Yan Yang

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. ncbi request reprint Loss of neuronal cell cycle control in ataxia-telangiectasia: a unified disease mechanism
    Yan Yang
    Department of Neurology, Alzheimer Research Laboratory E504, Case School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 25:2522-9. 2005
  2. pmc Cell division in the CNS: protective response or lethal event in post-mitotic neurons?
    Yan Yang
    Department of Neurology, University Hospitals of Cleveland, Alzheimer Research Lab, E504, Case Western Reserve University School of Medicine, 10900 Euclid Avenue Cleveland, OH 44106, USA
    Biochim Biophys Acta 1772:457-66. 2007
  3. pmc Complex seizure disorder caused by Brunol4 deficiency in mice
    Yan Yang
    The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS Genet 3:e124. 2007
  4. pmc NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease
    Nicholas H Varvel
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    J Clin Invest 119:3692-702. 2009
  5. ncbi request reprint Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models
    Yan Yang
    Department of Neurology, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Neurosci 26:775-84. 2006
  6. ncbi request reprint Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease
    Yan Yang
    Alzheimer Research Laboratory, University Hospitals of Cleveland and Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 23:2557-63. 2003
  7. pmc Cyclin dependent kinase 5 is required for the normal development of oligodendrocytes and myelin formation
    Yan Yang
    Department of Neurology, Case Western Reserve University, School of Medicine, 10900 Euclid, Ave, Cleveland, OH 44106, United States
    Dev Biol 378:94-106. 2013
  8. ncbi request reprint Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus
    Herve Lerat
    Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas 77555 1019, USA
    Gastroenterology 122:352-65. 2002
  9. pmc Nuclear localization of Cdk5 is a key determinant in the postmitotic state of neurons
    Jie Zhang
    Department of Cell Biology and Neuroscience, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 105:8772-7. 2008
  10. ncbi request reprint Mice carrying the szt1 mutation exhibit increased seizure susceptibility and altered sensitivity to compounds acting at the m-channel
    James F Otto
    Anticonvulsant Drug Development Program, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
    Epilepsia 45:1009-16. 2004

Collaborators

  • Jiaren Sun
  • Karl Herrup
  • Haibo Wang
  • Jie Zhang
  • Robert H Miller
  • Jun Li
  • Zhiren Zhang
  • H Steve White
  • Y Wang
  • Wei Wang
  • ELLIOTT JAY MUFSON
  • Jennifer A Kearney
  • R E Lanford
  • B T Lamb
  • Bin Wang
  • Yang Qin
  • James F Otto
  • Ming Xu Wei
  • Wayne N Frankel
  • Nicholas H Varvel
  • Shu Kun Wu
  • Xiaoming Xie
  • Yuhong Zou
  • Roger B Sher
  • Peng Cao
  • Peilin Xu
  • Yi Chen Ge
  • Rui Min Pan
  • Rene Rijnbrand
  • Karen S Wilcox
  • Tong Dai
  • Stanley M Lemon
  • Antje Pittner
  • Hong Lei
  • Abraham D Lee
  • Mats A Fernstrom
  • Sandra K Erickson
  • Sonia M Najjar
  • Gui Mei Zhang
  • Matthew N Poy
  • Herve Lerat
  • Steven L Wagner
  • Maria Z Kounnas
  • Kiran Bhaskar
  • Xin Hua Feng
  • Zhongkui Li
  • Zheng Li
  • Qingqing Ding
  • Bill Spohn
  • Xi ping Zhao
  • Dong Liang Yang
  • Yongkun Wei
  • Jing Yu Lang
  • Mien Chie Hung
  • Douglas B Evans
  • James L Abbruzzese
  • Weiya Xia
  • Su Zhang
  • Hsu Ping Kuo
  • Yuanfang Liu
  • Paul J Chiao
  • Chieko Aoyama
  • Dennis E Vance
  • Qiang Wu
  • Shu Rong Wang
  • Philip A Wood
  • Shaonin Ji
  • Kimberly A Huebsch
  • Janos Kerner
  • Gregory A Cox
  • Weiping Li
  • Charles L Hoppel
  • Lucy Beales
  • Kathryn Goettge
  • Lisette Cohen
  • Francis Bodola
  • Annette Martin
  • Xiao Bin Yu
  • Gary D Lopaschuk
  • George A Abou-Rjaily
  • Anthony M Deangelis
  • Qusai Y Al-Share'
  • Antonino Amato
  • Marzia Pasquali
  • Lawrence Sweetman
  • Marek Nalos
  • Wei Ping Li
  • Dong Li
  • Ai Wu Zhou
  • Min Zhu Chen

Detail Information

Publications32

  1. ncbi request reprint Loss of neuronal cell cycle control in ataxia-telangiectasia: a unified disease mechanism
    Yan Yang
    Department of Neurology, Alzheimer Research Laboratory E504, Case School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 25:2522-9. 2005
    ..These results suggest that loss of cell cycle control represents a common disease mechanism that underlies the defects in the affected tissues in both human and mouse diseases...
  2. pmc Cell division in the CNS: protective response or lethal event in post-mitotic neurons?
    Yan Yang
    Department of Neurology, University Hospitals of Cleveland, Alzheimer Research Lab, E504, Case Western Reserve University School of Medicine, 10900 Euclid Avenue Cleveland, OH 44106, USA
    Biochim Biophys Acta 1772:457-66. 2007
    ..What is not known is whether, in an adult neuron, the cell cycle event is part of the pathology or rather a desperate attempt of a neuron under stress to protect itself...
  3. pmc Complex seizure disorder caused by Brunol4 deficiency in mice
    Yan Yang
    The Jackson Laboratory, Bar Harbor, Maine, United States of America
    PLoS Genet 3:e124. 2007
    ....
  4. pmc NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease
    Nicholas H Varvel
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
    J Clin Invest 119:3692-702. 2009
    ....
  5. ncbi request reprint Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models
    Yan Yang
    Department of Neurology, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Neurosci 26:775-84. 2006
    ..Finally, the relative timing suggests that neither the activated microglia nor the amyloid plaques themselves are necessary to initiate the pathogenic events in AD...
  6. ncbi request reprint Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease
    Yan Yang
    Alzheimer Research Laboratory, University Hospitals of Cleveland and Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106, USA
    J Neurosci 23:2557-63. 2003
    ..The implication of the findings for human clinical trials is discussed...
  7. pmc Cyclin dependent kinase 5 is required for the normal development of oligodendrocytes and myelin formation
    Yan Yang
    Department of Neurology, Case Western Reserve University, School of Medicine, 10900 Euclid, Ave, Cleveland, OH 44106, United States
    Dev Biol 378:94-106. 2013
    ..Together, these findings suggest that Cdk5 function as a signaling integrator to regulate oligodendrocyte maturation and myelination...
  8. ncbi request reprint Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus
    Herve Lerat
    Department of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, Texas 77555 1019, USA
    Gastroenterology 122:352-65. 2002
    ..The aim of this study was to determine whether expression of hepatitis C virus proteins alters hepatic morphology or function in the absence of inflammation...
  9. pmc Nuclear localization of Cdk5 is a key determinant in the postmitotic state of neurons
    Jie Zhang
    Department of Cell Biology and Neuroscience, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 105:8772-7. 2008
    ..We propose that the nuclear Cdk5 plays an active role in allowing neurons to remain postmitotic as they mature and that loss of nuclear Cdk5 leads to cell cycle entry...
  10. ncbi request reprint Mice carrying the szt1 mutation exhibit increased seizure susceptibility and altered sensitivity to compounds acting at the m-channel
    James F Otto
    Anticonvulsant Drug Development Program, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
    Epilepsia 45:1009-16. 2004
    ....
  11. ncbi request reprint Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?
    Karl Herrup
    Department of Cell Biology and Neuroscience, Rutgers University, 604 Allison Road, Piscataway, New Jersey 08854, USA
    Nat Rev Neurosci 8:368-78. 2007
    ..Failure of cell cycle regulation might be a root cause of several neurodegenerative disorders and a final common pathway for others...
  12. ncbi request reprint [Effects of ectogenous FHIT gene on reversing malignant phenotype of human lung adenocarcinoma cells A549]
    Yun Wang
    Department of Thoraco Cardiac Surgery, West China Hospital, Basic Medical College, Cancer Institute, West China Hospital Sichuan University, Chengdu, Sichuan, 610041 P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 19:225-9. 2002
    ..To explore the role of fragile histidine triad(FHIT) gene in the proliferation, apoptosis and tumorigenesis of human lung cancer cells...
  13. ncbi request reprint Influence of sex, high-fat diet, and exercise training on potassium currents of swine coronary smooth muscle
    Yan Yang
    Department of Biomedical Science, University of Missouri Columbia, Columbia, MO 65211, USA
    Am J Physiol Heart Circ Physiol 293:H1553-63. 2007
    ..Importantly, HF reduced I(K) in males and females and nullified effects of EX, suggesting HF abrogates beneficial effects of EX on coronary smooth muscle...
  14. ncbi request reprint Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models
    Xiaoming Xie
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Cell 12:52-65. 2007
    ....
  15. ncbi request reprint Advances in SELEX and application of aptamers in the central nervous system
    Yan Yang
    Experimental Medical Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Biomol Eng 24:583-92. 2007
    ..This review presents recent advances in the field of SELEX with special emphasis on applications of aptamers as analytical, diagnostic and therapeutic tools in the central nervous system...
  16. ncbi request reprint Expression of PTEN, PPM1A and P-Smad2 in hepatocellular carcinomas and adjacent liver tissues
    Shu Kun Wu
    Division of Clinical Immunology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefangdadao, Wuhan, Hubei Province, China
    World J Gastroenterol 13:4554-9. 2007
    ..To investigate the expressions of PTEN, PPM1A and P-Smad2 in hepatocellular carcinoma (HCC) and their significance...
  17. doi request reprint Corollary discharge circuits for saccadic modulation of the pigeon visual system
    Yan Yang
    Laboratory for Visual Information Processing, State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China
    Nat Neurosci 11:595-602. 2008
    ..These signals might have important roles in visual perception...
  18. ncbi request reprint CEACAM1 regulates insulin clearance in liver
    Matthew N Poy
    Department of Pharmacology, 3035 Arlington Avenue, HSci Building Room 270, Toledo, Ohio 43614, USA
    Nat Genet 30:270-6. 2002
    ..These findings suggest a mechanism through which insulin signaling regulates insulin sensitivity by modulating hepatic insulin clearance...
  19. ncbi request reprint Prevention of hepatic injury by a traditional Chinese formulation, BJ-JN, in mice treated with Bacille-Calmette-Guérin and lipopolysaccharide
    Yuhong Zou
    School of Pharmacy, Anhui Medical University, Hefei, Anhui, China
    J Ethnopharmacol 107:442-8. 2006
    ..These results suggest that BJ-JN has a protective and therapeutic effect on ILI mice, which might be associated with its antioxidant properties, ability to reduce NO production and immunoregulatory function...
  20. ncbi request reprint A spontaneous mutation involving Kcnq2 (Kv7.2) reduces M-current density and spike frequency adaptation in mouse CA1 neurons
    James F Otto
    Anticonvulsant Drug Development Program, Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA
    J Neurosci 26:2053-9. 2006
    ..Finally, the changes in single-cell biophysical properties likely underlie the altered seizure threshold and pharmacosensitivity reported previously in Szt1 mice...
  21. ncbi request reprint Severe epilepsy resulting from genetic interaction between Scn2a and Kcnq2
    Jennifer A Kearney
    Department of Human Genetics, 4909 Buhl Building 0618, 1241 E Catherine Street, Ann Arbor, MI 48109 0618, USA
    Hum Mol Genet 15:1043-8. 2006
    ..In a screen of 23 SMEI patients with missense mutations of SCN1A, no second-site mutations in KCNQ2 were identified...
  22. ncbi request reprint Genetic approaches to studying mouse models of human seizure disorders
    Yan Yang
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Adv Exp Med Biol 548:1-11. 2004
    ....
  23. ncbi request reprint Interaction between altered insulin and lipid metabolism in CEACAM1-inactive transgenic mice
    Tong Dai
    Departments of Pharmacology and Therapeutics, Medical College of Ohio, Toledo, Ohio 43614, USA
    J Biol Chem 279:45155-61. 2004
    ..Taken together, these data suggest that chronic elevation in plasma FFAs levels contributes to the regulation of insulin metabolism and action in L-SACC1 mice...
  24. ncbi request reprint GDF-3 is an adipogenic cytokine under high fat dietary condition
    Wei Wang
    Human Genome Sciences, Inc, 9410 Key West Avenue, Rockville, MD 20850, USA
    Biochem Biophys Res Commun 321:1024-31. 2004
    ..In contrast, similar phenotypes were not observed in GDF-3 mice fed with normal chow, indicating that GDF-3 is only active under high lipid load. Thus, GDF-3 is a new non-diabetic adipogenic factor tightly coupled with fat metabolism...
  25. ncbi request reprint Anti-aging effect of astragalosides and its mechanism of action
    Hong Lei
    Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, China
    Acta Pharmacol Sin 24:230-4. 2003
    ..To study the anti-aging effect of astragalosides (AST) and its mechanism of action...
  26. ncbi request reprint A chimeric GB virus B with 5' nontranslated RNA sequence from hepatitis C virus causes hepatitis in tamarins
    Rene Rijnbrand
    Department of Microbiology and Immunology and Institute for Human Infections and Immunity, The University of Texas Medical Branch, Galveston, TX 77555 1019, USA
    Hepatology 41:986-94. 2005
    ..In conclusion, such novel chimeric flaviviruses offer opportunities for new insights into HCV replication mechanisms, while potentially facilitating the evaluation of candidate therapeutics in vivo...
  27. ncbi request reprint A microtubule associated protein (hNUDC) binds to the extracellular domain of thrombopoietin receptor (Mpl)
    Rui Min Pan
    Biotechnology Research Center, The Key Laboratory of Gene Engineering of Education Ministry, Zhongshan University, Guangzhou 510275, China
    J Cell Biochem 96:741-50. 2005
    ..Substantial colocalization of hNUDC with microtubules was also detected around nuclei and elongated microtubular structures, especially in proplatelet extensions...
  28. ncbi request reprint A rostrocaudal muscular dystrophy caused by a defect in choline kinase beta, the first enzyme in phosphatidylcholine biosynthesis
    Roger B Sher
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Biol Chem 281:4938-48. 2006
    ..The rmd mutant mouse offers the first demonstration of a defect in a phospholipid biosynthetic enzyme causing muscular dystrophy, representing a unique model for understanding mechanisms of muscle degeneration...
  29. ncbi request reprint Differential modulation of thalamic neurons by optokinetic nuclei in the pigeon
    Peng Cao
    Laboratory for Visual Information Processing, State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, PR China
    Brain Res 1069:159-65. 2006
    ..The results suggest that these optokinetic nuclei may dually modulate the transfer of visual information from the retina to the telencephalon at the thalamic level during eye movements...
  30. ncbi request reprint Mechanisms of inducible nitric oxide synthase (iNOS) inhibition-related improvement of gut mucosal acidosis during hyperdynamic porcine endotoxemia
    Antje Pittner
    Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Universitatsklinikum, Parkstrasse 11, 89073 Ulm, Germany
    Intensive Care Med 29:312-6. 2003
    ..To determine the mechanisms of improved gut mucosal acidosis associated with selective inducible nitric oxide synthase (iNOS) inhibition...
  31. ncbi request reprint Functional characterization of hNUDC as a novel accumulator that specifically acts on in vitro megakaryocytopoiesis and in vivo platelet production
    Ming Xu Wei
    State Key Laboratory of Biocontrol, Biotechnology Research Center, Zhongshan University, Guangzhou, The People s Republic of China
    J Cell Biochem 98:429-39. 2006
    ..In vivo experiments further demonstrate that the administration of hNUDC substantially enhance the number of circulating platelets in normal mice...
  32. ncbi request reprint Experimental study on therapeutic effect of in vivo expression of Cell I-Hep II recombinant polypeptide of fibronectin on murine H22 hepatocellular carcinoma
    Gui Mei Zhang
    Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
    World J Gastroenterol 9:1940-5. 2003
    ....