Affiliation: Case Western Reserve University
Zigmond R, Vaccariello S. Activating transcription factor 3 immunoreactivity identifies small populations of axotomized neurons in rat cervical sympathetic ganglia after transection of the preganglionic cervical sympathetic trunk. Brain Res. 2007;1159:119-23 pubmed
Zigmond R. Heat shock protein that facilitates myelination of regenerating axons. Proc Natl Acad Sci U S A. 2017;114:2103-2105 pubmed publisher
Niemi J, DeFrancesco Lisowitz A, Cregg J, Howarth M, Zigmond R. Overexpression of the monocyte chemokine CCL2 in dorsal root ganglion neurons causes a conditioning-like increase in neurite outgrowth and does so via a STAT3 dependent mechanism. Exp Neurol. 2016;275 Pt 1:25-37 pubmed publisher
..Thus, CCL2 overexpression is sufficient to induce macrophage accumulation in uninjured L5 DRGs and increase the regenerative capacity of DRG neurons via a STAT3-dependent mechanism. ..
Lindborg J, Niemi J, Howarth M, Liu K, Moore C, Mahajan D, et al
. Molecular and cellular identification of the immune response in peripheral ganglia following nerve injury. J Neuroinflammation. 2018;15:192 pubmed publisher
..This study demonstrates both molecular and cellular differences in the nerve injury-induced immune response between DRG and SCG and between WT and Ccr2 -/- mice. ..
Niemi J, Filous A, Defrancesco A, Lindborg J, Malhotra N, Wilson G, et al
. Injury-induced gp130 cytokine signaling in peripheral ganglia is reduced in diabetes mellitus. Exp Neurol. 2017;296:1-15 pubmed publisher
..Together, these data suggest a novel mechanism for the decreased response of diabetic sympathetic and sensory neurons to injury. ..
Lindborg J, Mack M, Zigmond R. Neutrophils Are Critical for Myelin Removal in a Peripheral Nerve Injury Model of Wallerian Degeneration. J Neurosci. 2017;37:10258-10277 pubmed publisher
..These degeneration studies may propel improvements in nerve regeneration and draw critical parallels to mechanisms of nerve degeneration and regeneration in the CNS and in the context of peripheral neuropathies. ..