Genomes and Genes
Affiliation: Case Western Reserve University
- Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse modelsYan Yang
Department of Neurology, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
J Neurosci 26:775-84. 2006..Finally, the relative timing suggests that neither the activated microglia nor the amyloid plaques themselves are necessary to initiate the pathogenic events in AD...
- Cell division in the CNS: protective response or lethal event in post-mitotic neurons?Yan Yang
Department of Neurology, University Hospitals of Cleveland, Alzheimer Research Lab, E504, Case Western Reserve University School of Medicine, 10900 Euclid Avenue Cleveland, OH 44106, USA
Biochim Biophys Acta 1772:457-66. 2007..What is not known is whether, in an adult neuron, the cell cycle event is part of the pathology or rather a desperate attempt of a neuron under stress to protect itself...
- DNA damage and cell cycle events implicate cerebellar dentate nucleus neurons as targets of Alzheimer's diseaseJianmin Chen
Dept, of Cell Biology and Neuroscience, Rutgers University, 604 Allison Road, Piscataway, NJ 08854, USA
Mol Neurodegener 5:60. 2010..abstract:..
- NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer diseaseNicholas H Varvel
Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA
J Clin Invest 119:3692-702. 2009....
- Loss of neuronal cell cycle control in ataxia-telangiectasia: a unified disease mechanismYan Yang
Department of Neurology, Alzheimer Research Laboratory E504, Case School of Medicine, Cleveland, Ohio 44106, USA
J Neurosci 25:2522-9. 2005..These results suggest that loss of cell cycle control represents a common disease mechanism that underlies the defects in the affected tissues in both human and mouse diseases...
- Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's diseaseYan Yang
Alzheimer Research Laboratory, University Hospitals of Cleveland and Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106, USA
J Neurosci 23:2557-63. 2003..The implication of the findings for human clinical trials is discussed...
- Cyclin dependent kinase 5 is required for the normal development of oligodendrocytes and myelin formationYan Yang
Department of Neurology, Case Western Reserve University, School of Medicine, 10900 Euclid, Ave, Cleveland, OH 44106, United States
Dev Biol 378:94-106. 2013..Together, these findings suggest that Cdk5 function as a signaling integrator to regulate oligodendrocyte maturation and myelination...