Xiaofeng Zhu

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc A unified association analysis approach for family and unrelated samples correcting for stratification
    Xiaofeng Zhu
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    Am J Hum Genet 82:352-65. 2008
  2. pmc Admixture mapping provides evidence of association of the VNN1 gene with hypertension
    Xiaofeng Zhu
    Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 2:e1244. 2007
  3. pmc Detecting rare variants for complex traits using family and unrelated data
    Xiaofeng Zhu
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Genet Epidemiol 34:171-87. 2010
  4. pmc Gene-gene and gene-environment interactions in ulcerative colitis
    Ming Hsi Wang
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, 9500 Euclid Avenue, Desk A31, Cleveland, OH, 44195, USA
    Hum Genet 133:547-58. 2014
  5. pmc Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium
    Xiaofeng Zhu
    Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Hum Mol Genet 20:2285-95. 2011
  6. ncbi request reprint EINVis: a visualization tool for analyzing and exploring genetic interactions in large-scale association studies
    Yubao Wu
    Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, Ohio
    Genet Epidemiol 37:675-85. 2013
  7. pmc What is the significance of difference in phenotypic variability across SNP genotypes?
    Xiangqing Sun
    Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Am J Hum Genet 93:390-7. 2013
  8. pmc Variants in CXADR and F2RL1 are associated with blood pressure and obesity in African-Americans in regions identified through admixture mapping
    Priya B Shetty
    Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    J Hypertens 30:1970-6. 2012
  9. pmc Improving power in contrasting linkage-disequilibrium patterns between cases and controls
    Tao Wang
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    Am J Hum Genet 80:911-20. 2007
  10. pmc Genome-wide searching of rare genetic variants in WTCCC data
    Tao Feng
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    Hum Genet 128:269-80. 2010

Collaborators

Detail Information

Publications64

  1. pmc A unified association analysis approach for family and unrelated samples correcting for stratification
    Xiaofeng Zhu
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    Am J Hum Genet 82:352-65. 2008
    ..This property is demonstrated in both a variety of simulation models and empirical data. The proposed approach can be equally applied to the analysis of both qualitative and quantitative traits...
  2. pmc Admixture mapping provides evidence of association of the VNN1 gene with hypertension
    Xiaofeng Zhu
    Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS ONE 2:e1244. 2007
    ..Despite these encouraging results, susceptibility loci for hypertension have been exceptionally difficult to localize and confirmation by independent studies will be necessary to establish these findings...
  3. pmc Detecting rare variants for complex traits using family and unrelated data
    Xiaofeng Zhu
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Genet Epidemiol 34:171-87. 2010
    ..These results suggest that searching for rare genetic variants is feasible and can be fruitful in current GWAS, candidate gene studies or resequencing studies...
  4. pmc Gene-gene and gene-environment interactions in ulcerative colitis
    Ming Hsi Wang
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, 9500 Euclid Avenue, Desk A31, Cleveland, OH, 44195, USA
    Hum Genet 133:547-58. 2014
    ..UC risk can be predicted by a 133 loci and improved by adding gene-gene and gene-environment interactions. ..
  5. pmc Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium
    Xiaofeng Zhu
    Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Hum Mol Genet 20:2285-95. 2011
    ..Our study highlights that admixture mapping analysis can help identify genetic variants missed by genome-wide association studies because of drastically reduced number of tests in the whole genome...
  6. ncbi request reprint EINVis: a visualization tool for analyzing and exploring genetic interactions in large-scale association studies
    Yubao Wu
    Department of Electrical Engineering and Computer Science, Case Western Reserve University, Cleveland, Ohio
    Genet Epidemiol 37:675-85. 2013
    ..It is publicly available with detailed documentation and online tutorial on the web at http://filer.case.edu/yxw407/einvis/. ..
  7. pmc What is the significance of difference in phenotypic variability across SNP genotypes?
    Xiangqing Sun
    Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Am J Hum Genet 93:390-7. 2013
    ..We find that, although they may detect differences in variability, these tests do not necessarily detect differences in variance. The same is true for permutation tests that use these three statistics. ..
  8. pmc Variants in CXADR and F2RL1 are associated with blood pressure and obesity in African-Americans in regions identified through admixture mapping
    Priya B Shetty
    Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    J Hypertens 30:1970-6. 2012
    ..Genetic variants in 296 genes in regions identified through admixture mapping of hypertension, BMI, and lipids were assessed for association with hypertension, blood pressure (BP), BMI, and high-density lipoprotein cholesterol (HDL-C)...
  9. pmc Improving power in contrasting linkage-disequilibrium patterns between cases and controls
    Tao Wang
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    Am J Hum Genet 80:911-20. 2007
    ..Finally, we illustrate our new method by applying it to real data from the International Collaborative Study on Hypertension in Blacks...
  10. pmc Genome-wide searching of rare genetic variants in WTCCC data
    Tao Feng
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    Hum Genet 128:269-80. 2010
    ....
  11. pmc Gene, pathway and network frameworks to identify epistatic interactions of single nucleotide polymorphisms derived from GWAS data
    Yu Liu
    Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, OH, USA
    BMC Syst Biol 6:S15. 2012
    ....
  12. pmc Power comparison of admixture mapping and direct association analysis in genome-wide association studies
    Huaizhen Qin
    Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Genet Epidemiol 36:235-43. 2012
    ..Surprisingly, our study also suggests that power can be improved when we use less strict criteria to define the candidate regions at stage 1...
  13. pmc Two-marker association tests yield new disease associations for coronary artery disease and hypertension
    Thomas P Slavin
    Department of Genetics, Center for Human Genetics, University Hospitals of Cleveland and Case Western Reserve University, 10524 Euclid Avenue, Cleveland, OH, USA
    Hum Genet 130:725-33. 2011
    ..We have shown that novel, multiple-marker, statistical methods can be of use in finding variants in GWAS. We describe many new, associated variants for both CAD and HTN and describe their known genetic mechanisms...
  14. pmc Interrogating local population structure for fine mapping in genome-wide association studies
    Huaizhen Qin
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH, USA
    Bioinformatics 26:2961-8. 2010
    ..Current association methods for correcting population stratification usually involve adjustment of global ancestry between study subjects...
  15. pmc Genome-wide association of anthropometric traits in African- and African-derived populations
    Sun J Kang
    Department of Biostatistics and Epidemiology, Case Western Reserve University, Cleveland, OH 44106, USA
    Hum Mol Genet 19:2725-38. 2010
    ..Meta-analysis of this data set with additional studies in African-ancestry populations will be helpful to improve power to detect novel associations...
  16. pmc Detecting rare and common variants for complex traits: sibpair and odds ratio weighted sum statistics (SPWSS, ORWSS)
    Tao Feng
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    Genet Epidemiol 35:398-409. 2011
    ..We demonstrated that family data are extremely informative in searching for rare variants underlying complex traits, and the odds ratio weighted sum statistic is more efficient than currently existing methods...
  17. pmc A novel approach to detect cumulative genetic effects and genetic interactions in Crohn's disease
    Ming Hsi Wang
    Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Inflamm Bowel Dis 19:1799-808. 2013
    ..The value of genetic variants in clinical practice is not defined because of limited explained heritability...
  18. pmc Capability of common SNPs to tag rare variants
    Xiangqing Sun
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    BMC Proc 5:S88. 2011
    ..Our results indicate that common SNPs can, to some extent, tag the presence of rare alleles and that including SNPs in strong linkage disequilibrium with each other among the tagging SNPs helps to detect rare alleles...
  19. pmc Estimating heritability using family and unrelated individuals data
    Priya B Shetty
    Case Western Reserve University School of Medicine, 2103 Cornell Road, Cleveland, OH 44106, USA
    BMC Proc 5:S34. 2011
    ..462 ± 0.1, and the calibrated restricted maximum-likelihood method yielded an average of 0.535 ± 0.121. Our results demonstrate discrepancies in heritability estimates using the family data and the unrelated individuals data...
  20. pmc Testing gene-environment interactions in gene-based association studies
    Xuefeng Wang
    Department of Epidemiology and Biostatistics, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH 44106 7281, USA
    BMC Proc 5:S26. 2011
    ..We demonstrate through a genome scan of the quantitative phenotype Q1 that the simulated gene-environment interaction effect in the data can be detected with reasonable power by using the least-squares kernel machine method...
  21. pmc Comparison of a unified analysis approach for family and unrelated samples with the transmission-disequilibrium test to study associations of hypertension in the Framingham Heart Study
    Xiangqing Sun
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    BMC Proc 3:S22. 2009
    ..We discuss the reasons for this inconsistency. After correcting for multiple tests, we did not detect any significant single-nucleotide polymorphisms by either FamCC or the TDT...
  22. pmc Admixture mapping of quantitative trait loci for BMI in African Americans: evidence for loci on chromosomes 3q, 5q, and 15q
    Analabha Basu
    Institute for Human Genetics, Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA
    Obesity (Silver Spring) 17:1226-31. 2009
    ..These results suggest that these regions may harbor genes influencing BMI in the AA population...
  23. ncbi request reprint Admixture mapping and the role of population structure for localizing disease genes
    Xiaofeng Zhu
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    Adv Genet 60:547-69. 2008
    ..In this chapter, we describe the recent methodology and software development, review successful applications, and comment on the future of this approach...
  24. pmc A novel method to detect rare variants using both family and unrelated case-control data
    Tao Feng
    Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH 44106, USA
    BMC Proc 5:S80. 2011
    ..We applied the proposed method to the simulated sequencing data in Genetic Analysis Workshop 17 and identified two genes associated with the disease...
  25. pmc Interrogating population structure and its impact on association tests
    Huaizhen Qin
    Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    BMC Proc 5:S25. 2011
    ..Adjusting for the principal components appeared more effective than did adjusting for ethnicity in terms of preventing false discoveries. This analysis was performed with knowledge of the causal loci...
  26. pmc Analysis of exome sequences with and without incorporating prior biological knowledge
    Junghyun Namkung
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    Genet Epidemiol 35:S48-55. 2011
    ..Another work group suggested that modeling local rather than global ancestry may be beneficial when controlling the effect of population structure in rare variant association analysis...
  27. doi request reprint Detecting rare variants
    Tao Feng
    Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Methods Mol Biol 850:453-64. 2012
    ..In this chapter, we introduce these methods as well as their applications in practice...
  28. pmc The meaning of interaction
    Xuefeng Wang
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106 7281, USA
    Hum Hered 70:269-77. 2010
    ....
  29. pmc Assessing the impact of global versus local ancestry in association studies
    Sun Jung Kang
    Department of Epidemiology and Biostatistics, Division of Genetic and Molecular Epidemiology, Case Western Reserve University School of Medicine, Wolstein Research Building, 2103 Cornell Road, Cleveland, Ohio 44106 USA
    BMC Proc 3:S107. 2009
    ....
  30. pmc A method to correct for population structure using a segregation model
    Qingfu Feng
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106 USA
    BMC Proc 3:S104. 2009
    ....
  31. pmc Evaluation of a LASSO regression approach on the unrelated samples of Genetic Analysis Workshop 17
    Wei Guo
    Department of Epidemiology and Biostatistics, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    BMC Proc 5:S12. 2011
    ..If a rare causal SNP is in strong linkage disequilibrium with a common marker in the same gene, power will be much improved...
  32. pmc Rare variant density across the genome and across populations
    Paola Raska
    Department of Epidemiology and Biostatistics, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    BMC Proc 5:S39. 2011
    ..This may suggest that differences between populations should be considered when delimiting genomic regions according to functionality and that these differences can create potential for disease heterogeneity...
  33. pmc The analysis of ethnic mixtures
    Xiaofeng Zhu
    Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Methods Mol Biol 850:465-81. 2012
    ..Therefore, admixture mapping can be more powerful because of the smaller penalty due to multiple tests. In this chapter, I introduce the theory behind admixture mapping and how we conduct the analysis in practice...
  34. pmc Allowing for population stratification in association analysis
    Huaizhen Qin
    Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Methods Mol Biol 850:399-409. 2012
    ..With an acceptable computation burden, the proposed algorithm successfully eliminates the known spurious association between SNPs in the LCT gene and height due to the population structure in European Americans...
  35. pmc Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies
    Hua Tang
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Am J Hum Genet 76:268-75. 2005
    ..S. population. Implications of this genetic structure for case-control association studies are discussed...
  36. pmc Linkage analysis of a complex disease through use of admixed populations
    Xiaofeng Zhu
    Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, Maywood, IL 60153, USA
    Am J Hum Genet 74:1136-53. 2004
    ..Our results show that the sample size required to obtain 90% power to detect a putative mutant allele at a genomewide significance level of 5% can usually be achieved in practice if informative markers are available at a density of 2 cM...
  37. ncbi request reprint Associations between hypertension and genes in the renin-angiotensin system
    Xiaofeng Zhu
    Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, Maywood, Ill, USA
    Hypertension 41:1027-34. 2003
    ..Thus, in this biracial population sample, we find evidence that interindividual variation in the renin-angiotensin system genes contributes to hypertension risk...
  38. pmc Linkage disequilibrium and haplotype diversity in the genes of the renin-angiotensin system: findings from the family blood pressure program
    Xiaofeng Zhu
    Department of Preventive Medicine and Epidemiology, Loyola Stritch School of Medicine, Maywood, Illinois 60153, USA
    Genome Res 13:173-81. 2003
    ..These findings have implications for candidate-gene association studies and indicate that variation between populations of European and African origin in haplotype diversity is characteristic of most genes...
  39. ncbi request reprint On a semiparametric test to detect associations between quantitative traits and candidate genes using unrelated individuals
    Shuanglin Zhang
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520 8034, USA
    Genet Epidemiol 24:44-56. 2003
    ....
  40. ncbi request reprint Genome scan among Nigerians linking blood pressure to chromosomes 2, 3, and 19
    Richard S Cooper
    Department of Preventive Medicine and Epidemiology, Loyola Medical School, Maywood, Ill 60153, USA
    Hypertension 40:629-33. 2002
    ..Study designs that make it possible to confirm these results with association analysis and narrow the genomic interval are needed in order to make progress in this field...
  41. ncbi request reprint Association mapping, using a mixture model for complex traits
    Xiaofeng Zhu
    Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, Maywood, Illinois 60153, USA
    Genet Epidemiol 23:181-96. 2002
    ..The proposed method can be effectively applied in the analysis of both qualitative and quantitative traits. Extensive simulations demonstrate that the method is valid in the presence of a population structure...
  42. ncbi request reprint Admixture mapping for hypertension loci with genome-scan markers
    Xiaofeng Zhu
    Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, 2160 S First Ave, Maywood, Illinois 60153, USA
    Nat Genet 37:177-81. 2005
    ..These results suggest that chromosome 6q24 and 21q21 may contain genes influencing risk of hypertension in African Americans...
  43. ncbi request reprint Transferability of tag SNPs in genetic association studies in multiple populations
    Paul I W de Bakker
    Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts, 02142, USA
    Nat Genet 38:1298-303. 2006
    ..These results demonstrate that the HapMap DNA samples can be used to select tags for genome-wide association studies in many samples around the world...
  44. pmc Genome-wide distribution of ancestry in Mexican Americans
    Analabha Basu
    Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Ave, Room 901H HSW, San Francisco, CA 94143, USA
    Hum Genet 124:207-14. 2008
    ..These locations may harbor genes that have been subjected to natural selection after the ancestral mixing giving rise to Mexicans...
  45. ncbi request reprint A combinatorial searching method for detecting a set of interacting loci associated with complex traits
    Qiuying Sha
    Department of Mathematical Sciences, Michigan Technological University, Houghton, 49931, USA
    Ann Hum Genet 70:677-92. 2006
    ..033, and similarly a two-locus gene-gene interaction model best predicts DBP with an overall p-value = 0.045...
  46. ncbi request reprint A classical likelihood based approach for admixture mapping using EM algorithm
    Xiaofeng Zhu
    Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, 2160 S First Ave, Maywood, IL 60153, USA
    Hum Genet 120:431-45. 2006
    ..The software ADMIXPROGRAM for performing admixture mapping is available from authors...
  47. ncbi request reprint Erythrocyte sodium-lithium countertransport and blood pressure: a genome-wide linkage study
    Alan B Weder
    Division of Hypertension, University of Michigan, Ann Arbor, MI 48109, USA
    Hypertension 41:842-6. 2003
    ..Further studies confirming the presence of a quantitative trait locus in this region and evaluating these candidate genes may help explain the association of elevated sodium-lithium countertransport and hypertension...
  48. ncbi request reprint Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity
    Helen N Lyon
    Division of Genetics, Children s Hospital Boston, Enders 561, 300 Longwood Ave, Boston, MA 02115, USA
    Diabetes 55:3180-4. 2006
    ..6 [0.42-0.88], P = 0.007). However, these findings are not supported by other studies. We did not observe a reproducible association between these three ENPP1 variants and BMI or type 2 diabetes...
  49. ncbi request reprint Racial admixture and its impact on BMI and blood pressure in African and Mexican Americans
    Hua Tang
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Hum Genet 119:624-33. 2006
    ..Excess obesity among Native Americans compared to whites is not consistent with a simple genetic explanation...
  50. ncbi request reprint Linkage disequilibrium analysis of the renin-angiotensin system genes
    Xiaofeng Zhu
    Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, 2160 S First Ave, Maywood, IL 60153, USA
    Curr Hypertens Rep 5:40-6. 2003
    ..In this review, the linkage disequilibrium among the polymorphisms within the four RAS genes and current association analyses involving the RAS are discussed, as well as some of the gaps of knowledge and possible solutions...
  51. ncbi request reprint Association studies of BMI and type 2 diabetes in the neuropeptide Y pathway: a possible role for NPY2R as a candidate gene for type 2 diabetes in men
    Catarina D Campbell
    Program in Genomics and Division of Endocrinology, Children s Hospital, Boston, Massachusetts 021115, USA
    Diabetes 56:1460-7. 2007
    ..73 x 10(-4), OR = 1.36) and not in women. Variation in this pathway likely does not have a major influence on BMI, although small effects cannot be ruled out; NPY2R should be considered a candidate gene for type 2 diabetes in men...
  52. pmc The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts
    Helen N Lyon
    Program in Genomics, Divisions of Genetics and Endocrinology, Children s Hospital, Boston, Massachusetts, USA
    PLoS Genet 3:e61. 2007
    ....
  53. pmc A combined analysis of genomewide linkage scans for body mass index from the National Heart, Lung, and Blood Institute Family Blood Pressure Program
    Xiaodong Wu
    Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, Maywood, IL 60153, USA
    Am J Hum Genet 70:1247-56. 2002
    ....
  54. ncbi request reprint Linkage for BMI at 3q27 region confirmed in an African-American population
    Amy Luke
    Department of Preventive Medicine and Epidemiology, Loyola University Stritch School of Medicine, 2160 South First Avenue, Maywood, IL 60153, USA
    Diabetes 52:1284-7. 2003
    ..The multiple replications of linkage evidence in the region on 3q27 strongly confirm its potential importance as a candidate region in the search for obesity-related genes...
  55. ncbi request reprint Analytical correction for multiple testing in admixture mapping
    Qiuying Sha
    Department of Mathematical Sciences, Michigan Technological University, Houghton, 49931, USA
    Hum Hered 62:55-63. 2006
    ..Our simulation studies show that the proposed method gives correct overall type I error rates for genome scans in all cases, and is much more computationally efficient than simulation-based methods...
  56. ncbi request reprint An association study of angiotensinogen polymorphisms with serum level and hypertension in an African-American population
    Xiaodong Wu
    Department of Preventive Medicine and Epidemiology, Loyola Stritch School of Medicine, Maywood, Illinois 60153, USA
    J Hypertens 21:1847-52. 2003
    ..To evaluate the association of angiotensinogen (AGT) gene with AGT level and hypertension based on the overall genetic variation of the AGT gene in among African-Americans...
  57. ncbi request reprint Angiotensin I-converting enzyme polymorphisms, ACE level and blood pressure among Nigerians, Jamaicans and African-Americans
    Nourdine Bouzekri
    Department of Biological Anthropology, University of Oxford, Oxford, UK
    Eur J Hum Genet 12:460-8. 2004
    ..We did observe, however, that the overtransmitted haplotypes among hypertensives were drawn from a single clade, suggesting that susceptibility may cluster in patterns not captured directly by our markers...
  58. ncbi request reprint A genome scan among Nigerians linking resting energy expenditure to chromosome 16
    Xiaodong Wu
    Department of Preventive Medicine and Epidemiology, Loyola Medical School, Maywood, Illinois 60153, USA
    Obes Res 12:577-81. 2004
    ..3) with a likelihood of odds of 2.96 (p = 0.08). Linkage evidence (likelihood of odds > 1) was detected on another three chromosomal regions, namely 2q12.1, 8q21.2, and 15p11.2...
  59. pmc Reconstructing genetic ancestry blocks in admixed individuals
    Hua Tang
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Am J Hum Genet 79:1-12. 2006
    ..One application of our method is to perform admixture mapping without genotyping special ancestry-informative-marker panels...
  60. ncbi request reprint Angiotensin-converting enzyme gene polymorphisms and obesity: an examination of three black populations
    Holly Kramer
    Loyola Medical Center, Department of Preventive Medicine, 2160 First Avenue, Maywood, IL 60153, USA
    Obes Res 13:823-8. 2005
    ..These data suggest that ACE gene polymorphisms may influence the development of weight gain...
  61. ncbi request reprint Refinement of the DFNA41 locus and candidate genes analysis
    Denise Yan
    Department of Otolaryngology D 48, University of Miami, Miami, FL 33136, USA
    J Hum Genet 50:516-22. 2005
    ..This study represents a significant refinement of the DFNA41 locus and should facilitate positional cloning of the disease gene...
  62. ncbi request reprint Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension
    Daniel L Dries
    Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiology, University of Texas at Southwestern Medical Center, Dallas, USA
    Circulation 112:2403-10. 2005
    ..The natriuretic peptide system contributes to blood pressure regulation. Atrial and brain natriuretic peptides are cleaved into smaller biologically active molecules by corin, a transmembrane serine protease expressed in cardiomyocytes...
  63. ncbi request reprint A common genetic variant is associated with adult and childhood obesity
    Alan Herbert
    Department of Genetics and Genomics, Boston University Medical School, E613, 715 Albany Street, Boston, MA 02118, USA
    Science 312:279-83. 2006
    ..The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity...
  64. ncbi request reprint A genome-wide scan of loci linked to serum adiponectin in two populations of African descent
    Chindo Hicks
    Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, 1219 Roosevelt Road, Maywood, IL 60153, USA
    Obesity (Silver Spring) 15:1207-14. 2007
    ..The objectives were to identify quantitative trait loci linked to serum adiponectin concentration and to estimate heritability in two populations of African descent...

Research Grants4

  1. Defining an Obesity QTL on Chromosome 3q
    Xiaofeng Zhu; Fiscal Year: 2007
    ..The methodologies applied have been used successfully to identify unique sequence variants in linkage peaks and to conduct fine mapping with specific physiologic candidate genes. ..
  2. LD Mapping Using Haplotype Block: Methods & Application
    Xiaofeng Zhu; Fiscal Year: 2007
    ..The results of this project would therefore provide a bridge between high throughput genotyping and efforts by genetic epidemiologists to localize informative SNPs. ..
  3. Fine Mapping of Hypertension Genes Detected by Admixture Mapping in the FBPP
    Xiaofeng Zhu; Fiscal Year: 2007
    ..Overall, our multi-stage design is likely to achieve greater power and higher resolution compared to a single-stage design. ..