Jackson T Wright
Affiliation: Case Western Reserve University
- Design and statistical aspects of the African American Study of Kidney Disease and Hypertension (AASK)Jennifer J Gassman
Cleveland Clinic Department of Biostatistics, Ohio, 44195, USA
J Am Soc Nephrol 14:S154-65. 2003..The main secondary patient outcome is a composite including the following events: (1) reduction in GFR by 50%, (2) end-stage renal disease, or (3) death...
- Prevention of cardiovascular disease in hypertensive patients with normal renal functionJ T Wright
Department of Medicine, Case Western Reserve University, School of Medicine, University Hospitals of Cleveland, OH 44106 4982, USA
Am J Kidney Dis 32:S66-79. 1998..However, with only 25% of hypertensive patients controlled to less than 140/90 mm Hg, achieving blood pressure control remains the most important goal in managing hypertension in this population...
- Determinants of salt sensitivity in black and white normotensive and hypertensive womenJackson T Wright
Department of Medicine, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Louis Stokes Cleveland VAMC, 11100 Euclid Ave, RB and C 7311, Cleveland, OH 44106 5041, USA
Hypertension 42:1087-92. 2003..In AA but not in whites, SS is positively associated with Na+i, Ca2+i, and the ratios of Na+i to K+i and of Ca2+i to Mg2+i...
- Antihypertensive efficacy of night-time graded-release diltiazem versus morning amlodipine in African AmericansJackson T Wright
Department of Medicine, Division of Hypertension, Case Western Reserve University, Cleveland, Ohio, USA
Am J Hypertens 17:734-42. 2004....
- Optimal treatment of hypertension and cardiovascular risk reduction in African Americans: treatment approaches for outpatientsJackson T Wright
Clinical Hypertension Program, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH 44106 4982, USA
J Clin Hypertens (Greenwich) 5:18-25. 2003....
- Effect of blood pressure lowering and antihypertensive drug class on progression of hypertensive kidney disease: results from the AASK trialJackson T Wright
Case Western Reserve University, Department of Medicine, University Hospitals of Cleveland and the Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106 5014, USA
JAMA 288:2421-31. 2002..Hypertension is a leading cause of end-stage renal disease (ESRD) in the United States, with no known treatment to prevent progressive declines leading to ESRD...
- The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT): clinical center recruitment experienceJ T Wright
Clinical Hypertension Program, Division of Hypertension, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106 4982, USA
Control Clin Trials 22:659-73. 2001..More than 22% of the principal investigators reported that they had no previous clinical research experience. In summary, ALLHAT was successful in recruiting a diverse group of clinical centers to achieve its patient recruitment goals...
- Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis: a randomized controlled trialL Y Agodoa
Case Western Reserve University, Clinical Hypertension Program, University Hospitals of Cleveland and the Louis Stokes Cleveland Veterans Affairs Medical Center, 10900 Euclid Ave, Wood Bldg Room W 165, Cleveland, OH 44106 4982, USA
JAMA 285:2719-28. 2001..Incidence of end-stage renal disease due to hypertension has increased in recent decades, but the optimal strategy for treatment of hypertension to prevent renal failure is unknown, especially among African Americans...
- Long-term renal and cardiovascular outcomes in Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) participants by baseline estimated GFRMahboob Rahman
Division of Nephrology and Hypertension, Case Western Reserve University, University Hospitals Case Medical Center, USA
Clin J Am Soc Nephrol 7:989-1002. 2012....
- Renal outcomes in hypertensive Black patients at high cardiovascular riskMatthew R Weir
Division of Nephrology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Kidney Int 81:568-76. 2012..Blacks have a modestly higher increased risk for more advanced increases in serum creatinine than non-Blacks...
- Cardiovascular outcomes in high-risk hypertensive patients stratified by baseline glomerular filtration rateMahboob Rahman
Case Western Reserve University, Cleveland, Ohio, USA
Ann Intern Med 144:172-80. 2006..Neither amlodipine nor lisinopril is superior to chlorthalidone in preventing CHD, stroke, or combined CVD, and chlorthalidone is superior to both for preventing heart failure, independent of level of renal function...
- Limitations of analyses based on achieved blood pressure: lessons from the African American study of kidney disease and hypertension trialEsa M Davis
Department of Medicine and Center for Research on Health Care, University of Pittsburgh, School of Medicine, 230 McKee Place, Suite 600, Pittsburgh, PA 15213, USA
Hypertension 57:1061-8. 2011..Clinicians and policy makers should exercise caution when making treatment recommendations based on analyses relating outcomes to achieved BP...
- A trial of 2 strategies to reduce nocturnal blood pressure in blacks with chronic kidney diseaseMahboob Rahman
Division of Nephrology and Hypertension, Case Western Reserve University, University Hospitals Case Medical Center, Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA
Hypertension 61:82-8. 2013....
- Kidney function can improve in patients with hypertensive CKDBo Hu
Cleveland Clinic, Cleveland, OH 44195, USA
J Am Soc Nephrol 23:706-13. 2012..In conclusion, the extended follow-up from this study provides strong evidence that kidney function can improve in some patients with hypertensive CKD...
- Longitudinal progression trajectory of GFR among patients with CKDLiang Li
Department of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH 44139, USA
Am J Kidney Dis 59:504-12. 2012..We describe individual GFR progression trajectories over 12 years of follow-up in participants in the African American Study of Kidney Disease and Hypertension (AASK)...
- Renal outcomes in high-risk hypertensive patients treated with an angiotensin-converting enzyme inhibitor or a calcium channel blocker vs a diuretic: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)Mahboob Rahman
Division of Nephrology and Hypertension, Case Western Reserve University, University Hospitals of Cleveland, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA
Arch Intern Med 165:936-46. 2005..Participants assigned to receive amlodipine had a higher GFR than those assigned to receive chlorthalidone, but rates of development of ESRD were not different between the groups...
- Malnutrition-inflammation modifies the relationship of cholesterol with cardiovascular diseaseGabriel Contreras
Department of Medicine, Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, 1120 NW 14th Street, Suite 360E, Miami, FL 33136, USA
J Am Soc Nephrol 21:2131-42. 2010..In the M-I group, the corresponding HRs did not vary significantly by cholesterol level. In conclusion, the presence of M-I modifies the risk relationship between cholesterol level and CVD in African Americans with hypertensive CKD...
- Sociodemographic factors contribute to the depressive affect among African Americans with chronic kidney diseaseMichael J Fischer
Department of Medicine, Jesse Brown VA Medical Center and University of Illinois Medical Center, Chicago, Illinois, USA
Kidney Int 77:1010-9. 2010..Sociodemographic factors have especially strong associations with this increased depressive affect. Because this study was conducted in an African-American cohort, its findings may not be generalized to other ethnic groups...
- Clinical outcomes by race in hypertensive patients with and without the metabolic syndrome: Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)Jackson T Wright
Department of Medicine, General Clinical Research Center, Cleveland, Ohio, USA
Arch Intern Med 168:207-17. 2008....
- Lowering blood pressure with beta-blockers in combination with other renin-angiotensin system blockers in patients with hypertension and type 2 diabetes: results from the GEMINI TrialJackson T Wright
Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA
J Clin Hypertens (Greenwich) 9:842-9. 2007..The use of carvedilol compared with metoprolol did not effect glycemic control...
- Rate of ESRD exceeds mortality among African Americans with hypertensive nephrosclerosisTahira P Alves
Department of Medicine, Division of Nephrology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
J Am Soc Nephrol 21:1361-9. 2010..In conclusion, AASK participants were more likely to reach ESRD than to die...
- Outcomes in hypertensive black and nonblack patients treated with chlorthalidone, amlodipine, and lisinoprilJackson T Wright
General Clinical Research Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
JAMA 293:1595-608. 2005..Few cardiovascular outcome data are available for blacks with hypertension treated with angiotensin-converting enzyme (ACE) inhibitors or calcium channel blockers (CCBs)...
- Successful blood pressure control in the African American Study of Kidney Disease and HypertensionJackson T Wright
Department of Medicine, Division of Hypertension, Case Western Reserve University, 10900 Euclid Ave, Wood Bldg, Room W-165, Cleveland, OH 44106-4982, USA
Arch Intern Med 162:1636-43. 2002..CONCLUSION: The blood pressure goals set and achieved in AASK participants clearly demonstrate that adequate blood pressure control can be achieved even in hypertensive populations whose blood pressure is the most difficult to control...
- 24-Hour ambulatory blood pressure response to combination valsartan/hydrochlorothiazide and amlodipine/hydrochlorothiazide in stage 2 hypertension by ethnicity: the EVALUATE studyJackson T Wright
Case Western Reserve University, Cleveland, OH, USA
J Clin Hypertens (Greenwich) 12:833-40. 2010..9/-9.7 vs -14.2/-7.2; P=.20/P=.17). Based on ABP monitoring, valsartan/HCTZ is more effective than amlodipine/HCTZ in lowering ABP in Caucasians. In African Americans and Hispanics, both regimens are similarly effective...
- The management of hypertension in the African American patientJackson T Wright
Medicine, Case Western Reserve University, Cleveland, OH, USA
J Clin Hypertens (Greenwich) 9:468-75. 2007..The authors maintained full control of the discussion and the resulting content of this article; Novartis had no input in the choice of topic, speakers, or content...
- Cardiovascular risk reduction in hypertensive black patients with left ventricular hypertrophy: the LIFE studyStevo Julius
Department of Internal Medicine, Division of Hypertension, University of Michigan Medical Center, 3918 Taubman Center, Ann Arbor, MI 48109 0356, USA
J Am Coll Cardiol 43:1047-55. 2004..We report on a subanalysis of the effects of losartan and atenolol on cardiovascular events in black patients in the Losartan Intervention For Endpoint reduction in hypertension (LIFE) study...
- The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 reportAram V Chobanian
Department of Medicine, Boston University School of Medicine, Boston, Mass, USA
JAMA 289:2560-72. 2003..Empathy builds trust and is a potent motivator. Finally, in presenting these guidelines, the committee recognizes that the responsible physician's judgment remains paramount...
- Cardiovascular disease among hispanics and non-hispanics in the chronic renal insufficiency cohort (CRIC) studyAna C Ricardo
Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
Clin J Am Soc Nephrol 6:2121-31. 2011..Hispanics are the largest minority group in the United States. The leading cause of death in patients with chronic kidney disease (CKD) is cardiovascular disease (CVD), yet little is known about its prevalence among Hispanics with CKD...
- Ethnic differences in electrocardiographic criteria for left ventricular hypertrophy: the LIFE study. Losartan Intervention For EndpointPeter M Okin
Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
Am J Hypertens 15:663-71. 2002..However, the high mortality associated with LVH in African American patients makes more accurate ECG detection of LVH in these patients a clinical priority...
- Which drug should be used to treat patients with uncomplicated essential hypertension?Arash Rashidi
Division of Nephrology and Hypertension, University Hospitals of Cleveland, Louis Stokes Cleveland VA Medical Center, Case Western Reserve University, Cleveland, OH 44106 5401, USA
Curr Opin Nephrol Hypertens 15:303-8. 2006..To review recent data and guidelines on selecting the initial antihypertensive drug...
- Drug treatment of hypertension in older hypertensivesArash Rashidi
Department of Medicine, Case Western Reserve University, 29325 Health Campus Drive, Suit 3, Westlake, Ohio 44145, USA
Clin Geriatr Med 25:235-44. 2009..This article reviews the evidence for drug treatment in this population...
- A comparison of standardized versus "usual" blood pressure measurements in hemodialysis patientsMahboob Rahman
Department of Medicine, Division of Hypertension, Case Western Reserve University University Hospitals of Cleveland, Cleveland, OH 44106, USA
Am J Kidney Dis 39:1226-30. 2002..In light of these findings, efforts should be made to standardize blood pressure readings in hemodialysis units based on American Heart Association recommendations for blood pressure measurement...
- A 59-year-old man with racial characteristicsJackson T Wright
General Clinical Research Center and Division of Nephrology and Hypertension, Case Western University, Cleveland, OH, USA
J Clin Hypertens (Greenwich) 9:128-33. 2007
- Chronic kidney disease and cognitive function in older adults: findings from the chronic renal insufficiency cohort cognitive studyKristine Yaffe
Department of Psychiatry, School of Medicine, University of California at San Francisco, San Francisco, California, USA
J Am Geriatr Soc 58:338-45. 2010....
- Diuretic-induced increase in blood glucose levels: clinical implicationsJackson T Wright
General Clinical Research Center, Clinical Hypertension Program, Case Western Reserve University, Cleveland, OH 44106, USA
J Cardiometab Syndr 2:133-5. 2007
- Metabolic syndrome, components, and cardiovascular disease prevalence in chronic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) StudyRaymond R Townsend
Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, 19104, USA
Am J Nephrol 33:477-84. 2011..We determined metabolic syndrome prevalence among individuals with a broad spectrum of kidney dysfunction, examining the role of the individual elements of metabolic syndrome and their relationship to prevalent CVD...
- Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trialVibha Bhatnagar
University of California San Diego, La Jolla, USA
J Hypertens 25:2082-92. 2007..It has yet to be determined whether genotyping at the angiotensin-converting enzyme (ACE) locus is predictive of blood pressure response to an ACE inhibitor...
- Metabolic and clinical outcomes in nondiabetic individuals with the metabolic syndrome assigned to chlorthalidone, amlodipine, or lisinopril as initial treatment for hypertension: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Henry R Black
New York University School of Medicine, New York, New York, USA
Diabetes Care 31:353-60. 2008..Optimal initial antihypertensive drug therapy in people with the metabolic syndrome is unknown...
- Relationship of antihypertensive treatment regimens and change in blood pressure to risk for heart failure in hypertensive patients randomly assigned to doxazosin or chlorthalidone: further analyses from the Antihypertensive and Lipid-Lowering treatment tBarry R Davis
The University of Texas School of Public Health, 1200 Herman Pressler Street, Houston, TX 77030, USA
Ann Intern Med 137:313-20. 2002..Sixty-eight percent (6167 of 9061) of the former patients and 59% (9081 of 15 256) of the latter patients were given additional medications to achieve a target blood pressure of less than 140/90 mm Hg...
- Antihypertensive use and adherence and blood pressure stress response among black caregivers and non-caregiversJalpa A Doshi
University of Maryland, School of Pharmacy, Baltimore, MD 21201, USA
Appl Nurs Res 16:266-77. 2003..These findings contradict previous findings among white caregivers and non-caregivers and suggest different practice implications...
- Angiotensin-converting-enzyme inhibitors and diuretics for hypertensionBarry R Davis
N Engl J Med 349:90-3; author reply 90-3. 2003
- Success and predictors of blood pressure control in diverse North American settings: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT)William C Cushman
J Clin Hypertens (Greenwich) 4:393-404. 2002..It is likely that the majority of people with hypertension could achieve a blood pressure <140/90 mm Hg with the antihypertensive medications available today...
- The rationale and design of the AASK cohort studyLawrence J Appel
Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland, 21205, USA
J Am Soc Nephrol 14:S166-72. 2003..Such results might eventually lead to new strategies that delay or prevent ESRD...
- Should ethnicity serve as the basis for clinical trial design? Importance of race/ethnicity in clinical trials: lessons from the African-American Heart Failure Trial (A-HeFT), the African-American Study of Kidney Disease and Hypertension (AASK), and the AAnne L Taylor
National Center of Excellence in Women s Health, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Circulation 112:3654-60; discussion 3666. 2005
- Blood pressure control in Hispanics in the antihypertensive and lipid-lowering treatment to prevent heart attack trialKaren L Margolis
HealthPartners Research Foundation PO Box 1524, Mailstop 21111R, Minneapolis, MN 55440 1524, USA
Hypertension 50:854-61. 2007....
- Body weight changes with beta-blocker use: results from GEMINIFranz H Messerli
St Luke s Roosevelt Hospital Center, New York City, NY 10019, USA
Am J Med 120:610-5. 2007....
- A comparison of iothalamate-GFR and serum creatinine-based outcomes: acceleration in the rate of GFR decline in the African American Study of Kidney Disease and HypertensionJulia Lewis
Nephrology Clinical Trials Center, Vanderbilt University Medical Center, 1211 21st Avenue South, 215 Medical Arts Building, Nashville, TN 37232 1371, USA
J Am Soc Nephrol 15:3175-83. 2004..This has important implications for the design of clinical trials with renal outcomes...
- The rationale and design of the Glycemic Effects in Diabetes Mellitus Carvedilol-Metoprolol Comparison in Hypertensives (GEMINI) trialGeorge L Bakris
Rush Hypertension Center, Rush Medical Center, Suite 470, 1700 W Van Buren, Chicago, IL 60612, USA
J Diabetes Complications 19:74-9. 2005..The GEMINI trial, therefore, is the first large randomized trial to assess whether utilizing a third-generation beta-blocker yields a favorable metabolic profile in the patient with Type 2 diabetes and hypertension...
- Clinical problems in the management of hypertension 1) Prehypertension: should we treat? 2)The very elderly: how should we treatMarvin Moser
Yale University School of Medicine, New Haven, CT, USA
J Clin Hypertens (Greenwich) 6:262-6. 2004
- Long-term effects of renin-angiotensin system-blocking therapy and a low blood pressure goal on progression of hypertensive chronic kidney disease in African AmericansLawrence J Appel
Welch Center for Prevention, Epidemiology, and Clinical Research, The Johns Hopkins Institutions, Johns Hopkins University, Baltimore, MD 21205 2223, USA
Arch Intern Med 168:832-9. 2008..A low blood pressure (BP) goal (BP, <130/80 mm Hg) is also recommended. The objective of this study was to determine the long-term effects of currently recommended BP therapy in 1094 African Americans with hypertensive CKD...
- Differential effects of beta-blockers on albuminuria in patients with type 2 diabetesGeorge L Bakris
Rush University Medical Center, Chicago, IL 60612, USA
Hypertension 46:1309-15. 2005..These differences cannot be explained by effects on blood pressure or alpha1-antagonism but may relate to antioxidant properties of carvedilol...
- Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood PressureAram V Chobanian
Boston University School of Medicine, Boston, Mass, USA
Hypertension 42:1206-52. 2003..Positive experiences, trust in the clinician, and empathy improve patient motivation and satisfaction. This report serves as a guide, and the committee continues to recognize that the responsible physician's judgment remains paramount...
- Differing effects of antihypertensive drugs on the incidence of diabetes mellitus among patients with hypertensive kidney diseaseDenyse Thornley-Brown
Division of Nephrology, University of Alabama at Birmingham, USA
Arch Intern Med 166:797-805. 2006..We compared the incidence of type 2 diabetes mellitus (DM) and the composite outcome of impaired fasting glucose or DM (IFG/DM) for the African American Study of Kidney Disease and Hypertension interventions...
- Metabolic effects of carvedilol vs metoprolol in patients with type 2 diabetes mellitus and hypertension: a randomized controlled trialGeorge L Bakris
Department of Preventive Medicine, Rush University Medical Center, Chicago, Ill, USA
JAMA 292:2227-36. 2004..The effects of the 2 beta-blockers on clinical outcomes need to be compared in long-term clinical trials...
- Cardiovascular outcomes in the African American Study of Kidney Disease and Hypertension (AASK) TrialKeith Norris
Charles R Drew University of Medicine and Science, Lynwood, CA 90262, USA
Am J Kidney Dis 48:739-51. 2006..Patients with chronic kidney disease are at increased risk for cardiovascular (CV) events...
- Clinical events in high-risk hypertensive patients randomly assigned to calcium channel blocker versus angiotensin-converting enzyme inhibitor in the antihypertensive and lipid-lowering treatment to prevent heart attack trialFrans H H Leenen
University of Ottawa Heart Institute, Ottawa, Ontario, Canada
Hypertension 48:374-84. 2006..Some, but not all, of these differences may be explained by less effective blood pressure control in the lisinopril arm...
- The metabolic syndrome: recognition and managementW Dallas Hall
Emory University School of Medicine, Atlanta, GA, USA
Dis Manag 9:16-33. 2006..Pharmacotherapy is typically needed for control of high blood pressure, hypercoagulability, and increased levels of blood glucose and triglycerides...
- Engaging black older adults and caregivers in urban communities in health researchPicotSandraJ Fulton
School of Nursing, University of Maryland, Baltimore 21201, USA
J Gerontol Nurs 28:19-27. 2002..This model was used in a recent study of Black older adults and their caregivers and will be described in this article. Effectively engaging Black individuals in health research is essential for improving their health...
- The Metabolic Syndrome in African Americans: a reviewW Dallas Hall
African American Lipid and Cardiovascular Council, USA
Ethn Dis 13:414-28. 2003..This comprehensive review is provided as part of the educational activities of the African-American Lipid and Cardiovascular Council (AALCC)...
- ALLHAT: setting the record straightBarry R Davis
The University of Texas Health Science Center at Houston School of Public Health, Houston, Texas 77030, USA
Ann Intern Med 141:39-46. 2004....
- Task Force 5: systemic hypertensionNorman M Kaplan
J Am Coll Cardiol 45:1346-8. 2005
- Ethnicity and blood pressureSuzanne Oparil
Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
J Clin Hypertens (Greenwich) 7:357-64. 2005..This brief review will discuss recent findings that bear on the management of hypertension in these special patient groups...
- How to treat hypertension in patients with coronary heart disease diseaseMarvin Moser
Yale University School of Medicine, New Haven, CT, USA
J Clin Hypertens (Greenwich) 10:390-7. 2008....
- Thiazide-induced dysglycemia: call for research from a working group from the national heart, lung, and blood instituteBarry L Carter
Division of Clinical and Administrative Pharmacy, Rm 527, College of Pharmacy, University of Iowa, Iowa City, IA 52242, USA
Hypertension 52:30-6. 2008
- For the patient. What is the Metabolic Syndrome and why is it important?W Dallas Hall
Ethn Dis 13:546. 2003
- The Chronic Renal Insufficiency Cohort (CRIC) Study: Design and MethodsHarold I Feldman
Center for Clinical Epidemiology, Philadelphia, 19104, USA
J Am Soc Nephrol 14:S148-53. 2003..Insights from CRIC should lead to the formulation of hypotheses regarding therapy that will serve as the basis for targeted interventional trials focused on reducing the burden of CRI and CVD...