84. 2010
    ....
  9. pmc Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain
    Wen Quan Zou
    Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    J Biol Chem 286:15095-105. 2011
    ..Although this work indicated the interaction of Aβ42 with huPrP in the AD brain, the pathophysiological relevance of the iPrP/Aβ42 interaction remains to be established...
  10. ncbi request reprint Prion: the chameleon protein
    W Q Zou
    Department of Pathology and National Prion Disease Pathology Surveillance Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Cell Mol Life Sci 64:3266-70. 2007
    ..Recent progress in modeling prion diseases and characterization of the various prion protein forms reveal that such a wide spectrum of the diseases is associated with the chameleon-like conformational features of prions...
  11. ncbi request reprint Classification of sporadic Creutzfeldt-Jakob disease revisited
    Ignazio Cali
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Brain 129:2266-77. 2006
    ..These data indicate that the differentiation of sCJDMM1 into two subgroups is not currently justified...
  12. pmc Co-existence of scrapie prion protein types 1 and 2 in sporadic Creutzfeldt-Jakob disease: its effect on the phenotype and prion-type characteristics
    Ignazio Cali
    Department of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Brain 132:2643-58. 2009
    ..All of these findings indicate that sCJDMM1-2 should be considered as a separate entity at this time...
  13. pmc Creutzfeldt-Jakob disease (CJD) with a mutation at codon 148 of prion protein gene: relationship with sporadic CJD
    Manuela Pastore
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Am J Pathol 167:1729-38. 2005
    ....
  14. ncbi request reprint Insoluble aggregates and protease-resistant conformers of prion protein in uninfected human brains
    Jue Yuan
    Department of Pathology and National Prion Disease Pathology Surveillance Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 281:34848-58. 2006
    ..This is the first study that provides experimental evidence supporting the hypothesis that there might be silent prions lying dormant in normal human brains...
  15. pmc A novel human disease with abnormal prion protein sensitive to protease
    Pierluigi Gambetti
    Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Ann Neurol 63:697-708. 2008
    ....
  16. pmc Molecular biology and pathology of prion strains in sporadic human prion diseases
    Pierluigi Gambetti
    Department of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH, 44106, USA
    Acta Neuropathol 121:79-90. 2011
    ..However, the intrinsic characteristics that distinguish at least four of these strains remain to be identified...
  17. ncbi request reprint Concealment of epitope by reduction and alkylation in prion protein
    Jue Yuan
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Biochem Biophys Res Commun 326:652-9. 2005
    ..The implications in the conversion of PrP(C) into PrP(Sc) and the therapeutics of prion diseases are discussed...
  18. ncbi request reprint Protease-resistant human prion protein and ferritin are cotransported across Caco-2 epithelial cells: implications for species barrier in prion uptake from the intestine
    Ravi Shankar Mishra
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurosci 24:11280-90. 2004
    ....
  19. doi request reprint Alkylating antitumor drug mechlorethamine conceals a structured PrP domain and inhibits in vitro prion amplification
    Xiaochen Zhou
    Department of Pathology, National Prion Disease Pathology Surveillance Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    J Toxicol Environ Health A 74:1493-503. 2011
    ..Our findings suggest that MCT may serve as a potential therapeutic agent for prion diseases...
  20. ncbi request reprint Identification of novel proteinase K-resistant C-terminal fragments of PrP in Creutzfeldt-Jakob disease
    Wen Quan Zou
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 278:40429-36. 2003
    ..The finding of PrP-CTF12/13 in CJD brains widens the heterogeneity of the PK-resistant PrP fragments associated with prion diseases and may provide useful insights toward the understanding of the PrPSc structure and its formation...
  21. pmc Evaluation of the human transmission risk of an atypical bovine spongiform encephalopathy prion strain
    Qingzhong Kong
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    J Virol 82:3697-701. 2008
    ..Minimal brain spongiosis and long incubation times are observed for the BASE strain-infected Tg mice. These results suggest that in humans, the BASE strain is a more virulent BSE strain and likely lymphotropic...
  22. pmc Antibody to DNA detects scrapie but not normal prion protein
    Wen Quan Zou
    Institute of Pathology, Case Western Reserve University and National Prion Disease Pathology Surveillance Center, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 101:1380-5. 2004
    ..Our finding that anti-DNA Abs and gene 5 protein specifically target disease-associated DNA-PrP complexes in a wide variety of species and disease phenotypes opens new avenues in the study and diagnosis of prion diseases...
  23. pmc Multiorgan detection and characterization of protease-resistant prion protein in a case of variant CJD examined in the United States
    Silvio Notari
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 5:e8765. 2010
    ..Three cases have been identified in the United States; however, these subjects were likely exposed to prion infection elsewhere. Here we report on the first of these subjects...
  24. pmc Failure to detect the presence of prions in the uterine and gestational tissues from a Gravida with Creutzfeldt-Jakob disease
    Xiangzhu Xiao
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Am J Pathol 174:1602-8. 2009
    ..Nevertheless, examination by a highly sensitive bioassay is ongoing to ascertain possible prion infectivity from CJD in the amniotic fluid...
  25. pmc Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death
    Wataru Kudo
    Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Hum Mol Genet 21:1138-44. 2012
    ..These findings are the first to demonstrate that PrP(C) is required for Aβ oligomer-induced neuronal cell death, the pathology essential to cognitive loss...
  26. doi request reprint Variably protease-sensitive prionopathy: a novel disease of the prion protein
    Pierluigi Gambetti
    Department of Pathology, National Prion Disease Pathology Surveillance Center, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
    J Mol Neurosci 45:422-4. 2011
    ..These findings suggest that VPSPr is basically different from classical prion diseases such as sCJD being perhaps more akin to other neurodegenerative dementias...
  27. ncbi request reprint From microbes to prions the final proof of the prion hypothesis
    Wen Quan Zou
    Division of Neuropathology, Department of Pathology, National Prion Disease Pathology Surveillance Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Cell 121:155-7. 2005
    ..In this issue of Cell, come very close to accomplishing this goal by producing a prion disease in a natural host from a prion entirely generated in vitro using a PCR-like amplification system...
  28. pmc Creutzfeldt-Jakob disease with unusually extensive neuropathology in a child treated with native human growth hormone
    Jacqueline Mikol
    Denis Diderot University
    Clin Neuropathol 31:127-34. 2012
    ..A transitional form of the disease between common iatrogenic and panencephalopathic CJD is suggested...
  29. ncbi request reprint Accessibility of a critical prion protein region involved in strain recognition and its implications for the early detection of prions
    J Yuan
    Department of Pathology and National Prion Disease Pathology Surveillance Center, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Cell Mol Life Sci 65:631-43. 2008
    ..Our study suggests that an increase in the level of PrP*20 characterizes the early stages of prion diseases...
  30. ncbi request reprint All or none fibrillogenesis of a prion peptide
    W Q Zou
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Ontario, Canada
    Eur J Biochem 268:4885-91. 2001
    ..This variation in whether oligomeric intermediates are stably populated during fibril formation indicates that amyloid proteins assemble into a common fibrillar structure; however, they do so through different pathways...

Research Grants2

  1. Pathogenicity of prion protein aggregates from uninfected cells and brains
    Wen Quan Zou; Fiscal Year: 2009
    ..The proposed study will improve our understanding of PrPSc formation in the spontaneous prion diseases, and facilitate the development of early diagnostic and therapeutic strategies. ..
  2. Pathogenicity of prion protein aggregates from uninfected cells and brains
    Wen Quan Zou; Fiscal Year: 2010
    ..The proposed study will improve our understanding of PrPSc formation in the spontaneous prion diseases, and facilitate the development of early diagnostic and therapeutic strategies. ..