Chao Xing

Summary

Affiliation: Case Western Reserve University
Country: USA

Publications

  1. pmc Comparison of missing data approaches in linkage analysis
    Chao Xing
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
    BMC Genet 4:S44. 2003
  2. ncbi request reprint Localization and replication of the systemic lupus erythematosus linkage signal at 4p16: interaction with 2p11, 12q24 and 19q13 in European Americans
    Chao Xing
    Division of Genetic and Molecular Epidemiology, Department of Biostatistics and Epidemiology, Case Western Reserve University, Wolstein Research Building Rm 1312, 10900 Euclid Avenue, Cleveland, OH 44106 7281, USA
    Hum Genet 120:623-31. 2007
  3. pmc Comparison of microsatellites, single-nucleotide polymorphisms (SNPs) and composite markers derived from SNPs in linkage analysis
    Chao Xing
    Department of Epidemiology and Biostatistics, Wolstein Research Building, Case Western Reserve University, Cleveland, OH 44106, USA
    BMC Genet 6:S29. 2005
  4. pmc The affected-/discordant-sib-pair design can guarantee validity of multipoint model-free linkage analysis of incomplete pedigrees when there is marker-marker disequilibrium
    Chao Xing
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH 44106, USA
    Am J Hum Genet 79:396-401. 2006
  5. ncbi request reprint Genetic linkage of systemic lupus erythematosus to 13q32 in African American families with affected male members
    Chao Xing
    Division of Genetic and Molecular Epidemiology, Department of Biostatistics and Epidemiology, Case Western Reserve University, Wolstein Research Building Rm 1312, 10900 Euclid Avenue, Cleveland, OH, 44106 7281, USA
    Hum Genet 118:309-21. 2005
  6. pmc Linkage analysis of alcohol dependence using both affected and discordant sib pairs
    Pei Ying Shih
    Department of Epidemiology and Biostatistics, Case Western Reserve University, 2103 Cornell Road, Wolstein Research Building, Cleveland, OH 44106, USA
    BMC Genet 6:S36. 2005
  7. pmc Linkage studies of catechol-O-methyltransferase (COMT) and dopamine-beta-hydroxylase (DBH) cDNA expression levels
    Chao Xing
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Wolstein Research Building 2103, Cornell Drive, Cleveland, Ohio 44106, USA
    BMC Proc 1:S95. 2007
  8. ncbi request reprint Distribution and magnitude of type I error of model-based multipoint lod scores: implications for multipoint mod scores
    Chao Xing
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Genet Epidemiol 30:447-58. 2006
  9. pmc A logistic mixture model for a family-based association study
    Guan Xing
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    BMC Proc 1:S44. 2007
  10. ncbi request reprint Genome-wide linkage study of retinal vessel diameters in the Beaver Dam Eye Study
    Chao Xing
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    Hypertension 47:797-802. 2006

Detail Information

Publications15

  1. pmc Comparison of missing data approaches in linkage analysis
    Chao Xing
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
    BMC Genet 4:S44. 2003
    ..Therefore, we compare here six methods of imputing missing repeated phenotypes on results from genome-wide linkage analyses of four quantitative traits from the Framingham Heart Study cohort...
  2. ncbi request reprint Localization and replication of the systemic lupus erythematosus linkage signal at 4p16: interaction with 2p11, 12q24 and 19q13 in European Americans
    Chao Xing
    Division of Genetic and Molecular Epidemiology, Department of Biostatistics and Epidemiology, Case Western Reserve University, Wolstein Research Building Rm 1312, 10900 Euclid Avenue, Cleveland, OH 44106 7281, USA
    Hum Genet 120:623-31. 2007
    ..These results provide important additional information about the SLE linkage effect at 4p16 and offer a unique approach to uncovering susceptibility loci involved in complex human diseases...
  3. pmc Comparison of microsatellites, single-nucleotide polymorphisms (SNPs) and composite markers derived from SNPs in linkage analysis
    Chao Xing
    Department of Epidemiology and Biostatistics, Wolstein Research Building, Case Western Reserve University, Cleveland, OH 44106, USA
    BMC Genet 6:S29. 2005
    ..Considering all factors, such as information content, flexibility of analysis method, map errors, and genotyping errors, a map of clustered SNPs can be an efficient design for a genome-wide linkage scan...
  4. pmc The affected-/discordant-sib-pair design can guarantee validity of multipoint model-free linkage analysis of incomplete pedigrees when there is marker-marker disequilibrium
    Chao Xing
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH 44106, USA
    Am J Hum Genet 79:396-401. 2006
    ..We advocate the ASP/DSP design with appropriate sib-pair statistics that test the difference in allele sharing between ASPs and DSPs...
  5. ncbi request reprint Genetic linkage of systemic lupus erythematosus to 13q32 in African American families with affected male members
    Chao Xing
    Division of Genetic and Molecular Epidemiology, Department of Biostatistics and Epidemiology, Case Western Reserve University, Wolstein Research Building Rm 1312, 10900 Euclid Avenue, Cleveland, OH, 44106 7281, USA
    Hum Genet 118:309-21. 2005
    ....
  6. pmc Linkage analysis of alcohol dependence using both affected and discordant sib pairs
    Pei Ying Shih
    Department of Epidemiology and Biostatistics, Case Western Reserve University, 2103 Cornell Road, Wolstein Research Building, Cleveland, OH 44106, USA
    BMC Genet 6:S36. 2005
    ..Further, it works better than the conventional LOD score ASP linkage method in these data in the sense of avoiding false-positive linkage evidence...
  7. pmc Linkage studies of catechol-O-methyltransferase (COMT) and dopamine-beta-hydroxylase (DBH) cDNA expression levels
    Chao Xing
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Wolstein Research Building 2103, Cornell Drive, Cleveland, Ohio 44106, USA
    BMC Proc 1:S95. 2007
    ..We also found that chromosome 19p13 showed both additive and interactive effects with 9q34 on DBH expression level. Furthermore, a potential interaction between COMT and DBH was indicated...
  8. ncbi request reprint Distribution and magnitude of type I error of model-based multipoint lod scores: implications for multipoint mod scores
    Chao Xing
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Genet Epidemiol 30:447-58. 2006
    ..Therefore, caution should be taken in interpreting results when employing multipoint lod score and mod score approaches, in particular when inferring the level of linkage significance and the mode of inheritance of a trait...
  9. pmc A logistic mixture model for a family-based association study
    Guan Xing
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    BMC Proc 1:S44. 2007
    ..The simplest version of the model only takes monogenic inheritance into account, but analysis of the GAW simulation data shows that even this simple model can be powerful for complex traits...
  10. ncbi request reprint Genome-wide linkage study of retinal vessel diameters in the Beaver Dam Eye Study
    Chao Xing
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA
    Hypertension 47:797-802. 2006
    ..In summary, we provide evidence demonstrating that genetic factors independent of hypertension affect retinal vessel diameters...
  11. pmc Adult-onset pulmonary fibrosis caused by mutations in telomerase
    Kalliopi D Tsakiri
    McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:7552-7. 2007
    ..Thus, mutations in TERT or TERC that result in telomere shortening over time confer a dramatic increase in susceptibility to adult-onset IPF...
  12. ncbi request reprint Using linkage and association to identify and model genetic effects: summary of GAW15 Group 4
    Qiong Yang
    Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Boston, MA 02118, USA
    Genet Epidemiol 31:S34-42. 2007
    ..Finally, modeling the disease using association evidence conditional on linkage may improve understanding of the etiology of disease...
  13. ncbi request reprint Summary of Genetic Analysis Workshop 15: Group 9 linkage analysis of the CEPH expression data
    Ellen M Wijsman
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Genet Epidemiol 31:S75-85. 2007
    ..Finally, there were computational and analytic challenges in working with a large public data set, along with need for more data documentation...
  14. pmc Refined mapping of X-linked reticulate pigmentary disorder and sequencing of candidate genes
    Lane J Jaeckle Santos
    McDermott Center for Human Growth and Development, The University of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75390 8591, USA
    Hum Genet 123:469-76. 2008
    ..PDR is most likely due to a mutation within the linked interval not affecting currently annotated coding exons...
  15. pmc Telomere shortening in familial and sporadic pulmonary fibrosis
    Jennifer T Cronkhite
    Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, TX 75390 8591, USA
    Am J Respir Crit Care Med 178:729-37. 2008
    ..Heterozygous mutations in the coding regions of the telomerase genes, TERT and TERC, have been found in familial and sporadic cases of idiopathic interstitial pneumonia. All affected patients with mutations have short telomeres...